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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:daunorubicin
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Accession:CHEBI:41977 term browser browse the term
Definition:A natural product found in Actinomadura roseola.
Synonyms:exact_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
 related_synonym: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione;   Daunomycin;   Formula=C27H29NO10;   InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1;   InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O;   acetyladriamycin;   daunorubicinum;   leukaemomycin C
 alt_id: CHEBI:23560;   CHEBI:41970;   CHEBI:4330;   CHEBI:65723
 xref: Beilstein:1445583;   CAS:20830-81-3;   DrugBank:DB00694;   Drug_Central:786;   KEGG:C01907;   KEGG:D07776;   LINCS:LSM-2962;   LIPID_MAPS_instance:LMPK13050002
 xref_mesh: MESH:D003630
 xref: PDBeChem:DM1;   PMID:10820108;   PMID:23414337;   PMID:23900905;   PMID:24396448;   Reaxys:1445583;   Wikipedia:Daunorubicin
 cyclic_relationship: is_conjugate_base_of CHEBI:64677


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daunorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases export
affects transport
decreases expression
increases transport
increases import
decreases uptake
increases response to substance
ISO
EXP
[5-methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of ABCB1 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of ABCB1 mRNA; [Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Sodium Azide co-treated with Iodoacetates] inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; ABCB1 mutant form promotes the reaction [Magnetite Nanoparticles results in increased susceptibility to Daunorubicin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Daunorubicin]; Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]; Daunorubicin promotes the reaction [Magnetite Nanoparticles results in decreased expression of ABCB1 protein]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form results in increased susceptibility to Daunorubicin]; Magnetite Nanoparticles promotes the reaction [Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; Mitotane inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Daunorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Verapamil inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]
ABCB1A affects the susceptibility to Daunorubicin
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
ABCB1 protein results in increased export of Daunorubicin; ABCB1A protein results in increased export of Daunorubicin
ABCB1 protein affects the transport of Daunorubicin
Daunorubicin results in decreased expression of ABCB1 mRNA; Daunorubicin results in decreased expression of ABCB1 protein
ABCB1 protein results in decreased uptake of Daunorubicin
ABCB1 affects the susceptibility to Daunorubicin; ABCB1 protein affects the susceptibility to Daunorubicin
CTD PMID:9794924, PMID:9815696, PMID:10617675, PMID:11231118, PMID:12107549, PMID:12174371, PMID:12526924, PMID:12642476, PMID:12708479, PMID:15466210, PMID:16636798, PMID:18955043, PMID:20957165, PMID:22114476, PMID:24954033, PMID:29079042 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb8 ATP binding cassette subfamily B member 8 decreases expression EXP Daunorubicin results in decreased expression of ABCB8 mRNA CTD PMID:27090888 NCBI chr 4:7,296,538...7,311,856
Ensembl chr 4:7,296,209...7,311,878
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
decreases response to substance
increases secretion
affects response to substance
multiple interactions
decreases uptake
ISO ABCC1 protein affects the export of Daunorubicin
ABCC1 results in decreased susceptibility to Daunorubicin
ABCC1 protein results in increased secretion of Daunorubicin
ABCC1 affects the susceptibility to Daunorubicin; ABCC1 protein affects the susceptibility to Daunorubicin
Benzbromarone inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]; Folic Acid deficiency inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; homocamptothecin inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
ABCC1 protein results in decreased susceptibility to Daunorubicin; ABCC1 results in decreased susceptibility to Daunorubicin
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
CTD PMID:7954421, PMID:8968083, PMID:9096673, PMID:9334814, PMID:10856430, PMID:12088114, PMID:12115804, PMID:12174371, PMID:12657726, PMID:15041471, PMID:15498506, PMID:18451141 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
multiple interactions
ISO ABCC2 affects the susceptibility to Daunorubicin
[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]
CTD PMID:18451141, PMID:29079042 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA] CTD PMID:20019844 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases response to substance ISO ABL1 results in decreased susceptibility to Daunorubicin CTD PMID:12410571 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Daunorubicin results in decreased expression of ACTA1 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Agrn agrin increases expression ISO Daunorubicin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein] CTD PMID:20888384 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
affects metabolic processing
multiple interactions
increases metabolic processing
ISO AKR1A1 protein results in increased reduction of Daunorubicin
AKR1A1 SNP affects the metabolism of Daunorubicin
[AKR1A1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol
CTD PMID:18276838, PMID:18322072 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Daunorubicin CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases response to substance
increases reduction
multiple interactions
ISO AKR1B10 protein results in decreased susceptibility to Daunorubicin
AKR1B10 protein results in increased reduction of Daunorubicin
[AKR1B10 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]
CTD PMID:19028477 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
decreases response to substance
multiple interactions
ISO AKR1C3 protein results in increased metabolism of Daunorubicin; AKR1C3 results in increased metabolism of Daunorubicin
AKR1C3 protein results in decreased susceptibility to Daunorubicin
[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol; [Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin; dinaciclib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; NVP-BKM120 inhibits the reaction [AKR1C3 protein results in increased reduction of and results in decreased susceptibility to Daunorubicin]; Tretinoin inhibits the reaction [[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol]; Tretinoin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
CTD PMID:20837989, PMID:29992508, PMID:30703376, PMID:32588086 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance ISO AKT1 protein results in decreased susceptibility to Daunorubicin CTD PMID:22252735 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angpt1 angiopoietin 1 decreases expression EXP Daunorubicin results in decreased expression of ANGPT1 mRNA; Daunorubicin results in decreased expression of ANGPT1 protein CTD PMID:16626513 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angpt2 angiopoietin 2 increases expression EXP Daunorubicin results in increased expression of ANGPT2 mRNA; Daunorubicin results in increased expression of ANGPT2 protein CTD PMID:16626513 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Daunorubicin results in decreased expression of ANK2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression EXP Daunorubicin results in decreased expression of ANKRD1 mRNA CTD PMID:9278441 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ano3 anoctamin 3 affects response to substance ISO ANO3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Anxa2 annexin A2 decreases expression ISO Daunorubicin results in decreased expression of ANXA2 mRNA; Daunorubicin results in decreased expression of ANXA2 protein CTD PMID:21223737 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa4 annexin A4 increases expression ISO Daunorubicin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO APEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin CTD PMID:10190555 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apob apolipoprotein B increases expression EXP Daunorubicin results in increased expression of APOB protein CTD PMID:7637207 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP Daunorubicin results in increased expression of APOC3 protein CTD PMID:7637207 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Ar androgen receptor increases activity
decreases activity
ISO Daunorubicin results in increased activity of AR protein
Daunorubicin results in decreased activity of AR protein
CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Daunorubicin results in increased expression of ATM mRNA CTD PMID:12656675 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Daunorubicin results in decreased expression of ATP1A2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atxn1 ataxin 1 decreases expression EXP Daunorubicin results in decreased expression of ATXN1 mRNA CTD PMID:27090888 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Aurka aurora kinase A decreases expression ISO Daunorubicin results in decreased expression of AURKA protein CTD PMID:23872705 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Daunorubicin affects the expression of BARD1 mRNA CTD PMID:12656675 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of BAX protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA]
Daunorubicin results in increased expression of BAX mRNA
CTD PMID:19421372, PMID:19918366, PMID:21720514, PMID:26537877, PMID:28940058 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
decreases response to substance
ISO [Bortezomib co-treated with Daunorubicin] results in decreased expression of BCL2 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in decreased expression of BCL2 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein]; bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]; bromotetrandrine promotes the reaction [Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]
Daunorubicin affects the expression of BCL2 mRNA
BCL2 results in decreased susceptibility to Daunorubicin
CTD PMID:19421372, PMID:19918366, PMID:21302442, PMID:21595920, PMID:21720514, PMID:27780733 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein CTD PMID:12780785 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
affects expression
ISO [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 protein
Daunorubicin results in increased expression of BIRC5 mRNA; Daunorubicin results in increased expression of BIRC5 protein
Daunorubicin affects the expression of BIRC5 mRNA
CTD PMID:16638212, PMID:21362215, PMID:21720514, PMID:27780733 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Daunorubicin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Daunorubicin results in decreased expression of CACNA1G mRNA CTD PMID:26537877, PMID:28940058 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S affects response to substance ISO CACNA1S affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr13:52,889,570...52,964,558
Ensembl chr13:52,889,737...52,964,155
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Daunorubicin results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 8:116,154,661...116,285,643
Ensembl chr 8:116,154,736...116,284,985
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
increases activity
ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of CASP3 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]
Daunorubicin affects the expression of CASP3 mRNA
Daunorubicin results in increased activity of CASP3 protein
CTD PMID:10766178, PMID:12780785, PMID:17699722, PMID:17965967, PMID:19421372, PMID:19698806, PMID:19918366, PMID:21720514, PMID:25003661, PMID:27780733 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:12780785 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 affects expression ISO Daunorubicin affects the expression of CASP9 mRNA CTD PMID:27780733 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Daunorubicin CTD PMID:11178967 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Daunorubicin results in decreased expression of CAVIN4 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 5:64,413,005...64,420,849
Ensembl chr 5:64,412,895...64,423,725
JBrowse link
G Cbr1 carbonyl reductase 1 increases metabolic processing
increases reduction
decreases metabolic processing
multiple interactions
ISO CBR1 protein results in increased metabolism of Daunorubicin; CBR1 results in increased metabolism of Daunorubicin
CBR1 protein results in increased reduction of Daunorubicin
CBR1 gene SNP results in decreased metabolism of Daunorubicin
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]
CTD PMID:18579125, PMID:19204081, PMID:20670211, PMID:23295225, PMID:25541467, PMID:30849340 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 affects response to substance
affects metabolic processing
ISO CBR3 gene SNP affects the susceptibility to Daunorubicin
CBR3 protein affects the metabolism of Daunorubicin; CBR3 protein alternative form affects the metabolism of Daunorubicin
CTD PMID:20007405 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Daunorubicin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Daunorubicin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Daunorubicin results in increased expression of CCND3 mRNA CTD PMID:12656675 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 affects expression ISO Daunorubicin affects the expression of CCNE1 mRNA CTD PMID:12656675 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Daunorubicin results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd34 CD34 molecule decreases expression EXP Daunorubicin results in decreased expression of CD34 mRNA CTD PMID:27090888 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Daunorubicin results in increased expression of CDC25A mRNA CTD PMID:12656675 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdh13 cadherin 13 affects response to substance ISO CDH13 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Daunorubicin results in increased expression of CDKN1A; Daunorubicin results in increased expression of CDKN1A mRNA; Daunorubicin results in increased expression of CDKN1A protein CTD PMID:12112851, PMID:12656675, PMID:23872705 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
affects expression
EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Daunorubicin affects the expression of CDKN2A mRNA CTD PMID:12656675 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Daunorubicin results in increased expression of CDKN2B mRNA CTD PMID:12656675 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Daunorubicin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Daunorubicin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:1,516,804...1,534,488
Ensembl chr 6:1,516,804...1,534,488
JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Daunorubicin results in decreased expression of CKM mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Clk2 CDC-like kinase 2 increases expression ISO Daunorubicin results in increased expression of CLK2 mRNA CTD PMID:12656675 NCBI chr 2:188,476,789...188,488,809
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Clybl citramalyl-CoA lyase affects response to substance ISO CLYBL affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
G Cmc2 C-x(9)-C motif containing 2 affects response to substance ISO CMC2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:49,433,332...49,457,641
Ensembl chr19:49,433,590...49,448,072
JBrowse link
G Cmip c-Maf-inducing protein affects response to substance ISO CMIP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:49,792,273...50,000,535
Ensembl chr19:49,792,273...50,000,535
JBrowse link
G Corin corin, serine peptidase decreases expression ISO Daunorubicin results in decreased expression of CORIN mRNA CTD PMID:26537877, PMID:28940058 NCBI chr14:38,247,379...38,474,931
Ensembl chr14:38,247,791...38,473,648
JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin affects response to substance ISO CWC27 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:34,716,420...34,923,060
Ensembl chr 2:34,719,344...34,923,024
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression EXP Daunorubicin results in decreased expression of CXCR4 mRNA CTD PMID:27090888 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein] CTD PMID:21054405 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Daunorubicin results in increased expression of CYBB mRNA CTD PMID:27090888 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Daunorubicin affects the expression of CYCS mRNA CTD PMID:27780733 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects response to substance ISO CYP1B1 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO Daunorubicin results in increased degradation of DFFA protein CTD PMID:12370496 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dmd dystrophin decreases expression ISO Daunorubicin results in decreased expression of DMD mRNA CTD PMID:26537877, PMID:28940058 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Daunorubicin results in increased expression of DUSP4 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Daunorubicin results in increased expression of E2F5 mRNA CTD PMID:12656675 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDN1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]
CTD PMID:20888384 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDNRA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]
CTD PMID:20888384 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDNRB protein
telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]
CTD PMID:20888384 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Daunorubicin inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Daunorubicin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation
multiple interactions
ISO Daunorubicin results in increased phosphorylation of EIF4EBP1 protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:21898527 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eng endoglin decreases expression EXP Daunorubicin results in decreased expression of ENG mRNA CTD PMID:27090888 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Daunorubicin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:119,524,039...119,531,387
Ensembl chr 8:119,524,039...119,531,387
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Daunorubicin results in decreased expression of ERBB3 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases activity
ISO Daunorubicin results in decreased activity of ESR1 protein
Daunorubicin results in increased activity of ESR1 protein
CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Daunorubicin results in increased expression of F3 mRNA; Daunorubicin results in increased expression of F3 protein CTD PMID:11721405 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Daunorubicin results in increased expression of FAS mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
EXP candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein] CTD PMID:16324756 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Daunorubicin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
JBrowse link
G Gapt Grb2-binding adaptor protein, transmembrane affects response to substance ISO GAPT affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:41,869,555...41,874,130
Ensembl chr 2:41,869,556...41,871,858
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Daunorubicin results in increased expression of GDF15 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpc5 glypican 5 affects response to substance ISO GPC5 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:100,283,131...101,776,838 JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Daunorubicin results in increased expression of GPX1 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G H2ax H2A.X variant histone affects expression ISO Daunorubicin affects the expression of H2AX mRNA CTD PMID:27780733 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects response to substance ISO HNRNPD affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Daunorubicin results in decreased expression of HRC mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of ICAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
CTD PMID:20888384 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon affects response to substance ISO IKBKE affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Daunorubicin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase affects response to substance ISO ILKAP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B affects response to substance ISO INPP4B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:29,592,889...30,341,528
Ensembl chr19:29,597,905...29,968,424
JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Daunorubicin results in decreased expression of IRX4 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:32,634,774...32,645,151
Ensembl chr 1:32,634,796...32,643,771
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Daunorubicin results in decreased expression of JAK2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Daunorubicin results in decreased expression of KCNH2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Daunorubicin results in increased expression of KCNJ2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Daunorubicin results in decreased expression of KCNQ1 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Kif1a kinesin family member 1A affects response to substance ISO KIF1A affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:100,171,851...100,253,626
Ensembl chr 9:100,171,772...100,253,609
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Daunorubicin results in decreased expression of KIT mRNA CTD PMID:27090888 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Kitlg KIT ligand decreases expression EXP Daunorubicin results in decreased expression of KITLG mRNA CTD PMID:27090888 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Krt19 keratin 19 increases expression EXP Daunorubicin results in increased expression of KRT19 protein CTD PMID:2444108 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt8 keratin 8 increases expression EXP Daunorubicin results in increased expression of KRT8 protein CTD PMID:2444108 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Daunorubicin results in decreased expression of LDB3 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr16:10,878,348...10,943,016
Ensembl chr16:10,878,334...10,941,501
JBrowse link
G LOC499643 similar to hypothetical protein FLJ25371 affects response to substance ISO C4ORF45 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:178,117,385...178,231,388
Ensembl chr 2:178,117,466...178,231,479
JBrowse link
G Lsamp limbic system-associated membrane protein affects response to substance ISO LSAMP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:58,795,884...59,442,772
Ensembl chr11:58,803,140...59,110,562
JBrowse link
G Luzp2 leucine zipper protein 2 affects response to substance ISO LUZP2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 1:111,849,494...112,067,502
NCBI chr 1:113,419,707...113,531,330
Ensembl chr 1:111,849,998...113,527,735
JBrowse link
G Map1b microtubule-associated protein 1B affects response to substance ISO MAP1B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Daunorubicin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Daunorubicin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Daunorubicin results in decreased expression of MAPT mRNA; Daunorubicin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression ISO Daunorubicin results in decreased expression of MDM4 mRNA CTD PMID:12656675 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Mir21 microRNA 21 decreases response to substance ISO MIR21 results in decreased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of MT1A mRNA; Daunorubicin results in increased expression of MT1A protein
Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A mRNA]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A protein]
CTD PMID:12204545 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
ISO Daunorubicin results in increased phosphorylation of MTOR protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]
CTD PMID:21898527 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO
EXP
Daunorubicin results in decreased expression of MYH6 mRNA CTD PMID:26537877, PMID:27090888, PMID:28940058 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 increases expression
decreases expression
EXP
ISO
Daunorubicin results in increased expression of MYH7 mRNA
Daunorubicin results in decreased expression of MYH7 mRNA
CTD PMID:26328012, PMID:26537877, PMID:27090888, PMID:28940058 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myom2 myomesin 2 decreases expression ISO Daunorubicin results in decreased expression of MYOM2 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr16:79,587,136...79,672,871
Ensembl chr16:79,587,640...79,671,719
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein] CTD PMID:21054405 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
CTD PMID:21054405 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Daunorubicin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ngef neuronal guanine nucleotide exchange factor affects response to substance ISO NGEF affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:94,569,286...94,601,852
Ensembl chr 9:94,569,286...94,601,852
JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of NOX4 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein]
CTD PMID:21054405 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases secretion
affects response to substance
ISO Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]; Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]
NPC1 affects the susceptibility to Daunorubicin
CTD PMID:16174794 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions
decreases expression
EXP Telmisartan inhibits the reaction [Daunorubicin results in decreased expression of NPHS1 protein] CTD PMID:20888384 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Daunorubicin results in increased expression of NPPA mRNA CTD PMID:26328012, PMID:27090888 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases expression
increases expression
EXP
ISO
Daunorubicin results in decreased expression of NPPB mRNA; Daunorubicin results in decreased expression of NPPB protein
Daunorubicin results in increased expression of NPPB mRNA
Daunorubicin results in increased expression of NPPB protein
CTD PMID:11279304, PMID:17673002, PMID:26328012, PMID:27090888 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
decreases expression
EXP
ISO
Daunorubicin results in increased activity of NQO1 protein
Daunorubicin results in decreased expression of NQO1 mRNA; Daunorubicin results in decreased expression of NQO1 protein
CTD PMID:3986001, PMID:8875677, PMID:9620540, PMID:22021338 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Daunorubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Daunorubicin results in decreased activity of NR1H4 protein
Daunorubicin results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Daunorubicin results in decreased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Daunorubicin results in decreased expression of NRAP mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:277,104,519...277,181,397
Ensembl chr 1:277,104,514...277,181,414
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases expression ISO Daunorubicin results in increased expression of NRAS mRNA CTD PMID:12656675 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
affects expression
increases cleavage
ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein
Daunorubicin affects the expression of PARP1 mRNA
Daunorubicin results in increased cleavage of PARP1 protein
CTD PMID:10766178, PMID:11082532, PMID:12780785, PMID:27780733 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP Daunorubicin results in decreased expression of PFKM mRNA CTD PMID:9038198 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects response to substance ISO PIK3R1 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Daunorubicin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Daunorubicin results in increased expression of PPARA mRNA CTD PMID:23834779 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases activity
EXP
ISO
[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA
Daunorubicin results in decreased activity of PPARD protein
CTD PMID:23834779, PMID:25257666 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases activity
increases expression
EXP
ISO
telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
Daunorubicin results in decreased activity of PPARG protein
CTD PMID:20888384, PMID:25257666 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like decreases response to substance ISO PPP1R13L results in decreased susceptibility to Daunorubicin CTD PMID:19299014 NCBI chr 1:80,271,288...80,290,946
Ensembl chr 1:80,279,706...80,290,408
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO Daunorubicin results in decreased expression of PPP1R3A mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 4:41,171,486...41,212,116
Ensembl chr 4:41,171,486...41,212,072
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Daunorubicin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prdm16 PR/SET domain 16 decreases expression ISO Daunorubicin results in decreased expression of PRDM16 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
JBrowse link
G Prkcd protein kinase C, delta increases cleavage ISO Daunorubicin results in increased cleavage of PRKCD protein CTD PMID:11082532 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcz protein kinase C, zeta decreases response to substance ISO PRKCZ protein results in decreased susceptibility to Daunorubicin CTD PMID:21863889 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Prkx protein kinase, X-linked increases expression ISO Daunorubicin results in increased expression of PRKX mRNA CTD PMID:26537877, PMID:28940058 NCBI chr  X:45,080,963...45,125,095
Ensembl chr  X:45,080,963...45,124,270
JBrowse link
G Prom1 prominin 1 decreases expression EXP Daunorubicin results in decreased expression of PROM1 mRNA CTD PMID:27090888 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN results in increased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of PTGS2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]
CTD PMID:20888384 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Daunorubicin results in decreased expression of PYGM mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:221,756,325...221,771,142
Ensembl chr 1:221,756,286...221,771,143
JBrowse link
G Ranbp17 RAN binding protein 17 affects response to substance ISO RANBP17 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:18,139,763...18,445,347
Ensembl chr10:18,139,766...18,443,964
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Daunorubicin results in increased expression of RB1 mRNA CTD PMID:12656675 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit affects expression ISO Daunorubicin affects the expression of RBBP5 mRNA CTD PMID:12656675 NCBI chr13:49,250,301...49,277,152
Ensembl chr13:49,250,301...49,277,152
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase increases expression ISO Daunorubicin results in increased expression of RBBP6 mRNA CTD PMID:12656675 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of RELA protein CTD PMID:21518493 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 affects expression
multiple interactions
EXP Daunorubicin affects the expression of ROCK1 mRNA
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]
CTD PMID:20037814 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
decreases expression
multiple interactions
ISO
EXP
Daunorubicin results in increased phosphorylation of RPS6KB1 protein
Daunorubicin results in decreased expression of RPS6KB1 mRNA
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:21898527, PMID:28099878 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
decreases expression
increases expression
EXP
ISO
Razoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA]
Daunorubicin results in increased expression of RYR2 protein
CTD PMID:10960060, PMID:26328012, PMID:26537877, PMID:28940058 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases expression ISO Daunorubicin results in decreased expression of SCN2B mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases expression ISO Daunorubicin results in decreased expression of SCN5A mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Sdc1 syndecan 1 increases expression ISO Daunorubicin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
decreases secretion
multiple interactions
ISO
EXP
Daunorubicin results in decreased expression of SERPINE1 mRNA; Daunorubicin results in decreased expression of SERPINE1 protein
Daunorubicin results in decreased secretion of SERPINE1 protein
[Daunorubicin results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein; fumonisin B1 inhibits the reaction [Daunorubicin results in decreased expression of SERPINE1 protein]
CTD PMID:11107162, PMID:11336794 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Daunorubicin inhibits the reaction [SLC22A16 protein results in increased uptake of Doxorubicin] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Daunorubicin results in decreased expression of SLC25A4 mRNA CTD PMID:9038198 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases expression
increases activity
ISO Daunorubicin results in increased expression of SMPD1 mRNA
Daunorubicin results in increased activity of SMPD1 protein
CTD PMID:19698806 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression
increases response to substance
ISO Daunorubicin results in increased expression of SMPD3 mRNA; Daunorubicin results in increased expression of SMPD3 protein
SMPD3 results in increased susceptibility to Daunorubicin
CTD PMID:19698806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sod2 superoxide dismutase 2 decreases secretion
multiple interactions
EXP Daunorubicin results in decreased secretion of SOD2 protein
nebivolol inhibits the reaction [Daunorubicin results in decreased secretion of SOD2 protein]
CTD PMID:18194856 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp110 SP110 nuclear body protein affects response to substance ISO SP110 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:92,593,909...92,618,867
Ensembl chr 9:92,593,910...92,616,165
JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Daunorubicin results in increased expression of SP3 protein CTD PMID:19698806 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Tagln3 transgelin 3 affects response to substance ISO TAGLN3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:60,072,983...60,086,552
Ensembl chr11:60,072,727...60,086,553
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Daunorubicin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member affects response to substance ISO TAP2 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr20:3,995,544...4,009,587
Ensembl chr20:3,995,544...4,009,587
JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Daunorubicin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:59,743,356...59,748,063
Ensembl chr10:59,743,544...59,748,062
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein] CTD PMID:20888384 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 decreases response to substance ISO TLR4 protein results in decreased susceptibility to Daunorubicin CTD PMID:18789402 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tm4sf20 transmembrane 4 L six family member 20 affects response to substance ISO TM4SF20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:88,521,193...88,534,710
Ensembl chr 9:88,521,193...88,534,710
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Daunorubicin results in increased expression of TNF protein CTD PMID:16626513 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA] CTD PMID:17204177 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA]; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10B mRNA] CTD PMID:12780785, PMID:17204177 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Daunorubicin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Tnnt1 troponin T1, slow skeletal type decreases expression ISO Daunorubicin results in decreased expression of TNNT1 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 1:72,889,270...72,899,629
Ensembl chr 1:72,889,270...72,899,659
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions
increases secretion
EXP nebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein]
Daunorubicin results in increased secretion of TNNT2 protein
CTD PMID:18194856 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity
increases expression
ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased activity of TP53 protein; Daunorubicin results in increased phosphorylation of and results in increased expression of TP53 protein
Daunorubicin results in increased activity of TP53 protein
Daunorubicin results in increased expression of TP53 mRNA
CTD PMID:12112851, PMID:12656675, PMID:21518493, PMID:23872705 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Daunorubicin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP Daunorubicin results in decreased expression of UQCRFS1 mRNA CTD PMID:9038198 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of VCAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein]
CTD PMID:20888384 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor affects response to substance
decreases activity
ISO VDR gene polymorphism affects the susceptibility to Daunorubicin
Daunorubicin results in decreased activity of VDR protein
CTD PMID:15713801, PMID:25257666 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO
EXP
Daunorubicin results in decreased expression of VEGFA protein
Daunorubicin results in decreased expression of VEGFA mRNA
CTD PMID:20116850, PMID:27090888 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin increases expression EXP Daunorubicin results in increased expression of VIM protein CTD PMID:2444108 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 affects response to substance ISO ZBTB20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Daunorubicin results in increased expression of ZMAT3 mRNA CTD PMID:26537877, PMID:28940058 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          carbohydrate-containing antibiotic 2547
            aminoglycoside antibiotic 2529
              daunorubicin 203
                10-carboxy-13-deoxydaunorubicin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      carbohydrate derivative 11804
                                        glycosyl compound 10848
                                          glycoside 9204
                                            aminoglycoside 8416
                                              aminoglycoside antibiotic 2529
                                                daunorubicin 203
                                                  10-carboxy-13-deoxydaunorubicin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.