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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:idarubicin
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Accession:CHEBI:42068 term browser browse the term
Definition:An anthracycline antibiotic that has formula 497.49392.
Synonyms:related_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside;   (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside;   4-Demethoxydaunomycin;   4-Demethoxydaunorubicin;   5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7S-cis)-;   Formula=C26H27NO9;   InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1;   InChIKey=XDXDZDZNSLXDNA-TZNDIEGXSA-N;   SMILES=C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O
 alt_id: CHEBI:35758;   CHEBI:42066
 xref: Beilstein:3641270;   CAS:58957-92-9;   DrugBank:DB01177;   Drug_Central:1414;   LINCS:LSM-5769
 xref_mesh: MESH:D015255
 xref: Wikipedia:Idarubicin


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idarubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Idarubicin binds to and affects the folding of ABCC1 protein CTD PMID:11278000 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G App amyloid beta precursor protein increases response to substance ISO APP gene mutant form results in increased susceptibility to Idarubicin CTD PMID:25926793 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor increases activity ISO Idarubicin results in increased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atrx ATRX, chromatin remodeler decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of ATRX mRNA
[Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA]
CTD PMID:28973540 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Idarubicin results in increased expression of BAX mRNA; Idarubicin results in increased expression of BAX protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein]
CTD PMID:28973540 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] CTD PMID:17965967 PMID:18438337 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA] CTD PMID:28973540 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases activity
ISO Idarubicin results in decreased activity of ESR1 protein
Idarubicin results in increased activity of ESR1 protein
CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Exo1 exonuclease 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]
Idarubicin results in decreased expression of EXO1 mRNA; Idarubicin results in decreased expression of EXO1 protein
CTD PMID:28973540 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA CTD PMID:28973540 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA] CTD PMID:28973540 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA] CTD PMID:28973540 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Idarubicin promotes the reaction [Glutaral results in decreased activity of GSR protein] CTD PMID:19490936 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Idarubicin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Idarubicin results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nppb natriuretic peptide B increases expression ISO Idarubicin results in increased expression of NPPB protein CTD PMID:16151589 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Idarubicin results in decreased activity of NR1H4 protein
Idarubicin results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of OGG1 mRNA; Idarubicin results in decreased expression of OGG1 protein
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]
CTD PMID:28973540 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Idarubicin results in increased expression of PARP1 mRNA; Idarubicin results in increased expression of PARP1 protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein]
CTD PMID:28973540 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases activity ISO Idarubicin results in decreased activity of PPARD protein CTD PMID:25257666 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO Idarubicin results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression
multiple interactions
ISO Idarubicin results in increased expression of PPP1R15A mRNA; Idarubicin results in increased expression of PPP1R15A protein
Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein]
CTD PMID:28973540 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein] CTD PMID:28973540 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] CTD PMID:28973540 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA CTD PMID:28973540 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rad9a RAD9 checkpoint clamp component A multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA] CTD PMID:28973540 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA] CTD PMID:28973540 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of TOPBP1 mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
CTD PMID:28973540 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA] CTD PMID:28973540 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ung uracil-DNA glycosylase decreases expression
multiple interactions
ISO Idarubicin results in decreased expression of UNG mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA]
CTD PMID:28973540 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Vdr vitamin D receptor decreases activity ISO Idarubicin results in decreased activity of VDR protein CTD PMID:25257666 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Idarubicin co-treated with triptolide] affects the expression of XIAP protein CTD PMID:18922616 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA CTD PMID:28973540 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein]
Idarubicin results in decreased expression of XRCC1 mRNA; Idarubicin results in decreased expression of XRCC1 protein
CTD PMID:28973540 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA CTD PMID:28973540 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          anthracycline antibiotic 7364
            idarubicin 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  cyclic hydrocarbon 17078
                                    arene 17074
                                      polycyclic arene 16894
                                        ortho-fused polycyclic arene 9665
                                          acene 7584
                                            tetracene 7581
                                              idarubicin 36
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