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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flufenamic acid
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Accession:CHEBI:42638 term browser browse the term
Definition:An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.
Synonyms:related_synonym: 2-[3-(trifluoromethyl)anilino]benzoic acid;   2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid;   3'-trifluoromethyldiphenylamine-2-carboxylic acid;   Achless;   FFA;   Flufenaminsaeure;   Formula=C14H10F3NO2;   InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20);   InChIKey=LPEPZBJOKDYZAD-UHFFFAOYSA-N;   N-(3-trifluoromethylphenyl)anthranilic acid;   N-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F;   acide flufenamique;   acido flufenamico;   acidum flufenamicum;   fluphenamic acid
 alt_id: CHEBI:31619;   CHEBI:42631
 xref: Beilstein:1996069;   CAS:530-78-9;   DrugBank:DB02266;   Drug_Central:1193;   Gmelin:1327188;   KEGG:C13038;   KEGG:D01581;   LINCS:LSM-2973
 xref_mesh: MESH:D005439
 xref: PDBeChem:FLF;   PMID:11093589;   PMID:15275834;   PMID:18436631;   PMID:20589945;   PMID:28166217;   Reaxys:1996069;   Wikipedia:Flufenamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:520819


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flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to Flufenamic Acid CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions
ISO Flufenamic Acid results in decreased activity of AKR1C4 protein
Flufenamic Acid inhibits the reaction [AKR1C4 protein results in increased metabolism of Dihydrotestosterone]
CTD PMID:12604236 PMID:14672942 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity
ISO Flufenamic Acid inhibits the reaction [AKR1C2 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8573067 PMID:12604236 PMID:14672942 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects binding
multiple interactions
decreases activity
ISO Flufenamic Acid binds to AKR1C3 protein
Flufenamic Acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C3 protein
CTD PMID:12604236 PMID:14672942 PMID:14996743 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO Flufenamic Acid analog binds to and results in decreased activity of AR protein; Flufenamic Acid binds to and results in decreased activity of AR protein
Flufenamic Acid results in decreased expression of AR mRNA; Flufenamic Acid results in decreased expression of AR protein
CTD PMID:10537180 PMID:19645433 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 multiple interactions ISO Flufenamic Acid binds to and results in increased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAD protein] CTD PMID:27957685 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAK1 protein] CTD PMID:27957685 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Best1 bestrophin 1 decreases activity ISO Flufenamic Acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BID protein] CTD PMID:27957685 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:27957685 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Flufenamic Acid results in decreased activity of CFTR protein CTD PMID:15277574 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA CTD PMID:8404651 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Flufenamic Acid results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of FSHB mRNA CTD PMID:8404651 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:10866999 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
Flufenamic Acid results in increased expression of IL6 mRNA
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:15135310 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:204,117,941...204,129,494
Ensembl chr 1:204,114,572...204,125,925
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
JBrowse link
G Kiss1r KISS1 receptor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]; Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]
Flufenamic Acid results in increased expression of LDLR mRNA; Flufenamic Acid results in increased expression of LDLR protein
CTD PMID:10395027 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin multiple interactions ISO Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of LHB mRNA CTD PMID:8404651 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Flufenamic Acid results in increased expression of NOS2 mRNA
CTD PMID:10866999 PMID:15135310 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Panx1 Pannexin 1 decreases activity ISO Flufenamic Acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Flufenamic Acid binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid binds to and results in increased activity of PPARG protein CTD PMID:9013583 PMID:10866999 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of PTGS2 mRNA; Flufenamic Acid results in increased expression of PTGS2 protein
CTD PMID:10866999 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sell selectin L decreases expression ISO Flufenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc6a11 solute carrier family 6 member 11 multiple interactions ISO Flufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid] CTD PMID:15981712 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of TNF mRNA
CTD PMID:10866999 PMID:15135310 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity
ISO
EXP
[Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium
Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]
CTD PMID:11535132 PMID:14551041 PMID:21562303 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP
Flufenamic Acid results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        solvent 16636
          (trifluoromethyl)benzene 380
            flufenamic acid 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    haloalkane 11706
                                      fluoroalkane 7212
                                        fluoromethanes 6408
                                          tetrafluoromethane 6408
                                            trifluoromethyl group 6408
                                              (trifluoromethyl)benzenes 6408
                                                (trifluoromethyl)benzene 380
                                                  flufenamic acid 42
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