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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gabapentin
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Accession:CHEBI:42797 term browser browse the term
Definition:A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Synonyms:exact_synonym: [1-(aminomethyl)cyclohexyl]acetic acid
 related_synonym: 1-(Aminomethyl)cyclohexaneacetic acid;   Formula=C9H17NO2;   InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12);   InChIKey=UGJMXCAKCUNAIE-UHFFFAOYSA-N;   Neurontin;   SMILES=NCC1(CCCCC1)CC(O)=O;   gabapentina;   gabapentine;   gabapentinum
 alt_id: CHEBI:5237
 xref: Beilstein:2359739;   CAS:60142-96-3;   DrugBank:DB00996;   Drug_Central:1264;   HMDB:HMDB0005015;   KEGG:D00332;   LINCS:LSM-5716
 xref_mesh: MESH:C040029
 xref: PDBeChem:GBN;   PMID:22048285;   PMID:22144034;   PMID:22240839;   PMID:22240859;   PMID:22279347;   PMID:22296650;   PMID:22345405;   PMID:22352861;   PMID:22419014;   PMID:22422817;   PMID:22464746;   PMID:22467888;   PMID:22556282;   PMID:22575516;   PMID:22612015;   PMID:22865488;   PMID:22888801;   PMID:22934077;   PMID:22946876;   PMID:23018586;   PMID:23053645;   Patent:EP1140793;   Patent:US2008103334;   Patent:US2008269326;   Patent:US2009043126;   Patent:US2009292138;   Patent:US2012046272;   Patent:WO2005037784;   Patent:WO2008060572;   Patent:WO2010023694;   Reaxys:2359739;   VSDB:2975;   Wikipedia:Gabapentin



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gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP gabapentin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO gabapentin results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP gabapentin results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases activity
multiple interactions
EXP
ISO
gabapentin results in decreased activity of CACNA1A protein
gabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]
CTD PMID:12770949 PMID:12817894 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases activity EXP gabapentin results in decreased activity of CACNA1B protein CTD PMID:12770949 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D multiple interactions EXP CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 multiple interactions
affects binding
ISO
EXP
[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride; [gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]
CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]
gabapentin binds to CACNA2D1 protein
CTD PMID:16380257 PMID:17442347 PMID:17881535 PMID:19796812 PMID:20340177 More... NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 affects activity
affects binding
ISO CACNA2D2 protein affects the activity of gabapentin
gabapentin binds to CACNA2D2 protein
CTD PMID:11687876 PMID:14660671 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 multiple interactions EXP CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
JBrowse link
G Cp ceruloplasmin decreases expression EXP gabapentin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP2E1 mRNA CTD PMID:17381134 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Gabapentin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:17381134 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G F10 coagulation factor X decreases expression EXP gabapentin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Gabapentin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO CGP 71872 inhibits the reaction [Gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; Gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP gabapentin results in decreased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP gabapentin results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP gabapentin results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP gabapentin results in decreased expression of HSP90AA1 mRNA CTD PMID:17381134 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP gabapentin results in increased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO gabapentin results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP gabapentin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Ncl nucleolin increases expression EXP gabapentin results in increased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP gabapentin results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP gabapentin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pnoc prepronociceptin decreases expression ISO gabapentin results in decreased expression of PNOC mRNA CTD PMID:18281898 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO gabapentin results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases expression
decreases expression
EXP gabapentin results in increased expression of SLC22A7 mRNA
gabapentin results in decreased expression of SLC22A7 mRNA
CTD PMID:17381134 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases import ISO SLC7A5 protein results in increased import of gabapentin CTD PMID:27818298 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP gabapentin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP gabapentin results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP gabapentin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tkt transketolase increases expression EXP gabapentin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP gabapentin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression EXP gabapentin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP gabapentin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          gabapentin 39
            gabapentin enacarbil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          fatty acid 16011
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7905
                                                butyric acid 6275
                                                  gamma-aminobutyric acid 153
                                                    gabapentin 39
                                                      gabapentin enacarbil 0
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