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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethidium
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Accession:CHEBI:42478 term browser browse the term
Definition:The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.
Synonyms:related_synonym: 3,8-diamino-5-ethyl-6-phenylphenanthridinium;   Formula=C21H20N3;   InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1;   InChIKey=QTANTQQOYSUMLC-UHFFFAOYSA-O;   SMILES=CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc12;   ethidium cation;   homidium
 xref: Beilstein:3627183;   CAS:3546-21-2;   Gmelin:981639
 xref_mesh: MESH:D004996
 xref: PDBeChem:ET


show annotations for term's descendants           Sort by:
ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CCND1 cyclin D1 multiple interactions EXP Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 multiple interactions EXP Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCNE2 cyclin E2 multiple interactions EXP Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) increases mutagenesis EXP Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha multiple interactions ISO [Pyruvic Acid co-treated with Uridine co-treated with Ethidium] inhibits the reaction [Rotenone inhibits the reaction [arsenite results in increased expression of ERO1A protein]] CTD PMID:37659621 NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900 		JBrowse link
G GJA1 gap junction protein alpha 1 increases uptake ISO GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 PMID:10571731 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Ethidium results in decreased expression of COX1 protein CTD PMID:18823003 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II decreases expression EXP Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MT-CYB mitochondrially encoded cytochrome b decreases expression EXP Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887 		JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression EXP Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262 		JBrowse link
G MT-ND4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression EXP Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,760...12,137
Ensembl chr MT:10,760...12,137 		JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression EXP Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082 		JBrowse link
G P2RX7 purinergic receptor P2X 7 decreases transport
increases transport		 EXP P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium		 CTD PMID:16263709 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RELA protein] CTD PMID:35032610 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions
affects uptake
increases uptake		 EXP
ISO		 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium		 CTD PMID:19357179 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 increases uptake
multiple interactions
affects uptake		 EXP
ISO		 SLC22A2 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
SLC22A2 protein affects the uptake of Ethidium		 CTD PMID:19357179 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 increases uptake
multiple interactions		 EXP SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]		 CTD PMID:19357179 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of STING1 protein] CTD PMID:35032610 NCBI chr 5:139,475,533...139,482,758
Ensembl chr 5:139,475,533...139,482,935 		JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of TNF mRNA] CTD PMID:35032610 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 affects activity EXP Ethidium affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        dye 3017
          fluorescent dye 2167
            fluorochrome 236
              ethidium 23
                ethidium bromide 0
                ethidium homodimer 0
                ethidium homodimer tetracation + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteropolycyclic compound 21329
                                    organic heterotricyclic compound 15986
                                      dibenzopyridine 174
                                        phenanthridines 60
                                          phenanthridine 23
                                            ethidium 23
                                              ethidium bromide 0
                                              ethidium homodimer 0
                                              ethidium homodimer tetracation + 0
paths to the root