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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fisetin
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Accession:CHEBI:42567 term browser browse the term
Definition:A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
 related_synonym: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one;   3,3',4',7-Tetrahydroxyflavone;   5-Desoxyquercetin;   7,3',4'-Trihydroxyflavonol;   Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H;   InChIKey=XHEFDIBZLJXQHF-UHFFFAOYSA-N;   SMILES=Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
 alt_id: CHEBI:42562;   CHEBI:5064
 xref: Beilstein:292829;   CAS:528-48-3;   Chemspider:4444933;   DrugBank:DB07795;   KEGG:C10041;   KNApSAcK:C00004579;   LINCS:LSM-6579;   LIPID_MAPS_instance:LMPK12111566
 xref_mesh: MESH:C017875
 xref: MetaCyc:CPD-13503;   PDBeChem:FSE;   PMID:12939617;   PMID:15254550;   PMID:15781213;   PMID:17551714;   PMID:22842629;   PMID:23054013;   PMID:23121441;   PMID:23277230;   Patent:CN102028680;   Patent:US2010010078;   Reaxys:292829;   Wikipedia:Fisetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:71992


show annotations for term's descendants           Sort by:
fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP fisetin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO fisetin results in increased localization of AIFM1 protein CTD PMID:28181380 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 fisetin results in increased phosphorylation of AKT1 protein
fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]		 CTD PMID:20153296 PMID:25428606 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; fisetin results in decreased stability of and results in decreased expression of AR protein
fisetin results in decreased expression of AR mRNA		 CTD PMID:18922931 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein] CTD PMID:28181380 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein] CTD PMID:28181380 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Cisplatin co-treated with fisetin] results in increased expression of BAK1 protein CTD PMID:21216935 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression		 EXP
ISO		 fisetin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
fisetin results in increased expression of BAX protein
fisetin inhibits the reaction [Lead results in increased expression of BAX protein]
fisetin affects the expression of BAX protein
[fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; U 0126 inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein]		 CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31044527 PMID:31539617 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 fisetin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
fisetin inhibits the reaction [Lead results in decreased expression of BCL2 protein]
fisetin results in decreased expression of BCL2 protein
[fisetin co-treated with Paclitaxel] results in increased expression of BCL2 mRNA		 CTD PMID:25184746 PMID:26884726 PMID:28181380 PMID:31539617 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein] CTD PMID:31044527 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of BDNF protein] CTD PMID:30890323 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO fisetin promotes the reaction [Lead results in increased expression of BECN1 protein] CTD PMID:31539617 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases cleavage		 ISO [Cisplatin co-treated with fisetin] results in increased cleavage of BID protein
fisetin affects the expression of BID protein
fisetin results in increased cleavage of BID protein		 CTD PMID:21216935 PMID:28181380 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Cisplatin co-treated with fisetin] results in decreased expression of BIRC5 protein CTD PMID:21216935 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Capn1 calpain 1 increases expression
multiple interactions		 ISO fisetin results in increased expression of CAPN1 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN1 protein]		 CTD PMID:28181380 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions		 ISO fisetin results in increased expression of CAPN2 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN2 protein]		 CTD PMID:28181380 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions		 ISO fisetin results in increased expression of CASP12 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP12 protein]		 CTD PMID:28181380 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased activity of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP3 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP3 protein; [fisetin co-treated with Paclitaxel] results in increased expression of CASP3 mRNA; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Lead results in increased cleavage of CASP3 protein]
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]		 CTD PMID:21216935 PMID:21964635 PMID:22931364 PMID:25184746 PMID:26884726 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression
multiple interactions		 ISO fisetin results in increased expression of CASP4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP4 protein]		 CTD PMID:28181380 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein] CTD PMID:21216935 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fisetin results in increased activity of CASP8 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP8 protein; fisetin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21216935 PMID:21964635 PMID:28181380 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO
EXP		 [Cisplatin co-treated with fisetin] promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP9 protein; fisetin promotes the reaction [CASP9 protein results in increased cleavage of CASP7 protein]; fisetin results in increased cleavage of and results in increased activity of CASP9 protein
fisetin results in increased activity of CASP9 protein
fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]		 CTD PMID:21216935 PMID:25184746 PMID:28181380 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:25184746 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions		 ISO fisetin results in decreased expression of CCN2 protein
[pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; U 0126 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]		 CTD PMID:31044527 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO fisetin results in decreased expression of CCNA2 protein CTD PMID:28181380 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression		 ISO [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein
fisetin results in decreased expression of CCNB1 protein		 CTD PMID:21216935 PMID:28181380 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO fisetin results in decreased expression of CD44 protein CTD PMID:30802432 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO fisetin results in decreased expression of CDC25C protein CTD PMID:28181380 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO fisetin results in increased expression of CDH1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of CDH1 protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:31606474 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO fisetin results in decreased expression of CDK1 protein CTD PMID:28181380 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO fisetin results in decreased expression of CDK2 protein CTD PMID:28181380 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [Cisplatin co-treated with fisetin] results in increased expression of CDKN1A protein
fisetin results in increased expression of CDKN1A protein		 CTD PMID:21216935 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO fisetin results in increased expression of CHEK2 protein CTD PMID:28181380 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cplx2 complexin 2 multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased phosphorylation of CREB1 protein] CTD PMID:31539617 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions		 ISO fisetin results in decreased expression of CTNNB1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CTNNB1 protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased expression of CYBB mRNA] CTD PMID:25184746 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO fisetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP fisetin inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA] CTD PMID:23524313 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein] CTD PMID:28181380 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddn dendrin multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of DDN mRNA] CTD PMID:30890323 NCBI chr 7:129,953,317...129,957,299
Ensembl chr 7:129,953,318...129,957,341 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity ISO fisetin results in increased activity of DIO2 protein CTD PMID:17327447 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of DLG4 protein] CTD PMID:31539617 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR protein modified form] CTD PMID:31606474 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein CTD PMID:28181380 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Endog endonuclease G increases localization ISO fisetin results in increased localization of ENDOG protein CTD PMID:28181380 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO fisetin results in decreased phosphorylation of and results in increased degradation of ERBB2 protein CTD PMID:30431692 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO fisetin results in decreased expression of ERBB3 protein CTD PMID:30431692 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Exoc8 exocyst complex component 8 multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of EXOC8 mRNA] CTD PMID:30890323 NCBI chr19:52,855,010...52,857,499
Ensembl chr19:52,852,578...52,857,491 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein
fisetin results in increased expression of FASLG protein		 CTD PMID:21216935 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO fisetin results in increased expression of and affects the localization of FOS protein CTD PMID:31044527 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of GDNF protein] CTD PMID:30890323 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in increased expression of GFAP protein] CTD PMID:30890323 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GSK3B protein modified form] CTD PMID:31606474 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:25184746 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
increases activity		 EXP
ISO		 cobaltous chloride promotes the reaction [fisetin results in increased activity of HIF1A protein]; fisetin promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; fisetin results in increased expression of and affects the localization of HIF1A protein
fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
fisetin results in increased expression of HIF1A mRNA		 CTD PMID:20153296 PMID:25428606 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO fisetin results in increased expression of HMOX1 protein
fisetin results in increased expression of HMOX1 mRNA; fisetin results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:30076913 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO fisetin results in increased expression of HSPA5 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein]		 CTD PMID:28181380 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:12789233 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein] CTD PMID:18958421 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
fisetin results in decreased expression of IL4 protein		 CTD PMID:12789233 PMID:16343431 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL5 protein]; fisetin inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]
fisetin inhibits the reaction [Lead results in increased expression of IL6 protein]		 CTD PMID:18958421 PMID:22931364 PMID:31539617 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; fisetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of JUN protein CTD PMID:31044527 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lats2 large tumor suppressor kinase 2 increases phosphorylation ISO fisetin results in increased phosphorylation of LATS2 protein CTD PMID:31044527 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220 		JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of LIN7A mRNA] CTD PMID:30890323 NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 increases expression ISO fisetin results in increased expression of MAP3K20 protein CTD PMID:31044527 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO
EXP		 fisetin results in increased phosphorylation of MAPK1 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]		 CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO
EXP		 fisetin results in increased phosphorylation of MAPK3 protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21964635 PMID:25428606 PMID:31044527 PMID:31606474 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO fisetin inhibits the reaction [Lead results in increased phosphorylation of MAPT protein] CTD PMID:31539617 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of MME protein] CTD PMID:31539617 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP2 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP2 protein]
fisetin results in decreased expression of MMP2 mRNA; fisetin results in decreased expression of MMP2 protein		 CTD PMID:30076913 PMID:31606474 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO fisetin inhibits the reaction [Silicon Dioxide results in increased expression of MMP9 mRNA]; fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MMP9 protein]
HMOX1 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; tin protoporphyrin IX inhibits the reaction [fisetin results in decreased expression of MMP9 protein]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]
fisetin results in decreased expression of MMP9 mRNA; fisetin results in decreased expression of MMP9 protein		 CTD PMID:22931364 PMID:30076913 PMID:31606474 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased activity of MPO protein] CTD PMID:25184746 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of MYD88 protein] CTD PMID:31539617 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO fisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein] CTD PMID:12789233 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO fisetin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP2 protein]; NFE2L2 protein promotes the reaction [fisetin results in decreased expression of MMP9 protein]; NFE2L2 protein promotes the reaction [fisetin results in increased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:30076913 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO fisetin results in decreased expression of NFKB1 protein CTD PMID:30802432 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:25184746 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 fisetin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
fisetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]		 CTD PMID:17177504 PMID:25184746 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA] CTD PMID:25184746 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP fisetin inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:25184746 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO fisetin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nrgn neurogranin multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of NRGN mRNA] CTD PMID:30890323 NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity ISO fisetin results in decreased activity of PARP1 protein CTD PMID:17884996 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prom1 prominin 1 decreases expression ISO fisetin results in decreased expression of PROM1 protein CTD PMID:30802432 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]
fisetin inhibits the reaction [Lead affects the localization of RELA protein]
fisetin inhibits the reaction [Cisplatin affects the localization of and results in increased activity of RELA protein]		 CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein]; fisetin results in increased activity of and results in increased phosphorylation of SIRT1 protein CTD PMID:31539617 PMID:34216621 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [fisetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO [fisetin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions ISO fisetin inhibits the reaction [Lead results in decreased expression of SNAP25 protein] CTD PMID:31539617 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO fisetin results in increased expression of SREBF2 protein alternative form CTD PMID:23524313 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]
fisetin results in decreased expression of STAT3 protein		 CTD PMID:20153296 PMID:30802432 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stx1a syntaxin 1A multiple interactions EXP fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of STX1A mRNA] CTD PMID:30890323 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO fisetin inhibits the reaction [Lead results in increased expression of TLR4 protein] CTD PMID:31539617 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]
fisetin inhibits the reaction [Lead results in increased expression of TNF protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:18958421 PMID:25184746 PMID:31539617 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
increases expression		 ISO
EXP		 [Cisplatin co-treated with fisetin] affects the localization of TP53 protein; [Cisplatin co-treated with fisetin] results in increased expression of TP53 protein; [Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein; fisetin inhibits the reaction [Silicon Dioxide results in increased expression of TP53 mRNA]; SB 203580 inhibits the reaction [[Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein]
fisetin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
fisetin affects the localization of TP53 protein
fisetin results in increased expression of TP53 protein		 CTD PMID:21216935 PMID:22931364 PMID:25184746 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of fisetin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO fisetin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; fisetin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; fisetin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO fisetin results in decreased expression of VIM protein
fisetin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]		 CTD PMID:30802432 PMID:31606474 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO fisetin results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:31044527 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      chemical role 19421
        antioxidant 15726
          fisetin 112
            fisetin 8-C-glucoside 0
            fustin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  oxacycle 17770
                                    benzopyran 11699
                                      1-benzopyran 11461
                                        flavonoid 6821
                                          anthoxanthin 4506
                                            flavones 4506
                                              hydroxyflavone 4492
                                                flavonols 4393
                                                  7-hydroxyflavonol 4370
                                                    fisetin 112
                                                      fisetin 8-C-glucoside 0
                                                      fustin + 0
paths to the root