Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxyflutamide
go back to main search page
Accession:CHEBI:43064 term browser browse the term
Definition:An anilide that has formula C11H11F3N2O4.
Synonyms:alt_id: CHEBI:34793
 xref_mesh: MESH:C014290


show annotations for term's descendants           Sort by:
hydroxyflutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 mRNA]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 protein] CTD PMID:17018655 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP hydroxyflutamide results in increased phosphorylation of AKT1 protein
hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]		 CTD PMID:26437446 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor decreases activity
multiple interactions
affects binding
affects activity
increases response to substance
decreases phosphorylation		 ISO
EXP		 hydroxyflutamide results in decreased activity of AR protein
hydroxyflutamide binds to and results in decreased activity of AR protein; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of AR mRNA]
hydroxyflutamide analog binds to AR protein; hydroxyflutamide binds to AR protein
hydroxyflutamide inhibits the reaction [Metribolone binds to AR protein]
hydroxyflutamide affects the activity of AR protein
[AR protein mutant form results in increased susceptibility to hydroxyflutamide] which results in increased activity of AR protein mutant form; hydroxyflutamide binds to and results in decreased activity of AR protein; hydroxyflutamide binds to and results in increased activity of AR protein; hydroxyflutamide binds to and results in increased activity of AR protein mutant form; hydroxyflutamide inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR mRNA]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR protein]; hydroxyflutamide inhibits the reaction [Cadmium Chloride binds to AR protein]; hydroxyflutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR mRNA]; hydroxyflutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Estradiol results in decreased expression of AR protein]]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; hydroxyflutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Testosterone results in increased phosphorylation of AR protein]; OSM protein promotes the reaction [hydroxyflutamide binds to and results in increased activity of AR protein]
hydroxyflutamide results in decreased phosphorylation of AR protein		 CTD PMID:10053169 PMID:11751618 PMID:11861974 PMID:11861975 PMID:12114440 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Avp arginine vasopressin affects expression EXP hydroxyflutamide affects the expression of AVP mRNA CTD PMID:20810896 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Cdh1 cadherin 1 increases phosphorylation
multiple interactions		 ISO hydroxyflutamide results in increased phosphorylation of CDH1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of CDH1 protein]		 CTD PMID:28163245 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases phosphorylation		 ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein] CTD PMID:28163245 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Ctnnb1 catenin beta 1 decreases phosphorylation
multiple interactions		 ISO hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]		 CTD PMID:28163245 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO hydroxyflutamide results in decreased expression of CYP11A1 mRNA CTD PMID:29556062 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO hydroxyflutamide results in increased expression of CYP17A1 mRNA CTD PMID:29556062 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO hydroxyflutamide binds to and results in increased activity of ESR1 protein; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein] CTD PMID:18275596 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [Testosterone co-treated with hydroxyflutamide] results in decreased expression of GJA1 protein; hydroxyflutamide results in decreased expression of and affects the localization of GJA1 protein; wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein] CTD PMID:26437446 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO hydroxyflutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [BCG Vaccine results in increased expression of IL6 mRNA]] CTD PMID:14532843 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 affects secretion
multiple interactions
increases secretion
decreases expression
affects expression		 ISO hydroxyflutamide affects the secretion of KLK3 protein
hydroxyflutamide inhibits the reaction [1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of KLK3 protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased secretion of KLK3 protein]
hydroxyflutamide results in increased secretion of KLK3 protein
hydroxyflutamide results in decreased expression of KLK3 mRNA
hydroxyflutamide affects the expression of KLK3 mRNA		 CTD PMID:20363314 PMID:25454221 PMID:29556062 PMID:35595151 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 decreases expression ISO hydroxyflutamide results in decreased expression of LCP1 mRNA CTD PMID:29556062 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 EXP
ISO		 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of MAPK1 protein]; hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]
hydroxyflutamide affects the phosphorylation of MAPK1 protein
hydroxyflutamide inhibits the reaction [Testosterone affects the phosphorylation of MAPK1 protein]		 CTD PMID:26437446 PMID:28163245 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
affects phosphorylation		 EXP
ISO		 hydroxyflutamide results in increased phosphorylation of MAPK3 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of MAPK3 protein]; hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]
hydroxyflutamide inhibits the reaction [Testosterone affects the phosphorylation of MAPK3 protein]
hydroxyflutamide affects the phosphorylation of MAPK3 protein		 CTD PMID:26437446 PMID:28163245 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Msmb microseminoprotein, beta decreases expression ISO hydroxyflutamide results in decreased expression of MSMB mRNA CTD PMID:29556062 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO hydroxyflutamide binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Osm oncostatin M multiple interactions ISO OSM protein promotes the reaction [hydroxyflutamide binds to and results in increased activity of AR protein] CTD PMID:12114440 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pip prolactin induced protein multiple interactions
decreases expression		 ISO hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]
hydroxyflutamide results in decreased expression of PIP mRNA		 CTD PMID:10402478 NCBI chr 4:70,787,627...70,791,921
Ensembl chr 4:70,787,627...70,791,921 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hydroxyflutamide binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Pten phosphatase and tensin homolog increases phosphorylation
multiple interactions		 EXP hydroxyflutamide results in increased phosphorylation of PTEN protein
hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of PTEN protein]		 CTD PMID:26437446 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases phosphorylation		 ISO wortmannin promotes the reaction [hydroxyflutamide results in increased phosphorylation of RAF1 protein] CTD PMID:28163245 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Sf1 splicing factor 1 decreases expression ISO hydroxyflutamide results in decreased expression of SF1 mRNA CTD PMID:29556062 NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation
multiple interactions		 EXP hydroxyflutamide results in decreased phosphorylation of SRC protein
hydroxyflutamide inhibits the reaction [Testosterone results in increased phosphorylation of SRC protein]		 CTD PMID:26437446 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO hydroxyflutamide results in decreased expression of SRD5A1 mRNA CTD PMID:29556062 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 multiple interactions ISO hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA] CTD PMID:15056816 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO hydroxyflutamide binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO hydroxyflutamide binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          nitrogen atom 18962
            nitrogen molecular entity 18934
              amide 17755
                aromatic amide 8430
                  anilide 1104
                    hydroxyflutamide 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        primary amino compound 9297
                                          primary amine 6317
                                            primary arylamine 3643
                                              aniline 3481
                                                anilide 1104
                                                  hydroxyflutamide 29
paths to the root