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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:geneticin
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Accession:CHEBI:42768 term browser browse the term
Definition:An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Synonyms:exact_synonym: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside
 related_synonym: Formula=C20H40N4O10;   G 418;   G418;   InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9+,10+,11-,12-,13+,14+,15+,16-,17+,18+,19+,20-/m0/s1;   InChIKey=BRZYSWJRSDMWLG-CAXSIQPQSA-N;   SMILES=CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@H](N)[C@@H](O[C@H]2O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@@H]1O;   antibiotic G 418
 alt_id: CHEBI:33028;   CHEBI:42764
 xref: Beilstein:1669188;   CAS:49863-47-0;   DrugBank:DB04263;   KEGG:C17703
 xref_mesh: MESH:C010680
 xref: PDBeChem:GET


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geneticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases transport
ISO antibiotic G 418 results in decreased expression of ABCB1 mRNA
ABCB1 protein results in increased transport of antibiotic G 418
CTD PMID:20018165 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport ISO ABCC2 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases transport ISO ABCC3 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO antibiotic G 418 results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Avpr2 arginine vasopressin receptor 2 multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of AVPR2 protein mutant form CTD PMID:12414899 PMID:14998935 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213
JBrowse link
G Capn2 calpain 2 increases cleavage ISO antibiotic G 418 results in increased cleavage of CAPN2 protein CTD PMID:15241557 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp12 caspase 12 increases cleavage ISO antibiotic G 418 results in increased cleavage of CASP12 protein CTD PMID:15241557 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 increases activity ISO antibiotic G 418 results in increased activity of CASP3 protein CTD PMID:15241557 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO antibiotic G 418 results in increased activity of CASP9 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein]
CTD PMID:15241557 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cftr CF transmembrane conductance regulator increases expression ISO antibiotic G 418 results in increased expression of CFTR protein mutant form CTD PMID:17541014 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G F7 coagulation factor VII multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of F7 protein CTD PMID:16706976 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO antibiotic G 418 affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 increases expression ISO antibiotic G 418 results in increased expression of KCNJ1 protein mutant form CTD PMID:12911542 NCBI chr 8:33,490,280...33,519,127
Ensembl chr 8:33,514,042...33,518,165
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression
multiple interactions
ISO antibiotic G 418 affects the expression of MMUT mRNA mutant form
[antibiotic G 418 co-treated with Gentamicins] affects the activity of MMUT protein mutant form; [antibiotic G 418 co-treated with Gentamicins] affects the expression of MMUT mRNA mutant form; antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MMUT protein mutant form]
CTD PMID:19427250 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO antibiotic G 418 results in increased expression of SLC4A4 protein mutant form CTD PMID:18614622 NCBI chr14:20,476,258...20,817,042
Ensembl chr14:20,479,323...20,920,286
JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO antibiotic G 418 results in increased expression of SMN2 protein CTD PMID:19150990 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO antibiotic G 418 affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          carbohydrate-containing antibiotic 2555
            aminoglycoside antibiotic 2537
              geneticin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            heteroorganic entity 19175
                              organochalcogen compound 18886
                                organooxygen compound 18809
                                  carbohydrates and carbohydrate derivatives 12196
                                    carbohydrate 12196
                                      carbohydrate derivative 11819
                                        glycosyl compound 10861
                                          glycoside 9213
                                            aminoglycoside 8424
                                              aminoglycoside antibiotic 2537
                                                geneticin 18
paths to the root