Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4-dinitrophenol
go back to main search page
Accession:CHEBI:42017 term browser browse the term
Definition:A dinitrophenol having the nitro groups at the 2- and 4-positions.
Synonyms:related_synonym: 1-hydroxy-2,4-dinitrobenzene;   2,4-DNP;   Formula=C6H4N2O5;   InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H;   InChIKey=UFBJCMHMOXMLKC-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O;   alpha-dinitrophenol
 alt_id: CHEBI:42013;   CHEBI:918
 xref: Beilstein:1246142;   CAS:51-28-5;   DrugBank:DB04528;   Gmelin:103005;   KEGG:C02496;   LINCS:LSM-20951
 xref_mesh: MESH:D019297
 xref: MetaCyc:CPD-8179;   PDBeChem:DNF;   PMID:10509480;   PMID:10888472;   PMID:13532746;   PMID:15307184;   PMID:16661637;   PMID:18505478;   PMID:25281383;   PMID:5959282;   PMID:9129253;   Reaxys:1246142;   Wikipedia:2\,4-Dinitrophenol
 cyclic_relationship: is_conjugate_acid_of CHEBI:84561


show annotations for term's descendants           Sort by:
 
2,4-dinitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form CTD PMID:17064354 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein affects localization
multiple interactions		 ISO 2,4-Dinitrophenol affects the localization of APP protein
2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium]		 CTD PMID:18949129 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of CIDEA mRNA CTD PMID:24872412 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO 2,4-Dinitrophenol results in increased expression of COX4I1 mRNA CTD PMID:11784294 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity		 ISO
EXP		 2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
2,4-Dinitrophenol results in increased activity of CYP1A1 protein		 CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO
EXP		 2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA CTD PMID:24872412 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA CTD PMID:24872412 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin] CTD PMID:15212170 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance EXP GPX4 protein results in decreased susceptibility to 2,4-Dinitrophenol CTD PMID:19818760 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO 2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]; Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]] CTD PMID:15949470 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Lep leptin multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of NRF1 mRNA CTD PMID:11784294 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of PRDM16 mRNA CTD PMID:24872412 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of SCD1 mRNA CTD PMID:24872412 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712 		JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO 2,4-Dinitrophenol results in increased expression of SMN1 mRNA alternative form CTD PMID:17064354 NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of UCP1 mRNA CTD PMID:24872412 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      biological role 19989
        aetiopathogenetic role 19245
          allergen 17531
            2,4-dinitrophenol 20
              4,6-dinitro-o-cresol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic molecule 19798
                              organic cyclic compound 19560
                                organic aromatic compound 19399
                                  phenols 18482
                                    nitrophenol 1202
                                      dinitrophenol 26
                                        2,4-dinitrophenol 20
                                          4,6-dinitro-o-cresol 0
paths to the root