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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:forskolin
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Accession:CHEBI:42471 term browser browse the term
Definition:A labdane diterpenoid isolated from the Indian Coleus plant.
Synonyms:exact_synonym: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
 related_synonym: 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one;   Coleonol;   Coleonolk;   Formula=C22H34O7;   InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1;   InChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N;   SMILES=[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C;   colforsin;   colforsina;   colforsine;   colforsinum
 xref: Beilstein:4300863;   CAS:66428-89-5;   CAS:66575-29-9;   DrugBank:DB02587;   KEGG:C09076;   KEGG:D03584;   KNApSAcK:C00003416;   PDBeChem:FOK;   PMID:11816015;   PMID:12676767;   PMID:12836714;   PMID:14691682;   PMID:15135319;   PMID:15380183;   PMID:1547891;   PMID:15525467;   PMID:16644480;   PMID:17570033;   PMID:19831022;   PMID:7755573;   PMID:7875530;   PMID:7898427;   PMID:7929167;   PMID:8489512;   PMID:8985363;   PMID:9478958;   PMID:9828101;   Patent:DE2557784;   Patent:US4088659;   Patent:US4476140;   Reaxys:4300863;   Wikipedia:Forskolin



show annotations for term's descendants           Sort by:
forskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 increases activity ISO forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:8408014 RGD:36947876 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
1,9-dideoxyforskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1A protein CTD PMID:12202523 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1B protein CTD PMID:12202523 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB4 protein CTD PMID:12202523 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19747
    role 19720
      biological role 19718
        antimicrobial agent 17883
          antiviral agent 10712
            anti-HIV agent 2474
              forskolin 4
                1,9-dideoxyforskolin 3
                colforsin daropate 0
                methylpiperazinoforskolin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19747
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19638
                        carbon atom 19634
                          organic molecular entity 19634
                            organic group 18850
                              organic divalent group 18836
                                organodiyl group 18836
                                  carbonyl group 18802
                                    carbonyl compound 18802
                                      ketone 17110
                                        oxyketone 8796
                                          alpha-oxyketone 8796
                                            alpha-hydroxy ketone 8796
                                              tertiary alpha-hydroxy ketone 8495
                                                forskolin 4
                                                  1,9-dideoxyforskolin 3
                                                  colforsin daropate 0
                                                  methylpiperazinoforskolin 0
paths to the root