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Accession:CHEBI:42549 term browser browse the term
Definition:An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).
Synonyms:exact_synonym: 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine
 related_synonym: (2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid;   (S)-(-)-5-fluorowillardiine;   (S)-F-Willardiine;   (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid;   2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID;   5-Fluorowillardiine;   Formula=C7H8FN3O4;   InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1;   InChIKey=DBWPFHJYSTVBCZ-BYPYZUCNSA-N;   SMILES=N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(O)=O
 xref: CAS:140187-23-1;   DrugBank:DB02966;   KEGG:C13671
 xref_mesh: MESH:C095178
 xref: PDBeChem:FWD;   PMID:11041846;   PMID:11487516;   PMID:1371315;   PMID:16256076;   PMID:7566471;   PMID:8640342;   PMID:8957243;   Reaxys:7817206;   Wikipedia:5-Fluorowillardiine

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3-(5-fluorouracil-1-yl)-L-alanine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 JBrowse link X 127,561,843 127,829,763 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      application 19363
        pro-agent 8836
          prodrug 8625
            uracil 5649
              3-(5-fluorouracil-1-yl)-L-alanine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18451
                              organic divalent group 18445
                                organodiyl group 18445
                                  carbonyl group 18346
                                    carbonyl compound 18346
                                      carboxylic acid 18019
                                        monocarboxylic acid 17277
                                          fatty acid 15815
                                            saturated fatty acid 15781
                                              propionic acid 3670
                                                alanine 104
                                                  L-alanine 96
                                                    L-alanine derivative 94
                                                      3-(5-fluorouracil-1-yl)-L-alanine 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.