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ONTOLOGY REPORT - ANNOTATIONS


Term:abacavir
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Accession:CHEBI:421707 term browser browse the term
Definition:A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
Synonyms:exact_synonym: {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
 related_synonym: ABC;   Formula=C14H18N6O;   InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1;   InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N;   SMILES=Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1;   {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
 alt_id: CHEBI:193608;   CHEBI:2360;   CHEBI:441792;   CHEBI:520984;   CHEBI:525912;   MESH:C106538
 xref: Beilstein:7493116 "Beilstein";   CAS:136470-78-5 "ChemIDplus";   CAS:136470-78-5 "KEGG COMPOUND";   DrugBank:DB01048;   Drug_Central:34 "DrugCentral";   KEGG:C07624;   KEGG:D07057
 xref_mesh: MESH:C106538
 xref: PMID:11678376 "Europe PMC";   PMID:11806176 "Europe PMC";   PMID:12781181 "ChEMBL";   PMID:15887959 "ChEMBL";   PMID:16458506 "ChEMBL";   PMID:16539393 "ChEMBL";   PMID:16759112 "ChEMBL";   PMID:17172311 "ChEMBL";   PMID:17870541 "ChEMBL";   PMID:18029175 "ChEMBL";   PMID:18549801 "Europe PMC";   PMID:24751900 "Europe PMC";   PMID:25017682 "Europe PMC";   PMID:25674793 "Europe PMC";   PMID:26024233 "Europe PMC";   Reaxys:7493116 "Reaxys";   Wikipedia:Abacavir


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abacavir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        antimicrobial agent 17222
          antiviral agent 3711
            antiviral drug 1779
              abacavir 14
                abacavir 5'-carboxylic acid 0
                abacavir 5'-glucuronide 0
                abacavir monophosphate 0
                abacavir sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19434
                              organic cyclic compound 19203
                                organic heterocyclic compound 18272
                                  organic heteropolycyclic compound 17577
                                    organic heterobicyclic compound 16244
                                      imidazopyrimidine 5416
                                        purines 5414
                                          aminopurine 4372
                                            2,6-diaminopurines 20
                                              abacavir 14
                                                abacavir 5'-carboxylic acid 0
                                                abacavir 5'-glucuronide 0
                                                abacavir monophosphate 0
                                                abacavir sulfate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.