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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylenediaminetetraacetic acid
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Accession:CHEBI:42191 term browser browse the term
Definition:A polyamino carboxylic acid that has formula C10H16N2O8.
Synonyms:exact_synonym: (ethane-1,2-diyldinitrilo)tetraacetate;   (ethane-1,2-diyldinitrilo)tetraacetic acid
 related_synonym: (ethylenedinitrilo)tetraacetic acid, ion(4-);   2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate;   Acide ethylenediaminetetracetique;   EDTA, ion(4-);   Formula=C10H16N2O8;   H4edta;   InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);   InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N;   N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine);   SMILES=OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O;   acide edetique;   acido edetico;   acidum edeticum;   edetic acid;   edta;   ethylenediaminetetraacetate;   {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
 alt_id: CHEBI:30378;   CHEBI:42189;   CHEBI:4735
 xref: Beilstein:1716295;   Beilstein:3914756;   CAS:150-43-6;   CAS:60-00-4;   DrugBank:DB00974;   Drug_Central:987;   Gmelin:144943;   KEGG:C00284;   KEGG:D00052
 xref_mesh: MESH:D004492
 xref: PDBeChem:EDT;   PPDB:1337;   Wikipedia:Edetate
 cyclic_relationship: is_conjugate_acid_of CHEBI:64755


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ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme multiple interactions
decreases activity
EXP Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ANPEP alanyl aminopeptidase, membrane multiple interactions EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr15:89,784,895...89,814,852
Ensembl chr15:89,784,895...89,815,401
JBrowse link
G APLP1 amyloid beta precursor like protein 1 multiple interactions EXP Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] CTD PMID:24855651 NCBI chr19:35,868,570...35,879,795
Ensembl chr19:35,867,899...35,879,791
Ensembl chr19:35,867,899...35,879,791
JBrowse link
G APLP2 amyloid beta precursor like protein 2 multiple interactions EXP Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein] CTD PMID:24855651 NCBI chr11:130,069,894...130,144,805
Ensembl chr11:130,068,147...130,144,811
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ASPA aspartoacylase decreases activity EXP Edetic Acid results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr17:3,473,646...3,503,405
Ensembl chr17:3,472,374...3,503,405
JBrowse link
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions ISO [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr16:28,878,488...28,904,466
Ensembl chr16:28,878,405...28,904,509
Ensembl chr16:28,878,405...28,904,509
JBrowse link
G BMP4 bone morphogenetic protein 4 multiple interactions EXP [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein] CTD PMID:18369157 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G CASP1 caspase 1 multiple interactions ISO Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CAT catalase multiple interactions ISO CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CP ceruloplasmin multiple interactions EXP Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl] CTD PMID:22824865 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Edetic Acid inhibits the reaction [Cadmium results in increased expression of CXCL8 protein] CTD PMID:8123758 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DLD dihydrolipoamide dehydrogenase multiple interactions ISO Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein] CTD PMID:29158198 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
JBrowse link
G DSPP dentin sialophosphoprotein affects localization ISO Edetic Acid affects the localization of DSPP protein CTD PMID:23525114 NCBI chr 4:87,608,529...87,616,873
Ensembl chr 4:87,608,529...87,616,873
JBrowse link
G DUSP23 dual specificity phosphatase 23 multiple interactions EXP Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543
JBrowse link
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 multiple interactions EXP Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein] CTD PMID:12885774 NCBI chr17:79,730,919...79,742,926
Ensembl chr17:79,730,943...79,742,219
JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP Edetic Acid results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G GH1 growth hormone 1 multiple interactions ISO Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 decreases degradation ISO Edetic Acid results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] CTD PMID:11238657 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M increases expression EXP Edetic Acid results in increased expression of ITGAM protein CTD PMID:8595612 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G MBP myelin basic protein affects expression ISO Edetic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MGP matrix Gla protein multiple interactions EXP [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein] CTD PMID:18369157 NCBI chr12:14,880,864...14,885,854
Ensembl chr12:14,880,864...14,885,857
JBrowse link
G MMP8 matrix metallopeptidase 8 decreases activity EXP Edetic Acid results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr11:102,711,796...102,724,967
Ensembl chr11:102,711,796...102,727,050
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]] CTD PMID:14998373 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MT3 metallothionein 3 increases alkylation
affects metabolic processing
EXP Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid
CTD PMID:12383939, PMID:14983064 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G NEIL1 nei like DNA glycosylase 1 multiple interactions EXP [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr15:75,346,638...75,357,115
Ensembl chr15:75,346,955...75,357,115
JBrowse link
G OPTC opticin multiple interactions EXP Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 1:203,494,153...203,508,949
Ensembl chr 1:203,494,153...203,508,949
JBrowse link
G PGP phosphoglycolate phosphatase decreases activity ISO Edetic Acid results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr16:2,211,593...2,214,840
Ensembl chr16:2,211,593...2,214,840
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein] CTD PMID:21615740 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PLG plasminogen multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,238...160,754,097
Ensembl chr 6:160,702,238...160,754,097
JBrowse link
G PRL prolactin multiple interactions EXP Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PRLR prolactin receptor multiple interactions EXP Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 5:35,048,756...35,230,724
Ensembl chr 5:35,048,756...35,230,487
JBrowse link
G PRNP prion protein multiple interactions ISO Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590
JBrowse link
G S100A2 S100 calcium binding protein A2 multiple interactions EXP Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Edetic Acid inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 1:153,561,108...153,565,844
Ensembl chr 1:153,561,108...153,567,890
JBrowse link
G S100A4 S100 calcium binding protein A4 multiple interactions EXP Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G SELL selectin L decreases expression EXP Edetic Acid results in decreased expression of SELL protein CTD PMID:8595612 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
JBrowse link
G SLC30A10 solute carrier family 30 member 10 increases expression
multiple interactions
EXP Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
CTD PMID:22341971, PMID:22926781 NCBI chr 1:219,910,395...219,959,098
Ensembl chr 1:219,685,427...219,958,647
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 multiple interactions ISO Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein] CTD PMID:17069801 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
G TNF tumor necrosis factor increases expression EXP Edetic Acid results in increased expression of TNF protein CTD PMID:29953848 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP63 tumor protein p63 multiple interactions EXP Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
JBrowse link
G TP73 tumor protein p73 multiple interactions EXP Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]] CTD PMID:17442041 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases activity
multiple interactions
EXP Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]
CTD PMID:16774913 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD3 thioredoxin reductase 3 increases activity
multiple interactions
ISO Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]
CTD PMID:16774913 NCBI chr 3:126,607,050...126,655,124
Ensembl chr 3:126,607,059...126,655,124
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO [XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24191
    role 24084
      chemical role 22471
        ligand 5961
          chelator 5935
            ethylenediaminetetraacetic acid 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 24191
    subatomic particle 24144
      composite particle 24144
        hadron 24144
          baryon 24144
            nucleon 24144
              atomic nucleus 24144
                atom 24144
                  main group element atom 23976
                    main group molecular entity 23976
                      s-block molecular entity 23116
                        hydrogen molecular entity 22925
                          hydrides 21045
                            inorganic hydride 19136
                              pnictogen hydride 19106
                                nitrogen hydride 18779
                                  azane 18660
                                    ammonia 18659
                                      organic amino compound 18658
                                        polyamine 8725
                                          diamine 8655
                                            primary diamine 6177
                                              alkane-alpha,omega-diamine 4096
                                                ethylenediamine 4074
                                                  ethylenediamine derivative 3895
                                                    ethylenediaminetetraacetic acid 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.