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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gabapentin
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Accession:CHEBI:42797 term browser browse the term
Definition:A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Synonyms:exact_synonym: [1-(aminomethyl)cyclohexyl]acetic acid
 related_synonym: 1-(Aminomethyl)cyclohexaneacetic acid;   Formula=C9H17NO2;   InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12);   InChIKey=UGJMXCAKCUNAIE-UHFFFAOYSA-N;   Neurontin;   SMILES=NCC1(CCCCC1)CC(O)=O;   gabapentina;   gabapentine;   gabapentinum
 alt_id: CHEBI:5237
 xref: Beilstein:2359739;   CAS:60142-96-3;   DrugBank:DB00996;   Drug_Central:1264;   HMDB:HMDB0005015;   KEGG:D00332;   LINCS:LSM-5716
 xref_mesh: MESH:C040029
 xref: PDBeChem:GBN;   PMID:22048285;   PMID:22144034;   PMID:22240839;   PMID:22240859;   PMID:22279347;   PMID:22296650;   PMID:22345405;   PMID:22352861;   PMID:22419014;   PMID:22422817;   PMID:22464746;   PMID:22467888;   PMID:22556282;   PMID:22575516;   PMID:22612015;   PMID:22865488;   PMID:22888801;   PMID:22934077;   PMID:22946876;   PMID:23018586;   PMID:23053645;   Patent:EP1140793;   Patent:US2008103334;   Patent:US2008269326;   Patent:US2009043126;   Patent:US2009292138;   Patent:US2012046272;   Patent:WO2005037784;   Patent:WO2008060572;   Patent:WO2010023694;   Reaxys:2359739;   VSDB:2975;   Wikipedia:Gabapentin


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gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP gabapentin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO gabapentin results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP gabapentin results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases activity
multiple interactions
EXP
ISO
gabapentin results in decreased activity of CACNA1A protein
gabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]
CTD PMID:12770949 PMID:12817894 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases activity EXP gabapentin results in decreased activity of CACNA1B protein CTD PMID:12770949 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D multiple interactions EXP CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 multiple interactions
affects binding
ISO
EXP
[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride; [gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]
CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]
gabapentin binds to CACNA2D1 protein
CTD PMID:16380257 PMID:17442347 PMID:17881535 PMID:19796812 PMID:20340177 PMID:21182903 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 affects activity
affects binding
ISO CACNA2D2 protein affects the activity of gabapentin
gabapentin binds to CACNA2D2 protein
CTD PMID:11687876 PMID:14660671 NCBI chr 8:116,154,661...116,285,643
Ensembl chr 8:116,154,736...116,284,985
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 multiple interactions EXP CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]; gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]; gabapentin affects the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium] CTD PMID:19796812 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cp ceruloplasmin decreases expression EXP gabapentin results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP2E1 mRNA CTD PMID:17381134 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Gabapentin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:17381134 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP gabapentin results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G F10 coagulation factor X decreases expression EXP gabapentin results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Gabapentin results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO CGP 71872 inhibits the reaction [Gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]; Gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein] CTD PMID:11125035 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP gabapentin results in decreased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP gabapentin results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP gabapentin results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP gabapentin results in decreased expression of HSP90AA1 mRNA CTD PMID:17381134 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP gabapentin results in increased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO gabapentin results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP gabapentin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Ncl nucleolin increases expression EXP gabapentin results in increased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP gabapentin results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP gabapentin results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pnoc prepronociceptin decreases expression ISO gabapentin results in decreased expression of PNOC mRNA CTD PMID:18281898 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO gabapentin results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases expression
decreases expression
EXP gabapentin results in increased expression of SLC22A7 mRNA
gabapentin results in decreased expression of SLC22A7 mRNA
CTD PMID:17381134 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases import ISO SLC7A5 protein results in increased import of gabapentin CTD PMID:27818298 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP gabapentin results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP gabapentin results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP gabapentin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tkt transketolase increases expression EXP gabapentin results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP gabapentin results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression EXP gabapentin results in decreased expression of UGDH mRNA CTD PMID:17381134 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP gabapentin results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          gabapentin 39
            gabapentin enacarbil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          fatty acid 16014
                                            short-chain fatty acid 15702
                                              fatty acid 4:0 7858
                                                butyric acid 6207
                                                  gamma-aminobutyric acid 153
                                                    gabapentin 39
                                                      gabapentin enacarbil 0
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