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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:K-252a
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Accession:CHEBI:43616 term browser browse the term
Definition:A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a
Synonyms:exact_synonym: methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate
 related_synonym: Antibiotic K 252a;   Antibiotic SF 2370;   Formula=C27H21N3O5;   InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1;   InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N;   K252a;   SF 2370;   SMILES=COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
 xref: CAS:99533-80-9;   PDBeChem:KSA;   PMID:24356881;   PMID:24406154;   PMID:24612679;   PMID:3759657;   Reaxys:7419675


show annotations for term's descendants           Sort by:
KT 5720 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] CTD PMID:21908651 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO KT 5720 results in decreased activity of ABCB1 protein CTD PMID:15725475 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP		 KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 protein]
KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]		 CTD PMID:26049102 PMID:29052767 PMID:31300867 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium] CTD PMID:15365637 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:31300867 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form] CTD PMID:26049102 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 KT 5720 inhibits the reaction [cilostazol results in increased activity of CASP3 protein]; KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]
KT 5720 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]		 CTD PMID:20131233 PMID:21873648 PMID:32115946 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5720 affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]; Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]] CTD PMID:10860942 PMID:16439611 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP KT 5720 binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO KT 5720 inhibits the reaction [Isoproterenol results in increased expression of CIDEC protein] CTD PMID:21097823 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein] CTD PMID:24254769 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein] CTD PMID:24254769 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]] CTD PMID:15264218 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA1 mRNA] CTD PMID:26049102 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA2 mRNA] CTD PMID:26049102 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA4 mRNA] CTD PMID:26049102 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 KT 5720 inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]
Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]		 CTD PMID:16439612 PMID:24003391 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]] CTD PMID:21457779 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein modified form]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein] CTD PMID:26049102 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein] CTD PMID:21908651 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]] CTD PMID:11675405 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]] CTD PMID:11675405 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17438462 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nucb2 nucleobindin 2 multiple interactions EXP KT 5720 inhibits the reaction [NUCB2 protein results in increased import of Calcium] CTD PMID:17627999 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353 		JBrowse link
G Pla2g6 phospholipase A2 group VI multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP KT 5720 inhibits the reaction [Bucladesine results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein] CTD PMID:31300867 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [KT 5720 co-treated with Dinoprostone] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; KT 5720 affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:24003391 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] CTD PMID:24254769 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA] CTD PMID:21969073 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions		 EXP KT 5720 results in decreased expression of TH mRNA
KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]		 CTD PMID:18992715 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA] CTD PMID:11675405 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP KT 5720 inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA] CTD PMID:29649498 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Ucn urocortin multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] CTD PMID:21969073 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        antimicrobial agent 18062
          K-252a 43
            KT 5720 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      carboxylic acid 18622
                                        carboacyl group 17704
                                          univalent carboacyl group 17704
                                            carbamoyl group 17550
                                              carboxamide 17550
                                                lactam 8384
                                                  gamma-lactam 6637
                                                    K-252a 43
                                                      KT 5720 43
paths to the root