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ONTOLOGY REPORT - ANNOTATIONS


Term:dapsone
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Accession:CHEBI:4325 term browser browse the term
Definition:A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
Synonyms:exact_synonym: 4,4'-sulfonyldianiline
 related_synonym: 1,1'-sulfonylbis(4-aminobenzene);   4,4'-Sulfonylbisbenzenamine;   4,4'-dapsone;   4,4'-diaminodiphenyl sulfone;   4,4'-sulfonylbisaniline;   4-(4-amino-benzenesulfonyl)-phenylamine;   4-(4-aminophenylsulfonyl)aniline;   4-(4-aminophenylsulfonyl)benzenamine;   4-aminophenyl sulfone;   Bis(p-aminophenyl) sulfone;   DADPS;   DDS;   DIAPHENYLSULFONE;   Formula=C12H12N2O2S;   InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2;   InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N;   SMILES=Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1;   bis(4-aminophenyl)sulfone;   dapsona;   dapsonum;   p,p'-diaminodiphenyl sulfone;   p,p-sulphonylbisbenzamine;   p,p-sulphonylbisbenzenamine;   p-aminophenyl sulfone
 alt_id: CHEBI:226356
 xref: Beilstein:788055;   CAS:80-08-0;   DrugBank:DB00250;   Drug_Central:782;   HMDB:HMDB0014395;   KEGG:C07666;   KEGG:D00592;   LINCS:LSM-5714
 xref_mesh: MESH:D003622
 xref: PMID:16361748;   PMID:18035772;   PMID:24232126;   PMID:24512442;   PMID:28434260;   PMID:28699887;   PMID:28732451;   PMID:29045131;   PMID:29192974;   PMID:29192999;   PMID:29233746;   PMID:29280553;   Patent:FR829926;   Reaxys:788055;   Wikipedia:Dapsone


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dapsone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cxcr4 chemokine (C-X-C motif) receptor 4 JBrowse link 1 128,588,199 128,592,299 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 JBrowse link 19 39,287,044 39,330,713 RGD:6480464
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 JBrowse link 19 39,389,556 39,463,103 RGD:6480464
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 JBrowse link 19 39,061,006 39,093,948 RGD:6480464
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 JBrowse link 19 39,113,898 39,186,756 RGD:6480464
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 JBrowse link 15 82,370,527 82,380,260 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Elk4 ELK4, member of ETS oncogene family JBrowse link 1 132,007,565 132,026,448 RGD:6480464
G Fkbp5 FK506 binding protein 5 JBrowse link 17 28,398,753 28,486,149 RGD:6480464
G G6pdx glucose-6-phosphate dehydrogenase X-linked JBrowse link X 74,409,483 74,428,880 RGD:6480464
G Greb1 gene regulated by estrogen in breast cancer protein JBrowse link 12 16,670,615 16,801,394 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G Gstp1 glutathione S-transferase, pi 1 JBrowse link 19 4,035,411 4,037,912 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Igf1r insulin-like growth factor I receptor JBrowse link 7 67,952,257 68,233,668 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Maf avian musculoaponeurotic fibrosarcoma oncogene homolog JBrowse link 8 115,703,253 115,706,894 RGD:6480464
G Mak male germ cell-associated kinase JBrowse link 13 41,025,007 41,079,706 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) JBrowse link 8 67,494,875 67,502,644 RGD:6480464
G Nkx3-1 NK3 homeobox 1 JBrowse link 14 69,190,692 69,194,658 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 7 87,244,430 87,398,710 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 15 101,253,902 101,274,795 RGD:6480464
G Per1 period circadian clock 1 JBrowse link 11 69,095,108 69,109,965 RGD:6480464
G Plcb2 phospholipase C, beta 2 JBrowse link 2 118,705,003 118,728,661 RGD:6480464
G Prkd1 protein kinase D1 JBrowse link 12 50,341,226 50,649,271 RGD:6480464
G Prmt1 protein arginine N-methyltransferase 1 JBrowse link 7 44,976,755 44,986,420 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Slc4a2 solute carrier family 4 (anion exchanger), member 2 JBrowse link 5 24,423,761 24,440,947 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tmprss2 transmembrane protease, serine 2 JBrowse link 16 97,564,682 97,659,541 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21270
    role 21254
      application 20691
        anti-inflammatory agent 15412
          anti-inflammatory drug 13996
            dapsone 41
              acedapsone 0
              monoacetyldapsone 0
              nitroso-dapsone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21270
    subatomic particle 21266
      composite particle 21266
        hadron 21266
          baryon 21266
            nucleon 21266
              atomic nucleus 21266
                atom 21266
                  main group element atom 21135
                    main group molecular entity 21135
                      s-block molecular entity 20610
                        hydrogen molecular entity 20521
                          hydrides 19489
                            inorganic hydride 17598
                              pnictogen hydride 17549
                                nitrogen hydride 17364
                                  azane 17235
                                    ammonia 17234
                                      organic amino compound 17233
                                        aromatic amine 14042
                                          anilines 12602
                                            substituted aniline 12090
                                              dapsone 41
                                                acedapsone 0
                                                monoacetyldapsone 0
                                                nitroso-dapsone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.