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ONTOLOGY REPORT - ANNOTATIONS


Term:dapsone
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Accession:CHEBI:4325 term browser browse the term
Definition:A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
Synonyms:exact_synonym: 4,4'-sulfonyldianiline
 related_synonym: 1,1'-sulfonylbis(4-aminobenzene);   4,4'-Sulfonylbisbenzenamine;   4,4'-dapsone;   4,4'-diaminodiphenyl sulfone;   4,4'-sulfonylbisaniline;   4-(4-amino-benzenesulfonyl)-phenylamine;   4-(4-aminophenylsulfonyl)aniline;   4-(4-aminophenylsulfonyl)benzenamine;   4-aminophenyl sulfone;   Bis(p-aminophenyl) sulfone;   DADPS;   DDS;   DIAPHENYLSULFONE;   Formula=C12H12N2O2S;   InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2;   InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N;   SMILES=Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1;   bis(4-aminophenyl)sulfone;   dapsona;   dapsonum;   p,p'-diaminodiphenyl sulfone;   p,p-sulphonylbisbenzamine;   p,p-sulphonylbisbenzenamine;   p-aminophenyl sulfone
 alt_id: CHEBI:226356
 xref: Beilstein:788055;   CAS:80-08-0;   DrugBank:DB00250;   Drug_Central:782;   HMDB:HMDB0014395;   KEGG:C07666;   KEGG:D00592;   LINCS:LSM-5714
 xref_mesh: MESH:D003622
 xref: PMID:16361748;   PMID:18035772;   PMID:24232126;   PMID:24512442;   PMID:28434260;   PMID:28699887;   PMID:28732451;   PMID:29045131;   PMID:29192974;   PMID:29192999;   PMID:29233746;   PMID:29280553;   Patent:FR829926;   Reaxys:788055;   Wikipedia:Dapsone


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dapsone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCC2 ATP binding cassette subfamily C member 2 JBrowse link 10 99,782,602 99,853,741 RGD:6480464
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:6480464
G CCL3 C-C motif chemokine ligand 3 JBrowse link 17 36,088,256 36,090,143 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G CXCR4 C-X-C motif chemokine receptor 4 JBrowse link 2 136,114,349 136,118,149 RGD:6480464
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 JBrowse link 15 74,719,542 74,725,528 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 JBrowse link 10 94,762,681 94,855,547 RGD:6480464
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 JBrowse link 10 95,036,772 95,069,497 RGD:6480464
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 JBrowse link 10 94,938,658 94,990,091 RGD:6480464
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 JBrowse link 22 42,126,499 42,130,810 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G ELK4 ETS transcription factor ELK4 JBrowse link 1 205,607,943 205,632,872 RGD:6480464
G FKBP5 FKBP prolyl isomerase 5 JBrowse link 6 35,573,585 35,728,583 RGD:6480464
G G6PD glucose-6-phosphate dehydrogenase JBrowse link X 154,531,390 154,547,569 RGD:6480464
G GREB1 growth regulating estrogen receptor binding 1 JBrowse link 2 11,481,675 11,642,788 RGD:6480464
G GSR glutathione-disulfide reductase JBrowse link 8 30,678,061 30,727,999 RGD:6480464
G GSTP1 glutathione S-transferase pi 1 JBrowse link 11 67,583,812 67,586,653 RGD:6480464
G IFNG interferon gamma JBrowse link 12 68,154,768 68,159,740 RGD:6480464
G IGF1R insulin like growth factor 1 receptor JBrowse link 15 98,648,539 98,964,530 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL2 interleukin 2 JBrowse link 4 122,451,470 122,456,725 RGD:6480464
G MAF MAF bZIP transcription factor JBrowse link 16 79,202,624 79,601,952 RGD:6480464
G MAK male germ cell associated kinase JBrowse link 6 10,762,723 10,838,954 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G NAT2 N-acetyltransferase 2 JBrowse link 8 18,386,585 18,401,219 RGD:6480464
G NKX3-1 NK3 homeobox 1 JBrowse link 8 23,678,693 23,682,938 RGD:6480464
G NOX4 NADPH oxidase 4 JBrowse link 11 89,324,353 89,589,557 RGD:6480464
G NR4A1 nuclear receptor subfamily 4 group A member 1 JBrowse link 12 52,022,832 52,059,507 RGD:6480464
G PER1 period circadian regulator 1 JBrowse link 17 8,140,470 8,156,360 RGD:6480464
G PLCB2 phospholipase C beta 2 JBrowse link 15 40,285,496 40,307,945 RGD:6480464
G PRKD1 protein kinase D1 JBrowse link 14 29,576,479 29,927,847 RGD:6480464
G PRMT1 protein arginine methyltransferase 1 JBrowse link 19 49,676,166 49,688,447 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SLC4A2 solute carrier family 4 member 2 JBrowse link 7 151,058,200 151,076,527 RGD:6480464
G SOD2 superoxide dismutase 2 JBrowse link 6 159,669,069 159,762,281 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TMPRSS2 transmembrane serine protease 2 JBrowse link 21 41,464,305 41,508,158 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23948
    role 23836
      application 23245
        anti-inflammatory agent 15968
          anti-inflammatory drug 14505
            dapsone 41
              acedapsone 0
              monoacetyldapsone 0
              nitroso-dapsone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23948
    subatomic particle 23899
      composite particle 23899
        hadron 23899
          baryon 23899
            nucleon 23899
              atomic nucleus 23899
                atom 23899
                  main group element atom 23720
                    main group molecular entity 23720
                      s-block molecular entity 22918
                        hydrogen molecular entity 22714
                          hydrides 20684
                            inorganic hydride 18811
                              pnictogen hydride 18773
                                nitrogen hydride 18476
                                  azane 18334
                                    ammonia 18333
                                      organic amino compound 18332
                                        aromatic amine 14376
                                          anilines 13059
                                            substituted aniline 12477
                                              dapsone 41
                                                acedapsone 0
                                                monoacetyldapsone 0
                                                nitroso-dapsone 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.