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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:equilin
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Accession:CHEBI:42309 term browser browse the term
Definition:A 17-oxo steroid that has formula C18H20O2.
Synonyms:exact_synonym: 3-hydroxyestra-1,3,5(10),7-tetraen-17-one
 related_synonym: 1,3,5,7-Estratetraen-3-ol-17-one;   7-Dehydroestrone;   Dihydroequilenin;   Formula=C18H20O2;   InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1;   InChIKey=WKRLQDKEXYKHJB-HFTRVMKXSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])C1=CCc1cc(O)ccc21
 alt_id: CHEBI:34740;   CHEBI:42304
 xref: Beilstein:2624302;   CAS:474-86-2;   DrugBank:DB02187;   KEGG:C14392;   KEGG:D04041;   LINCS:LSM-2063;   LIPID_MAPS_instance:LMST02010026
 xref_mesh: MESH:D004857
 xref: PDBeChem:EQI


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equilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO Equilin affects the localization of AR protein
Equilin binds to and results in increased activity of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity
affects binding
multiple interactions
EXP
ISO
Equilin results in increased activity of ESR1 protein
Equilin binds to ESR1 protein
fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]
CTD PMID:11750080, PMID:12504345, PMID:21138273, PMID:22562034 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Equilin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Equilin binds to RXRA protein CTD PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO Equilin results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Equilin results in increased expression of TFF1 mRNA]
CTD PMID:22562034 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Utrn utrophin increases expression ISO Equilin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        polyatomic entity 19727
          heteroatomic molecular entity 19653
            hydroxides 19107
              organic hydroxy compound 18661
                hydroxy steroid 12380
                  3-hydroxy steroid 10008
                    equilin 9
                      equilin sodium sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxo steroid 9283
                                          17-oxo steroid 257
                                            equilin 9
                                              equilin sodium sulfate 0
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