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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dacarbazine
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Accession:CHEBI:4305 term browser browse the term
Definition:A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Synonyms:exact_synonym: 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
 related_synonym: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide;   5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;   5-(3,3-dimethyltriazeno)imidazole-4-carboxamide;   5-(dimethyltriazeno)imidazole-4-carboxamide;   DIC;   DTIC;   Di-me-triazenoimidazolecarboxamide;   Dtic-Dome (TN);   Formula=C6H10N6O;   HSDB 3219;   ICDMT;   InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9);   InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N;   NCI-C04717;   NSC 45388;   SMILES=C=1NC(=C(N1)C(=O)N)N=NN(C)C;   dacarbazina;   dacarbazinum;   deticene
 xref: Beilstein:521487;   CAS:4342-03-4;   DrugBank:DB00851;   Drug_Central:773;   HMDB:HMDB0014989;   KEGG:C06936;   KEGG:D00288;   LINCS:LSM-5487
 xref_mesh: MESH:D003606
 xref: PMID:10751609;   PMID:11318431;   PMID:12195827;   PMID:15010317;   PMID:20082117;   PMID:21471822;   PMID:21654834;   PMID:23029050;   PMID:23318786;   PMID:26940170;   PMID:28096700;   PMID:28250333;   PMID:28387914;   PMID:28419676;   PMID:29076951;   PMID:29184162;   PMID:29287706;   PMID:29296081;   PMID:29305638;   PMID:29344241;   Reaxys:521487;   Wikipedia:Dacarbazine


show annotations for term's descendants           Sort by:
dacarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance		 ISO APEX1 protein mutant form results in increased susceptibility to Dacarbazine
APEX1 protein results in decreased susceptibility to Dacarbazine		 CTD PMID:16373707 PMID:19470598 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Dacarbazine results in increased expression of BIRC5 protein CTD PMID:15577328 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17410615 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein; [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD38 protein; Dacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein] CTD PMID:11583285 PMID:14669796 PMID:16078447 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 protein; [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]; Dacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein] CTD PMID:14669796 PMID:17973783 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Dacarbazine CTD PMID:15955107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP1A1 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A1 protein results in increased metabolism of Dacarbazine metabolite]		 CTD PMID:11751525 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO CYP1A2 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A2 protein results in increased metabolism of Dacarbazine metabolite]		 CTD PMID:11751525 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Dacarbazine CTD PMID:15743794 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO [Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein; Dacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein] CTD PMID:11583285 PMID:16078447 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA CTD PMID:12202904 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IL6 mRNA CTD PMID:12202904 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf1 interferon regulatory factor 1 increases expression
multiple interactions		 ISO Dacarbazine results in increased expression of IRF1 mRNA
Isotretinoin promotes the reaction [Dacarbazine results in increased expression of IRF1 mRNA]		 CTD PMID:17973783 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases response to substance ISO MAP3K1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance ISO MAPK1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases response to substance ISO MAPK3 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Dacarbazine CTD PMID:12787138 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity
decreases expression
affects response to substance
increases response to substance
decreases response to substance		 ISO Dacarbazine results in decreased activity of MGMT protein
Dacarbazine results in decreased expression of MGMT protein
MGMT protein affects the susceptibility to Dacarbazine
MGMT gene mutant form results in increased susceptibility to Dacarbazine
MGMT protein results in decreased susceptibility to Dacarbazine		 CTD PMID:10751609 PMID:11023546 PMID:12170182 PMID:12494480 PMID:14562026 More... NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases response to substance ISO SLC2A1 protein results in decreased susceptibility to Dacarbazine CTD PMID:17520257 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA CTD PMID:12202904 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
decreases response to substance
increases expression		 ISO Dacarbazine results in increased secretion of VEGFA protein
VEGFA protein results in decreased susceptibility to Dacarbazine
Dacarbazine results in increased expression of VEGFA mRNA; Dacarbazine results in increased expression of VEGFA protein		 CTD PMID:12939465 PMID:15026559 PMID:15123733 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19825
      application 19667
        pro-agent 11548
          prodrug 11310
            dacarbazine 23
              (E)-dacarbazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19492
                              organochalcogen compound 19254
                                organooxygen compound 19170
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17706
                                        univalent carboacyl group 17706
                                          carbamoyl group 17559
                                            carboxamide 17559
                                              monocarboxylic acid amide 15737
                                                dacarbazine 23
                                                  (E)-dacarbazine 0
paths to the root