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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:daunorubicin
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Accession:CHEBI:41977 term browser browse the term
Definition:A natural product found in Actinomadura roseola.
Synonyms:exact_synonym: (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
 related_synonym: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione;   Daunomycin;   Formula=C27H29NO10;   InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1;   InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O;   acetyladriamycin;   daunorubicinum;   leukaemomycin C
 alt_id: CHEBI:23560;   CHEBI:41970;   CHEBI:4330;   CHEBI:65723
 xref: Beilstein:1445583;   CAS:20830-81-3;   DrugBank:DB00694;   Drug_Central:786;   KEGG:C01907;   KEGG:D07776;   LINCS:LSM-2962;   LIPID_MAPS_instance:LMPK13050002
 xref_mesh: MESH:D003630
 xref: PDBeChem:DM1;   PMID:10820108;   PMID:23414337;   PMID:23900905;   PMID:24396448;   Reaxys:1445583;   Wikipedia:Daunorubicin
 cyclic_relationship: is_conjugate_base_of CHEBI:64677


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daunorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases response to substance
decreases uptake
increases import
increases transport
decreases expression
affects transport
increases export
increases expression
decreases response to substance		 ISO
EXP		 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Daunorubicin results in increased expression of ABCB1 mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; 5-hydroxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; [5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of ABCB1 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of ABCB1 mRNA; [enasidenib inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; [ginkgolic acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [glabridin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [Imatinib Mesylate inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]] which results in decreased export of Daunorubicin; [matairesinol affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [MLN 8237 affects the activity of ABCB1 protein] which affects the export of Daunorubicin; [phyllodulcin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [sesamin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; [Sodium Azide co-treated with Iodoacetates] inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; [venetoclax inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]] which results in decreased export of Daunorubicin; [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of Daunorubicin; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; ABCB1 mutant form promotes the reaction [Magnetite Nanoparticles results in increased susceptibility to Daunorubicin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; baicalein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; biochanin A inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; biochanin A promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Daunorubicin]; Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]; Daunorubicin promotes the reaction [Magnetite Nanoparticles results in decreased expression of ABCB1 protein]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; dihydromyricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; enasidenib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; flavone promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; galangin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; glycitein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; Imatinib Mesylate inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]; isovitexin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferide inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferide inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Luteolin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [ABCB1 mutant form results in increased susceptibility to Daunorubicin]; Magnetite Nanoparticles promotes the reaction [Daunorubicin promotes the reaction [ABCB1 mutant form results in decreased expression of ABCB1 protein]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 mRNA]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of ABCB1 protein]; Mitotane inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]; puerarin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; schaftoside inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Daunorubicin]; Silybin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Silybin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; venetoclax inhibits the reaction [Daunorubicin results in increased expression of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; zosuquidar trihydrochloride inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]
ABCB1 affects the susceptibility to Daunorubicin; ABCB1 protein affects the susceptibility to Daunorubicin
Daunorubicin results in decreased expression of ABCB1 mRNA; Daunorubicin results in decreased expression of ABCB1 protein
ABCB1 protein affects the transport of Daunorubicin
ABCB1 protein results in increased export of Daunorubicin; ABCB1A protein results in increased export of Daunorubicin
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
ABCB1A affects the susceptibility to Daunorubicin
Daunorubicin results in increased expression of ABCB1 mRNA; Daunorubicin results in increased expression of ABCB1 protein		 CTD PMID:9794924 PMID:9815696 PMID:10617675 PMID:11231118 PMID:12107549 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb8 ATP binding cassette subfamily B member 8 decreases expression EXP Daunorubicin results in decreased expression of ABCB8 mRNA CTD PMID:27090888 NCBI chr 4:10,766,206...10,783,598
Ensembl chr 4:10,768,281...10,783,589 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects response to substance
multiple interactions
decreases response to substance
decreases uptake
increases secretion
increases export		 ISO ABCC1 protein affects the export of Daunorubicin
ABCC1 affects the susceptibility to Daunorubicin; ABCC1 protein affects the susceptibility to Daunorubicin
[enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; [MLN 8237 results in decreased activity of ABCC1 protein] which results in increased susceptibility to Daunorubicin; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; Benzbromarone inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCC1 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]; Folic Acid deficiency inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; homocamptothecin inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin]; PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]
ABCC1 protein results in decreased susceptibility to Daunorubicin; ABCC1 results in decreased susceptibility to Daunorubicin
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]		 CTD PMID:7954421 PMID:8968083 PMID:9096673 PMID:9334814 PMID:10856430 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
multiple interactions		 ISO ABCC2 affects the susceptibility to Daunorubicin
[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; [Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]		 CTD PMID:18451141 PMID:29079042 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
decreases response to substance
increases export		 ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Daunorubicin]; [enasidenib inhibits the reaction [ABCG2 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA]; enasidenib inhibits the reaction [ABCG2 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCG2 protein results in increased export of Daunorubicin] CTD PMID:20019844 PMID:35972551 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases response to substance ISO ABL1 results in decreased susceptibility to Daunorubicin CTD PMID:12410571 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Daunorubicin results in decreased expression of ACTA1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Agrn agrin increases expression ISO Daunorubicin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein] CTD PMID:20888384 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
increases metabolic processing
multiple interactions
affects metabolic processing		 ISO AKR1A1 protein results in increased reduction of Daunorubicin
AKR1A1 results in increased metabolism of Daunorubicin
[AKR1A1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol
AKR1A1 SNP affects the metabolism of Daunorubicin		 CTD PMID:18276838 PMID:18322072 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Daunorubicin CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases response to substance
multiple interactions
increases reduction		 ISO AKR1B10 protein results in decreased susceptibility to Daunorubicin
[AKR1B10 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]		 CTD PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
multiple interactions
decreases response to substance
increases reduction		 ISO AKR1C3 protein results in increased metabolism of Daunorubicin; AKR1C3 results in increased metabolism of Daunorubicin
[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol; [AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol; [Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin; dinaciclib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [[AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol]; enasidenib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [AKR1C3 protein results in increased reduction of Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]; NVP-BKM120 inhibits the reaction [AKR1C3 protein results in increased reduction of and results in decreased susceptibility to Daunorubicin]; Tretinoin inhibits the reaction [[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol]; Tretinoin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]		 CTD PMID:20837989 PMID:29992508 PMID:30703376 PMID:32588086 PMID:33025066 More... NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases phosphorylation		 ISO AKT1 protein results in decreased susceptibility to Daunorubicin
[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with AKT1 protein] inhibits the reaction [Daunorubicin results in decreased expression of MCL1 mRNA]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with AKT1 protein] inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of AKT1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 mRNA]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:22252735 PMID:34963561 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Angpt1 angiopoietin 1 decreases expression EXP Daunorubicin results in decreased expression of ANGPT1 mRNA; Daunorubicin results in decreased expression of ANGPT1 protein CTD PMID:16626513 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 increases expression EXP Daunorubicin results in increased expression of ANGPT2 mRNA; Daunorubicin results in increased expression of ANGPT2 protein CTD PMID:16626513 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Daunorubicin results in decreased expression of ANK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression EXP Daunorubicin results in decreased expression of ANKRD1 mRNA CTD PMID:9278441 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Ano3 anoctamin 3 affects response to substance ISO ANO3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Anxa2 annexin A2 decreases expression ISO Daunorubicin results in decreased expression of ANXA2 mRNA; Daunorubicin results in decreased expression of ANXA2 protein CTD PMID:21223737 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa4 annexin A4 increases expression ISO Daunorubicin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO APEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin CTD PMID:10190555 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apob apolipoprotein B increases expression EXP Daunorubicin results in increased expression of APOB protein CTD PMID:7637207 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP Daunorubicin results in increased expression of APOC3 protein CTD PMID:7637207 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Ar androgen receptor increases activity
decreases activity		 ISO Daunorubicin results in increased activity of AR protein
Daunorubicin results in decreased activity of AR protein		 CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Daunorubicin results in increased expression of ATM mRNA CTD PMID:12656675 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Daunorubicin results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atxn1 ataxin 1 decreases expression EXP Daunorubicin results in decreased expression of ATXN1 mRNA CTD PMID:27090888 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Aurka aurora kinase A decreases expression ISO Daunorubicin results in decreased expression of AURKA protein CTD PMID:23872705 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Daunorubicin affects the expression of BARD1 mRNA CTD PMID:12656675 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of BAX protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of BAX protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of BAX protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of BAX mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of BAX mRNA]
Daunorubicin results in increased expression of BAX mRNA		 CTD PMID:19421372 PMID:19918366 PMID:21720514 PMID:26537877 PMID:28940058 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
decreases expression
affects expression		 ISO [Bortezomib co-treated with Daunorubicin] results in decreased expression of BCL2 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in decreased expression of BCL2 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein]; bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]; bromotetrandrine promotes the reaction [Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]
BCL2 results in decreased susceptibility to Daunorubicin
Daunorubicin affects the expression of BCL2 mRNA		 CTD PMID:19421372 PMID:19918366 PMID:21302442 PMID:21595920 PMID:21720514 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein CTD PMID:12780785 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
increases expression		 ISO [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BIRC5 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BIRC5 protein
Daunorubicin affects the expression of BIRC5 mRNA
Daunorubicin results in increased expression of BIRC5 mRNA; Daunorubicin results in increased expression of BIRC5 protein		 CTD PMID:16638212 PMID:21362215 PMID:21720514 PMID:27780733 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase multiple interactions
increases expression		 ISO BTRC protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; BTRC protein modified form inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; Daunorubicin results in increased expression of and results in increased stability of BTRC mRNA; MAP2K1 protein inhibits the reaction [Daunorubicin results in increased expression of BTRC mRNA]; MAP2K1 protein inhibits the reaction [Daunorubicin results in increased expression of BTRC protein]
Daunorubicin results in increased expression of BTRC mRNA; Daunorubicin results in increased expression of BTRC protein		 CTD PMID:34963561 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Daunorubicin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:86,463,008...86,524,545
Ensembl chr 9:86,463,095...86,524,544 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Daunorubicin results in decreased expression of CACNA1G mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S affects response to substance ISO CACNA1S affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Daunorubicin results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
affects expression
increases cleavage		 ISO [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 protein; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in increased expression of CASP3 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased expression of CASP3 mRNA; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in increased expression of CASP3 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 protein; bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]; Magnetite Nanoparticles promotes the reaction [[bromotetrandrine co-treated with Daunorubicin] results in increased expression of CASP3 mRNA]
Daunorubicin results in increased activity of CASP3 protein
Daunorubicin affects the expression of CASP3 mRNA
Daunorubicin results in increased cleavage of CASP3 protein		 CTD PMID:10766178 PMID:12780785 PMID:17699722 PMID:17965967 PMID:19421372 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:12780785 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 affects expression
increases cleavage		 ISO Daunorubicin affects the expression of CASP9 mRNA
Daunorubicin results in increased cleavage of CASP9 protein		 CTD PMID:27780733 PMID:34963561 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Daunorubicin CTD PMID:11178967 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Daunorubicin results in decreased expression of CAVIN4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:62,996,975...63,004,819
Ensembl chr 5:62,996,865...63,007,678 		JBrowse link
G Cbr1 carbonyl reductase 1 increases metabolic processing
decreases metabolic processing
increases reduction
multiple interactions		 ISO CBR1 protein results in increased metabolism of Daunorubicin; CBR1 results in increased metabolism of Daunorubicin
CBR1 gene SNP results in decreased metabolism of Daunorubicin
CBR1 protein results in increased reduction of Daunorubicin
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]		 CTD PMID:18579125 PMID:19204081 PMID:20670211 PMID:23295225 PMID:25541467 More... NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr3 carbonyl reductase 3 affects response to substance
affects metabolic processing		 ISO CBR3 gene SNP affects the susceptibility to Daunorubicin
CBR3 protein affects the metabolism of Daunorubicin; CBR3 protein alternative form affects the metabolism of Daunorubicin		 CTD PMID:20007405 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Daunorubicin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Daunorubicin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Daunorubicin results in increased expression of CCND3 mRNA CTD PMID:12656675 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Daunorubicin affects the expression of CCNE1 mRNA CTD PMID:12656675 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Daunorubicin results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd34 CD34 molecule decreases expression EXP Daunorubicin results in decreased expression of CD34 mRNA CTD PMID:27090888 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Daunorubicin results in increased expression of CDC25A mRNA CTD PMID:12656675 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdh13 cadherin 13 affects response to substance ISO CDH13 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Daunorubicin results in increased expression of CDKN1A; Daunorubicin results in increased expression of CDKN1A mRNA; Daunorubicin results in increased expression of CDKN1A protein CTD PMID:12112851 PMID:12656675 PMID:23872705 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
affects expression		 EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Daunorubicin affects the expression of CDKN2A mRNA CTD PMID:12656675 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Daunorubicin results in increased expression of CDKN2B mRNA CTD PMID:12656675 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Daunorubicin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Daunorubicin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:16,119,871...16,137,600
Ensembl chr 6:16,119,872...16,137,600 		JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Daunorubicin results in decreased expression of CKM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Clk2 CDC-like kinase 2 increases expression ISO Daunorubicin results in increased expression of CLK2 mRNA CTD PMID:12656675 NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985 		JBrowse link
G Clybl citramalyl-CoA lyase affects response to substance ISO CLYBL affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695 		JBrowse link
G Cmc2 C-x(9)-C motif containing 2 affects response to substance ISO CMC2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:44,943,283...44,997,408
Ensembl chr19:44,943,285...44,971,983 		JBrowse link
G Cmip c-Maf-inducing protein affects response to substance ISO CMIP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709 		JBrowse link
G Corin corin, serine peptidase decreases expression ISO Daunorubicin results in decreased expression of CORIN mRNA CTD PMID:26537877 PMID:28940058 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions		 ISO Daunorubicin results in decreased phosphorylation of CREB1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Daunorubicin results in decreased phosphorylation of CREB1 protein]; Okadaic Acid inhibits the reaction [Daunorubicin results in decreased phosphorylation of CREB1 protein]		 CTD PMID:34963561 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin affects response to substance ISO CWC27 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression EXP Daunorubicin results in decreased expression of CXCR4 mRNA CTD PMID:27090888 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein] CTD PMID:21054405 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Daunorubicin results in increased expression of CYBB mRNA CTD PMID:27090888 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Daunorubicin affects the expression of CYCS mRNA CTD PMID:27780733 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects response to substance ISO CYP1B1 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO Daunorubicin results in increased degradation of DFFA protein CTD PMID:12370496 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dmd dystrophin decreases expression ISO Daunorubicin results in decreased expression of DMD mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Daunorubicin results in increased expression of DUSP4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Daunorubicin results in increased expression of E2F5 mRNA CTD PMID:12656675 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of EDN1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]		 CTD PMID:20888384 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of EDNRA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]		 CTD PMID:20888384 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of EDNRB protein
telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]		 CTD PMID:20888384 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Daunorubicin inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Daunorubicin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation
multiple interactions		 ISO Daunorubicin results in increased phosphorylation of EIF4EBP1 protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:21898527 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eng endoglin decreases expression EXP Daunorubicin results in decreased expression of ENG mRNA CTD PMID:27090888 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Daunorubicin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Daunorubicin results in decreased expression of ERBB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases activity		 ISO Daunorubicin results in decreased activity of ESR1 protein
Daunorubicin results in increased activity of ESR1 protein		 CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Daunorubicin results in increased expression of F3 mRNA; Daunorubicin results in increased expression of F3 protein CTD PMID:11721405 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Daunorubicin results in increased expression of FAS mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 EXP candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein] CTD PMID:16324756 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Daunorubicin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658 		JBrowse link
G Gapt Grb2-binding adaptor protein, transmembrane affects response to substance ISO GAPT affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:41,927,533...41,932,120
Ensembl chr 2:41,927,532...41,932,093 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Daunorubicin results in increased expression of GDF15 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpc5 glypican 5 affects response to substance ISO GPC5 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr15:92,207,275...93,644,054
Ensembl chr15:92,239,176...93,643,282 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Daunorubicin results in increased expression of GPX1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G H2ax H2A.X variant histone affects expression
increases expression		 ISO Daunorubicin affects the expression of H2AX mRNA
Daunorubicin results in increased expression of H2AX protein		 CTD PMID:27780733 PMID:34963561 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects response to substance ISO HNRNPD affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Daunorubicin results in decreased expression of HRC mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of ICAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]		 CTD PMID:20888384 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon affects response to substance ISO IKBKE affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Daunorubicin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ilkap ILK associated serine/threonine phosphatase affects response to substance ISO ILKAP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892 		JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B affects response to substance ISO INPP4B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634 		JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Daunorubicin results in decreased expression of IRX4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549 		JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Daunorubicin results in decreased expression of JAK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Daunorubicin results in decreased expression of KCNH2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Daunorubicin results in increased expression of KCNJ2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Daunorubicin results in decreased expression of KCNQ1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Kif1a kinesin family member 1A affects response to substance ISO KIF1A affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Daunorubicin results in decreased expression of KIT mRNA CTD PMID:27090888 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kitlg KIT ligand decreases expression EXP Daunorubicin results in decreased expression of KITLG mRNA CTD PMID:27090888 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Krt19 keratin 19 increases expression EXP Daunorubicin results in increased expression of KRT19 protein CTD PMID:2444108 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt8 keratin 8 increases expression EXP Daunorubicin results in increased expression of KRT8 protein CTD PMID:2444108 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Daunorubicin results in decreased expression of LDB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532 		JBrowse link
G Lsamp limbic system-associated membrane protein affects response to substance ISO LSAMP affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:58,547,533...60,717,329
Ensembl chr11:58,554,805...60,717,029 		JBrowse link
G Luzp2 leucine zipper protein 2 affects response to substance ISO LUZP2 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183 		JBrowse link
G Map1b microtubule-associated protein 1B affects response to substance ISO MAP1B affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in increased expression of BTRC mRNA]; MAP2K1 protein inhibits the reaction [Daunorubicin results in increased expression of BTRC protein] CTD PMID:34963561 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Daunorubicin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Daunorubicin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein] CTD PMID:34963561 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein] CTD PMID:34963561 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Daunorubicin results in decreased expression of MAPT mRNA; Daunorubicin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Daunorubicin results in decreased expression of MCL1 mRNA; Daunorubicin results in decreased expression of MCL1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Daunorubicin results in decreased expression of MCL1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with AKT1 protein] inhibits the reaction [Daunorubicin results in decreased expression of MCL1 mRNA]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with AKT1 protein] inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 mRNA]; AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]		 CTD PMID:34963561 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression ISO Daunorubicin results in decreased expression of MDM4 mRNA CTD PMID:12656675 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mir21 microRNA 21 decreases response to substance ISO MIR21 results in decreased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of MT1A mRNA; Daunorubicin results in increased expression of MT1A protein
Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A mRNA]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A protein]		 CTD PMID:12204545 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 ISO Daunorubicin results in increased phosphorylation of MTOR protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]		 CTD PMID:21898527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO
EXP		 Daunorubicin results in decreased expression of MYH6 mRNA CTD PMID:26537877 PMID:27090888 PMID:28940058 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression
decreases expression		 EXP
ISO		 Daunorubicin results in increased expression of MYH7 mRNA
Daunorubicin results in decreased expression of MYH7 mRNA		 CTD PMID:26328012 PMID:26537877 PMID:27090888 PMID:28940058 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myom2 myomesin 2 decreases expression ISO Daunorubicin results in decreased expression of MYOM2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression		 EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein] CTD PMID:21054405 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]		 CTD PMID:21054405 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Daunorubicin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ngef neuronal guanine nucleotide exchange factor affects response to substance ISO NGEF affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 EXP
ISO		 Daunorubicin results in increased expression of NOX4 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein]
Daunorubicin results in increased expression of NOX4 mRNA		 CTD PMID:21054405 PMID:34963561 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
affects response to substance
increases secretion		 ISO Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]; Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]
NPC1 affects the susceptibility to Daunorubicin		 CTD PMID:16174794 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions
decreases expression		 EXP Telmisartan inhibits the reaction [Daunorubicin results in decreased expression of NPHS1 protein] CTD PMID:20888384 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A increases expression EXP Daunorubicin results in increased expression of NPPA mRNA CTD PMID:26328012 PMID:27090888 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B decreases expression
increases expression		 EXP
ISO		 Daunorubicin results in decreased expression of NPPB mRNA; Daunorubicin results in decreased expression of NPPB protein
Daunorubicin results in increased expression of NPPB protein
Daunorubicin results in increased expression of NPPB mRNA		 CTD PMID:11279304 PMID:17673002 PMID:26328012 PMID:27090888 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
decreases expression		 EXP
ISO		 Daunorubicin results in increased activity of NQO1 protein
Daunorubicin results in decreased expression of NQO1 mRNA; Daunorubicin results in decreased expression of NQO1 protein		 CTD PMID:3986001 PMID:8875677 PMID:9620540 PMID:22021338 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
decreases activity		 ISO Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Daunorubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Daunorubicin results in increased activity of NR1H4 protein
Daunorubicin results in decreased activity of NR1H4 protein		 CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Daunorubicin results in decreased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Daunorubicin results in decreased expression of NRAP mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693 		JBrowse link
G Nras NRAS proto-oncogene, GTPase increases expression ISO Daunorubicin results in increased expression of NRAS mRNA CTD PMID:12656675 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
affects expression		 ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein
Daunorubicin results in increased cleavage of PARP1 protein
Daunorubicin affects the expression of PARP1 mRNA		 CTD PMID:10766178 PMID:11082532 PMID:12780785 PMID:27780733 PMID:34963561 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP Daunorubicin results in decreased expression of PFKM mRNA CTD PMID:9038198 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects response to substance ISO PIK3R1 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Daunorubicin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Daunorubicin results in increased expression of PPARA mRNA CTD PMID:23834779 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases activity		 EXP
ISO		 [Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA
Daunorubicin results in decreased activity of PPARD protein		 CTD PMID:23834779 PMID:25257666 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
decreases activity		 EXP
ISO		 telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
Daunorubicin results in decreased activity of PPARG protein		 CTD PMID:20888384 PMID:25257666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like decreases response to substance ISO PPP1R13L results in decreased susceptibility to Daunorubicin CTD PMID:19299014 NCBI chr 1:79,010,997...79,030,714
Ensembl chr 1:79,011,745...79,030,712 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO Daunorubicin results in decreased expression of PPP1R3A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha increases expression
multiple interactions		 ISO Daunorubicin results in increased expression of PPP2CA protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Daunorubicin results in increased expression of PPP2CA protein]		 CTD PMID:34963561 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Daunorubicin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prdm16 PR/SET domain 16 decreases expression ISO Daunorubicin results in decreased expression of PRDM16 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Prkcd protein kinase C, delta increases cleavage ISO Daunorubicin results in increased cleavage of PRKCD protein CTD PMID:11082532 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcz protein kinase C, zeta decreases response to substance ISO PRKCZ protein results in decreased susceptibility to Daunorubicin CTD PMID:21863889 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit increases expression ISO Daunorubicin results in increased expression of PRKX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Prom1 prominin 1 decreases expression EXP Daunorubicin results in decreased expression of PROM1 mRNA CTD PMID:27090888 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN results in increased susceptibility to Daunorubicin CTD PMID:21187093 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of PTGS2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]		 CTD PMID:20888384 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Daunorubicin results in decreased expression of PYGM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Ranbp17 RAN binding protein 17 affects response to substance ISO RANBP17 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:17,800,406...18,102,947
Ensembl chr10:17,800,999...18,102,831 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Daunorubicin results in increased expression of RB1 mRNA CTD PMID:12656675 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit affects expression ISO Daunorubicin affects the expression of RBBP5 mRNA CTD PMID:12656675 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107 		JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase increases expression ISO Daunorubicin results in increased expression of RBBP6 mRNA CTD PMID:12656675 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of RELA protein CTD PMID:21518493 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 affects expression
multiple interactions		 EXP Daunorubicin affects the expression of ROCK1 mRNA
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]		 CTD PMID:20037814 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions
decreases expression		 ISO
EXP		 Daunorubicin results in increased phosphorylation of RPS6KB1 protein
Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]
Daunorubicin results in decreased expression of RPS6KB1 mRNA		 CTD PMID:21898527 PMID:28099878 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
decreases expression
increases expression		 EXP
ISO		 Razoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA]
Daunorubicin results in increased expression of RYR2 protein		 CTD PMID:10960060 PMID:26328012 PMID:26537877 PMID:28940058 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases expression ISO Daunorubicin results in decreased expression of SCN2B mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases expression ISO Daunorubicin results in decreased expression of SCN5A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO Daunorubicin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions
decreases secretion		 ISO
EXP		 Daunorubicin results in decreased expression of SERPINE1 mRNA; Daunorubicin results in decreased expression of SERPINE1 protein
[Daunorubicin results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein; fumonisin B1 inhibits the reaction [Daunorubicin results in decreased expression of SERPINE1 protein]
Daunorubicin results in decreased secretion of SERPINE1 protein		 CTD PMID:11107162 PMID:11336794 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Daunorubicin inhibits the reaction [SLC22A16 protein results in increased uptake of Doxorubicin] CTD PMID:15963465 NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Daunorubicin results in decreased expression of SLC25A4 mRNA CTD PMID:9038198 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases expression
increases activity		 ISO Daunorubicin results in increased expression of SMPD1 mRNA
Daunorubicin results in increased activity of SMPD1 protein		 CTD PMID:19698806 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression
increases response to substance		 ISO Daunorubicin results in increased expression of SMPD3 mRNA; Daunorubicin results in increased expression of SMPD3 protein
SMPD3 results in increased susceptibility to Daunorubicin		 CTD PMID:19698806 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sod2 superoxide dismutase 2 decreases secretion
multiple interactions		 EXP Daunorubicin results in decreased secretion of SOD2 protein
nebivolol inhibits the reaction [Daunorubicin results in decreased secretion of SOD2 protein]		 CTD PMID:18194856 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression
multiple interactions		 ISO Daunorubicin results in decreased expression of SP1 protein
AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; BTRC protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; BTRC protein modified form inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein]; SP1 protein inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]		 CTD PMID:34963561 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp110 SP110 nuclear body protein affects response to substance ISO SP110 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:86,200,503...86,225,355
Ensembl chr 9:86,200,503...86,222,670 		JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Daunorubicin results in increased expression of SP3 protein CTD PMID:19698806 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Spmip2 sperm microtubule inner protein 2 affects response to substance ISO C4ORF45 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 2:164,490,211...164,604,379
Ensembl chr 2:164,490,252...164,604,379 		JBrowse link
G Tagln3 transgelin 3 affects response to substance ISO TAGLN3 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:55,099,887...55,113,457
Ensembl chr11:55,099,743...55,113,485 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Daunorubicin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member affects response to substance ISO TAP2 affects the susceptibility to Daunorubicin CTD PMID:18451141 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407 		JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Daunorubicin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:57,795,785...57,800,363
Ensembl chr10:57,795,382...57,800,363 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein] CTD PMID:20888384 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 decreases response to substance ISO TLR4 protein results in decreased susceptibility to Daunorubicin CTD PMID:18789402 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tm4sf20 transmembrane 4 L six family member 20 affects response to substance ISO TM4SF20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr 9:84,038,715...84,052,615
Ensembl chr 9:84,038,715...84,052,615 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP Daunorubicin results in increased expression of TNF protein CTD PMID:16626513 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA] CTD PMID:17204177 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [Daunorubicin co-treated with TNFSF10 protein] results in increased expression of BID protein; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10A mRNA]; Daunorubicin promotes the reaction [TNFSF10 results in increased expression of TNFRSF10B mRNA] CTD PMID:12780785 PMID:17204177 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Daunorubicin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type decreases expression ISO Daunorubicin results in decreased expression of TNNT1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions
increases secretion		 EXP nebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein]
Daunorubicin results in increased secretion of TNNT2 protein		 CTD PMID:18194856 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases activity
affects activity		 ISO [Daunorubicin co-treated with Magnetite Nanoparticles] results in increased activity of TP53 protein; Daunorubicin results in increased phosphorylation of and results in increased expression of TP53 protein
Daunorubicin results in increased expression of TP53 mRNA
Daunorubicin results in increased activity of TP53 protein
Daunorubicin affects the activity of TP53 protein		 CTD PMID:12112851 PMID:12656675 PMID:21518493 PMID:23872705 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Daunorubicin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr 6:27,818,327...27,827,030 JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Daunorubicin CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP Daunorubicin results in decreased expression of UQCRFS1 mRNA CTD PMID:9038198 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 EXP Daunorubicin results in increased expression of VCAM1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein]		 CTD PMID:20888384 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor affects response to substance
decreases activity		 ISO VDR gene polymorphism affects the susceptibility to Daunorubicin
Daunorubicin results in decreased activity of VDR protein		 CTD PMID:15713801 PMID:25257666 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO
EXP		 Daunorubicin results in decreased expression of VEGFA protein
Daunorubicin results in decreased expression of VEGFA mRNA		 CTD PMID:20116850 PMID:27090888 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression EXP Daunorubicin results in increased expression of VIM protein CTD PMID:2444108 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 affects response to substance ISO ZBTB20 affects the susceptibility to Daunorubicin CTD PMID:17545624 NCBI chr11:57,052,129...57,823,679
Ensembl chr11:57,072,880...57,510,210 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Daunorubicin results in increased expression of ZMAT3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        antimicrobial agent 17941
          carbohydrate-containing antibiotic 7537
            aminoglycoside antibiotic 7525
              daunorubicin 212
                10-carboxy-13-deoxydaunorubicin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            heteroorganic entity 19450
                              organochalcogen compound 19236
                                organooxygen compound 19149
                                  carbohydrates and carbohydrate derivatives 14948
                                    carbohydrate 14948
                                      carbohydrate derivative 14219
                                        glycosyl compound 12949
                                          glycoside 11759
                                            aminoglycoside 11185
                                              aminoglycoside antibiotic 7525
                                                daunorubicin 212
                                                  10-carboxy-13-deoxydaunorubicin 0
paths to the root