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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:25-hydroxycholesterol
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Accession:CHEBI:42977 term browser browse the term
Definition:A 25-hydroxy steroid that has formula 402.65294.
Synonyms:related_synonym: 5-Cholestene-3beta,25-diol;   Cholest-5-ene-3beta,25-diol;   Formula=C27H46O2;   InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1;   InChIKey=INBGSXNNRGWLJU-ZHHJOTBYSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O
 alt_id: CHEBI:37616;   CHEBI:42972
 xref: CAS:2140-46-7;   KEGG:C15519;   LIPID_MAPS_instance:LMST01010018
 xref_mesh: MESH:C007997


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25-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in increased expression of ABCA1 mRNA
[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]
[Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA		 CTD PMID:12595494 PMID:16023994 PMID:17526932 PMID:19260826 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 increases expression ISO 25-hydroxycholesterol results in increased expression of ABCG1 mRNA CTD PMID:31011801 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO 25-hydroxycholesterol results in increased expression of ACTA2 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]		 CTD PMID:17161435 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G ADIPOR1 adiponectin receptor 1 multiple interactions
decreases expression		 EXP [25-hydroxycholesterol co-treated with alitretinoin] results in decreased expression of ADIPOR1 mRNA
25-hydroxycholesterol results in decreased expression of ADIPOR1 mRNA		 CTD PMID:16023994 NCBI chr 1:202,940,825...202,958,572
Ensembl chr 1:202,940,826...202,958,572 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein] CTD PMID:25845326 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions		 ISO 25-hydroxycholesterol results in increased activity of CASP8 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]		 CTD PMID:25845326 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions		 ISO 25-hydroxycholesterol results in increased activity of CASP9 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]		 CTD PMID:25845326 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression ISO 25-hydroxycholesterol results in increased expression of CDKN1B mRNA CTD PMID:17161435 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CNN1 calponin 1 multiple interactions
increases expression		 ISO 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA] CTD PMID:17161435 NCBI chr19:11,538,851...11,550,323
Ensembl chr19:11,538,767...11,550,323 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion
increases expression		 EXP 25-hydroxycholesterol results in increased secretion of CXCL8 protein
25-hydroxycholesterol results in increased expression of CXCL8 mRNA		 CTD PMID:16142584 PMID:19426978 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 multiple interactions
increases chemical synthesis		 EXP
ISO		 [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 25-hydroxycholesterol		 CTD PMID:8078928 PMID:17890683 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP
ISO		 CYP7A1 protein results in increased metabolism of 25-hydroxycholesterol CTD PMID:10882719 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 increases metabolic processing
increases abundance		 ISO CYP7B1 protein results in increased metabolism of 25-hydroxycholesterol
CYP7B1 gene mutant form results in increased abundance of 25-hydroxycholesterol		 CTD PMID:10748047 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 25-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:17873880 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP 25-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:17873880 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FADS1 fatty acid desaturase 1 multiple interactions
decreases expression		 EXP 25-hydroxycholesterol inhibits the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]
25-hydroxycholesterol results in decreased expression of FADS1 mRNA		 CTD PMID:17655842 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318 		JBrowse link
G FAS Fas cell surface death receptor increases expression ISO 25-hydroxycholesterol results in increased expression of FAS mRNA CTD PMID:19260826 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FHL1 four and a half LIM domains 1 multiple interactions
increases expression		 ISO 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Brefeldin A inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Cycloheximide promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Dactinomycin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Genistein inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:136,146,702...136,211,359
Ensembl chr  X:136,146,702...136,211,359 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
decreases activity		 EXP
ISO		 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein; [25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]
25-hydroxycholesterol results in decreased expression of HMGCR protein
25-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 25-hydroxycholesterol results in decreased activity of HMGCR protein
25-hydroxycholesterol results in decreased expression of HMGCR mRNA; 25-hydroxycholesterol results in decreased expression of HMGCR protein		 CTD PMID:7749852 PMID:7751816 PMID:9059514 PMID:12477733 PMID:18024962 More... NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases secretion
increases expression		 EXP 25-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
25-hydroxycholesterol results in increased secretion of IL1B protein
25-hydroxycholesterol results in increased expression of IL1B mRNA		 CTD PMID:11851725 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 increases secretion
multiple interactions		 EXP
ISO		 25-hydroxycholesterol results in increased secretion of IL6 protein
25-hydroxycholesterol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
25-hydroxycholesterol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]		 CTD PMID:11851725 PMID:27052460 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INHA inhibin subunit alpha increases expression ISO 25-hydroxycholesterol results in increased expression of INHA mRNA; 25-hydroxycholesterol results in increased expression of INHA protein CTD PMID:19464342 NCBI chr 2:219,572,310...219,575,711
Ensembl chr 2:219,569,162...219,575,711 		JBrowse link
G INHBA inhibin subunit beta A increases expression
decreases expression		 ISO 25-hydroxycholesterol results in increased expression of INHBA mRNA
25-hydroxycholesterol results in decreased expression of INHBA protein		 CTD PMID:19464342 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834 		JBrowse link
G INHBB inhibin subunit beta B increases expression ISO 25-hydroxycholesterol results in increased expression of INHBB mRNA; 25-hydroxycholesterol results in increased expression of INHBB protein CTD PMID:19464342 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803 		JBrowse link
G INSIG1 insulin induced gene 1 decreases expression ISO 25-hydroxycholesterol results in decreased expression of INSIG1 mRNA CTD PMID:19260826 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235 		JBrowse link
G LDLR low density lipoprotein receptor decreases expression
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in decreased expression of LDLR mRNA; 25-hydroxycholesterol results in decreased expression of LDLR protein
25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased expression of LDLR mRNA]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; LDLR gene mutant form results in increased susceptibility to [25-hydroxycholesterol co-treated with Cholesterol]		 CTD PMID:12477733 PMID:19260826 PMID:22153697 PMID:27447558 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LPL lipoprotein lipase decreases expression
decreases activity		 EXP 25-hydroxycholesterol results in decreased expression of LPL mRNA
25-hydroxycholesterol results in decreased activity of LPL protein		 CTD PMID:8567968 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MARCHF6 membrane associated ring-CH-type finger 6 increases stability EXP 25-hydroxycholesterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr 5:10,353,695...10,440,388
Ensembl chr 5:10,353,695...10,440,388 		JBrowse link
G NOS2 nitric oxide synthase 2 increases expression EXP
ISO		 25-hydroxycholesterol results in increased expression of NOS2 mRNA CTD PMID:12085989 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP 25-hydroxycholesterol results in decreased expression of NOS3 mRNA CTD PMID:19426978 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases activity
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in increased activity of NR1H3 protein
[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; SULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]		 CTD PMID:9603267 PMID:12595494 PMID:27052460 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 increases activity
multiple interactions		 EXP 25-hydroxycholesterol results in increased activity of NR5A1 protein
25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 9:124,481,236...124,507,399
Ensembl chr 9:124,481,236...124,507,420 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] CTD PMID:12595494 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] CTD PMID:12595494 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G RORA RAR related orphan receptor A affects binding EXP 25-hydroxycholesterol binds to RORA protein CTD PMID:31195007 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G RORC RAR related orphan receptor C multiple interactions
affects binding		 EXP bisphenol A analog inhibits the reaction [25-hydroxycholesterol binds to RORC protein]; T0901317 inhibits the reaction [25-hydroxycholesterol binds to RORC protein] CTD PMID:22659100 PMID:31195007 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP 25-hydroxycholesterol results in decreased expression of SCD protein CTD PMID:27447558 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in increased expression of SREBF1 protein
[25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF1 protein		 CTD PMID:19260826 PMID:27324795 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 decreases activity
multiple interactions		 EXP 25-hydroxycholesterol results in decreased activity of SREBF2 protein
25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased expression of SREBF2 protein modified form]; [25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein; Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]		 CTD PMID:17052361 PMID:22153697 PMID:27324795 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions EXP 25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] CTD PMID:9804848 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO 25-hydroxycholesterol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] CTD PMID:27052460 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G SULT2B1 sulfotransferase family 2B member 1 multiple interactions EXP
ISO		 SULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]		 CTD PMID:27052460 NCBI chr19:48,552,172...48,599,427
Ensembl chr19:48,552,172...48,599,425 		JBrowse link
G TNFSF15 TNF superfamily member 15 increases expression EXP 25-hydroxycholesterol results in increased expression of TNFSF15 mRNA CTD PMID:19426978 NCBI chr 9:114,784,635...114,806,039
Ensembl chr 9:114,784,652...114,806,039 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP 25-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          metabolite 25092
            eukaryotic metabolite 24514
              algal metabolite 17307
                cholesterol 354
                  25-hydroxycholesterol 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic polycyclic compound 18800
                                  steroid 15855
                                    hydroxy steroid 15533
                                      3-hydroxy steroid 13523
                                        3beta-hydroxy steroid 2534
                                          3beta-hydroxy-Delta(5)-steroid 2362
                                            cholesterol 354
                                              oxysterol 106
                                                25-hydroxycholesterol 44
paths to the root