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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-(2-methylpiperazine-1-sulfonyl)isoquinoline
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Accession:CHEBI:43385 term browser browse the term
Definition:A N-sulfonylpiperazine that has formula C14H17N3O2S.
Synonyms:related_synonym: 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE;   1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine;   Formula=C14H17N3O2S;   InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3;   InChIKey=BDVFVCGFMNCYPV-UHFFFAOYSA-N;   SMILES=CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
 xref: Beilstein:5482740;   CAS:84477-87-2;   DrugBank:DB07996
 xref_mesh: MESH:D019307
 xref: PDBeChem:IQP

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5-(2-methylpiperazine-1-sulfonyl)isoquinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein] CTD PMID:16452108 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA] CTD PMID:7900855 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1D mRNA] CTD PMID:7900855 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1D mRNA] CTD PMID:7900855 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases activity EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of ALPL protein CTD PMID:11171635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA] CTD PMID:22298391 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression
multiple interactions		 EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased expression of ATP1B1 mRNA
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]		 CTD PMID:11204457 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Silicon Dioxide results in increased expression of CD69 protein] CTD PMID:15790520 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA] CTD PMID:9013560 PMID:16081525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
increases expression		 EXP [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein		 CTD PMID:15767673 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein] CTD PMID:15654655 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein] CTD PMID:15654655 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lead results in increased expression of FOS mRNA]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin results in increased expression of FOS mRNA]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]		 CTD PMID:1932749 PMID:7945571 PMID:10381381 PMID:10693946 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein] CTD PMID:23996089 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] CTD PMID:12755590 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dimaprit results in increased expression of HRH2 mRNA] CTD PMID:9187264 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein] CTD PMID:11164475 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Paraquat results in increased expression of JUN mRNA]		 CTD PMID:7662713 PMID:7945571 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [5,8,11,14-Eicosatetraynoic Acid analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Arachidonic Acid analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Calcimycin results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [ciprofibrate analog results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Clofibrate results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [pirinixic acid results in increased expression of JUNB mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Thapsigargin analog results in increased expression of JUNB mRNA] CTD PMID:1932749 PMID:8764118 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases phosphorylation		 ISO [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein		 CTD PMID:14654170 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions
decreases phosphorylation		 ISO [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K2 protein		 CTD PMID:14654170 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Copper results in increased activity of MT1 promoter]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased expression of MT1 mRNA		 CTD PMID:11551972 PMID:14576086 PMID:15142038 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] CTD PMID:18938131 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] CTD PMID:14678745 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] CTD PMID:14678745 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 protein]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:18305957 PMID:18938131 PMID:19063610 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] CTD PMID:8940178 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] CTD PMID:11882386 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of TERT protein CTD PMID:9434777 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of TGFB1 protein		 CTD PMID:8940178 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein; [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K2 protein; [TNF protein co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] results in increased activity of NFKB protein
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA]		 CTD PMID:14654170 PMID:22298391 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tonsl tonsoku-like, DNA repair protein multiple interactions ISO [TNF protein co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] results in increased activity of NFKB protein CTD PMID:14654170 NCBI chr 7:117,688,397...117,703,139
Ensembl chr 7:117,688,397...117,703,094 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:19063610 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                organonitrogen heterocyclic compound 17526
                  isoquinolines 440
                    5-(2-methylpiperazine-1-sulfonyl)isoquinoline 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      chalcogen 19391
                        oxygen atom 19354
                          oxygen molecular entity 19354
                            hydroxides 19077
                              oxoacid 18278
                                chalcogen oxoacid 11495
                                  sulfur oxoacid 11101
                                    sulfonic acid 7355
                                      sulfonic acid derivative 7355
                                        sulfonamide 3190
                                          N-sulfonylpiperazine 39
                                            5-(2-methylpiperazine-1-sulfonyl)isoquinoline 39
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