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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:daunorubicin
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Accession:CHEBI:41977 term browser browse the term
Definition:A natural product found in Actinomadura roseola.
Synonyms:exact_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
 related_synonym: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione;   Daunomycin;   Formula=C27H29NO10;   InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1;   InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O;   acetyladriamycin;   daunorubicinum;   leukaemomycin C
 alt_id: CHEBI:23560;   CHEBI:41970;   CHEBI:4330;   CHEBI:65723
 xref: Beilstein:1445583;   CAS:20830-81-3;   DrugBank:DB00694;   Drug_Central:786;   KEGG:C01907;   KEGG:D07776;   LINCS:LSM-2962;   LIPID_MAPS_instance:LMPK13050002
 xref_mesh: MESH:D003630
 xref: PDBeChem:DM1;   PMID:10820108;   PMID:23414337;   PMID:23900905;   PMID:24396448;   Reaxys:1445583;   Wikipedia:Daunorubicin
 cyclic_relationship: is_conjugate_base_of CHEBI:64677



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daunorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases export
affects transport
decreases expression
increases transport
increases import
decreases uptake
increases response to substance
ISO
EXP
[5-methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of ABCB1 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of ABCB1 mRNA; [Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Sodium Azide co-treated with Iodoacetates] inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; ABCB1 mutant form promotes the reaction [Magnetite Nanoparticles results in increased susceptibility to Daunorubicin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Daunorubicin]; Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]; Daunorubicin promotes the reaction [Magnetite Nanoparticles results in decreased expression of ABCB1 protein]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form results in increased susceptibility to Daunorubicin]; Magnetite Nanoparticles promotes the reaction [Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; Mitotane inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Daunorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Verapamil inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]
ABCB1A affects the susceptibility to Daunorubicin
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
ABCB1 protein results in increased export of Daunorubicin; ABCB1A protein results in increased export of Daunorubicin
ABCB1 protein affects the transport of Daunorubicin
Daunorubicin results in decreased expression of ABCB1 mRNA; Daunorubicin results in decreased expression of ABCB1 protein
ABCB1 protein results in decreased uptake of Daunorubicin
ABCB1 affects the susceptibility to Daunorubicin; ABCB1 protein affects the susceptibility to Daunorubicin
CTD PMID:9794924 PMID:9815696 PMID:10617675 PMID:11231118 PMID:12107549 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb8 ATP binding cassette subfamily B member 8 decreases expression EXP Daunorubicin results in decreased expression of ABCB8 mRNA CTD PMID:27090888 NCBI chr 4:10,766,206...10,783,598
Ensembl chr 4:10,768,281...10,783,589
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
decreases response to substance
increases secretion
affects response to substance
multiple interactions
decreases uptake
ISO ABCC1 protein affects the export of Daunorubicin
ABCC1 results in decreased susceptibility to Daunorubicin
ABCC1 protein results in increased secretion of Daunorubicin
ABCC1 affects the susceptibility to Daunorubicin; ABCC1 protein affects the susceptibility to Daunorubicin
Benzbromarone inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]; Folic Acid deficiency inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; homocamptothecin inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
ABCC1 protein results in decreased susceptibility to Daunorubicin; ABCC1 results in decreased susceptibility to Daunorubicin
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
CTD PMID:7954421 PMID:8968083 PMID:9096673 PMID:9334814 PMID:10856430 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
multiple interactions
ISO ABCC2 affects the susceptibility to Daunorubicin
[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]
CTD PMID:18451141 PMID:29079042 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA] CTD PMID:20019844 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases response to substance ISO ABL1 results in decreased susceptibility to Daunorubicin CTD PMID:12410571 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Daunorubicin results in decreased expression of ACTA1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Agrn agrin increases expression ISO Daunorubicin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein] CTD PMID:20888384 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
affects metabolic processing
multiple interactions
increases metabolic processing
ISO AKR1A1 protein results in increased reduction of Daunorubicin
AKR1A1 SNP affects the metabolism of Daunorubicin
[AKR1A1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol
CTD PMID:18276838 PMID:18322072 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Daunorubicin CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases response to substance
increases reduction
multiple interactions
ISO AKR1B10 protein results in decreased susceptibility to Daunorubicin
AKR1B10 protein results in increased reduction of Daunorubicin
[AKR1B10 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]
CTD PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
increases reduction
decreases response to substance
multiple interactions
ISO AKR1C3 protein results in increased metabolism of Daunorubicin; AKR1C3 results in increased metabolism of Daunorubicin
AKR1C3 protein results in increased reduction of Daunorubicin
AKR1C3 protein results in decreased susceptibility to Daunorubicin
[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol; [AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol; [Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin; dinaciclib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]; NVP-BKM120 inhibits the reaction [AKR1C3 protein results in increased reduction of and results in decreased susceptibility to Daunorubicin]; Tretinoin inhibits the reaction [[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol]; Tretinoin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
CTD PMID:20837989 PMID:29992508 PMID:30703376 PMID:32588086 PMID:33025066 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance ISO AKT1 protein results in decreased susceptibility to Daunorubicin CTD PMID:22252735 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Angpt1 angiopoietin 1 decreases expression EXP Daunorubicin results in decreased expression of ANGPT1 mRNA; Daunorubicin results in decreased expression of ANGPT1 protein CTD PMID:16626513 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angpt2 angiopoietin 2 increases expression EXP Daunorubicin results in increased expression of ANGPT2 mRNA; Daunorubicin results in increased expression of ANGPT2 protein CTD PMID:16626513 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Daunorubicin results in decreased expression of ANK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression EXP Daunorubicin results in decreased expression of ANKRD1 mRNA CTD PMID:9278441 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Ano3 anoctamin 3 affects response to substance ISO ANO3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa2 annexin A2 decreases expression ISO Daunorubicin results in decreased expression of ANXA2 mRNA; Daunorubicin results in decreased expression of ANXA2 protein CTD PMID:21223737 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa4 annexin A4 increases expression ISO Daunorubicin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO APEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin CTD PMID:10190555 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apob apolipoprotein B increases expression EXP Daunorubicin results in increased expression of APOB protein CTD PMID:7637207 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP Daunorubicin results in increased expression of APOC3 protein CTD PMID:7637207 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Ar androgen receptor increases activity
decreases activity
ISO Daunorubicin results in increased activity of AR protein
Daunorubicin results in decreased activity of AR protein
CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Daunorubicin results in increased expression of ATM mRNA CTD PMID:12656675 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Daunorubicin results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atxn1 ataxin 1 decreases expression EXP Daunorubicin results in decreased expression of ATXN1 mRNA CTD PMID:27090888 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Aurka aurora kinase A decreases expression ISO Daunorubicin results in decreased expression of AURKA protein CTD PMID:23872705 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Daunorubicin affects the expression of BARD1 mRNA CTD PMID:12656675 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of BAX protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA]
Daunorubicin results in increased expression of BAX mRNA
CTD PMID:19421372 PMID:19918366 PMID:21720514 PMID:26537877 PMID:28940058 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
decreases response to substance
ISO [Bortezomib co-treated with Daunorubicin] results in decreased expression of BCL2 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in decreased expression of BCL2 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein]; bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]; bromotetrandrine promotes the reaction [Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]
Daunorubicin affects the expression of BCL2 mRNA
BCL2 results in decreased susceptibility to Daunorubicin
CTD PMID:19421372 PMID:19918366 PMID:21302442 PMID:21595920 PMID:21720514 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein CTD PMID:12780785 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
affects expression
ISO [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 protein
Daunorubicin results in increased expression of BIRC5 mRNA; Daunorubicin results in increased expression of BIRC5 protein
Daunorubicin affects the expression of BIRC5 mRNA
CTD PMID:16638212 PMID:21362215 PMID:21720514 PMID:27780733 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Daunorubicin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:86,463,008...86,524,545
Ensembl chr 9:86,463,095...86,524,544
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Daunorubicin results in decreased expression of CACNA1G mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S affects response to substance ISO CACNA1S affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Daunorubicin results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
increases activity
ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of CASP3 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]
Daunorubicin affects the expression of CASP3 mRNA
Daunorubicin results in increased activity of CASP3 protein
CTD PMID:10766178 PMID:12780785 PMID:17699722 PMID:17965967 PMID:19421372 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:12780785 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 affects expression ISO Daunorubicin affects the expression of CASP9 mRNA CTD PMID:27780733 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Daunorubicin CTD PMID:11178967 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Daunorubicin results in decreased expression of CAVIN4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:62,996,975...63,004,819
Ensembl chr 5:62,996,865...63,007,678
JBrowse link
G Cbr1 carbonyl reductase 1 increases metabolic processing
increases reduction
decreases metabolic processing
multiple interactions
ISO CBR1 protein results in increased metabolism of Daunorubicin; CBR1 results in increased metabolism of Daunorubicin
CBR1 protein results in increased reduction of Daunorubicin
CBR1 gene SNP results in decreased metabolism of Daunorubicin
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]
CTD PMID:18579125 PMID:19204081 PMID:20670211 PMID:23295225 PMID:25541467 More... NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbr3 carbonyl reductase 3 affects response to substance
affects metabolic processing
ISO CBR3 gene SNP affects the susceptibility to Daunorubicin
CBR3 protein affects the metabolism of Daunorubicin; CBR3 protein alternative form affects the metabolism of Daunorubicin
CTD PMID:20007405 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Daunorubicin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Daunorubicin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Daunorubicin results in increased expression of CCND3 mRNA CTD PMID:12656675 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 affects expression ISO Daunorubicin affects the expression of CCNE1 mRNA CTD PMID:12656675 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Daunorubicin results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd34 CD34 molecule decreases expression EXP Daunorubicin results in decreased expression of CD34 mRNA CTD PMID:27090888 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Daunorubicin results in increased expression of CDC25A mRNA CTD PMID:12656675 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdh13 cadherin 13 affects response to substance ISO CDH13 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Daunorubicin results in increased expression of CDKN1A; Daunorubicin results in increased expression of CDKN1A mRNA; Daunorubicin results in increased expression of CDKN1A protein CTD PMID:12112851 PMID:12656675 PMID:23872705 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
affects expression
EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Daunorubicin affects the expression of CDKN2A mRNA CTD PMID:12656675 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Daunorubicin results in increased expression of CDKN2B mRNA CTD PMID:12656675 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Daunorubicin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Daunorubicin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:16,119,871...16,137,600
Ensembl chr 6:16,119,872...16,137,600
JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Daunorubicin results in decreased expression of CKM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Clybl citramalyl-CoA lyase affects response to substance ISO CLYBL affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695
JBrowse link
G Cmc2 C-x(9)-C motif containing 2 affects response to substance ISO CMC2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:44,943,283...44,997,408 JBrowse link
G Cmip c-Maf-inducing protein affects response to substance ISO CMIP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709
JBrowse link
G Corin corin, serine peptidase decreases expression ISO Daunorubicin results in decreased expression of CORIN mRNA CTD PMID:26537877 PMID:28940058 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin affects response to substance ISO CWC27 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression EXP Daunorubicin results in decreased expression of CXCR4 mRNA CTD PMID:27090888 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein] CTD PMID:21054405 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Daunorubicin results in increased expression of CYBB mRNA CTD PMID:27090888 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Daunorubicin affects the expression of CYCS mRNA CTD PMID:27780733 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects response to substance ISO CYP1B1 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO Daunorubicin results in increased degradation of DFFA protein CTD PMID:12370496 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dmd dystrophin decreases expression ISO Daunorubicin results in decreased expression of DMD mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Daunorubicin results in increased expression of DUSP4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Daunorubicin results in increased expression of E2F5 mRNA CTD PMID:12656675 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDN1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]
CTD PMID:20888384 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDNRA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]
CTD PMID:20888384 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B increases expression
multiple interactions
EXP Daunorubicin results in increased expression of EDNRB protein
telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]
CTD PMID:20888384 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Daunorubicin inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Daunorubicin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation
multiple interactions
ISO Daunorubicin results in increased phosphorylation of EIF4EBP1 protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:21898527 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eng endoglin decreases expression EXP Daunorubicin results in decreased expression of ENG mRNA CTD PMID:27090888 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Daunorubicin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Daunorubicin results in decreased expression of ERBB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases activity
ISO Daunorubicin results in decreased activity of ESR1 protein
Daunorubicin results in increased activity of ESR1 protein
CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Daunorubicin results in increased expression of F3 mRNA; Daunorubicin results in increased expression of F3 protein CTD PMID:11721405 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Daunorubicin results in increased expression of FAS mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
EXP candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein] CTD PMID:16324756 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Daunorubicin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
JBrowse link
G Gapt Grb2-binding adaptor protein, transmembrane affects response to substance ISO GAPT affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:41,927,533...41,932,120
Ensembl chr 2:41,927,532...41,932,093
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Daunorubicin results in increased expression of GDF15 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpc5 glypican 5 affects response to substance ISO GPC5 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:92,207,275...93,644,054
Ensembl chr15:92,239,176...93,643,282
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Daunorubicin results in increased expression of GPX1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone affects expression ISO Daunorubicin affects the expression of H2AX mRNA CTD PMID:27780733 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects response to substance ISO HNRNPD affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Daunorubicin results in decreased expression of HRC mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of ICAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
CTD PMID:20888384 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon affects response to substance ISO IKBKE affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Daunorubicin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase affects response to substance ISO ILKAP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B affects response to substance ISO INPP4B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634
JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Daunorubicin results in decreased expression of IRX4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Daunorubicin results in decreased expression of JAK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Daunorubicin results in decreased expression of KCNH2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Daunorubicin results in increased expression of KCNJ2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Daunorubicin results in decreased expression of KCNQ1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Kif1a kinesin family member 1A affects response to substance ISO KIF1A affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Daunorubicin results in decreased expression of KIT mRNA CTD PMID:27090888 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Kitlg KIT ligand decreases expression EXP Daunorubicin results in decreased expression of KITLG mRNA CTD PMID:27090888 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Krt19 keratin 19 increases expression EXP Daunorubicin results in increased expression of KRT19 protein CTD PMID:2444108 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Krt8 keratin 8 increases expression EXP Daunorubicin results in increased expression of KRT8 protein CTD PMID:2444108 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Daunorubicin results in decreased expression of LDB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532
JBrowse link
G LOC499643 similar to hypothetical protein FLJ25371 affects response to substance ISO C4ORF45 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:164,490,211...164,604,379
Ensembl chr 2:164,490,252...164,604,379
JBrowse link
G Lsamp limbic system-associated membrane protein affects response to substance ISO LSAMP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:58,547,533...60,717,329
Ensembl chr11:58,554,805...60,717,029
JBrowse link
G Luzp2 leucine zipper protein 2 affects response to substance ISO LUZP2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183
JBrowse link
G Map1b microtubule-associated protein 1B affects response to substance ISO MAP1B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Daunorubicin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Daunorubicin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Daunorubicin results in decreased expression of MAPT mRNA; Daunorubicin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression ISO Daunorubicin results in decreased expression of MDM4 mRNA CTD PMID:12656675 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
JBrowse link
G Mir21 microRNA 21 decreases response to substance ISO MIR21 results in decreased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of MT1A mRNA; Daunorubicin results in increased expression of MT1A protein
Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A mRNA]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A protein]
CTD PMID:12204545 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
ISO Daunorubicin results in increased phosphorylation of MTOR protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]
CTD PMID:21898527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO
EXP
Daunorubicin results in decreased expression of MYH6 mRNA CTD PMID:26537877 PMID:27090888 PMID:28940058 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 increases expression
decreases expression
EXP
ISO
Daunorubicin results in increased expression of MYH7 mRNA
Daunorubicin results in decreased expression of MYH7 mRNA
CTD PMID:26328012 PMID:26537877 PMID:27090888 PMID:28940058 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myom2 myomesin 2 decreases expression ISO Daunorubicin results in decreased expression of MYOM2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein] CTD PMID:21054405 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
CTD PMID:21054405 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Daunorubicin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ngef neuronal guanine nucleotide exchange factor affects response to substance ISO NGEF affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of NOX4 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein]
CTD PMID:21054405 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases secretion
affects response to substance
ISO Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]; Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]
NPC1 affects the susceptibility to Daunorubicin
CTD PMID:16174794 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Daunorubicin results in increased expression of NPPA mRNA CTD PMID:26328012 PMID:27090888 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B decreases expression
increases expression
EXP
ISO
Daunorubicin results in decreased expression of NPPB mRNA; Daunorubicin results in decreased expression of NPPB protein
Daunorubicin results in increased expression of NPPB mRNA
Daunorubicin results in increased expression of NPPB protein
CTD PMID:11279304 PMID:17673002 PMID:26328012 PMID:27090888 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
decreases expression
EXP
ISO
Daunorubicin results in increased activity of NQO1 protein
Daunorubicin results in decreased expression of NQO1 mRNA; Daunorubicin results in decreased expression of NQO1 protein
CTD PMID:3986001 PMID:8875677 PMID:9620540 PMID:22021338 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Daunorubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Daunorubicin results in decreased activity of NR1H4 protein
Daunorubicin results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Daunorubicin results in decreased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Daunorubicin results in decreased expression of NRAP mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases expression ISO Daunorubicin results in increased expression of NRAS mRNA CTD PMID:12656675 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
affects expression
increases cleavage
ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein
Daunorubicin affects the expression of PARP1 mRNA
Daunorubicin results in increased cleavage of PARP1 protein
CTD PMID:10766178 PMID:11082532 PMID:12780785 PMID:27780733 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP Daunorubicin results in decreased expression of PFKM mRNA CTD PMID:9038198 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects response to substance ISO PIK3R1 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Daunorubicin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Daunorubicin results in increased expression of PPARA mRNA CTD PMID:23834779 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases activity
EXP
ISO
[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA
Daunorubicin results in decreased activity of PPARD protein
CTD PMID:23834779 PMID:25257666 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases activity
increases expression
EXP
ISO
telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
Daunorubicin results in decreased activity of PPARG protein
CTD PMID:20888384 PMID:25257666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like decreases response to substance ISO PPP1R13L results in decreased susceptibility to Daunorubicin CTD PMID:19299014 NCBI chr 1:79,010,997...79,030,714
Ensembl chr 1:79,011,745...79,030,712
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO Daunorubicin results in decreased expression of PPP1R3A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Daunorubicin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prdm16 PR/SET domain 16 decreases expression ISO Daunorubicin results in decreased expression of PRDM16 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Prkcd protein kinase C, delta increases cleavage ISO Daunorubicin results in increased cleavage of PRKCD protein CTD PMID:11082532 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkcz protein kinase C, zeta decreases response to substance ISO PRKCZ protein results in decreased susceptibility to Daunorubicin CTD PMID:21863889 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkx protein kinase, X-linked increases expression ISO Daunorubicin results in increased expression of PRKX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669
JBrowse link
G Prom1 prominin 1 decreases expression EXP Daunorubicin results in decreased expression of PROM1 mRNA CTD PMID:27090888 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN results in increased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of PTGS2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]
CTD PMID:20888384 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Daunorubicin results in decreased expression of PYGM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
JBrowse link
G Ranbp17 RAN binding protein 17 affects response to substance ISO RANBP17 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:17,800,406...18,102,947
Ensembl chr10:17,800,999...18,102,831
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Daunorubicin results in increased expression of RB1 mRNA CTD PMID:12656675 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit affects expression ISO Daunorubicin affects the expression of RBBP5 mRNA CTD PMID:12656675 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase increases expression ISO Daunorubicin results in increased expression of RBBP6 mRNA CTD PMID:12656675 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of RELA protein CTD PMID:21518493 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 affects expression
multiple interactions
EXP Daunorubicin affects the expression of ROCK1 mRNA
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]
CTD PMID:20037814 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
decreases expression
multiple interactions
ISO
EXP
Daunorubicin results in increased phosphorylation of RPS6KB1 protein
Daunorubicin results in decreased expression of RPS6KB1 mRNA
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:21898527 PMID:28099878 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
decreases expression
increases expression
EXP
ISO
Razoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA]
Daunorubicin results in increased expression of RYR2 protein
CTD PMID:10960060 PMID:26328012 PMID:26537877 PMID:28940058 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases expression ISO Daunorubicin results in decreased expression of SCN2B mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases expression ISO Daunorubicin results in decreased expression of SCN5A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sdc1 syndecan 1 increases expression ISO Daunorubicin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
decreases secretion
multiple interactions
ISO
EXP
Daunorubicin results in decreased expression of SERPINE1 mRNA; Daunorubicin results in decreased expression of SERPINE1 protein
Daunorubicin results in decreased secretion of SERPINE1 protein
[Daunorubicin results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein; fumonisin B1 inhibits the reaction [Daunorubicin results in decreased expression of SERPINE1 protein]
CTD PMID:11107162 PMID:11336794 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Daunorubicin inhibits the reaction [SLC22A16 protein results in increased uptake of Doxorubicin] CTD PMID:15963465 NCBI chr20:43,972,808...44,068,447 JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Daunorubicin results in decreased expression of SLC25A4 mRNA CTD PMID:9038198 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases expression
increases activity
ISO Daunorubicin results in increased expression of SMPD1 mRNA
Daunorubicin results in increased activity of SMPD1 protein
CTD PMID:19698806 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression
increases response to substance
ISO Daunorubicin results in increased expression of SMPD3 mRNA; Daunorubicin results in increased expression of SMPD3 protein
SMPD3 results in increased susceptibility to Daunorubicin
CTD PMID:19698806 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sod2 superoxide dismutase 2 decreases secretion
multiple interactions
EXP Daunorubicin results in decreased secretion of SOD2 protein
nebivolol inhibits the reaction [Daunorubicin results in decreased secretion of SOD2 protein]
CTD PMID:18194856 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp110 SP110 nuclear body protein affects response to substance ISO SP110 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:86,200,503...86,225,355
Ensembl chr 9:86,200,503...86,222,670
JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Daunorubicin results in increased expression of SP3 protein CTD PMID:19698806 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Tagln3 transgelin 3 affects response to substance ISO TAGLN3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:55,099,887...55,113,457
Ensembl chr11:55,099,743...55,113,485
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Daunorubicin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member affects response to substance ISO TAP2 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Daunorubicin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:57,795,785...57,800,363
Ensembl chr10:57,795,382...57,800,363
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein] CTD PMID:20888384 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 decreases response to substance ISO TLR4 protein results in decreased susceptibility to Daunorubicin CTD PMID:18789402 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tm4sf20 transmembrane 4 L six family member 20 affects response to substance ISO TM4SF20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:84,038,715...84,052,615
Ensembl chr 9:84,038,715...84,052,615
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Daunorubicin results in increased expression of TNF protein CTD PMID:16626513 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA] CTD PMID:17204177 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA]; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10B mRNA] CTD PMID:12780785 PMID:17204177 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Daunorubicin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
JBrowse link
G Tnnt1 troponin T1, slow skeletal type decreases expression ISO Daunorubicin results in decreased expression of TNNT1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions
increases secretion
EXP nebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein]
Daunorubicin results in increased secretion of TNNT2 protein
CTD PMID:18194856 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity
increases expression
ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased activity of TP53 protein; Daunorubicin results in increased phosphorylation of and results in increased expression of TP53 protein
Daunorubicin results in increased activity of TP53 protein
Daunorubicin results in increased expression of TP53 mRNA
CTD PMID:12112851 PMID:12656675 PMID:21518493 PMID:23872705 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Daunorubicin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr13:69,612,605...69,655,018
Ensembl chr13:69,620,792...69,652,475
JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP Daunorubicin results in decreased expression of UQCRFS1 mRNA CTD PMID:9038198 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
EXP Daunorubicin results in increased expression of VCAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein]
CTD PMID:20888384 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdr vitamin D receptor affects response to substance
decreases activity
ISO VDR gene polymorphism affects the susceptibility to Daunorubicin
Daunorubicin results in decreased activity of VDR protein
CTD PMID:15713801 PMID:25257666 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO
EXP
Daunorubicin results in decreased expression of VEGFA protein
Daunorubicin results in decreased expression of VEGFA mRNA
CTD PMID:20116850 PMID:27090888 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin increases expression EXP Daunorubicin results in increased expression of VIM protein CTD PMID:2444108 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 affects response to substance ISO ZBTB20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:57,052,129...57,823,679
Ensembl chr11:57,072,880...57,510,210
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Daunorubicin results in increased expression of ZMAT3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        antimicrobial agent 17401
          carbohydrate-containing antibiotic 2557
            aminoglycoside antibiotic 2539
              daunorubicin 202
                10-carboxy-13-deoxydaunorubicin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            heteroorganic entity 19280
                              organochalcogen compound 19051
                                organooxygen compound 19001
                                  carbohydrates and carbohydrate derivatives 12344
                                    carbohydrate 12344
                                      carbohydrate derivative 11948
                                        glycosyl compound 10980
                                          glycoside 9262
                                            aminoglycoside 8436
                                              aminoglycoside antibiotic 2539
                                                daunorubicin 202
                                                  10-carboxy-13-deoxydaunorubicin 0
paths to the root