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ONTOLOGY REPORT - ANNOTATIONS


Term:dapsone
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Accession:CHEBI:4325 term browser browse the term
Definition:A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
Synonyms:exact_synonym: 4,4'-sulfonyldianiline
 related_synonym: 1,1'-sulfonylbis(4-aminobenzene);   4,4'-Sulfonylbisbenzenamine;   4,4'-dapsone;   4,4'-diaminodiphenyl sulfone;   4,4'-sulfonylbisaniline;   4-(4-amino-benzenesulfonyl)-phenylamine;   4-(4-aminophenylsulfonyl)aniline;   4-(4-aminophenylsulfonyl)benzenamine;   4-aminophenyl sulfone;   Bis(p-aminophenyl) sulfone;   DADPS;   DDS;   DIAPHENYLSULFONE;   Formula=C12H12N2O2S;   InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2;   InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N;   SMILES=Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1;   bis(4-aminophenyl)sulfone;   dapsona;   dapsonum;   p,p'-diaminodiphenyl sulfone;   p,p-sulphonylbisbenzamine;   p,p-sulphonylbisbenzenamine;   p-aminophenyl sulfone
 alt_id: CHEBI:226356
 xref: Beilstein:788055 "Beilstein";   CAS:80-08-0 "ChemIDplus";   CAS:80-08-0 "KEGG COMPOUND";   CAS:80-08-0 "NIST Chemistry WebBook";   DrugBank:DB00250;   Drug_Central:782 "DrugCentral";   HMDB:HMDB0014395;   KEGG:C07666;   KEGG:D00592;   LINCS:LSM-5714
 xref_mesh: MESH:D003622
 xref: PMID:16361748 "Europe PMC";   PMID:18035772 "Europe PMC";   PMID:24232126 "Europe PMC";   PMID:24512442 "Europe PMC";   PMID:28434260 "Europe PMC";   PMID:28699887 "Europe PMC";   PMID:28732451 "Europe PMC";   PMID:29045131 "Europe PMC";   PMID:29192974 "Europe PMC";   PMID:29192999 "Europe PMC";   PMID:29233746 "Europe PMC";   PMID:29280553 "Europe PMC";   Patent:FR829926;   Reaxys:788055 "Reaxys";   Wikipedia:Dapsone


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dapsone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Elk4 ETS transcription factor ELK4 JBrowse link 13 48,788,262 48,813,267 RGD:6480464
G Fkbp5 FKBP prolyl isomerase 5 JBrowse link 20 7,976,704 8,097,290 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Greb1 growth regulating estrogen receptor binding 1 JBrowse link 6 41,932,941 42,002,770 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:6480464
G Mak male germ cell-associated kinase JBrowse link 17 21,531,651 21,567,742 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nat2 N-acetyltransferase 2 JBrowse link 16 23,960,709 23,991,570 RGD:6480464
G Nkx3-1 NK3 homeobox 1 JBrowse link 15 51,065,316 51,067,908 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6480464
G Prkd1 protein kinase D1 JBrowse link 6 71,035,017 71,349,531 RGD:6480464
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc4a2 solute carrier family 4 member 2 JBrowse link 4 7,264,677 7,282,355 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tmprss2 transmembrane serine protease 2 JBrowse link 11 38,063,914 38,103,406 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-inflammatory agent 14907
          anti-inflammatory drug 13590
            dapsone 38
              acedapsone 0
              monoacetyldapsone 0
              nitroso-dapsone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        aromatic amine 13572
                                          anilines 12285
                                            substituted aniline 11780
                                              dapsone 38
                                                acedapsone 0
                                                monoacetyldapsone 0
                                                nitroso-dapsone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.