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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:digitoxigenin
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Accession:CHEBI:42219 term browser browse the term
Definition:A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22).
Synonyms:exact_synonym: 3beta,14-dihydroxy-5beta-card-20(22)-enolide
 related_synonym: Cerberigenin;   Echujetin;   Evonogenin;   Formula=C23H34O4;   InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,19-,21+,22-,23+/m1/s1;   InChIKey=XZTUSOXSLKTKJQ-CESUGQOBSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2;   Thevetigenin
 alt_id: CHEBI:38073;   CHEBI:42214
 xref: Beilstein:95448;   CAS:143-62-4;   LIPID_MAPS_instance:LMST01120001
 xref_mesh: MESH:D004073
 xref: PDBeChem:DTX;   PMID:10438974;   Wikipedia:Digitoxigenin



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digitoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digitoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digitoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Digitoxigenin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digitoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digitoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin
CTD PMID:23104431 PMID:26708294 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ar androgen receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein CTD PMID:22037315 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
ISO Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]
CTD PMID:22037315 PMID:34717917 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]
CTD PMID:22037315 PMID:34717917 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein CTD PMID:22037315 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] CTD PMID:19446813 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein
CTD PMID:22037315 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]
Digitoxin results in decreased expression of CCND1 protein
CTD PMID:34717917 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
CTD PMID:22037315 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein CTD PMID:22037315 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein CTD PMID:22037315 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein CTD PMID:22037315 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
ISO Digitoxin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF4EBP1 protein]
Digitoxin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:34717917 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fanci FA complementation group I multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]] CTD PMID:34717917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] CTD PMID:19446813 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] CTD PMID:19446813 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] CTD PMID:19446813 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO Digitoxin results in decreased phosphorylation of NFKBIA protein CTD PMID:15136726 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] CTD PMID:19446813 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 increases expression ISO Digitoxin results in increased expression of PIAS3 protein CTD PMID:34717917 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Digitoxin results in increased expression of PTEN protein CTD PMID:34717917 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression ISO Digitoxin results in increased expression of PTPN6 protein CTD PMID:34717917 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO Digitoxin results in decreased phosphorylation of RPS6KB1 protein
[Digitoxin co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:34717917 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; Digitoxin results in decreased expression of and results in decreased phosphorylation of STAT3 protein; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]] CTD PMID:34717917 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Digitoxin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Digitoxin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein CTD PMID:22037315 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        polyatomic entity 19984
          heteroatomic molecular entity 19921
            hydroxides 19412
              organic hydroxy compound 18953
                alcohol 15177
                  secondary alcohol 7421
                    3beta-hydroxy steroid 2018
                      digitoxigenin 41
                        digitoxigenin 3-O-[beta-D-glucosyl-(1->4)-alpha-L-acofrioside] 0
                        digitoxin + 37
                        evomonoside 0
                        neriifolin + 0
                        thevetin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic ester 15933
                                        lactone 11283
                                          steroid lactone 423
                                            cardanolide 49
                                              5beta-cardanolide 49
                                                digitoxigenin 41
                                                  digitoxigenin 3-O-[beta-D-glucosyl-(1->4)-alpha-L-acofrioside] 0
                                                  digitoxin + 37
                                                  evomonoside 0
                                                  neriifolin + 0
                                                  thevetin B 0
paths to the root