The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
flavone results in decreased expression of ABCB1 protein flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] flavone results in increased activity of ABCB1 protein
flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione] flavone results in decreased activity of ABCC1 protein
flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] flavone binds to AHR protein
flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] flavone results in increased expression of CYP1A1 mRNA flavone results in decreased activity of CYP1A1 protein flavone results in increased expression of CYP1A1 mRNA; flavone results in increased expression of CYP1A1 protein
flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] flavone results in decreased activity of CYP1A2 protein
flavone results in increased activity of CYP3A4 protein [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; flavone binds to and results in decreased activity of CYP3A4 protein; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]
flavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; flavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
flavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; flavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
dorsomorphin inhibits the reaction [flavone results in increased expression of SOCS3 protein] flavone results in increased expression of SOCS3 mRNA 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 protein]; AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]; AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein] flavone results in increased expression of SOCS3 mRNA; flavone results in increased expression of SOCS3 protein
cirsiliol results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of cirsiliol cirsiliol results in increased expression of CYP1A1 mRNA
cirsiliol results in increased expression of CYP1B1 mRNA CYP1B1 protein results in increased metabolism of cirsiliol cirsiliol results in decreased activity of CYP1B1 protein
nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]
nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]
[nobiletin co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein
nobiletin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] nobiletin inhibits the reaction [Arsenic results in increased expression of BAX protein]; nobiletin inhibits the reaction [nonylphenol results in increased expression of BAX mRNA]
nobiletin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] nobiletin inhibits the reaction [Arsenic results in decreased expression of BCL2 protein]; nobiletin inhibits the reaction [nonylphenol results in decreased expression of BCL2 mRNA]
AGN 193109 inhibits the reaction [nobiletin results in decreased expression of and results in increased cleavage of CASP3 protein]; nobiletin results in decreased expression of and results in increased cleavage of CASP3 protein nobiletin inhibits the reaction [Arsenic results in increased expression of CASP3 protein]; nobiletin inhibits the reaction [nonylphenol results in increased expression of CASP3 mRNA]
AGN 193109 inhibits the reaction [nobiletin results in decreased expression of and results in increased cleavage of CASP9 protein]; nobiletin results in decreased expression of and results in increased cleavage of CASP9 protein nobiletin inhibits the reaction [Arsenic results in increased expression of CASP9 protein]
nobiletin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; nobiletin inhibits the reaction [nonylphenol results in decreased activity of CAT protein]
CYP1A1 protein results in increased metabolism of nobiletin nobiletin results in increased expression of CYP1A1 protein nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
nobiletin results in increased activity of CYP3A4 protein [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA
nobiletin inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of GPT protein]
nobiletin inhibits the reaction [Arsenic results in decreased activity of GSR protein]; nobiletin inhibits the reaction [nonylphenol results in decreased activity of GSR protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of IL1B protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of IL6 protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA
AGN 193109 inhibits the reaction [nobiletin results in decreased expression of and results in increased cleavage of PARP1 protein]; nobiletin results in decreased expression of and results in increased cleavage of PARP1 protein
AGN 193109 inhibits the reaction [nobiletin results in increased expression of RARB protein] nobiletin results in increased expression of RARB mRNA; nobiletin results in increased expression of RARB protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; nobiletin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of TNF protein]
sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] sinensetin analog results in decreased activity of ABCB1 protein; sinensetin results in decreased activity of ABCB1 protein
sinensetin analog results in increased activity of CYP3A4 protein; sinensetin results in increased activity of CYP3A4 protein [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam
sinensetin results in decreased activity of SLCO1B1 protein [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan
[tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine] ABCB1 protein results in decreased susceptibility to tectochrysin