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ONTOLOGY REPORT - ANNOTATIONS


Term:geneticin
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Accession:CHEBI:42768 term browser browse the term
Definition:An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Synonyms:exact_synonym: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside
 related_synonym: Formula=C20H40N4O10;   G 418;   G418;   InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9+,10+,11-,12-,13+,14+,15+,16-,17+,18+,19+,20-/m0/s1;   InChIKey=BRZYSWJRSDMWLG-CAXSIQPQSA-N;   SMILES=CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@H](N)[C@@H](O[C@H]2O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@@H]1O;   antibiotic G 418
 alt_id: CHEBI:33028;   CHEBI:42764
 xref: Beilstein:1669188 "ChemIDplus";   CAS:49863-47-0 "ChemIDplus";   CAS:49863-47-0 "KEGG COMPOUND";   DrugBank:DB04263;   KEGG:C17703
 xref_mesh: MESH:C010680
 xref: PDBeChem:GET


show annotations for term's descendants       view all columns           Sort by:
 
geneticin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 156,889,006 156,892,707 RGD:6480464
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:6480464
G Mmut methylmalonyl-CoA mutase JBrowse link 9 23,323,934 23,352,144 RGD:6480464
G Slc4a4 solute carrier family 4 member 4 JBrowse link 14 20,476,258 20,817,042 RGD:6480464
G Smn1 survival of motor neuron 1, telomeric JBrowse link 2 30,360,101 30,371,147 RGD:6480464
G Upf1 UPF1, RNA helicase and ATPase JBrowse link 16 20,824,888 20,845,632 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          carbohydrate-containing antibiotic 2492
            aminoglycoside antibiotic 2476
              geneticin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            heteroorganic entity 19003
                              organochalcogen compound 18718
                                organooxygen compound 18629
                                  carbohydrates and carbohydrate derivatives 11703
                                    carbohydrate 11703
                                      carbohydrate derivative 11314
                                        glycosyl compound 10294
                                          glycoside 9110
                                            aminoglycoside 8326
                                              aminoglycoside antibiotic 2476
                                                geneticin 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.