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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indoline
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Accession:CHEBI:43295 term browser browse the term
Definition:An indole that has formula C8H9N.
Synonyms:related_synonym: 2,3-dihydro-1H-indole;   Formula=C8H9N;   InChI=1S/C8H9N/c1-2-4-8-7(3-1)5-6-9-8/h1-4,9H,5-6H2;   InChIKey=LPAGFVYQRIESJQ-UHFFFAOYSA-N;   SMILES=C1Cc2ccccc2N1;   dihydroindole
 alt_id: CHEBI:33071;   CHEBI:43292;   CHEBI:471711
 xref: Beilstein:111915;   CAS:496-15-1;   Gmelin:27284
 xref_mesh: MESH:C057812
 xref: PDBeChem:IDM;   PMID:17378546



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indoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of indoline CTD PMID:17502430 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]] CTD PMID:34351043 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL6 protein]] CTD PMID:34351043 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Thiazoles analog binds to indoline analog] inhibits the reaction [SESN2 protein promotes the reaction [Hydrogen Peroxide results in increased activity of NFE2L2 protein]]; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein]]; [Thiazoles analog binds to indoline analog] which results in decreased activity of NFE2L2 protein CTD PMID:32275923 PMID:34351043 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 multiple interactions EXP [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein]]; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL6 protein]]; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TNF protein]] CTD PMID:34351043 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP [Thiazoles analog binds to indoline analog] inhibits the reaction [SESN2 protein promotes the reaction [Hydrogen Peroxide results in increased activity of NFE2L2 protein]] CTD PMID:32275923 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TNF protein]] CTD PMID:34351043 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      atom 19738
        nonmetal atom 19678
          nitrogen atom 18877
            nitrogen molecular entity 18877
              organonitrogen compound 18712
                organonitrogen heterocyclic compound 17995
                  benzopyrrole 9603
                    indoles 9275
                      indoline 7
                        3,5,6-trihydroxyindoline 0
                        leukoaminochrome 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  organic heteropolycyclic compound 18254
                                    organic heterobicyclic compound 17226
                                      benzopyrrole 9603
                                        indoles 9275
                                          indoline 7
                                            3,5,6-trihydroxyindoline 0
                                            leukoaminochrome 0
paths to the root