Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flufenamic acid
go back to main search page
Accession:CHEBI:42638 term browser browse the term
Definition:An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.
Synonyms:related_synonym: 2-[3-(trifluoromethyl)anilino]benzoic acid;   2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid;   3'-trifluoromethyldiphenylamine-2-carboxylic acid;   Achless;   FFA;   Flufenaminsaeure;   Formula=C14H10F3NO2;   InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20);   InChIKey=LPEPZBJOKDYZAD-UHFFFAOYSA-N;   N-(3-trifluoromethylphenyl)anthranilic acid;   N-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F;   acide flufenamique;   acido flufenamico;   acidum flufenamicum;   fluphenamic acid
 alt_id: CHEBI:31619;   CHEBI:42631
 xref: Beilstein:1996069;   CAS:530-78-9;   DrugBank:DB02266;   Drug_Central:1193;   Gmelin:1327188;   KEGG:C13038;   KEGG:D01581;   LINCS:LSM-2973
 xref_mesh: MESH:D005439
 xref: PDBeChem:FLF;   PMID:11093589;   PMID:15275834;   PMID:18436631;   PMID:20589945;   PMID:28166217;   Reaxys:1996069;   Wikipedia:Flufenamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:520819


show annotations for term's descendants           Sort by:
 
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to Flufenamic Acid CTD PMID:12147693 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions
ISO Flufenamic Acid results in decreased activity of AKR1C4 protein
Flufenamic Acid inhibits the reaction [AKR1C4 protein results in increased metabolism of Dihydrotestosterone]
CTD PMID:12604236, PMID:14672942 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity
ISO Flufenamic Acid inhibits the reaction [AKR1C2 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8573067, PMID:12604236, PMID:14672942 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects binding
multiple interactions
decreases activity
ISO Flufenamic Acid binds to AKR1C3 protein
Flufenamic Acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C3 protein
CTD PMID:12604236, PMID:14672942, PMID:14996743, PMID:23933386 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO Flufenamic Acid analog binds to and results in decreased activity of AR protein; Flufenamic Acid binds to and results in decreased activity of AR protein
Flufenamic Acid results in decreased expression of AR mRNA; Flufenamic Acid results in decreased expression of AR protein
CTD PMID:10537180, PMID:19645433 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 multiple interactions ISO Flufenamic Acid binds to and results in increased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAD protein] CTD PMID:27957685 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAK1 protein] CTD PMID:27957685 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Best1 bestrophin 1 decreases activity ISO Flufenamic Acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:226,033,146...226,049,893
Ensembl chr 1:226,030,875...226,049,929
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BID protein] CTD PMID:27957685 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:27957685 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Flufenamic Acid results in decreased activity of CFTR protein CTD PMID:15277574 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA CTD PMID:8404651 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Flufenamic Acid results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of FSHB mRNA CTD PMID:8404651 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:10866999 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
Flufenamic Acid results in increased expression of IL6 mRNA
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:15135310, PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:122,417,079...122,549,532
Ensembl chr 6:122,419,046...122,545,899
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:222,182,997...222,192,139
Ensembl chr 1:222,183,276...222,189,604
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
JBrowse link
G Kiss1r KISS1 receptor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]; Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]
Flufenamic Acid results in increased expression of LDLR mRNA; Flufenamic Acid results in increased expression of LDLR protein
CTD PMID:10395027 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin multiple interactions ISO Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of LHB mRNA CTD PMID:8404651 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Flufenamic Acid results in increased expression of NOS2 mRNA
CTD PMID:10866999, PMID:15135310 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Panx1 Pannexin 1 decreases activity ISO Flufenamic Acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Flufenamic Acid binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid binds to and results in increased activity of PPARG protein CTD PMID:9013583, PMID:10866999 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of PTGS2 mRNA; Flufenamic Acid results in increased expression of PTGS2 protein
CTD PMID:10866999 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sell selectin L decreases expression ISO Flufenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc6a11 solute carrier family 6 member 11 multiple interactions ISO Flufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid] CTD PMID:15981712 NCBI chr 4:146,106,386...146,223,228
Ensembl chr 4:146,106,386...146,223,228
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of TNF mRNA
CTD PMID:10866999, PMID:15135310 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity
ISO
EXP
[Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium
Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]
CTD PMID:11535132, PMID:14551041, PMID:21562303 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP
Flufenamic Acid results in decreased activity of TRPM4 protein CTD PMID:16966582, PMID:17188667 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        solvent 16475
          (trifluoromethyl)benzene 373
            flufenamic acid 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            organic hydride 17773
                              organic fundamental parent 17773
                                hydrocarbon 17294
                                  alkane 13699
                                    methane 9963
                                      halomethane 9963
                                        fluoromethanes 6338
                                          fluoroform 6338
                                            trifluoromethyl group 6338
                                              (trifluoromethyl)benzenes 6338
                                                (trifluoromethyl)benzene 373
                                                  flufenamic acid 42
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.