Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-chlorosalicylic acid
go back to main search page
Accession:CHEBI:420128 term browser browse the term
Definition:A monohydroxybenzoic acid that is 2-hydroxybenzoic acid (salicylic acid) in which the hydrogen at position 5 is replaced by chlorine.
Synonyms:related_synonym: 2-Hydroxy-5-chlorobenzoic acid;   5 CSA;   5-Chloro-2-hydroxybenzoic acid;   Formula=C7H5ClO3;   InChI=1S/C7H5ClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11);   InChIKey=NKBASRXWGAGQDP-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(Cl)ccc1O
 xref: AGR:IND43635496;   Beilstein:2046665;   CAS:321-14-2;   Gmelin:561203;   PMID:1650428;   PMID:18819808;   PMID:1944396;   PMID:20062845;   PMID:21689976;   PMID:22365879;   PMID:22476141;   PMID:28166217;   Patent:CN101684061;   Reaxys:2046665
 cyclic_relationship: is_conjugate_acid_of CHEBI:59131


show annotations for term's descendants           Sort by:
 
niclosamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Niclosamide results in decreased expression of ACACA mRNA CTD PMID:22576131 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Niclosamide results in decreased expression of ACSL1 mRNA CTD PMID:22576131 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]		 CTD PMID:26643609 PMID:28318631 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Niclosamide results in decreased expression of ADH4 mRNA CTD PMID:28284560 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases cleavage ISO Niclosamide results in increased cleavage of AIFM1 protein CTD PMID:22576131 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:20215516 PMID:26792726 PMID:29843133 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Niclosamide results in decreased expression of ALDH1A1 protein CTD PMID:24736023 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Niclosamide results in increased expression of ALDOB mRNA CTD PMID:22576131 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Niclosamide results in decreased expression of ALDOC mRNA CTD PMID:22576131 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression
decreases response to substance
multiple interactions		 ISO Niclosamide results in increased expression of ALOX12B mRNA
ALOX12B protein results in decreased susceptibility to Niclosamide
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]		 CTD PMID:30258081 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
decreases response to substance		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide		 CTD PMID:30258081 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO Niclosamide results in decreased expression of ALPL mRNA CTD PMID:28824321 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apof apolipoprotein F decreases expression ISO Niclosamide results in decreased expression of APOF mRNA CTD PMID:28284560 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form		 CTD PMID:24740322 PMID:25970160 PMID:28500234 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein CTD PMID:28284560 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Niclosamide results in decreased expression of ASF1B mRNA CTD PMID:28284560 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]		 CTD PMID:26917416 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein CTD PMID:26917416 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Niclosamide results in increased expression of ATP5F1A mRNA CTD PMID:22576131 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression ISO Niclosamide results in increased expression of ATP5F1D mRNA CTD PMID:22576131 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Niclosamide results in decreased expression of ATP5MC3 mRNA CTD PMID:22576131 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279 		JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Niclosamide results in decreased expression of ATP5MF mRNA CTD PMID:22576131 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236 		JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression ISO Niclosamide results in decreased expression of ATP5MG mRNA CTD PMID:22576131 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b decreases expression ISO Niclosamide results in decreased expression of ATP5PB mRNA CTD PMID:22576131 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 decreases expression ISO Niclosamide results in decreased expression of ATP6AP1 mRNA CTD PMID:22576131 NCBI chr  X:152,079,954...152,087,034
Ensembl chr  X:152,079,865...152,087,034 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:26792726 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Niclosamide results in decreased expression of AURKB mRNA CTD PMID:28284560 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axin2 axin 2 multiple interactions
decreases expression		 ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein		 CTD PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA CTD PMID:25988281 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA CTD PMID:25988281 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression
multiple interactions		 ISO Niclosamide results in increased expression of BAX protein
Niclosamide results in decreased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]		 CTD PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA] CTD PMID:30258081 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]		 CTD PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein		 CTD PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]		 CTD PMID:23894143 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein] CTD PMID:33632240 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression EXP Niclosamide results in decreased expression of BCL9 mRNA CTD PMID:27338550 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
affects expression		 ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 protein
Niclosamide affects the expression of BIRC5 protein		 CTD PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression
decreases phosphorylation		 ISO Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein		 CTD PMID:28284560 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]		 CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
decreases expression
increases expression		 ISO
EXP		 Niclosamide results in increased cleavage of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]
Niclosamide results in decreased expression of CASP3 protein
Niclosamide results in increased expression of CASP3 protein modified form
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]		 CTD PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression		 ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:26116531 PMID:28500234 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases expression		 ISO TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 protein modified form		 CTD PMID:26116531 PMID:26703449 PMID:30258081 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]		 CTD PMID:24561310 PMID:28318631 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]		 CTD PMID:28318631 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:24561310 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein] CTD PMID:24561310 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Niclosamide results in decreased expression of CCNB1 mRNA CTD PMID:28284560 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein		 CTD PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression
increases expression		 ISO Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA		 CTD PMID:22576131 PMID:27226553 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Niclosamide results in decreased expression of CCND3 mRNA CTD PMID:22576131 PMID:27226553 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein] CTD PMID:24561310 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein] CTD PMID:24561310 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein] CTD PMID:24561310 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO CDC37 protein binds to and results in increased susceptibility to Niclosamide analog CTD PMID:28284560 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression
decreases phosphorylation		 ISO Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein		 CTD PMID:29251334 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Niclosamide results in decreased expression of CDC6 mRNA CTD PMID:28284560 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO Niclosamide results in decreased expression of CDCA2 mRNA CTD PMID:28284560 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611 		JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO Niclosamide results in decreased expression of CDCA5 mRNA CTD PMID:28284560 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023 		JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Niclosamide results in decreased expression of CDCA8 mRNA CTD PMID:28284560 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein		 CTD PMID:25174399 PMID:26643609 PMID:30143678 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein] CTD PMID:26643609 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Niclosamide results in decreased expression of CDK2 protein CTD PMID:29031202 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Niclosamide results in decreased expression of CDK4 protein CTD PMID:29031202 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] CTD PMID:30258081 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Niclosamide results in decreased expression of CDKN3 mRNA CTD PMID:28284560 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 increases expression ISO Niclosamide results in increased expression of CELSR3 mRNA CTD PMID:28284560 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354 		JBrowse link
G Cenpa centromere protein A decreases expression ISO Niclosamide results in decreased expression of CENPA mRNA CTD PMID:28284560 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675 		JBrowse link
G Cfp complement factor properdin increases expression ISO Niclosamide results in increased expression of CFP mRNA CTD PMID:28284560 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein CTD PMID:26116531 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Niclosamide results in decreased expression of COL1A1 mRNA CTD PMID:28824321 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Colec10 collectin subfamily member 10 increases expression ISO Niclosamide results in increased expression of COLEC10 mRNA CTD PMID:28284560 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Niclosamide results in increased expression of CREBBP mRNA CTD PMID:22576131 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] CTD PMID:28824321 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO Niclosamide results in increased expression of CSNK1E mRNA CTD PMID:22576131 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Niclosamide results in increased expression of CSRNP1 mRNA CTD PMID:28284560 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183 		JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Niclosamide results in increased expression of CTBP1 mRNA CTD PMID:22576131 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
decreases expression
decreases activity
increases ubiquitination		 ISO
EXP		 Niclosamide results in increased expression of CTNNB1 mRNA
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased expression of CTNNB1 mRNA		 CTD PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] CTD PMID:24534281 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Ctsc cathepsin C decreases expression ISO Niclosamide results in decreased expression of CTSC protein CTD PMID:29480568 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ctsd cathepsin D decreases expression ISO Niclosamide results in decreased expression of CTSD protein CTD PMID:29480568 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:26792726 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA] CTD PMID:33632240 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Niclosamide results in increased expression of CYCS protein CTD PMID:26703449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Niclosamide results in increased activity of CYP1A1 protein CTD PMID:12451431 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA		 CTD PMID:11124226 PMID:28284560 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Niclosamide results in increased expression of CYP39A1 mRNA CTD PMID:28284560 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Niclosamide results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]		 CTD PMID:26917416 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression ISO Niclosamide results in decreased expression of DECR1 mRNA CTD PMID:22576131 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Niclosamide results in decreased expression of DMAC2L mRNA CTD PMID:22576131 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Niclosamide results in increased expression of DVL1 mRNA CTD PMID:22576131 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]		 CTD PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression ISO Niclosamide results in increased expression of DVL3 mRNA CTD PMID:22576131 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of E2F1 mRNA CTD PMID:29843133 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO Niclosamide results in decreased expression of E2F8 mRNA CTD PMID:28284560 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665 		JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 decreases expression ISO Niclosamide results in decreased expression of ECHDC1 mRNA CTD PMID:22576131 NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Niclosamide results in decreased expression of ECHS1 mRNA CTD PMID:22576131 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Egf epidermal growth factor decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]		 CTD PMID:30779072 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
decreases phosphorylation		 ISO Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
Niclosamide results in decreased phosphorylation of EGFR protein		 CTD PMID:28284560 PMID:28426875 PMID:30779072 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Niclosamide results in increased expression of EGR1 mRNA CTD PMID:28284560 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:26917416 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Niclosamide results in increased phosphorylation of EIF2S1 protein CTD PMID:26917416 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
decreases phosphorylation
multiple interactions		 ISO Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]		 CTD PMID:19771169 PMID:28284560 PMID:30258081 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,123...11,238,680
Ensembl chr 8:11,211,110...11,238,892 		JBrowse link
G Eno2 enolase 2 increases expression ISO Niclosamide results in increased expression of ENO2 mRNA CTD PMID:22576131 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Eno3 enolase 3 decreases expression ISO Niclosamide results in decreased expression of ENO3 mRNA CTD PMID:22576131 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eps8l3 EPS8 like 3 increases expression ISO Niclosamide results in increased expression of EPS8L3 mRNA CTD PMID:28284560 Ensembl chr 2:195,514,692...195,528,085 JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO Niclosamide results in decreased expression of FAM83D mRNA CTD PMID:28284560 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP		 Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]		 CTD PMID:28318631 PMID:33632240 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein CTD PMID:25174399 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA		 CTD PMID:28500234 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]		 CTD PMID:28318631 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]		 CTD PMID:26792726 PMID:28824321 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSB mRNA CTD PMID:28284560 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSL1 mRNA CTD PMID:22576131 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression		 ISO Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein] CTD PMID:27492973 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] CTD PMID:29733962 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fzd1 frizzled class receptor 1 affects localization ISO Niclosamide affects the localization of FZD1 protein CTD PMID:19772353 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO Niclosamide results in decreased expression of FZD2 mRNA CTD PMID:22576131 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Fzd5 frizzled class receptor 5 increases expression ISO Niclosamide results in increased expression of FZD5 mRNA CTD PMID:22576131 NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Fzd9 frizzled class receptor 9 decreases expression ISO Niclosamide results in decreased expression of FZD9 mRNA CTD PMID:22576131 NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398 		JBrowse link
G Gcg glucagon multiple interactions EXP Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein] CTD PMID:26964897 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression ISO Niclosamide results in increased expression of GOT2 mRNA CTD PMID:22576131 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
decreases phosphorylation		 ISO Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in decreased phosphorylation of GSK3B protein		 CTD PMID:22576131 PMID:30143678 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 decreases expression ISO Niclosamide results in decreased expression of GTSE1 mRNA CTD PMID:28284560 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Niclosamide results in decreased expression of HADH mRNA CTD PMID:22576131 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
increases expression		 ISO Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA		 CTD PMID:25633564 PMID:28284560 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]		 CTD PMID:19160421 PMID:28318631 PMID:32961231 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]		 CTD PMID:27542212 PMID:28318631 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression		 EXP
ISO		 Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide results in increased expression of HEY2 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]		 CTD PMID:19160421 PMID:28318631 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]		 CTD PMID:30779072 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]		 CTD PMID:28318631 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Niclosamide results in decreased expression of HMMR mRNA CTD PMID:28284560 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hoxa1 homeobox A1 increases expression ISO Niclosamide results in increased expression of HOXA1 CTD PMID:26820057 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]		 CTD PMID:28318631 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Niclosamide CTD PMID:27497986 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igll1 immunoglobulin lambda-like polypeptide 1 decreases expression ISO Niclosamide results in decreased expression of IGLL1 mRNA CTD PMID:27226553 NCBI chr11:84,138,847...84,142,238
Ensembl chr11:84,138,910...84,142,216 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects localization ISO Niclosamide affects the localization of IKBKB protein CTD PMID:26116531 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects localization ISO Niclosamide affects the localization of IKBKG protein CTD PMID:26116531 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] CTD PMID:33524445 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il21 interleukin 21 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein] CTD PMID:33632240 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]		 CTD PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA] CTD PMID:26792726 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization
increases expression
increases phosphorylation
multiple interactions		 EXP
ISO		 Niclosamide affects the localization of JUN protein
Niclosamide results in increased expression of JUN mRNA
Niclosamide results in increased phosphorylation of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]		 CTD PMID:24750999 PMID:27338550 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO Niclosamide results in decreased expression of KIF11 mRNA CTD PMID:28284560 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Niclosamide results in decreased expression of KIF20A mRNA CTD PMID:28284560 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO Niclosamide results in decreased expression of KIFC1 mRNA CTD PMID:28284560 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Niclosamide results in increased expression of LCAT mRNA CTD PMID:28284560 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO Niclosamide results in increased expression of LDHA mRNA CTD PMID:22576131 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] CTD PMID:32961231 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]		 CTD PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Niclosamide results in decreased expression of MAD2L1 mRNA CTD PMID:28284560 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Niclosamide results in increased expression of MAP1LC3B protein modified form CTD PMID:30258081 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein		 CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:28824321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:28824321 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Niclosamide results in decreased expression of MCL1 protein CTD PMID:20215516 PMID:26116531 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein CTD PMID:28284560 PMID:29031202 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Niclosamide results in decreased expression of MCM7 protein CTD PMID:29031202 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP Niclosamide results in decreased expression of MET mRNA CTD PMID:27338550 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Niclosamide results in decreased expression of MKI67 mRNA CTD PMID:28284560 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein CTD PMID:29480568 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein CTD PMID:29251334 PMID:30143678 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]
Niclosamide results in decreased expression of MMP7 mRNA
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]		 CTD PMID:27338550 PMID:28318631 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]		 CTD PMID:28824321 PMID:29480568 PMID:30143678 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO Niclosamide results in increased expression of MT2A mRNA CTD PMID:28284560 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
increases expression
multiple interactions		 ISO Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein
Niclosamide results in increased expression of MTOR mRNA
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]
[Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein		 CTD PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 More... NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 decreases expression ISO Niclosamide results in decreased expression of NDUFA10 mRNA CTD PMID:22576131 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 increases expression ISO Niclosamide results in increased expression of NDUFA4L2 mRNA CTD PMID:22576131 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010 		JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression ISO Niclosamide results in decreased expression of NDUFA7 mRNA CTD PMID:22576131 NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976 		JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression ISO Niclosamide results in decreased expression of NDUFA8 mRNA CTD PMID:22576131 NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 decreases expression ISO Niclosamide results in decreased expression of NDUFB10 mRNA CTD PMID:22576131 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO Niclosamide results in decreased expression of NDUFB6 mRNA CTD PMID:22576131 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181 		JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 increases expression ISO Niclosamide results in increased expression of NDUFC1 mRNA CTD PMID:22576131 NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression ISO Niclosamide results in decreased expression of NDUFS2 mRNA CTD PMID:22576131 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 decreases expression ISO Niclosamide results in decreased expression of NDUFS3 mRNA CTD PMID:22576131 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 decreases expression ISO Niclosamide results in decreased expression of NDUFS7 mRNA CTD PMID:22576131 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 decreases expression ISO Niclosamide results in decreased expression of NDUFS8 mRNA CTD PMID:22576131 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression ISO Niclosamide results in increased expression of NDUFV3 mRNA CTD PMID:22576131 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Niclosamide affects the localization of NFKB1 protein CTD PMID:26116531 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO Niclosamide results in decreased phosphorylation of NFKBIA protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]
Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]		 CTD PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions
increases expression		 ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA]
Niclosamide results in increased expression of NKD1 mRNA		 CTD PMID:22576131 PMID:24534281 NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380 		JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA
Niclosamide results in decreased expression of NKX3-1 mRNA		 CTD PMID:28500234 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Notch1 notch receptor 1 decreases activity
multiple interactions		 ISO
EXP		 Niclosamide results in decreased activity of NOTCH1 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]		 CTD PMID:19160421 PMID:32961231 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Niclosamide binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA] CTD PMID:28824321 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991 		JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO Niclosamide results in decreased expression of ORC1 mRNA CTD PMID:28284560 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
decreases expression		 ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in decreased expression of PARP1 protein		 CTD PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pc pyruvate carboxylase increases expression ISO Niclosamide results in increased expression of PC mRNA CTD PMID:22576131 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression ISO Niclosamide results in decreased expression of PFKM mRNA CTD PMID:22576131 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Niclosamide results in increased expression of PHLDA1 mRNA CTD PMID:28284560 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression
multiple interactions		 ISO Niclosamide results in increased expression of PIK3CA mRNA
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]		 CTD PMID:27542212 PMID:29843133 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO Niclosamide results in increased expression of PKM mRNA CTD PMID:22576131 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of POU5F1 protein CTD PMID:23333246 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Niclosamide results in increased expression of PPARD mRNA CTD PMID:22576131 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO Niclosamide results in decreased expression of PPP2CB mRNA CTD PMID:22576131 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Niclosamide results in increased expression of PPP2R1A mRNA CTD PMID:22576131 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Niclosamide results in decreased expression of PPP2R2B mRNA CTD PMID:22576131 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025 		JBrowse link
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma decreases expression ISO Niclosamide results in decreased expression of PPP2R2C mRNA CTD PMID:22576131 NCBI chr14:73,846,547...73,931,178
Ensembl chr14:73,846,547...73,931,864 		JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA] CTD PMID:33632240 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prkcq protein kinase C, theta increases expression ISO Niclosamide results in increased expression of PRKCQ mRNA CTD PMID:22576131 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Niclosamide results in increased expression of PTEN mRNA CTD PMID:29843133 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rad54l RAD54 like increases expression ISO Niclosamide results in increased expression of RAD54L mRNA CTD PMID:28284560 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation
decreases expression		 ISO Niclosamide analog results in decreased phosphorylation of RAF1 protein
Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein		 CTD PMID:28284560 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO
EXP		 Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]
Niclosamide results in decreased expression of RELA protein
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]		 CTD PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhof ras homolog family member F, filopodia associated multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA] CTD PMID:29733962 NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703 		JBrowse link
G Ripor3 RIPOR family member 3 increases expression ISO Niclosamide results in increased expression of FAM65C mRNA CTD PMID:28284560 NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein CTD PMID:29251334 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rps6 ribosomal protein S6 affects phosphorylation ISO Niclosamide affects the phosphorylation of RPS6 protein CTD PMID:27542212 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 PMID:30258081 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO Niclosamide results in decreased expression of RRM2 mRNA CTD PMID:28284560 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO Niclosamide results in decreased expression of RUNX2 mRNA CTD PMID:28824321 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]		 CTD PMID:21685359 PMID:29733962 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA] CTD PMID:28318631 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions EXP Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA] CTD PMID:28318631 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Niclosamide results in decreased expression of SLC2A1 mRNA CTD PMID:22576131 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Niclosamide results in decreased expression of SLC2A3 mRNA CTD PMID:22576131 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP		 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein]		 CTD PMID:28318631 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression		 ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]
Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein		 CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression		 ISO WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased expression of SNAI2 protein		 CTD PMID:25174399 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein] CTD PMID:26643609 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
decreases expression
multiple interactions		 ISO Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein
Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]		 CTD PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 More... NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO Niclosamide results in decreased expression of TACC3 mRNA CTD PMID:28284560 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219 		JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein] CTD PMID:33632240 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tcim transcriptional and immune response regulator increases expression ISO Niclosamide results in increased expression of TCIM mRNA CTD PMID:28284560 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:28318631 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Niclosamide results in increased expression of TIMP2 mRNA CTD PMID:30143678 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO Niclosamide results in decreased expression of TK1 mRNA CTD PMID:28284560 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Niclosamide results in decreased activity of TNF protein
Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]		 CTD PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]		 CTD PMID:26792726 PMID:28824321 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases response to substance
decreases response to substance		 ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]
Niclosamide results in increased expression of TRP53 protein
TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide
TP53 protein results in decreased susceptibility to Niclosamide
Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form		 CTD PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO Niclosamide results in increased expression of TPI1 mRNA CTD PMID:22576131 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Niclosamide results in decreased expression of TPX2 mRNA CTD PMID:28284560 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein] CTD PMID:28824321 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 decreases expression ISO Niclosamide results in decreased expression of TRIP13 mRNA CTD PMID:28284560 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of TWIST1 protein CTD PMID:29480568 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA
Niclosamide results in decreased expression of UBE2C mRNA		 CTD PMID:28500234 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO Niclosamide results in decreased expression of UHRF1 mRNA CTD PMID:28284560 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Niclosamide results in decreased expression of UTP3 mRNA CTD PMID:27226553 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein CTD PMID:29251334 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]
Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein		 CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO Niclosamide results in decreased expression of VPREB1 mRNA CTD PMID:27226553 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846 		JBrowse link
G Wnt2b Wnt family member 2B decreases expression ISO Niclosamide results in decreased expression of WNT2B mRNA CTD PMID:22576131 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308 		JBrowse link
G Wnt3 Wnt family member 3 decreases expression ISO Niclosamide results in decreased expression of WNT3 mRNA CTD PMID:22576131 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions
decreases expression		 ISO
EXP		 Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]
Niclosamide results in decreased expression of WNT3A mRNA
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]		 CTD PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt7a Wnt family member 7A increases response to substance
decreases activity
multiple interactions		 ISO WNT7A protein results in increased susceptibility to Niclosamide
Niclosamide results in decreased activity of WNT7A protein
WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]		 CTD PMID:25174399 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Niclosamide results in decreased expression of XIAP protein CTD PMID:20215516 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Niclosamide results in increased expression of ZFP36 mRNA CTD PMID:28284560 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
G Zic2 Zic family member 2 increases expression ISO Niclosamide results in increased expression of ZIC2 mRNA CTD PMID:28284560 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        antimicrobial agent 17788
          antimicrobial food preservative 11946
            benzoic acid 4335
              5-chlorosalicylic acid 269
                niclosamide 269
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        aromatic carboxylic acid 11816
                                          benzoic acids 11791
                                            benzoic acid 4335
                                              hydroxybenzoic acid 3743
                                                monohydroxybenzoic acid 1466
                                                  5-chlorosalicylic acid 269
                                                    niclosamide 269
paths to the root