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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylenediaminetetraacetic acid
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Accession:CHEBI:42191 term browser browse the term
Definition:A polyamino carboxylic acid that has formula C10H16N2O8.
Synonyms:exact_synonym: (ethane-1,2-diyldinitrilo)tetraacetate;   (ethane-1,2-diyldinitrilo)tetraacetic acid
 related_synonym: (ethylenedinitrilo)tetraacetic acid, ion(4-);   2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate;   Acide ethylenediaminetetracetique;   EDTA, ion(4-);   Formula=C10H16N2O8;   H4edta;   InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);   InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N;   N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine);   SMILES=OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O;   acide edetique;   acido edetico;   acidum edeticum;   edetic acid;   edta;   ethylenediaminetetraacetate;   {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
 alt_id: CHEBI:30378;   CHEBI:42189;   CHEBI:4735
 xref: Beilstein:1716295;   Beilstein:3914756;   CAS:150-43-6;   CAS:60-00-4;   DrugBank:DB00974;   Drug_Central:987;   Gmelin:144943;   KEGG:C00284;   KEGG:D00052
 xref_mesh: MESH:D004492
 xref: PDBeChem:EDT;   PPDB:1337;   Wikipedia:Edetate
 cyclic_relationship: is_conjugate_acid_of CHEBI:64755

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ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity		 ISO Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273 		JBrowse link
G Aplp1 amyloid beta precursor like protein 1 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] CTD PMID:24855651 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein] CTD PMID:24855651 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aspa aspartoacylase decreases activity ISO Edetic Acid results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:59,839,693...59,888,244
Ensembl chr10:59,839,852...59,892,960 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein] CTD PMID:18369157 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Cat catalase multiple interactions ISO CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl] CTD PMID:22824865 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein] CTD PMID:29158198 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694 		JBrowse link
G Dspp dentin sialophosphoprotein affects localization EXP Edetic Acid affects the localization of DSPP protein CTD PMID:23525114 NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070 		JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:91,018,670...91,019,862
Ensembl chr13:91,018,510...91,020,112 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein] CTD PMID:12885774 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Edetic Acid results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP Edetic Acid results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] CTD PMID:11238657 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Edetic Acid results in increased expression of ITGAM protein CTD PMID:8595612 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Mbp myelin basic protein affects expression EXP Edetic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310 		JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein] CTD PMID:18369157 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Edetic Acid results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]] CTD PMID:14998373 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt3 metallothionein 3 increases alkylation
affects metabolic processing		 ISO Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid		 CTD PMID:12383939, PMID:14983064 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102 		JBrowse link
G Optc opticin multiple interactions ISO Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr13:50,735,509...50,748,908
Ensembl chr13:50,735,599...50,746,354 		JBrowse link
G Pgp phosphoglycolate phosphatase decreases activity ISO Edetic Acid results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr10:13,836,105...13,838,731
Ensembl chr10:13,836,128...13,838,765 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein] CTD PMID:21615740 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Plg plasminogen multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776 		JBrowse link
G Prl prolactin multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prlr prolactin receptor multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692 		JBrowse link
G Prnp prion protein multiple interactions ISO Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604 		JBrowse link
G Sell selectin L decreases expression ISO Edetic Acid results in decreased expression of SELL protein CTD PMID:8595612 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 increases expression
multiple interactions		 ISO Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]		 CTD PMID:22341971, PMID:22926781 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions EXP Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein] CTD PMID:17069801 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Edetic Acid results in increased expression of TNF protein CTD PMID:29953848 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp63 tumor protein p63 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]] CTD PMID:17442041 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
multiple interactions		 ISO Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]		 CTD PMID:16774913 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Txnrd3 thioredoxin reductase 3 increases activity
multiple interactions		 ISO Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]		 CTD PMID:16774913 NCBI chr 4:121,612,332...121,650,543
Ensembl chr 4:121,612,332...121,650,571 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        ligand 5754
          chelator 5731
            ethylenediaminetetraacetic acid 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        polyamine 8104
                                          diamine 8032
                                            primary diamine 5623
                                              alkane-alpha,omega-diamine 3733
                                                ethylenediamine 3711
                                                  ethylenediamine derivative 3548
                                                    ethylenediaminetetraacetic acid 51
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