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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dacarbazine
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Accession:CHEBI:4305 term browser browse the term
Definition:A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Synonyms:exact_synonym: 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
 related_synonym: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide;   4-(dimethyltriazeno)imidazole-5-carboxamide;   5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;   5-(3,3-dimethyltriazeno)imidazole-4-carboxamide;   DIC;   DTIC;   Di-me-triazenoimidazolecarboxamide;   Dtic-Dome (TN);   Formula=C6H10N6O;   HSDB 3219;   ICDMT;   InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9);   InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N;   NCI-C04717;   NSC-45388;   SMILES=C=1NC(=C(N1)C(=O)N)N=NN(C)C;   dacarbazina;   dacarbazinum;   deticene
 xref: Beilstein:521487;   CAS:4342-03-4;   DrugBank:DB00851;   Drug_Central:773;   KEGG:C06936;   KEGG:D00288
 xref_mesh: MESH:D003606
 xref: PMID:10751609;   PMID:11318431;   PMID:12195827;   PMID:15010317;   PMID:20082117;   PMID:21471822;   PMID:21654834;   PMID:23029050;   PMID:23318786;   PMID:26940170;   PMID:28096700;   PMID:28250333;   PMID:28387914;   PMID:28419676;   PMID:29076951;   PMID:29184162;   PMID:29287706;   PMID:29296081;   PMID:29305638;   PMID:29344241;   Reaxys:521487;   Wikipedia:Dacarbazine


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dacarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance
ISO APEX1 protein mutant form results in increased susceptibility to Dacarbazine
APEX1 protein results in decreased susceptibility to Dacarbazine
CTD PMID:16373707 PMID:19470598 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Dacarbazine results in increased expression of BIRC5 protein CTD PMID:15577328 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17410615 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein; [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD38 protein; Dacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein] CTD PMID:11583285 PMID:14669796 PMID:16078447 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 protein; [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]; Dacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein] CTD PMID:14669796 PMID:17973783 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Dacarbazine CTD PMID:15955107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1A1 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A1 protein results in increased metabolism of Dacarbazine metabolite]
CTD PMID:11751525 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A2 protein results in increased metabolism of Dacarbazine metabolite]
CTD PMID:11751525 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Dacarbazine CTD PMID:15743794 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA CTD PMID:12202904 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IL6 mRNA CTD PMID:12202904 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression
multiple interactions
ISO Dacarbazine results in increased expression of IRF1 mRNA
Isotretinoin promotes the reaction [Dacarbazine results in increased expression of IRF1 mRNA]
CTD PMID:17973783 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases response to substance ISO MAP3K1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance ISO MAPK1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases response to substance ISO MAPK3 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Dacarbazine CTD PMID:12787138 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity
decreases response to substance
increases response to substance
affects response to substance
decreases expression
ISO Dacarbazine results in decreased activity of MGMT protein
MGMT protein results in decreased susceptibility to Dacarbazine
MGMT gene mutant form results in increased susceptibility to Dacarbazine
MGMT protein affects the susceptibility to Dacarbazine
Dacarbazine results in decreased expression of MGMT protein
CTD PMID:10751609 PMID:11023546 PMID:12170182 PMID:12494480 PMID:14562026 More... NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases response to substance ISO SLC2A1 protein results in decreased susceptibility to Dacarbazine CTD PMID:17520257 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA CTD PMID:12202904 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
decreases response to substance
ISO Dacarbazine results in increased secretion of VEGFA protein
Dacarbazine results in increased expression of VEGFA mRNA; Dacarbazine results in increased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Dacarbazine
CTD PMID:12939465 PMID:15026559 PMID:15123733 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pro-agent 10099
          prodrug 9902
            dacarbazine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  dacarbazine 22
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