CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2,4-dinitrophenol
Accession: CHEBI:42017
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Definition: A dinitrophenol having the nitro groups at the 2- and 4-positions.
Synonyms: related_synonym: 1-hydroxy-2,4-dinitrobenzene; 2,4-DNP; Formula=C6H4N2O5; InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H; InChIKey=UFBJCMHMOXMLKC-UHFFFAOYSA-N; SMILES=Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O; alpha-dinitrophenol
alt_id: CHEBI:42013; CHEBI:918
xref: Beilstein:1246142; CAS:51-28-5; DrugBank:DB04528; Gmelin:103005; KEGG:C02496; LINCS:LSM-20951
xref_mesh: MESH:D019297
xref: MetaCyc:CPD-8179; PDBeChem:DNF; PMID:10509480; PMID:10888472; PMID:13532746; PMID:15307184; PMID:16661637; PMID:25281383; PMID:5959282; PMID:9129253; Reaxys:1246142; Wikipedia:2\,4-Dinitrophenol
cyclic_relationship: is_conjugate_acid_of CHEBI:84561
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form
CTD
PMID:17064354
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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App
amyloid beta precursor protein
affects localization multiple interactions
ISO
2,4-Dinitrophenol affects the localization of APP protein 2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium]
CTD
PMID:18949129
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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Cidea
cell death-inducing DFFA-like effector a
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of CIDEA mRNA
CTD
PMID:24872412
NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
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Cox4i1
cytochrome c oxidase subunit 4i1
increases expression
ISO
2,4-Dinitrophenol results in increased expression of COX4I1 mRNA
CTD
PMID:11784294
NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases activity
ISO EXP
2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] 2,4-Dinitrophenol results in increased activity of CYP1A1 protein
CTD
PMID:18493746
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO EXP
2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD
PMID:18493746
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Dio2
iodothyronine deiodinase 2
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA
CTD
PMID:24872412
NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
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Fgf21
fibroblast growth factor 21
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA
CTD
PMID:24872412
NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
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Gnrhr
gonadotropin releasing hormone receptor
multiple interactions
ISO
2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin]
CTD
PMID:15212170
NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
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Gpx4
glutathione peroxidase 4
decreases response to substance
EXP
GPX4 protein results in decreased susceptibility to 2,4-Dinitrophenol
CTD
PMID:19818760
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
multiple interactions
ISO
2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]; Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]
CTD
PMID:15949470
NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
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Lep
leptin
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA
CTD
PMID:24872412
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Nrf1
nuclear respiratory factor 1
increases expression
ISO
2,4-Dinitrophenol results in increased expression of NRF1 mRNA
CTD
PMID:11784294
NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
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Prdm16
PR/SET domain 16
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of PRDM16 mRNA
CTD
PMID:24872412
NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
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Scd
stearoyl-CoA desaturase
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of SCD1 mRNA
CTD
PMID:24872412
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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Slc16a1
solute carrier family 16 member 1
multiple interactions
ISO
2,4-Dinitrophenol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]
CTD
PMID:15804185
NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
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Slc5a6
solute carrier family 5 member 6
multiple interactions
ISO
2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
CTD
PMID:15561972
NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
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Smn1
survival of motor neuron 1, telomeric
increases expression
ISO
2,4-Dinitrophenol results in increased expression of SMN1 mRNA alternative form
CTD
PMID:17064354
NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147
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Srxn1
sulfiredoxin 1
increases expression
ISO
2,4-Dinitrophenol results in increased expression of SRXN1 protein
CTD
PMID:27358234
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
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Ucp1
uncoupling protein 1
multiple interactions
ISO
[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of UCP1 mRNA
CTD
PMID:24872412
NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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