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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:geneticin
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Accession:CHEBI:42768 term browser browse the term
Definition:An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Synonyms:exact_synonym: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside
 related_synonym: Formula=C20H40N4O10;   G 418;   G418;   InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9+,10+,11-,12-,13+,14+,15+,16-,17+,18+,19+,20-/m0/s1;   InChIKey=BRZYSWJRSDMWLG-CAXSIQPQSA-N;   SMILES=CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@H](N)[C@@H](O[C@H]2O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@@H]1O;   antibiotic G 418
 alt_id: CHEBI:33028;   CHEBI:42764
 xref: Beilstein:1669188;   CAS:49863-47-0;   DrugBank:DB04263;   KEGG:C17703
 xref_mesh: MESH:C010680
 xref: PDBeChem:GET



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geneticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases transport
ISO antibiotic G 418 results in decreased expression of ABCB1 mRNA
ABCB1 protein results in increased transport of antibiotic G 418
CTD PMID:20018165 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport ISO ABCC2 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases transport ISO ABCC3 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO antibiotic G 418 results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Avpr2 arginine vasopressin receptor 2 multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of AVPR2 protein mutant form CTD PMID:12414899 PMID:14998935 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Capn2 calpain 2 increases cleavage ISO antibiotic G 418 results in increased cleavage of CAPN2 protein CTD PMID:15241557 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp12 caspase 12 increases cleavage ISO antibiotic G 418 results in increased cleavage of CASP12 protein CTD PMID:15241557 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity ISO antibiotic G 418 results in increased activity of CASP3 protein CTD PMID:15241557 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO antibiotic G 418 results in increased activity of CASP9 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein]
CTD PMID:15241557 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cftr CF transmembrane conductance regulator increases expression ISO antibiotic G 418 results in increased expression of CFTR protein mutant form CTD PMID:17541014 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G F7 coagulation factor VII multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of F7 protein CTD PMID:16706976 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO antibiotic G 418 affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO antibiotic G 418 results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 increases expression ISO antibiotic G 418 results in increased expression of KCNJ1 protein mutant form CTD PMID:12911542 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression
multiple interactions
ISO antibiotic G 418 affects the expression of MMUT mRNA mutant form
[antibiotic G 418 co-treated with Gentamicins] affects the activity of MMUT protein mutant form; [antibiotic G 418 co-treated with Gentamicins] affects the expression of MMUT mRNA mutant form; antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MMUT protein mutant form]
CTD PMID:19427250 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO antibiotic G 418 results in increased expression of SLC4A4 protein mutant form CTD PMID:18614622 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO antibiotic G 418 results in increased expression of SMN2 protein CTD PMID:19150990 NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO antibiotic G 418 affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          carbohydrate-containing antibiotic 2559
            aminoglycoside antibiotic 2541
              geneticin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      carbohydrate derivative 11946
                                        glycosyl compound 10983
                                          glycoside 9266
                                            aminoglycoside 8436
                                              aminoglycoside antibiotic 2541
                                                geneticin 19
paths to the root