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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:idarubicin
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Accession:CHEBI:42068 term browser browse the term
Definition:An anthracycline antibiotic that has formula 497.49392.
Synonyms:related_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside;   (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside;   4-Demethoxydaunomycin;   4-Demethoxydaunorubicin;   5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7S-cis)-;   Formula=C26H27NO9;   InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1;   InChIKey=XDXDZDZNSLXDNA-TZNDIEGXSA-N;   SMILES=C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O
 alt_id: CHEBI:35758;   CHEBI:42066
 xref: Beilstein:3641270;   CAS:58957-92-9;   DrugBank:DB01177;   Drug_Central:1414;   LINCS:LSM-5769
 xref_mesh: MESH:D015255
 xref: Wikipedia:Idarubicin


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idarubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Idarubicin binds to and affects the folding of ABCC1 protein CTD PMID:11278000 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G App amyloid beta precursor protein increases response to substance ISO APP gene mutant form results in increased susceptibility to Idarubicin CTD PMID:25926793 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor increases activity ISO Idarubicin results in increased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atrx ATRX, chromatin remodeler decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of ATRX mRNA
[Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA]
CTD PMID:28973540 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Idarubicin results in increased expression of BAX mRNA; Idarubicin results in increased expression of BAX protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein]
CTD PMID:28973540 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] CTD PMID:17965967, PMID:18438337 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA] CTD PMID:28973540 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases activity
ISO Idarubicin results in decreased activity of ESR1 protein
Idarubicin results in increased activity of ESR1 protein
CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Exo1 exonuclease 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]
Idarubicin results in decreased expression of EXO1 mRNA; Idarubicin results in decreased expression of EXO1 protein
CTD PMID:28973540 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA CTD PMID:28973540 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA] CTD PMID:28973540 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA] CTD PMID:28973540 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Idarubicin promotes the reaction [Glutaral results in decreased activity of GSR protein] CTD PMID:19490936 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Idarubicin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Idarubicin results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nppb natriuretic peptide B increases expression ISO Idarubicin results in increased expression of NPPB protein CTD PMID:16151589 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Idarubicin results in decreased activity of NR1H4 protein
Idarubicin results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of OGG1 mRNA; Idarubicin results in decreased expression of OGG1 protein
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]
CTD PMID:28973540 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Idarubicin results in increased expression of PARP1 mRNA; Idarubicin results in increased expression of PARP1 protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein]
CTD PMID:28973540 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases activity ISO Idarubicin results in decreased activity of PPARD protein CTD PMID:25257666 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO Idarubicin results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression
multiple interactions
ISO Idarubicin results in increased expression of PPP1R15A mRNA; Idarubicin results in increased expression of PPP1R15A protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein]
CTD PMID:28973540 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein] CTD PMID:28973540 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] CTD PMID:28973540 NCBI chr 2:30,634,353...30,664,618
Ensembl chr 2:30,634,354...30,664,163
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA CTD PMID:28973540 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rad9a RAD9 checkpoint clamp component A multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA] CTD PMID:28973540 NCBI chr 1:219,443,347...219,450,574
Ensembl chr 1:219,444,092...219,450,451
JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA] CTD PMID:28973540 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of TOPBP1 mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
CTD PMID:28973540 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA] CTD PMID:28973540 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ung uracil-DNA glycosylase decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of UNG mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA]
CTD PMID:28973540 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Vdr vitamin D receptor decreases activity ISO Idarubicin results in decreased activity of VDR protein CTD PMID:25257666 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Idarubicin co-treated with triptolide] affects the expression of XIAP protein CTD PMID:18922616 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA CTD PMID:28973540 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein]
Idarubicin results in decreased expression of XRCC1 mRNA; Idarubicin results in decreased expression of XRCC1 protein
CTD PMID:28973540 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA CTD PMID:28973540 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          anthracycline antibiotic 7346
            idarubicin 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho-fused polycyclic arene 9641
                                          acene 7566
                                            tetracene 7563
                                              idarubicin 36
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.