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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Indican inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] |
CTD |
PMID:21483698 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] |
CTD |
PMID:21483698 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ace |
angiotensin I converting enzyme |
increases expression |
EXP |
Indican results in increased expression of ACE mRNA |
CTD |
PMID:25056788 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases expression increases activity |
ISO |
Flavones inhibits the reaction [Indican results in increased activity of AHR protein]; Indican binds to and results in increased activity of AHR protein; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Indican results in increased expression of AHR mRNA] Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] |
CTD |
PMID:20000589 PMID:21493753 PMID:23639249 PMID:26259605 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] |
CTD |
PMID:26259605 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Casp3 |
caspase 3 |
increases cleavage |
EXP |
Indican results in increased cleavage of CASP3 protein |
CTD |
PMID:25056788 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
Indican results in increased expression of CCL2 mRNA; Indican results in increased expression of CCL2 protein |
CTD |
PMID:22056374 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
multiple interactions |
ISO |
Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] |
CTD |
PMID:26259605 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
Indican results in increased expression of CDKN1A protein Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] |
CTD |
PMID:29734669 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Indican results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20000589 PMID:23639249 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
ISO |
Indican results in increased expression of CYP1A2 mRNA |
CTD |
PMID:20000589 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
Indican results in increased expression of CYP1B1 mRNA |
CTD |
PMID:20000589 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression |
ISO |
Indican results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:30639138 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
ISO |
Indican results in increased phosphorylation of EIF2S1 protein Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:29380555 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Indican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein] |
CTD |
PMID:21863063 |
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NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
Indican inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]; Indican inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] |
CTD |
PMID:21863063 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Indican results in increased expression of FBXO32 protein]; pyrazolanthrone inhibits the reaction [Indican results in increased expression of FBXO32 protein] Indican results in increased expression of FBXO32 mRNA; Indican results in increased expression of FBXO32 protein |
CTD |
PMID:29380555 PMID:30849338 |
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NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions decreases expression |
EXP |
Indican results in decreased expression of and affects the localization of GJA1 protein; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA] Indican results in decreased expression of GJA1 mRNA; Indican results in decreased expression of GJA1 protein modified form |
CTD |
PMID:32045570 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Indican inhibits the reaction [cobaltous chloride affects the localization of HIF1A protein] |
CTD |
PMID:21863063 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Indican results in increased expression of HSPA5 mRNA |
CTD |
PMID:29380555 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
Indican results in increased expression of ICAM1 mRNA; Indican results in increased expression of ICAM1 protein |
CTD |
PMID:22056374 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Kl |
Klotho |
multiple interactions decreases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]; Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]; isohelenin inhibits the reaction [Indican results in decreased expression of KL mRNA]; isohelenin inhibits the reaction [Indican results in decreased expression of KL protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL protein] Indican results in decreased expression of KL mRNA; Indican results in decreased expression of KL protein |
CTD |
PMID:21389697 |
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NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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G |
Lepr |
leptin receptor |
affects abundance |
ISO |
LEPR affects the abundance of Indican |
CTD |
PMID:20567778 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
ISO |
Indican results in increased expression of MAP1LC3B protein Acetylcysteine inhibits the reaction [Indican results in increased expression of MAP1LC3B protein] |
CTD |
PMID:30849338 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:30849338 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Indican results in increased phosphorylation of MAPK3 protein Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:30849338 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO EXP |
Indican results in increased expression of and results in increased phosphorylation of MAPK8 protein Indican results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:30849338 PMID:32045570 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
EXP |
Indican results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:32045570 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Myh2 |
myosin heavy chain 2 |
decreases expression |
ISO |
Indican results in decreased expression of MYH2 mRNA |
CTD |
PMID:29380555 |
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NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236
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G |
Myh3 |
myosin heavy chain 3 |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYH3 protein] |
CTD |
PMID:29380555 |
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NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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G |
Myh7 |
myosin heavy chain 7 |
increases expression |
EXP |
Indican results in increased expression of MYH7 mRNA |
CTD |
PMID:25703824 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myl9 |
myosin light chain 9 |
multiple interactions |
ISO |
Indican results in decreased expression of and results in increased phosphorylation of MYL9 protein |
CTD |
PMID:30849338 |
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NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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G |
Myod1 |
myogenic differentiation 1 |
decreases expression |
ISO |
Indican results in decreased expression of MYOD1 protein |
CTD |
PMID:29380555 |
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NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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G |
Myog |
myogenin |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYOG protein] Indican results in decreased expression of MYOG mRNA; Indican results in decreased expression of MYOG protein |
CTD |
PMID:29380555 |
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NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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G |
Nox4 |
NADPH oxidase 4 |
increases expression |
ISO |
Indican results in increased expression of NOX4 mRNA |
CTD |
PMID:23325087 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nppa |
natriuretic peptide A |
increases expression |
EXP |
Indican results in increased expression of NPPA mRNA |
CTD |
PMID:25703824 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
increases expression |
EXP |
Indican results in increased expression of NPPB mRNA |
CTD |
PMID:25703824 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Prnp |
prion protein |
multiple interactions |
ISO |
PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] |
CTD |
PMID:29734669 |
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NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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G |
Ren |
renin |
increases expression |
EXP |
Indican results in increased expression of REN mRNA |
CTD |
PMID:25056788 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Rgn |
regucalcin |
decreases expression multiple interactions |
ISO |
Indican results in decreased expression of RGN protein Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] |
CTD |
PMID:29734669 |
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NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
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G |
Rorc |
RAR-related orphan receptor C |
increases expression |
ISO |
Indican results in increased expression of RORC mRNA |
CTD |
PMID:23639249 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression |
ISO |
Indican results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:30639138 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
decreases expression |
ISO |
Indican results in decreased expression of SLCO1B3 mRNA |
CTD |
PMID:30639138 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Slco3a1 |
solute carrier organic anion transporter family, member 3a1 |
multiple interactions |
ISO |
Indican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] |
CTD |
PMID:28887287 |
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NCBI chr 1:128,115,184...128,387,887
Ensembl chr 1:128,106,228...128,387,925
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions increases phosphorylation |
ISO |
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of SRC protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:23639249 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein]; Indican results in increased phosphorylation of and results in increased activity of STAT3 protein |
CTD |
PMID:23639249 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions decreases expression decreases response to substance |
EXP |
AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA] UCP2 protein results in decreased susceptibility to Indican |
CTD |
PMID:25703824 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
Indican results in increased expression of UGT1A1 mRNA |
CTD |
PMID:20000589 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
ISO |
Indican results in increased expression of UGT1A6 mRNA |
CTD |
PMID:20000589 |
|
NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
ISO |
Indican results in increased expression of VCAM1 mRNA; Indican results in increased expression of VCAM1 protein |
CTD |
PMID:22056374 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Xbp1 |
X-box binding protein 1 |
increases splicing |
ISO |
Indican results in increased splicing of XBP1 mRNA |
CTD |
PMID:29380555 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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