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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-methyl-3H-imidazo[4,5-f]quinolin-2-amine
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Accession:CHEBI:42725 term browser browse the term
Definition:An imidazoquinoline that is 3H-imidazo[4,5-f]quinoline substituted by a methyl group at position 3 and an amino group at position 2.
Synonyms:related_synonym: Formula=C11H10N4;   IQ;   InChI=1S/C11H10N4/c1-15-9-5-4-8-7(3-2-6-13-8)10(9)14-11(15)12/h2-6H,1H3,(H2,12,14);   InChIKey=ARZWATDYIYAUTA-UHFFFAOYSA-N;   SMILES=Cn1c(N)nc2c1ccc1ncccc21
 xref: CAS:76180-96-6;   HMDB:HMDB0029706;   KEGG:C19180
 xref_mesh: MESH:C029216
 xref: PDBeChem:GIQ;   PMID:24135607;   Reaxys:5014055



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3-methyl-3H-imidazo[4,5-f]quinolin-2-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport ISO ABCC2 protein affects the transport of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:16611851 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Apc APC regulator of WNT signaling pathway increases mutagenesis ISO
EXP
2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of APC gene CTD PMID:7846077 PMID:8608549 PMID:12034317 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Aprt adenine phosphoribosyl transferase multiple interactions ISO [NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene
[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT gene
CTD PMID:2023932 PMID:9150757 NCBI chr19:50,626,436...50,628,404
Ensembl chr19:50,626,202...50,628,431
JBrowse link
G Asf1a anti-silencing function 1A histone chaperone decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of ASF1A mRNA CTD PMID:26198647 NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808
JBrowse link
G Bik BCL2-interacting killer increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of CDH1 protein CTD PMID:22094457 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of CDKN1A protein
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CDKN1A mRNA
CTD PMID:22094457 PMID:31542801 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis
multiple interactions
EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene
[chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]
CTD PMID:9515794 PMID:12628520 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects activity
increases expression
ISO CYP1A1 affects the activity of 2-amino-3-methylimidazo(4,5-f)quinoline
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CYP1A1 mRNA
CTD PMID:2334931 PMID:27644595 PMID:31542801 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
multiple interactions
increases activity
affects response to substance
ISO
EXP
CYP1A2 protein affects the metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline
2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CYP1A2 mRNA
Quercetin inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline]
[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT gene
CYP1A2 protein affects the susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
CYP1A2 protein results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline
[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
CTD PMID:2023932 PMID:2334931 PMID:2655891 PMID:9581821 PMID:10503888 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of FBXO30 mRNA CTD PMID:26198647 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein] CTD PMID:12628520 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of HRAS gene CTD PMID:2009133 PMID:8844820 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of JUN protein CTD PMID:22094457 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of KRAS gene CTD PMID:8844820 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance
multiple interactions
ISO NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline; [NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline
CTD PMID:7625840 PMID:9150757 PMID:28160022 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:9581821 PMID:10503888 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:9581821 PMID:10503888 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinoline CTD PMID:11159734 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of SULT1B1 mRNA CTD PMID:31542801 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR1 protein CTD PMID:22094457 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR2 protein CTD PMID:22094457 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of UGT1A1 mRNA CTD PMID:31542801 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Wnt1 Wnt family member 1 increases expression ISO 2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of WNT1 protein CTD PMID:22094457 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link

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  CHEBI ontology 19823
    role 19773
      biological role 19773
        aetiopathogenetic role 19050
          carcinogenic agent 18381
            3-methyl-3H-imidazo[4,5-f]quinolin-2-amine 33
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organic heteropolycyclic compound 18067
                                    organic heterotricyclic compound 14649
                                      imidazoquinoline 169
                                        3-methyl-3H-imidazo[4,5-f]quinolin-2-amine 33
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