Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dithionite(2-)
go back to main search page
Accession:CHEBI:42160 term browser browse the term
Definition:A sulfur oxide that has formula O4S2.
Synonyms:exact_synonym: 2,3-dioxido-1,4-dioxy-2,3-disulfy-[4]catenate(2-);   bis(dioxidosulfate)(S--S)(2-)
 related_synonym: DITHIONITE;   Dithionit;   Formula=O4S2;   InChI=1S/H2O4S2/c1-5(2)6(3)4/h(H,1,2)(H,3,4)/p-2;   InChIKey=GRWZHXKQBITJKP-UHFFFAOYSA-L;   SMILES=[O-]S(=O)S([O-])=O;   [O2SSO2](2-);   [S2O4](2-)
 alt_id: CHEBI:29206;   CHEBI:42154
 xref: CAS:14844-07-6;   Gmelin:2516
 xref_mesh: MESH:D004227
 xref: PDBeChem:DTN
 cyclic_relationship: is_conjugate_base_of CHEBI:33487



show annotations for term's descendants           Sort by:
dithionite(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Dithionite results in increased activity of ACHE protein CTD PMID:33617922 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity
multiple interactions
EXP Dithionite results in decreased activity of ACP5 protein
ferrous chloride inhibits the reaction [Dithionite results in decreased activity of ACP5 protein]
CTD PMID:6886379 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; [Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein] CTD PMID:21803128 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein]
Dithionite results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Dithionite results in increased expression of BAX protein]
CTD PMID:21803128 PMID:33617922 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]; [Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]
Dithionite results in decreased expression of BCL2 protein
dihydroactinidiolide inhibits the reaction [Dithionite results in decreased expression of BCL2 protein]
CTD PMID:21803128 PMID:33617922 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G C5 complement C5 multiple interactions ISO Dithionite inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]; Dithionite inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein] CTD PMID:10777245 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
EXP
ISO
[Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Dithionite co-treated with Glucose deficiency] results in increased cleavage of CASP3 protein; [Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of CASP3 protein]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]
Dithionite results in increased activity of CASP3 protein
Dithionite results in increased expression of CASP3 protein
CTD PMID:21803128 PMID:33617922 PMID:34078833 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO [[Dithionite results in increased reduction of Paraquat] which co-treated with SLC6A3 protein] results in increased expression of DNM1L protein; [Dithionite results in increased reduction of Paraquat] which results in increased expression of DNM1L protein CTD PMID:35511227 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP [Dithionite co-treated with Glucose deficiency] results in decreased expression of GRIA2 protein; Genistein inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of GRIA2 protein] CTD PMID:27238724 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [dihydroactinidiolide co-treated with Dithionite] results in increased expression of HMOX1 mRNA CTD PMID:33617922 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [dihydroactinidiolide co-treated with Dithionite] results in increased expression of NFE2L2 mRNA CTD PMID:33617922 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [[Dithionite results in increased reduction of Paraquat] which co-treated with SLC6A3 protein] results in increased expression of DNM1L protein CTD PMID:35511227 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        inorganic molecular entity 19628
          inorganic oxide 7751
            sulfur oxide 638
              dithionite(2-) 14
                sodium dithionite 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      chalcogen 19534
                        oxygen atom 19509
                          oxygen molecular entity 19509
                            oxide 12754
                              oxoanion 10302
                                chalcogen oxoanion 659
                                  sulfur oxoanion 657
                                    dithionite(2-) 14
                                      sodium dithionite 0
paths to the root