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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fisetin
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Accession:CHEBI:42567 term browser browse the term
Definition:A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
 related_synonym: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one;   3,3',4',7-Tetrahydroxyflavone;   5-Desoxyquercetin;   7,3',4'-Trihydroxyflavonol;   Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H;   InChIKey=XHEFDIBZLJXQHF-UHFFFAOYSA-N;   SMILES=Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
 alt_id: CHEBI:42562;   CHEBI:5064
 xref: Beilstein:292829;   CAS:528-48-3;   DrugBank:DB07795;   KEGG:C10041;   KNApSAcK:C00004579;   LINCS:LSM-6579;   LIPID_MAPS_instance:LMPK12111566
 xref_mesh: MESH:C017875
 xref: MetaCyc:CPD-13503;   PDBeChem:FSE;   PMID:15781213;   PMID:22842629;   PMID:23054013;   PMID:23121441;   PMID:23277230;   Patent:CN102028680;   Patent:US2010010078;   Reaxys:292829;   Wikipedia:Fisetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:71992


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fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP fisetin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO fisetin results in increased localization of AIFM1 protein CTD PMID:28181380 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
fisetin results in increased phosphorylation of AKT1 protein
fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
CTD PMID:20153296 PMID:25428606 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; fisetin results in decreased stability of and results in decreased expression of AR protein
fisetin results in decreased expression of AR mRNA
CTD PMID:18922931 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein] CTD PMID:28181380 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein] CTD PMID:28181380 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein CTD PMID:21216935 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
EXP
ISO
fisetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
fisetin results in increased expression of BAX protein
fisetin inhibits the reaction [Lead results in increased expression of BAX protein]
fisetin affects the expression of BAX protein
[fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; U 0126 inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein]
CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
fisetin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
fisetin inhibits the reaction [Lead results in decreased expression of BCL2 protein]
fisetin results in decreased expression of BCL2 protein
[fisetin co-treated with Paclitaxel] results in increased expression of BCL2 mRNA
CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31539617 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein] CTD PMID:31044527 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of BDNF protein] CTD PMID:30890323 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions ISO fisetin promotes the reaction [Lead results in increased expression of BECN1 protein] CTD PMID:31539617 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases cleavage
ISO [Cisplatin co-treated with fisetin] results in increased cleavage of BID protein
fisetin affects the expression of BID protein
fisetin results in increased cleavage of BID protein
CTD PMID:21216935 PMID:28181380 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Cisplatin co-treated with fisetin] results in decreased expression of BIRC5 protein CTD PMID:21216935 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Capn1 calpain 1 increases expression
multiple interactions
ISO fisetin results in increased expression of CAPN1 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN1 protein]
CTD PMID:28181380 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
ISO fisetin results in increased expression of CAPN2 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN2 protein]
CTD PMID:28181380 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions
ISO fisetin results in increased expression of CASP12 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP12 protein]
CTD PMID:28181380 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased activity of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP3 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP3 protein; [fisetin co-treated with Paclitaxel] results in increased expression of CASP3 mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Lead results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD PMID:21216935 PMID:21964635 PMID:22931364 PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression
multiple interactions
ISO fisetin results in increased expression of CASP4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP4 protein]
CTD PMID:28181380 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein] CTD PMID:21216935 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein; fisetin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21216935 PMID:21964635 PMID:28181380 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
[Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP9 protein; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin results in increased cleavage of and results in increased activity of CASP9 protein
fisetin results in increased activity of CASP9 protein
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD PMID:21216935 PMID:25184746 PMID:28181380 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:25184746 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO fisetin results in decreased expression of CCN2 protein
[pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]
CTD PMID:31044527 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO fisetin results in decreased expression of CCNA2 protein CTD PMID:28181380 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein
fisetin results in decreased expression of CCNB1 protein
CTD PMID:21216935 PMID:28181380 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO fisetin results in decreased expression of CD44 protein CTD PMID:30802432 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO fisetin results in decreased expression of CDC25C protein CTD PMID:28181380 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO fisetin results in increased expression of CDH1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of CDH1 protein]
CTD PMID:30802432 PMID:31606474 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:31606474 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO fisetin results in decreased expression of CDK1 protein CTD PMID:28181380 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO fisetin results in decreased expression of CDK2 protein CTD PMID:28181380 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [Cisplatin co-treated with fisetin] results in increased expression of CDKN1A protein
fisetin results in increased expression of CDKN1A protein
CTD PMID:21216935 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO fisetin results in increased expression of CHEK2 protein CTD PMID:28181380 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cplx2 complexin 2 multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased phosphorylation of CREB1 protein] CTD PMID:31539617 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
ISO fisetin results in decreased expression of CTNNB1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CTNNB1 protein]
CTD PMID:30802432 PMID:31606474 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA] CTD PMID:25184746 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO fisetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP fisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA] CTD PMID:23524313 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein] CTD PMID:28181380 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddn dendrin multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of DDN mRNA] CTD PMID:30890323 NCBI chr 7:140,479,707...140,486,093
Ensembl chr 7:140,479,711...140,483,693
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity ISO fisetin results in increased activity of DIO2 protein CTD PMID:17327447 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of DLG4 protein] CTD PMID:31539617 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR protein modified form] CTD PMID:31606474 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein CTD PMID:28181380 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Endog endonuclease G increases localization ISO fisetin results in increased localization of ENDOG protein CTD PMID:28181380 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO fisetin results in decreased phosphorylation of and results in increased degradation of ERBB2 protein CTD PMID:30431692 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO fisetin results in decreased expression of ERBB3 protein CTD PMID:30431692 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Exoc8 exocyst complex component 8 multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of EXOC8 mRNA] CTD PMID:30890323 NCBI chr19:57,647,305...57,649,794
Ensembl chr19:57,647,291...57,649,827
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein
fisetin results in increased expression of FASLG protein
CTD PMID:21216935 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO fisetin results in increased expression of and affects the localization of FOS protein CTD PMID:31044527 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of GDNF protein] CTD PMID:30890323 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in increased expression of GFAP protein] CTD PMID:30890323 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GSK3B protein modified form] CTD PMID:31606474 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:25184746 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
increases activity
EXP
ISO
cobaltous chloride promotes the reaction [fisetin results in increased activity of HIF1A protein]; fisetin promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; fisetin results in increased expression of and affects the localization of HIF1A protein
fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
fisetin results in increased expression of HIF1A mRNA
CTD PMID:20153296 PMID:25428606 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO fisetin results in increased expression of HMOX1 protein
fisetin results in increased expression of HMOX1 mRNA; fisetin results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]
CTD PMID:16799064 PMID:30076913 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO fisetin results in increased expression of HSPA5 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein]
CTD PMID:28181380 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il13 interleukin 13 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:12789233 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein] CTD PMID:18958421 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
fisetin results in decreased expression of IL4 protein
CTD PMID:12789233 PMID:16343431 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL5 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]
fisetin inhibits the reaction [Lead results in increased expression of IL6 protein]
CTD PMID:18958421 PMID:22931364 PMID:31539617 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of JUN protein CTD PMID:31044527 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lats2 large tumor suppressor kinase 2 increases phosphorylation ISO fisetin results in increased phosphorylation of LATS2 protein CTD PMID:31044527 NCBI chr15:37,943,609...37,995,175
Ensembl chr15:37,943,609...37,983,882
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of LIN7A mRNA] CTD PMID:30890323 NCBI chr 7:49,429,613...49,627,835
Ensembl chr 7:49,385,705...49,656,856
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 increases expression ISO fisetin results in increased expression of MAP3K20 protein CTD PMID:31044527 NCBI chr 3:58,965,025...59,120,507
Ensembl chr 3:58,965,552...59,067,369
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
fisetin results in increased phosphorylation of MAPK1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
fisetin results in increased phosphorylation of MAPK3 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO fisetin inhibits the reaction [Lead results in increased phosphorylation of MAPT protein] CTD PMID:31539617 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of MME protein] CTD PMID:31539617 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP2 protein]
fisetin results in decreased expression of MMP2 mRNA; fisetin results in decreased expression of MMP2 protein
CTD PMID:30076913 PMID:31606474 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO fisetin inhibits the reaction [Silicon Dioxide results in increased expression of MMP9 mRNA]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP9 protein]
HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]
fisetin results in decreased expression of MMP9 mRNA; fisetin results in decreased expression of MMP9 protein
CTD PMID:22931364 PMID:30076913 PMID:31606474 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased activity of MPO protein] CTD PMID:25184746 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of MYD88 protein] CTD PMID:31539617 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO fisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein] CTD PMID:12789233 NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO fisetin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]
CTD PMID:16799064 PMID:30076913 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO fisetin results in decreased expression of NFKB1 protein CTD PMID:30802432 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:25184746 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
fisetin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
fisetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:17177504 PMID:25184746 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA] CTD PMID:25184746 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:25184746 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO fisetin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nrgn neurogranin multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of NRGN mRNA] CTD PMID:30890323 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity ISO fisetin results in decreased activity of PARP1 protein CTD PMID:17884996 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prom1 prominin 1 decreases expression ISO fisetin results in decreased expression of PROM1 protein CTD PMID:30802432 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]
fisetin inhibits the reaction [Lead affects the localization of RELA protein]
fisetin inhibits the reaction [Cisplatin affects the localization of and results in increased activity of RELA protein]
CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [fisetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO [fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO fisetin results in increased expression of SREBF2 protein alternative form CTD PMID:23524313 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]
fisetin results in decreased expression of STAT3 protein
CTD PMID:20153296 PMID:30802432 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stx1a syntaxin 1A multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of STX1A mRNA] CTD PMID:30890323 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of TLR4 protein] CTD PMID:31539617 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]
fisetin inhibits the reaction [Lead results in increased expression of TNF protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
increases expression
ISO
EXP
[Cisplatin co-treated with fisetin] affects the localization of TP53 protein; [Cisplatin co-treated with fisetin] results in increased expression of TP53 protein; [Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of TP53 mRNA]; SB 203580 inhibits the reaction [[Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
fisetin affects the localization of TP53 protein
fisetin results in increased expression of TP53 protein
CTD PMID:21216935 PMID:22931364 PMID:25184746 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO fisetin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; fisetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO fisetin results in decreased expression of VIM protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
CTD PMID:30802432 PMID:31606474 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:31044527 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          fisetin 111
            fisetin 8-C-glucoside 0
            fustin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  oxacycle 17539
                                    benzopyran 10267
                                      1-benzopyran 9989
                                        flavonoid 6509
                                          flavones 4197
                                            hydroxyflavone 4185
                                              flavonols 4096
                                                7-hydroxyflavonol 4075
                                                  fisetin 111
                                                    fisetin 8-C-glucoside 0
                                                    fustin + 0
paths to the root