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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
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Accession:CHEBI:43561 term browser browse the term
Definition:An isoquinoline that has formula C12H15N3O2S.
Synonyms:related_synonym: Formula=C12H15N3O2S;   InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3;   InChIKey=PJWUXKNZVMEPPH-UHFFFAOYSA-N;   N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide;   SMILES=CNCCNS(=O)(=O)c1cccc2cnccc12
 xref: Beilstein:6337250;   CAS:84478-11-5;   DrugBank:DB07997;   LINCS:LSM-2410
 xref_mesh: MESH:C053177
 xref: PDBeChem:IQS


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N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polr2a RNA polymerase II subunit A multiple interactions
decreases phosphorylation
ISO sodium arsenite inhibits the reaction [N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of POLR2A protein] CTD PMID:8126066 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          sulfur atom 16297
            sulfur molecular entity 16297
              organosulfur compound 15227
                sulfonamide 3181
                  N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              oxoacid 18243
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11095
                                    sulfonic acid 7347
                                      sulfonic acid derivative 7347
                                        sulfonamide 3181
                                          N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
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