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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-(1H-indol-3-yl)propanoic acid
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Accession:CHEBI:43580 term browser browse the term
Definition:An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.
Synonyms:related_synonym: Formula=C11H11NO2;   InChI=1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14);   InChIKey=GOLXRNDWAUTYKT-UHFFFAOYSA-N;   Indole-3-propionic acid;   Indolepropionic acid;   SMILES=OC(=O)CCc1c[nH]c2ccccc12;   beta-(3-Indolyl)propionic acid
 xref: CAS:830-96-6;   HMDB:HMDB0002302
 xref_mesh: MESH:C015292
 xref: PDBeChem:IOP;   PMID:12212784;   PMID:14606996;   PMID:21307383;   PMID:22885049;   PMID:24510403;   Reaxys:147733
 cyclic_relationship: is_conjugate_acid_of CHEBI:82916


show annotations for term's descendants           Sort by:
3-(1H-indol-3-yl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-(1H-indol-3-yl)propanoic acid inhibits the reaction [indoxyl sulfate increases expression of mRNA, protein] in HK-2 human kidney proximal tubule cell line RGD PMID:29238104 RGD:401793752 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 3-(1H-indol-3-yl)propanoic acid inhibits the reaction [indoxyl sulfate increases expression of mRNA, protein] in HK-2 human kidney proximal tubule cell line RGD PMID:29238104 RGD:401793752 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 3-(1H-indol-3-yl)propanoic acid inhibits the reaction [indoxyl sulfate increases expression of mRNA, protein] in HK-2 human kidney proximal tubule cell line RGD PMID:29238104 RGD:401793752 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO indolepropionic acid analog results in increased expression of NFKBIA protein CTD PMID:23499788 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO indolepropionic acid analog results in increased cleavage of PARP1 protein CTD PMID:23499788 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 3-(1H-indol-3-yl)propanoic acid inhibits the reaction [indoxyl sulfate increases expression and increases phosphorylation of Stat3] in HK-2 human kidney proximal tubule cell line RGD PMID:29238104 RGD:401793752 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 3-(1H-indol-3-yl)propanoic acid inhibits the reaction [indoxyl sulfate increases expression of mRNA, protein] in HK-2 human kidney proximal tubule cell line RGD PMID:29238104 RGD:401793752 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        molecular messenger 18659
          hormone 18489
            plant hormone 8874
              auxin 1591
                3-(1H-indol-3-yl)propanoic acid 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      benzopyrrole 9739
                                        indoles 9427
                                          indolyl carboxylic acid 3463
                                            indol-3-yl carboxylic acid 3462
                                              3-(1H-indol-3-yl)propanoic acid 7
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