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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6;   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269;   PMID:20978709;   PMID:21241664;   PMID:21319187;   PMID:21674264;   PMID:21964808;   PMID:22094120;   PMID:22162577;   PMID:22183330;   PMID:22221098;   PMID:22280430;   PMID:22323082;   PMID:22350416;   PMID:22382323;   PMID:22387538;   Reaxys:5769490



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      CHEBI ontology 19803
        role 19779
          chemical role 19414
            antioxidant 16134
              4-hydroxyphenyl retinamide 3994
    Path 2
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      CHEBI ontology 19803
        subatomic particle 19801
          composite particle 19801
            hadron 19830
              baryon 19830
                nucleon 19830
                  atomic nucleus 19830
                    atom 19801
                      main group element atom 19780
                        p-block element atom 19780
                          carbon group element atom 19728
                            carbon atom 19725
                              organic molecular entity 19725
                                heteroorganic entity 19479
                                  organochalcogen compound 19214
                                    organooxygen compound 19129
                                      carbon oxoacid 18617
                                        carboxylic acid 18578
                                          carboacyl group 17692
                                            univalent carboacyl group 17692
                                              carbamoyl group 17542
                                                carboxamide 17542
                                                  monocarboxylic acid amide 15681
                                                    4-hydroxyphenyl retinamide 3994
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