dequalinium - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dequalinium	go back to main search page
Accession:	CHEBI:41872	browse the term
Definition:	A quinolinium ion comprising decane in which one methyl hydrogen at each end of the molecule has been replaced by a 4-amino-2-methylquinolin-1-yl group.
Synonyms:	related_synonym:	Formula=C30H40N4; InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2; InChIKey=PCSWXVJAIHCTMO-UHFFFAOYSA-P; SMILES=Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc12
	xref:	CAS:6707-58-0; Drug_Central:4376; LINCS:LSM-5846
	xref_mesh:	MESH:D003868
	xref:	PDBeChem:DEQ; Reaxys:3741219; Wikipedia:Dequalinium

show annotations for term's descendants Sort by:
Rat (11) Mouse (12) Human (12) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (11)

dequalinium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Dequalinium results in decreased activity of ACHE protein

NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

C-C motif chemokine ligand 2

decreases expression

Dequalinium results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

decreases expression

Dequalinium results in decreased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression

Dequalinium results in decreased expression of CCL4 protein

NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

decreases expression

Dequalinium results in decreased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377

G

interleukin 6 receptor

decreases expression

Dequalinium results in decreased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

potassium calcium-activated channel subfamily N member 1

decreases activity

Dequalinium results in decreased activity of KCNN1 protein

NCBI chr16:18,574,858...18,597,780
Ensembl chr16:18,585,992...18,597,482

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Dequalinium results in decreased activity of KCNN2 protein

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

solute carrier family 22 member 2

multiple interactions

Dequalinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

tumor protein p53

increases expression

Dequalinium results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

decreases expression

Dequalinium results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19818
role	19790
biological role	19788
antimicrobial agent	17945
antifungal agent	16379
dequalinium	11
dequalinium chloride	0
Path 2
Term	Annotations
CHEBI ontology	19818
subatomic particle	19816
composite particle	19816
hadron	19816
baryon	19816
nucleon	19816
atomic nucleus	19816
atom	19816
main group element atom	19761
p-block element atom	19761
carbon group element atom	19703
carbon group molecular entity	19703
organic molecular entity	19698
organic ion	9272
organic cation	8222
quinolinium ion	45
dequalinium	11
dequalinium chloride	0

paths to the root