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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein] |
CTD |
PMID:16452108 |
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NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA] |
CTD |
PMID:7900855 |
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NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
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G |
Adra1d |
adrenoceptor alpha 1D |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1D mRNA] |
CTD |
PMID:7900855 |
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NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1D mRNA] |
CTD |
PMID:7900855 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
decreases activity |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of ALPL protein |
CTD |
PMID:11171635 |
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NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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G |
Aqp4 |
aquaporin 4 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA] |
CTD |
PMID:22298391 |
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NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
decreases expression multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased expression of ATP1B1 mRNA 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] |
CTD |
PMID:11204457 |
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NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
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G |
Cd69 |
Cd69 molecule |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Silicon Dioxide results in increased expression of CD69 protein] |
CTD |
PMID:15790520 |
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NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
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G |
Cntf |
ciliary neurotrophic factor |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] |
CTD |
PMID:11882386 |
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NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:9013560 PMID:16081525 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions increases expression |
EXP |
[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein |
CTD |
PMID:15767673 |
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NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein] |
CTD |
PMID:15654655 |
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NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein] |
CTD |
PMID:15654655 |
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NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] |
CTD |
PMID:7945571 |
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NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lead results in increased expression of FOS mRNA] 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin results in increased expression of FOS mRNA] 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA] |
CTD |
PMID:1932749 PMID:7945571 PMID:10381381 PMID:10693946 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Gdf15 |
growth differentiation factor 15 |
multiple interactions |
ISO |
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein] |
CTD |
PMID:23996089 |
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NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] |
CTD |
PMID:12755590 |
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NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] |
CTD |
PMID:26275128 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hrh2 |
histamine receptor H 2 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dimaprit results in increased expression of HRH2 mRNA] |
CTD |
PMID:9187264 |
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NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein] |
CTD |
PMID:11164475 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA] 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Paraquat results in increased expression of JUN mRNA] |
CTD |
PMID:7662713 PMID:7945571 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [5,8,11,14-Eicosatetraynoic Acid analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Arachidonic Acid analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [ciprofibrate analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Clofibrate results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [pirinixic acid results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Thapsigargin analog results in increased expression of JUNB mRNA] |
CTD |
PMID:1932749 PMID:8764118 |
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NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein |
CTD |
PMID:14654170 |
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NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions decreases phosphorylation |
ISO |
[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K2 protein |
CTD |
PMID:14654170 |
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NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
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G |
Mt1 |
metallothionein 1 |
multiple interactions decreases expression |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Copper results in increased activity of MT1 promoter]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased expression of MT1 mRNA |
CTD |
PMID:11551972 PMID:14576086 PMID:15142038 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Pla2g4a |
phospholipase A2 group IVA |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:18938131 |
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NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] |
CTD |
PMID:14678745 |
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NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] |
CTD |
PMID:14678745 |
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NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18305957 PMID:18938131 PMID:19063610 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] |
CTD |
PMID:8940178 |
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NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
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G |
Slc30a1 |
solute carrier family 30 member 1 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] |
CTD |
PMID:15142038 |
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NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] |
CTD |
PMID:11882386 |
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NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] |
CTD |
PMID:11882386 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tert |
telomerase reverse transcriptase |
decreases activity |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of TERT protein |
CTD |
PMID:9434777 |
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NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases activity |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of TGFB1 protein |
CTD |
PMID:8940178 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] |
CTD |
PMID:16716901 |
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NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein; [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein; [TNF protein co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] results in increased activity of NFKB protein 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA] |
CTD |
PMID:14654170 PMID:22298391 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Tonsl |
tonsoku-like, DNA repair protein |
multiple interactions |
ISO |
[TNF protein co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] results in increased activity of NFKB protein |
CTD |
PMID:14654170 |
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NCBI chr 7:117,688,397...117,703,139
Ensembl chr 7:117,688,397...117,703,094
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] |
CTD |
PMID:19063610 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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