CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ethylenediaminetetraacetic acid
Accession: CHEBI:42191
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Definition: A polyamino carboxylic acid that has formula C10H16N2O8.
Synonyms: exact_synonym: (ethane-1,2-diyldinitrilo)tetraacetate; (ethane-1,2-diyldinitrilo)tetraacetic acid
related_synonym: (ethylenedinitrilo)tetraacetic acid, ion(4-); 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate; Acide ethylenediaminetetracetique; EDTA, ion(4-); Formula=C10H16N2O8; H4edta; InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20); InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N; N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine); SMILES=OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O; acide edetique; acido edetico; acidum edeticum; edetic acid; edta; ethylenediaminetetraacetate; {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
alt_id: CHEBI:30378; CHEBI:42189; CHEBI:4735
xref: Beilstein:1716295; Beilstein:3914756; CAS:150-43-6; CAS:60-00-4; Chemspider:5826; DrugBank:DB00974; Drug_Central:987; Gmelin:144943; KEGG:C00284; KEGG:D00052
xref_mesh: MESH:D004492
xref: PDBeChem:EDT; PMID:11370764; PMID:16472851; PMID:31704581; PMID:32821617; PMID:33811400; PMID:34152137; PMID:34277313; PPDB:1337; Wikipedia:Edetate
cyclic_relationship: is_conjugate_acid_of CHEBI:64755
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Ace
angiotensin I converting enzyme
multiple interactions decreases activity
ISO
Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein]
CTD
PMID:28544013
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ache
acetylcholinesterase
multiple interactions
ISO
Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein
CTD
PMID:23047022
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ahr
aryl hydrocarbon receptor
multiple interactions
EXP
Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
CTD
PMID:1322109
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Anpep
alanyl aminopeptidase, membrane
multiple interactions
ISO
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]
CTD
PMID:17109655
NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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Aplp1
amyloid beta precursor like protein 1
multiple interactions
ISO
Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein]
CTD
PMID:24855651
NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
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Aplp2
amyloid beta precursor like protein 2
multiple interactions
ISO
Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein]
CTD
PMID:24855651
NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
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App
amyloid beta precursor protein
multiple interactions
ISO
Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]
CTD
PMID:17964426
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Aspa
aspartoacylase
decreases activity
ISO
Edetic Acid results in decreased activity of ASPA protein
CTD
PMID:17027983
NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272
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Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
multiple interactions
EXP
[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]
CTD
PMID:12870653
NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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Bmp4
bone morphogenetic protein 4
multiple interactions
ISO
[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]
CTD
PMID:18369157
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Casp1
caspase 1
multiple interactions
ISO
Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]
CTD
PMID:25929180
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Cat
catalase
multiple interactions
ISO
CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens]
CTD
PMID:1567206
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cp
ceruloplasmin
multiple interactions
ISO
Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]
CTD
PMID:22824865
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP
Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
CTD
PMID:1322109
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
CTD
PMID:9143349
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dld
dihydrolipoamide dehydrogenase
multiple interactions
ISO
Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein]
CTD
PMID:29158198
NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
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Dspp
dentin sialophosphoprotein
affects localization
EXP
Edetic Acid affects the localization of DSPP protein
CTD
PMID:23525114
NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
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Dusp23
dual specificity phosphatase 23
multiple interactions
ISO
Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]
CTD
PMID:15147733
NCBI chr13:85,098,792...85,099,984
Ensembl chr13:85,097,899...85,100,093
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Enpp7
ectonucleotide pyrophosphatase/phosphodiesterase 7
multiple interactions
ISO
Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein]
CTD
PMID:12885774
NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
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Esr1
estrogen receptor 1
increases expression
ISO
Edetic Acid results in increased expression of ESR1 mRNA
CTD
PMID:22083529
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gh1
growth hormone 1
multiple interactions
EXP
Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]
CTD
PMID:10720163
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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Igfbp5
insulin-like growth factor binding protein 5
decreases degradation
EXP
Edetic Acid results in decreased degradation of IGFBP5 protein
CTD
PMID:8894652
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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Il6
interleukin 6
multiple interactions
ISO
Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]
CTD
PMID:11238657
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgam
integrin subunit alpha M
increases expression
ISO
Edetic Acid results in increased expression of ITGAM protein
CTD
PMID:8595612
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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Keap1
Kelch-like ECH-associated protein 1
multiple interactions
ISO
Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]
CTD
PMID:15865434
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Mbp
myelin basic protein
affects expression
EXP
Edetic Acid affects the expression of MBP mRNA
CTD
PMID:22954530
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mgp
matrix Gla protein
multiple interactions
ISO
[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein]
CTD
PMID:18369157
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
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Mmp8
matrix metallopeptidase 8
decreases activity
ISO
Edetic Acid results in decreased activity of MMP8 protein
CTD
PMID:15057751
NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
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Mt3
metallothionein 3
increases alkylation affects metabolic processing
ISO
Edetic Acid results in increased alkylation of MT3 protein MT3 protein polymorphism affects the metabolism of Edetic Acid
CTD
PMID:12383939 PMID:14983064
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Neil1
nei-like DNA glycosylase 1
multiple interactions
ISO
[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]
CTD
PMID:20622253
NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
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Optc
opticin
multiple interactions
ISO
Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein]
CTD
PMID:22534113
NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237
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Pgp
phosphoglycolate phosphatase
decreases activity
ISO
Edetic Acid results in decreased activity of PGP protein
CTD
PMID:24338473
NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858
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Plat
plasminogen activator, tissue type
multiple interactions
ISO
Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]
CTD
PMID:21615740
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plg
plasminogen
multiple interactions
ISO
Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein]
CTD
PMID:21615740
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
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Prl
prolactin
multiple interactions
ISO
Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein]
CTD
PMID:6197504
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prlr
prolactin receptor
multiple interactions
ISO
Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein]
CTD
PMID:6197504
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
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Prnp
prion protein
multiple interactions
ISO
Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]
CTD
PMID:16595185
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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S100a2
S100 calcium binding protein A2
multiple interactions
ISO
Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Edetic Acid inhibits the reaction [S100A2 protein binds to S100A2 protein]
CTD
PMID:21924240
NCBI chr 2:176,075,060...176,078,782
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S100a4
S100 calcium-binding protein A4
multiple interactions
ISO
Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]
CTD
PMID:21924240
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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Sell
selectin L
decreases expression
ISO
Edetic Acid results in decreased expression of SELL protein
CTD
PMID:8595612
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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Slc30a10
solute carrier family 30, member 10
increases expression multiple interactions
ISO
Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
CTD
PMID:22341971 PMID:22926781
NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
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Sptan1
spectrin, alpha, non-erythrocytic 1
multiple interactions
EXP
Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein]
CTD
PMID:17069801
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
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Srr
serine racemase
multiple interactions
ISO
Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]
CTD
PMID:27387750
NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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Tnf
tumor necrosis factor
increases expression
ISO
Edetic Acid results in increased expression of TNF protein
CTD
PMID:29953848
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions
ISO
Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]
CTD
PMID:25446071
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp63
tumor protein p63
multiple interactions
ISO
Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]
CTD
PMID:25446071
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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Tp73
tumor protein p73
multiple interactions
ISO
Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]
CTD
PMID:25446071
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
ISO
Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]
CTD
PMID:17442041
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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Txnrd1
thioredoxin reductase 1
increases activity multiple interactions
ISO
Edetic Acid results in increased activity of TXNRD1 protein Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]
CTD
PMID:16774913
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Txnrd3
thioredoxin reductase 3
increases activity multiple interactions
ISO
Edetic Acid results in increased activity of TXNRD3 protein Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]
CTD
PMID:16774913
NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein]
CTD
PMID:22534113
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
multiple interactions
ISO
[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens]
CTD
PMID:1567206
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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