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ONTOLOGY REPORT - ANNOTATIONS


Term:flavone
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Accession:CHEBI:42491 term browser browse the term
Definition:The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.
Synonyms:related_synonym: 2-PHENYL-4H-CHROMEN-4-ONE;   2-Phenyl-4-benzopyron;   2-Phenyl-4-chromone;   2-Phenylbenzopyran-4-one;   2-phenyl-4H-1-benzopyran-4-one;   2-phenyl-4H-benzopyran-4-one;   2-phenyl-gamma-benzopyrone;   2-phenylchromone;   Flavon;   Formula=C15H10O2;   InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H;   InChIKey=VHBFFQKBGNRLFZ-UHFFFAOYSA-N;   SMILES=O=c1cc(oc2ccccc12)-c1ccccc1
 alt_id: CHEBI:42486;   CHEBI:5076
 xref: Beilstein:157598 "Beilstein";   CAS:525-82-6 "ChemIDplus";   CAS:525-82-6 "KEGG COMPOUND";   CAS:525-82-6 "NIST Chemistry WebBook";   DrugBank:DB07776;   Gmelin:1224858 "Gmelin";   HMDB:HMDB0003075;   KEGG:C10043;   KEGG:C15608;   KNApSAcK:C00001040;   LIPID_MAPS_instance:LMPK12110097 "LIPID MAPS"
 xref_mesh: MESH:C043562
 xref: MetaCyc:CPD-8485;   PDBeChem:FLN;   PMID:11370674 "Europe PMC";   PMID:12063116 "Europe PMC";   PMID:17347140 "Europe PMC";   PMID:18596412 "Europe PMC";   Reaxys:157598 "Reaxys"


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flavone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cenpj centromere protein J JBrowse link 15 36,745,672 36,809,228 RGD:6480464
G Cep83 centrosomal protein 83 JBrowse link 7 35,739,553 35,847,618 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G Esrrb estrogen-related receptor beta JBrowse link 6 110,360,940 110,458,406 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6480464
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Krt8 keratin 8 JBrowse link 7 143,596,511 143,603,745 RGD:6480464
G Lmnb2 lamin B2 JBrowse link 7 11,657,870 11,676,936 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Myo5a myosin VA JBrowse link 8 82,038,966 82,156,507 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:6480464
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:6480464
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:6480464
G Psmc1 proteasome 26S subunit, ATPase 1 JBrowse link 6 124,123,283 124,135,644 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Sycp1 synaptonemal complex protein 1 JBrowse link 2 205,274,766 205,426,869 RGD:6480464
cirsiliol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
nevadensin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
nobiletin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6480464
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Depdc1 DEP domain containing 1 JBrowse link 2 264,704,738 264,738,265 RGD:6480464
G E2f8 E2F transcription factor 8 JBrowse link 1 104,185,436 104,203,683 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6480464
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G H1f5 H1.5 linker histone, cluster member JBrowse link 17 44,766,313 44,766,981 RGD:6480464
G Kif11 kinesin family member 11 JBrowse link 1 256,035,866 256,088,299 RGD:6480464
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:6480464
G Slc6a9 solute carrier family 6 member 9 JBrowse link 5 136,669,674 136,703,702 RGD:6480464
G Tmem116 transmembrane protein 116 JBrowse link 12 40,537,261 40,618,805 RGD:6480464
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
sinensetin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
tectochrysin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            flavone 65
              2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone 0
              2-(2,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(2,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(3,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
              2-[4-(acetyloxy)phenyl]-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              5,7,2'-trihydroxy-6-methoxyflavone 0
              5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
              6-hydroxy-2'-methoxyflavone 0
              7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
              7-hydroxy-5-methoxy-6,8-dimethylflavone 0
              arcapillin 0
              cirsilineol 0
              cirsiliol 2
              cirsimaritin 0
              diplotrin A 0
              diplotrin B 0
              diplotrin C 0
              eupatolitin 0
              hernancorizin 0
              neocarlinoside 0
              nevadensin 1
              nobiletin 26
              oxyayanin A 0
              oxyayanin B 0
              santin 0
              scullcapflavone II 0
              sideroxylin + 0
              sinensetin 3
              spinosin 0
              tectochrysin 1
              thymonin 0
              violanthin 0
              xanthomicrol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  oxacycle 16954
                                    benzopyran 9473
                                      1-benzopyran 9168
                                        flavonoid 6319
                                          flavones 4144
                                            flavone 65
                                              2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone 0
                                              2-(2,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(2,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(3,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                                              2-[4-(acetyloxy)phenyl]-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              5,7,2'-trihydroxy-6-methoxyflavone 0
                                              5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                                              6-hydroxy-2'-methoxyflavone 0
                                              7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                                              7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                                              arcapillin 0
                                              cirsilineol 0
                                              cirsiliol 2
                                              cirsimaritin 0
                                              diplotrin A 0
                                              diplotrin B 0
                                              diplotrin C 0
                                              eupatolitin 0
                                              hernancorizin 0
                                              neocarlinoside 0
                                              nevadensin 1
                                              nobiletin 26
                                              oxyayanin A 0
                                              oxyayanin B 0
                                              santin 0
                                              scullcapflavone II 0
                                              sideroxylin + 0
                                              sinensetin 3
                                              spinosin 0
                                              tectochrysin 1
                                              thymonin 0
                                              violanthin 0
                                              xanthomicrol 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.