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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:forskolin
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Accession:CHEBI:42471 term browser browse the term
Definition:A labdane diterpenoid isolated from the Indian Coleus plant.
Synonyms:exact_synonym: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
 related_synonym: 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one;   Coleonol;   Coleonolk;   Formula=C22H34O7;   InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1;   InChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N;   SMILES=[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C;   colforsin;   colforsina;   colforsine;   colforsinum
 xref: CAS:66428-89-5;   CAS:66575-29-9;   DrugBank:DB02587;   KEGG:C09076;   KEGG:D03584;   KNApSAcK:C00003416;   PDBeChem:FOK;   PMID:11816015;   PMID:12676767;   PMID:12836714;   PMID:14691682;   PMID:15135319;   PMID:15380183;   PMID:1547891;   PMID:15525467;   PMID:16644480;   PMID:17570033;   PMID:19831022;   PMID:7755573;   PMID:7875530;   PMID:7898427;   PMID:7929167;   PMID:8489512;   PMID:8985363;   PMID:9478958;   PMID:9828101;   Patent:DE2557784;   Patent:US4088659;   Patent:US4476140;   Reaxys:4300863;   Wikipedia:Forskolin


show annotations for term's descendants           Sort by:
forskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 increases activity ISO forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:8408014 RGD:36947876 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
1,9-dideoxyforskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1A protein CTD PMID:12202523 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1B protein CTD PMID:12202523 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB4 protein CTD PMID:12202523 NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        antimicrobial agent 18276
          antiviral agent 11395
            anti-HIV agent 2931
              forskolin 4
                1,9-dideoxyforskolin 3
                colforsin daropate 0
                methylpiperazinoforskolin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbon oxoacid 18696
                                    carboxylic acid 18693
                                      monocarboxylic acid 18028
                                        acetic acid 11102
                                          acetate ester 4068
                                            forskolin 4
                                              1,9-dideoxyforskolin 3
                                              colforsin daropate 0
                                              methylpiperazinoforskolin 0
paths to the root