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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4-dinitrophenol
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Accession:CHEBI:42017 term browser browse the term
Definition:A dinitrophenol having the nitro groups at the 2- and 4-positions.
Synonyms:related_synonym: 1-hydroxy-2,4-dinitrobenzene;   2,4-DNP;   Formula=C6H4N2O5;   InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H;   InChIKey=UFBJCMHMOXMLKC-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O;   alpha-dinitrophenol
 alt_id: CHEBI:42013;   CHEBI:918
 xref: Beilstein:1246142;   CAS:51-28-5;   DrugBank:DB04528;   Gmelin:103005;   KEGG:C02496;   LINCS:LSM-20951
 xref_mesh: MESH:D019297
 xref: MetaCyc:CPD-8179;   PDBeChem:DNF;   PMID:10509480;   PMID:10888472;   PMID:13532746;   PMID:15307184;   PMID:16661637;   PMID:25281383;   PMID:5959282;   PMID:9129253;   Reaxys:1246142;   Wikipedia:2\,4-Dinitrophenol
 cyclic_relationship: is_conjugate_acid_of CHEBI:84561

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2,4-dinitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form CTD PMID:17064354 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G App amyloid beta precursor protein affects localization
multiple interactions		 ISO 2,4-Dinitrophenol affects the localization of APP protein
2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium]		 CTD PMID:18949129 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of CIDEA mRNA CTD PMID:24872412 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO 2,4-Dinitrophenol results in increased expression of COX4I1 mRNA CTD PMID:11784294 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity		 ISO
EXP		 2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
2,4-Dinitrophenol results in increased activity of CYP1A1 protein		 CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO
EXP		 2,4-Dinitrophenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA CTD PMID:24872412 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA CTD PMID:24872412 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin] CTD PMID:15212170 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance EXP GPX4 protein results in decreased susceptibility to 2,4-Dinitrophenol CTD PMID:19818760 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO 2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]; Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]] CTD PMID:15949470 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127 		JBrowse link
G Lep leptin multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of NRF1 mRNA CTD PMID:11784294 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341 		JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of PRDM16 mRNA CTD PMID:24872412 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of SCD1 mRNA CTD PMID:24872412 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO 2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116 		JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO 2,4-Dinitrophenol results in increased expression of SMN1 mRNA alternative form CTD PMID:17064354 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 2,4-Dinitrophenol results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO [2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of UCP1 mRNA CTD PMID:24872412 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        aetiopathogenetic role 19006
          allergen 16968
            2,4-dinitrophenol 20
              4,6-dinitro-o-cresol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic aromatic compound 19220
                                  phenols 18176
                                    nitrophenol 1187
                                      dinitrophenol 26
                                        2,4-dinitrophenol 20
                                          4,6-dinitro-o-cresol 0
paths to the root