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ONTOLOGY REPORT - ANNOTATIONS


Term:dacarbazine
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Accession:CHEBI:4305 term browser browse the term
Definition:A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Synonyms:exact_synonym: 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
 related_synonym: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide;   4-(dimethyltriazeno)imidazole-5-carboxamide;   5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;   5-(3,3-dimethyltriazeno)imidazole-4-carboxamide;   DIC;   DTIC;   Di-me-triazenoimidazolecarboxamide;   Dtic-Dome (TN);   Formula=C6H10N6O;   HSDB 3219;   ICDMT;   InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9);   InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N;   NCI-C04717;   NSC-45388;   SMILES=C=1NC(=C(N1)C(=O)N)N=NN(C)C;   dacarbazina;   dacarbazinum;   deticene
 xref: Beilstein:521487 "Beilstein";   CAS:4342-03-4 "ChemIDplus";   CAS:4342-03-4 "KEGG DRUG";   CAS:4342-03-4 "NIST Chemistry WebBook";   DrugBank:DB00851;   Drug_Central:773 "DrugCentral";   KEGG:C06936;   KEGG:D00288
 xref_mesh: MESH:D003606
 xref: PMID:10751609 "Europe PMC";   PMID:11318431 "Europe PMC";   PMID:12195827 "Europe PMC";   PMID:15010317 "Europe PMC";   PMID:20082117 "Europe PMC";   PMID:21471822 "Europe PMC";   PMID:21654834 "Europe PMC";   PMID:23029050 "Europe PMC";   PMID:23318786 "Europe PMC";   PMID:26940170 "Europe PMC";   PMID:28096700 "Europe PMC";   PMID:28250333 "Europe PMC";   PMID:28387914 "Europe PMC";   PMID:28419676 "Europe PMC";   PMID:29076951 "Europe PMC";   PMID:29184162 "Europe PMC";   PMID:29287706 "Europe PMC";   PMID:29296081 "Europe PMC";   PMID:29305638 "Europe PMC";   PMID:29344241 "Europe PMC";   Reaxys:521487 "Reaxys";   Wikipedia:Dacarbazine


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dacarbazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:6480464
G Cd69 Cd69 molecule JBrowse link 4 163,041,147 163,049,065 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6480464
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pro-agent 8768
          prodrug 8565
            dacarbazine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  dacarbazine 22
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