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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flavone
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Accession:CHEBI:42491 term browser browse the term
Definition:The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.
Synonyms:related_synonym: 2-PHENYL-4H-CHROMEN-4-ONE;   2-Phenyl-4-benzopyron;   2-Phenyl-4-chromone;   2-Phenylbenzopyran-4-one;   2-phenyl-4H-1-benzopyran-4-one;   2-phenyl-4H-benzopyran-4-one;   2-phenyl-gamma-benzopyrone;   2-phenylchromone;   Flavon;   Formula=C15H10O2;   InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H;   InChIKey=VHBFFQKBGNRLFZ-UHFFFAOYSA-N;   SMILES=O=c1cc(oc2ccccc12)-c1ccccc1
 alt_id: CHEBI:42486;   CHEBI:5076
 xref: Beilstein:157598;   CAS:525-82-6;   DrugBank:DB07776;   Gmelin:1224858;   HMDB:HMDB0003075;   KEGG:C10043;   KEGG:C15608;   KNApSAcK:C00001040;   LIPID_MAPS_instance:LMPK12110097
 xref_mesh: MESH:C043562
 xref: MetaCyc:CPD-8485;   PDBeChem:FLN;   PMID:11370674;   PMID:12063116;   PMID:17347140;   PMID:18596412;   Reaxys:157598


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flavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
flavone results in decreased activity of ABCC1 protein
CTD PMID:15041478 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO flavone results in increased expression of ABCG2 mRNA; flavone results in increased expression of ABCG2 protein CTD PMID:17077187 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression ISO flavone results in increased expression of ACAA2 protein CTD PMID:14750173 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
ISO flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
flavone binds to AHR protein
CTD PMID:17090139, PMID:20436506, PMID:20450880 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO flavone results in increased expression of APAF1 protein CTD PMID:14750173 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor affects binding EXP flavone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein] CTD PMID:15289867, PMID:15800915 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO flavone results in decreased expression of CCL2 mRNA CTD PMID:23782265 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP flavone results in increased localization of and results in increased activity of CEBPB protein CTD PMID:12663507 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpj centromere protein J decreases expression ISO flavone results in decreased expression of CENPJ protein CTD PMID:14750173 NCBI chr15:36,745,672...36,809,228
Ensembl chr15:36,746,088...36,798,814
JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO flavone results in increased expression of CEP83 protein CTD PMID:14750173 NCBI chr 7:35,739,553...35,847,618
Ensembl chr 7:35,773,928...35,847,617
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO flavone results in increased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
flavone results in increased expression of CYP1A1 mRNA
flavone results in decreased activity of CYP1A1 protein
flavone results in increased expression of CYP1A1 mRNA; flavone results in increased expression of CYP1A1 protein
CTD PMID:15890477, PMID:17090139, PMID:20930378, PMID:21053930, PMID:31655123 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
flavone results in decreased activity of CYP1A2 protein
CTD PMID:17090139, PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO flavone results in increased expression of CYP1B1 mRNA
flavone binds to and results in decreased activity of CYP1B1 protein
CTD PMID:15890477, PMID:19563207, PMID:21053930 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO flavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO flavone binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding
ISO flavone binds to and results in increased activity of ESRRA protein
flavone binds to ESRRA protein mutant form
CTD PMID:14638870 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Esrrb estrogen-related receptor beta multiple interactions ISO flavone binds to and results in increased activity of ESRRB protein CTD PMID:14638870 NCBI chr 6:110,360,940...110,458,406
Ensembl chr 6:110,410,141...110,455,906
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP flavone results in increased expression of GSTA2 CTD PMID:12663507 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO flavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO flavone results in decreased expression of HSPA1A protein CTD PMID:14750173 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO flavone results in decreased expression of HSPD1 protein CTD PMID:14750173 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:29960001 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Krt18 keratin 18 decreases expression ISO flavone results in decreased expression of KRT18 protein CTD PMID:14750173 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression ISO flavone results in increased expression of KRT8 protein CTD PMID:14750173 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lmnb2 lamin B2 decreases expression ISO flavone results in decreased expression of LMNB2 protein CTD PMID:14750173 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO flavone results in decreased activity of MAOA protein CTD PMID:23009399 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Myo5a myosin VA increases expression ISO flavone results in increased expression of MYO5A protein CTD PMID:14750173 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO flavone promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NFKBIA mRNA] CTD PMID:17643414 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO flavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; flavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18274639 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO flavone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
decreases activity
ISO flavone results in increased cleavage of PARP1 protein
flavone results in decreased activity of PARP1 protein
CTD PMID:15289867, PMID:17643414 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phb prohibitin decreases expression ISO flavone results in decreased expression of PHB protein CTD PMID:14750173 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO flavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO flavone results in increased expression of PON1 mRNA CTD PMID:15169886 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO flavone results in increased expression of PSMC1 protein CTD PMID:14750173 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO flavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; flavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21341175 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO flavone results in increased expression of RAD50 protein CTD PMID:14750173 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO flavone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:18274639 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO flavone results in increased expression of SERPINB1 protein CTD PMID:14750173 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression
ISO dorsomorphin inhibits the reaction [flavone results in increased expression of SOCS3 protein]
flavone results in increased expression of SOCS3 mRNA
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 protein]; AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]; AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein]
flavone results in increased expression of SOCS3 mRNA; flavone results in increased expression of SOCS3 protein
CTD PMID:23782265 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sycp1 synaptonemal complex protein 1 increases expression ISO flavone results in increased expression of SYCP1 protein CTD PMID:14750173 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression
ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA
CTD PMID:19601638, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
decreases activity
ISO cirsiliol results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of cirsiliol
cirsiliol results in decreased activity of CYP1B1 protein
CTD PMID:19601638, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
nevadensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity
EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [nevadensin results in increased activity of ACHE protein] CTD PMID:31034797 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
nobiletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043, PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon] CTD PMID:18955043 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [nobiletin co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein CTD PMID:29687528 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO
EXP
nobiletin results in increased expression of ASNS mRNA; nobiletin results in increased expression of ASNS protein CTD PMID:23321314 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO nobiletin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] CTD PMID:29687528 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO nobiletin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:29687528 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO
EXP
nobiletin results in decreased expression of CCNA2 mRNA CTD PMID:23321314 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO
EXP
nobiletin results in decreased expression of CCNE2 mRNA CTD PMID:23321314 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd74 CD74 molecule decreases expression ISO nobiletin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
multiple interactions
ISO CYP1A1 protein results in increased metabolism of nobiletin
nobiletin results in increased expression of CYP1A1 protein
nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:20865247, PMID:22743247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of nobiletin CTD PMID:22743247 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO nobiletin results in increased expression of CYP1B1 mRNA CTD PMID:22743247 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO
EXP
nobiletin results in increased expression of DDIT3 mRNA; nobiletin results in increased expression of DDIT3 protein CTD PMID:23321314 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Depdc1 DEP domain containing 1 decreases expression ISO
EXP
nobiletin results in decreased expression of DEPDC1 mRNA CTD PMID:23321314 NCBI chr 2:264,704,738...264,738,265
Ensembl chr 2:264,704,769...264,738,257
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO
EXP
nobiletin results in decreased expression of E2F8 mRNA CTD PMID:23321314 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP nobiletin results in increased expression of FOS mRNA CTD PMID:24964900 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31777137 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP nobiletin results in increased expression of GRIN1 mRNA CTD PMID:24964900 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP nobiletin results in increased expression of GRIN2A mRNA CTD PMID:24964900 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression EXP nobiletin results in increased expression of GRIN2B mRNA CTD PMID:24964900 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G H1f5 H1.5 linker histone, cluster member decreases expression ISO
EXP
nobiletin results in decreased expression of H1-5 mRNA
nobiletin results in decreased expression of H1F5 mRNA
CTD PMID:23321314 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein] CTD PMID:31777137 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein] CTD PMID:31777137 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL6 protein] CTD PMID:31777137 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO
EXP
nobiletin results in decreased expression of KIF11 mRNA CTD PMID:23321314 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO nobiletin results in decreased expression of MMP7 mRNA; nobiletin results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein] CTD PMID:31777137 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression ISO
EXP
nobiletin results in increased expression of SLC6A9 mRNA CTD PMID:23321314 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Tmem116 transmembrane protein 116 increases expression ISO
EXP
nobiletin results in increased expression of TMEM116 mRNA CTD PMID:23321314 NCBI chr12:40,537,261...40,618,805
Ensembl chr12:40,557,677...40,590,361
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of TNF protein] CTD PMID:31777137 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO
EXP
nobiletin results in increased expression of TRIB3 mRNA CTD PMID:23321314 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO
EXP
nobiletin results in decreased expression of TXNIP mRNA; nobiletin results in decreased expression of TXNIP protein CTD PMID:23321314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
scullcapflavone II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 affects binding ISO skullcapflavone II binds to CASP3 protein CTD PMID:32913905 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects binding ISO skullcapflavone II binds to MAPK14 protein CTD PMID:32913905 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
sinensetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
sinensetin analog results in decreased activity of ABCB1 protein; sinensetin results in decreased activity of ABCB1 protein
CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing ISO CYP1B1 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            flavone 73
              2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone 0
              2-(2,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(2,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(3,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
              2-[4-(acetyloxy)phenyl]-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
              5,7,2'-trihydroxy-6-methoxyflavone 0
              5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
              6-hydroxy-2'-methoxyflavone 0
              7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
              7-hydroxy-5-methoxy-6,8-dimethylflavone 0
              arcapillin 0
              cirsilineol 0
              cirsiliol 2
              cirsimaritin 0
              diplotrin A 0
              diplotrin B 0
              diplotrin C 0
              eupatolitin 0
              hernancorizin 0
              neocarlinoside 0
              nevadensin 1
              nobiletin 32
              oxyayanin A 0
              oxyayanin B 0
              santin 0
              scullcapflavone II 2
              sideroxylin + 0
              sinensetin 5
              spinosin 0
              tectochrysin 1
              thymonin 0
              violanthin 0
              xanthomicrol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        flavonoid 6374
                                          flavones 4166
                                            flavone 73
                                              2'-hydroxy-3,7,8,4',5'-pentamethoxyflavone 0
                                              2-(2,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(2,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(3,5-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                                              2-[4-(acetyloxy)phenyl]-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                              5,7,2'-trihydroxy-6-methoxyflavone 0
                                              5,7,3'-trihydroxy-3,5'-dimethoxy-2'-(3'-methylbut-2-enyl)flavone 0
                                              6-hydroxy-2'-methoxyflavone 0
                                              7,3',4'-trihydroxy-3,8-dimethoxyflavone 0
                                              7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                                              arcapillin 0
                                              cirsilineol 0
                                              cirsiliol 2
                                              cirsimaritin 0
                                              diplotrin A 0
                                              diplotrin B 0
                                              diplotrin C 0
                                              eupatolitin 0
                                              hernancorizin 0
                                              neocarlinoside 0
                                              nevadensin 1
                                              nobiletin 32
                                              oxyayanin A 0
                                              oxyayanin B 0
                                              santin 0
                                              scullcapflavone II 2
                                              sideroxylin + 0
                                              sinensetin 5
                                              spinosin 0
                                              tectochrysin 1
                                              thymonin 0
                                              violanthin 0
                                              xanthomicrol 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.