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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
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Accession:CHEBI:43561 term browser browse the term
Definition:An isoquinoline that has formula C12H15N3O2S.
Synonyms:related_synonym: Formula=C12H15N3O2S;   InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3;   InChIKey=PJWUXKNZVMEPPH-UHFFFAOYSA-N;   N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide;   SMILES=CNCCNS(=O)(=O)c1cccc2cnccc12
 xref: Beilstein:6337250;   CAS:84478-11-5;   DrugBank:DB07997;   LINCS:LSM-2410
 xref_mesh: MESH:C053177
 xref: PDBeChem:IQS



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N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polr2a RNA polymerase II subunit A multiple interactions
decreases phosphorylation
ISO sodium arsenite inhibits the reaction [N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of POLR2A protein] CTD PMID:8126066 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          sulfur atom 16418
            sulfur molecular entity 16418
              organosulfur compound 15318
                sulfonamide 3196
                  N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                chalcogen oxoacid 11498
                                  sulfur oxoacid 11106
                                    sulfonic acid 7371
                                      sulfonic acid derivative 7371
                                        sulfonamide 3196
                                          N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide 2
paths to the root