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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dithionite(2-)
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Accession:CHEBI:42160 term browser browse the term
Definition:A sulfur oxide that has formula O4S2.
Synonyms:exact_synonym: 2,3-dioxido-1,4-dioxy-2,3-disulfy-[4]catenate(2-);   bis(dioxidosulfate)(S--S)(2-)
 related_synonym: DITHIONITE;   Dithionit;   Formula=O4S2;   InChI=1S/H2O4S2/c1-5(2)6(3)4/h(H,1,2)(H,3,4)/p-2;   InChIKey=GRWZHXKQBITJKP-UHFFFAOYSA-L;   SMILES=[O-]S(=O)S([O-])=O;   [O2SSO2](2-);   [S2O4](2-)
 alt_id: CHEBI:29206;   CHEBI:42154
 xref: CAS:14844-07-6;   Gmelin:2516
 xref_mesh: MESH:D004227
 xref: PDBeChem:DTN
 cyclic_relationship: is_conjugate_base_of CHEBI:33487



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dithionite(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) increases activity EXP Dithionite results in increased activity of ACHE protein CTD PMID:33617922 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant decreases activity
multiple interactions
ISO Dithionite results in decreased activity of ACP5 protein
ferrous chloride inhibits the reaction [Dithionite results in decreased activity of ACP5 protein]
CTD PMID:6886379 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; [Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein] CTD PMID:21803128 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein]
Dithionite results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Dithionite results in increased expression of BAX protein]
CTD PMID:21803128 PMID:33617922 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]; [Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]
dihydroactinidiolide inhibits the reaction [Dithionite results in decreased expression of BCL2 protein]
CTD PMID:21803128 PMID:33617922 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G C5 complement C5 multiple interactions EXP Dithionite inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of C5 protein]; Dithionite inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein] CTD PMID:10777245 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
[Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Dithionite co-treated with Glucose deficiency] results in increased cleavage of CASP3 protein; [Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of CASP3 protein]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]
Dithionite results in increased activity of CASP3 protein
Dithionite results in increased expression of CASP3 protein
CTD PMID:21803128 PMID:33617922 PMID:34078833 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO [[Dithionite results in increased reduction of Paraquat] which co-treated with SLC6A3 protein] results in increased expression of DNM1L protein; [Dithionite results in increased reduction of Paraquat] which results in increased expression of DNM1L protein CTD PMID:35511227 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO [Dithionite co-treated with Glucose deficiency] results in decreased expression of GRIA2 protein; Genistein inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of GRIA2 protein] CTD PMID:27238724 NCBI chr 4:157,220,120...157,366,075
Ensembl chr 4:157,204,182...157,387,146
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [dihydroactinidiolide co-treated with Dithionite] results in increased expression of HMOX1 mRNA CTD PMID:33617922 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G MIR205 microRNA 205 multiple interactions ISO [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr 1:209,432,133...209,432,242
Ensembl chr 1:209,432,133...209,432,242
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [dihydroactinidiolide co-treated with Dithionite] results in increased expression of NFE2L2 mRNA CTD PMID:33617922 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions ISO [Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions ISO [[Dithionite results in increased reduction of Paraquat] which co-treated with SLC6A3 protein] results in increased expression of DNM1L protein CTD PMID:35511227 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      molecular entity 25991
        inorganic molecular entity 25314
          inorganic oxide 8408
            sulfur oxide 709
              dithionite(2-) 14
                sodium dithionite 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            oxide 13767
                              oxoanion 10848
                                chalcogen oxoanion 725
                                  sulfur oxoanion 723
                                    dithionite(2-) 14
                                      sodium dithionite 0
paths to the root