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ONTOLOGY REPORT - ANNOTATIONS


Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6 "ChemIDplus";   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269 "Europe PMC";   PMID:20978709 "Europe PMC";   PMID:21241664 "Europe PMC";   PMID:21319187 "Europe PMC";   PMID:21674264 "Europe PMC";   PMID:21964808 "Europe PMC";   PMID:22094120 "Europe PMC";   PMID:22162577 "Europe PMC";   PMID:22183330 "Europe PMC";   PMID:22221098 "Europe PMC";   PMID:22280430 "Europe PMC";   PMID:22323082 "Europe PMC";   PMID:22350416 "Europe PMC";   PMID:22382323 "Europe PMC";   PMID:22387538 "Europe PMC";   Reaxys:5769490 "Reaxys"


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  CHEBI ontology 23758
    role 23647
      chemical role 22196
        antioxidant 14745
          4-hydroxyphenyl retinamide 4026
Path 2
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  CHEBI ontology 23758
    subatomic particle 23707
      composite particle 23707
        hadron 23707
          baryon 23707
            nucleon 23707
              atomic nucleus 23707
                atom 23707
                  main group element atom 23527
                    p-block element atom 23527
                      carbon group element atom 23238
                        carbon atom 23215
                          organic molecular entity 23215
                            organic group 21900
                              organic divalent group 21872
                                organodiyl group 21872
                                  carbonyl group 21843
                                    carbonyl compound 21843
                                      carboxylic acid 20891
                                        carboacyl group 18987
                                          univalent carboacyl group 18987
                                            carbamoyl group 18375
                                              carboxamide 18375
                                                monocarboxylic acid amide 15340
                                                  4-hydroxyphenyl retinamide 4026
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