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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-phenylbutyric acid
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Accession:CHEBI:41500 term browser browse the term
Definition:A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Synonyms:exact_synonym: 4-phenylbutanoic acid
 related_synonym: 4-PHENYL-BUTANOIC ACID;   4-Phenyl-n-butyric acid;   Benzenebutyric acid;   Formula=C10H12O2;   InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12);   InChIKey=OBKXEAXTFZPCHS-UHFFFAOYSA-N;   PBA;   SMILES=OC(=O)CCCc1ccccc1;   gamma-Phenyl-n-butyric acid;   gamma-phenylbutyric acid;   omega-Phenylbutanoic acid;   omega-phenylbutyric acid
 alt_id: CHEBI:64058
 xref: CAS:1821-12-1;   Drug_Central:24;   HMDB:HMDB0000543;   LINCS:LSM-5751
 xref_mesh: MESH:C075773
 xref: MetaCyc:CPD-14367;   PDBeChem:CLT;   PMID:19918981;   PMID:20399799;   PMID:21237159;   PMID:21726539;   PMID:21887297;   PMID:21894430;   PMID:22101259;   PMID:22359472;   Reaxys:638180
 cyclic_relationship: is_conjugate_acid_of CHEBI:75317


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4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression
increases expression		 ISO 4-phenylbutyric acid results in decreased expression of AARS1 mRNA
4-phenylbutyric acid results in increased expression of AARS1 mRNA		 CTD PMID:14583596 NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of ACSL4 protein] CTD PMID:36700298 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta increases expression ISO 4-phenylbutyric acid results in increased expression of ACTA2 mRNA CTD PMID:30481203 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ADAM17 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ADAM17 protein] CTD PMID:27638906 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Agt angiotensinogen multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Ahsa1 AHA1, activator of heat shock protein ATPase 1 increases expression ISO 4-phenylbutyric acid results in increased expression of AHSA1 mRNA CTD PMID:14583596 NCBI chr12:87,313,189...87,320,772
Ensembl chr12:87,313,253...87,320,772 		JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of AJUBA mRNA CTD PMID:14583596 NCBI chr14:54,804,926...54,815,118
Ensembl chr14:54,804,929...54,815,015 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 increases expression ISO 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]
4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
4-phenylbutyric acid inhibits the reaction [titanium dioxide results in decreased phosphorylation of AKT1 protein]		 CTD PMID:25398788 PMID:28245985 PMID:31298478 PMID:32283200 PMID:36640941 More... NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein] CTD PMID:36640941 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Akt3 thymoma viral proto-oncogene 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein] CTD PMID:36640941 NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein] CTD PMID:32407927 NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions		 ISO 4-phenylbutyric acid results in decreased expression of APAF1 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]		 CTD PMID:33651226 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G App amyloid beta precursor protein affects activity ISO 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased phosphorylation of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]
4-phenylbutyric acid results in decreased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]		 CTD PMID:27470132 PMID:27484784 PMID:27634458 PMID:28063906 PMID:28844859 More... NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Sodium Selenite results in increased expression of ATF6 protein]; [4-phenylbutyric acid co-treated with alpha-Chlorohydrin] results in decreased expression of ATF6 protein
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased cleavage of ATF6 protein]; [4-phenylbutyric acid co-treated with Palmitic Acid] results in decreased expression of ATF6 protein
4-phenylbutyric acid results in decreased expression of ATF6 protein		 CTD PMID:20165829 PMID:26804720 PMID:27578021 PMID:27638906 PMID:28245985 More... NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of ATF6B protein] CTD PMID:34214594 NCBI chr17:34,866,120...34,874,048
Ensembl chr17:34,866,120...34,874,048 		JBrowse link
G Atg12 autophagy related 12 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG12 mRNA]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG12 protein] CTD PMID:34175825 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647 		JBrowse link
G Atg3 autophagy related 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of ATG3 protein] CTD PMID:35398186 NCBI chr16:44,979,192...45,008,901
Ensembl chr16:44,979,148...45,008,901 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression
multiple interactions		 ISO 4-phenylbutyric acid results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]		 CTD PMID:36640941 NCBI chr 1:93,682,627...93,717,328
Ensembl chr 1:93,679,222...93,718,332 		JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG5 mRNA]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG5 protein] CTD PMID:34175825 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
increases expression		 EXP
ISO		 4-phenylbutyric acid results in decreased expression of BAX protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of BAX protein]]
4-phenylbutyric acid results in increased expression of BAX protein		 CTD PMID:25450231 PMID:27816613 PMID:29306025 PMID:30980806 PMID:31364909 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BBC3 protein] CTD PMID:34214594 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]
4-phenylbutyric acid results in increased expression of BCL2 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]		 CTD PMID:27816613 PMID:29306025 PMID:33651226 PMID:34214594 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BCL2L11 protein] CTD PMID:34214594 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 increases expression ISO 4-phenylbutyric acid results in increased expression of BCL6 mRNA CTD PMID:14583596 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of BECN1 protein] CTD PMID:27511942 PMID:33127495 PMID:35398186 PMID:36058351 PMID:36700298 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein] CTD PMID:33127495 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of CAMKK2 protein] CTD PMID:33651226 NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472 		JBrowse link
G Capn2 calpain 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in increased expression of CAPN2 protein] CTD PMID:34973135 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression
increases expression		 ISO 4-phenylbutyric acid results in decreased expression of CARS1 mRNA
4-phenylbutyric acid results in increased expression of CARS1 mRNA		 CTD PMID:14583596 NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP1 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased cleavage of CASP1 protein]		 CTD PMID:30796460 PMID:35297523 PMID:36646296 PMID:37692514 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in decreased expression of CASP12 protein]]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased activity of CASP12 protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid results in increased expression of and results in decreased cleavage of CASP12 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased degradation of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein]		 CTD PMID:17459145 PMID:27638049 PMID:28245985 PMID:33651226 PMID:33771661 More... NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]
4-phenylbutyric acid results in decreased expression of CASP3 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased activity of and results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]		 CTD PMID:21804221 PMID:24865413 PMID:25450231 PMID:25870318 PMID:27578021 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein]		 CTD PMID:24865413 PMID:25870318 PMID:33771661 PMID:33922211 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] CTD PMID:31364909 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP9 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP9 protein modified form] CTD PMID:29306025 PMID:32569804 PMID:33651226 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 EXP 4-phenylbutyric acid results in decreased expression of CCL2 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA]		 CTD PMID:28698385 PMID:35413383 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl8 C-C motif chemokine ligand 8 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CCL8 mRNA] CTD PMID:35413383 NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CCNB1 protein] CTD PMID:36058351 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cd36 CD36 molecule multiple interactions EXP 4-phenylbutyric acid promotes the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of CD36 mRNA] CTD PMID:32434321 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein] CTD PMID:36058351 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein] CTD PMID:36058351 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN1A mRNA
4-phenylbutyric acid results in increased expression of CDKN1A protein		 CTD PMID:17210717 PMID:23770000 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN2A mRNA CTD PMID:17210717 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased activity of CEBPB protein] CTD PMID:34973135 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
increases activity		 ISO 4-phenylbutyric acid results in increased activity of and affects the localization of CFTR protein mutant form; 4-phenylbutyric acid results in increased stability of and affects the localization of CFTR protein
4-phenylbutyric acid results in increased activity of CFTR protein mutant form		 CTD PMID:14583596 PMID:15191910 PMID:15880796 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA] CTD PMID:28962527 NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CITED2 mRNA CTD PMID:14583596 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CLDN1 mRNA CTD PMID:14583596 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Cldn11 claudin 11 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of CLDN11 protein] CTD PMID:35533795 NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473 		JBrowse link
G Cmss1 cms small ribosomal subunit 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CMSS1 mRNA CTD PMID:14583596 NCBI chr16:57,122,362...57,427,230
Ensembl chr16:57,122,363...57,427,227 		JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNIH4 mRNA CTD PMID:14583596 NCBI chr 1:180,977,437...180,996,559
Ensembl chr 1:180,972,258...180,996,559 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNOT2 mRNA CTD PMID:14583596 NCBI chr10:116,321,065...116,418,891
Ensembl chr10:116,321,066...116,417,416 		JBrowse link
G Col10a1 collagen, type X, alpha 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein] CTD PMID:29653943 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081 		JBrowse link
G Col5a1 collagen, type V, alpha 1 increases expression ISO 4-phenylbutyric acid results in increased expression of COL5A1 mRNA CTD PMID:14583596 NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of COX4I1 protein] CTD PMID:36473502 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Csde1 cold shock domain containing E1, RNA binding decreases expression ISO 4-phenylbutyric acid results in decreased expression of CSDE1 mRNA CTD PMID:14583596 NCBI chr 3:102,927,347...102,965,502
Ensembl chr 3:102,927,742...102,965,502 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA] CTD PMID:35413383 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein] CTD PMID:35413383 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF3 mRNA] CTD PMID:35413383 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 increases expression ISO 4-phenylbutyric acid results in increased expression of CSPG5 mRNA CTD PMID:14583596 NCBI chr 9:110,072,851...110,091,644
Ensembl chr 9:110,072,851...110,091,644 		JBrowse link
G Cst3 cystatin C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of CST3 protein] CTD PMID:33651226 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CTSD protein] CTD PMID:27638906 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; [4-phenylbutyric acid co-treated with N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide] results in decreased expression of CXCL8 protein
4-phenylbutyric acid results in decreased expression of CXCL8 protein		 CTD PMID:17709599 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of CYCS protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CYCS protein] CTD PMID:29306025 PMID:37741534 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
decreases phosphorylation		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of and affects the localization of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
4-phenylbutyric acid results in decreased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA]
4-phenylbutyric acid results in decreased phosphorylation of DDIT3 protein		 CTD PMID:24053669 PMID:24865413 PMID:25295624 PMID:25450231 PMID:26513129 More... NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Ddx55 DEAD box helicase 55 decreases expression ISO 4-phenylbutyric acid results in decreased expression of DDX55 mRNA CTD PMID:14583596 NCBI chr 5:124,690,895...124,707,723
Ensembl chr 5:124,690,927...124,707,723 		JBrowse link
G Derl1 Der1-like domain family, member 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DERL1 protein] CTD PMID:30980806 NCBI chr15:57,732,898...57,755,814
Ensembl chr15:57,732,898...57,755,844 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of DGAT1 mRNA] CTD PMID:36670177 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions
decreases expression		 EXP 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]
4-phenylbutyric acid results in decreased expression of DNAJB9 mRNA		 CTD PMID:28698385 PMID:28962527 NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
increases phosphorylation		 ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of DNM1L protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of DNM1L protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DNM1L protein]
4-phenylbutyric acid results in increased phosphorylation of DNM1L protein		 CTD PMID:33651226 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 multiple interactions
decreases expression		 EXP 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]
4-phenylbutyric acid results in decreased expression of EDEM1 mRNA		 CTD PMID:23274897 PMID:28698385 NCBI chr 6:108,800,984...108,836,317
Ensembl chr 6:108,805,602...108,836,317 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EEF1E1 mRNA CTD PMID:14583596 NCBI chr13:38,829,667...38,843,004
Ensembl chr13:38,828,183...38,843,034 		JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EFTUD2 mRNA CTD PMID:14583596 NCBI chr11:102,729,298...102,771,999
Ensembl chr11:102,729,299...102,771,811 		JBrowse link
G Egfl7 EGF-like domain 7 increases expression
multiple interactions		 ISO 4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form
[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form		 CTD PMID:19116145 NCBI chr 2:26,471,095...26,482,694
Ensembl chr 2:26,470,026...26,483,132 		JBrowse link
G Ehd3 EH-domain containing 3 increases expression ISO 4-phenylbutyric acid results in increased expression of EHD3 mRNA CTD PMID:14583596 NCBI chr17:74,111,836...74,139,088
Ensembl chr17:74,111,129...74,139,089 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2A protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of EIF2A mRNA]		 CTD PMID:31364909 PMID:34175825 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions		 ISO
EXP		 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]
4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of EIF2AK3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of EIF2AK3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased phosphorylation of EIF2AK3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form]
4-phenylbutyric acid results in decreased expression of EIF2AK3 protein; 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:27470132 PMID:27484784 PMID:27638906 PMID:28063906 PMID:28245985 More... NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Sodium Selenite results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid results in decreased expression of and results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid results in decreased expression of EIF2S1 protein modified form
4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [anandamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:20876807 PMID:25295624 PMID:26513129 PMID:26804720 PMID:27484784 More... NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]
4-phenylbutyric acid results in decreased expression of ERN1 protein
4-phenylbutyric acid results in increased expression of ERN1 protein
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid promotes the reaction [Palmitic Acid results in increased expression of ERN1 mRNA]		 CTD PMID:20399799 PMID:23885834 PMID:29444456 PMID:30796460 PMID:33651226 More... NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO 4-phenylbutyric acid results in increased expression of FAAH mRNA CTD PMID:14583596 NCBI chr 4:115,853,866...115,876,034
Ensembl chr 4:115,824,342...115,875,123 		JBrowse link
G Farsb phenylalanyl-tRNA synthetase, beta subunit decreases expression ISO 4-phenylbutyric acid results in decreased expression of FARSB mRNA CTD PMID:14583596 NCBI chr 1:78,394,593...78,465,530
Ensembl chr 1:78,394,612...78,465,534 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of FASN mRNA]
4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of FASN mRNA]		 CTD PMID:32407927 PMID:36670177 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fbln1 fibulin 1 increases expression ISO 4-phenylbutyric acid results in increased expression of FBLN1 mRNA CTD PMID:14583596 NCBI chr15:85,090,150...85,170,495
Ensembl chr15:85,090,150...85,170,736 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of FBXO32 protein] CTD PMID:30980806 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of FGF2 mRNA CTD PMID:14583596 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:33651226 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Fkbp11 FK506 binding protein 11 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 protein] CTD PMID:36030031 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein]		 CTD PMID:33127495 PMID:34214594 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS5 mRNA CTD PMID:14583596 NCBI chr 1:160,862,171...160,866,109
Ensembl chr 1:160,861,992...160,866,116 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS6 mRNA CTD PMID:14583596 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of GJA1 protein] CTD PMID:35533795 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA] CTD PMID:23274897 NCBI chr 2:57,127,690...57,260,731
Ensembl chr 2:57,127,647...57,260,731 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [TAK-875 results in increased expression of GPT protein]; 4-phenylbutyric acid inhibits the reaction [triptolide results in increased expression of GPT protein]		 CTD PMID:27470132 PMID:28063906 PMID:28844859 PMID:30243991 PMID:36520315 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO 4-phenylbutyric acid results in increased expression of GPX3 mRNA CTD PMID:14583596 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of GPX4 protein] CTD PMID:36700298 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO 4-phenylbutyric acid results in increased expression of GRB10 mRNA CTD PMID:14583596 NCBI chr11:11,880,499...11,987,428
Ensembl chr11:11,880,508...11,988,683 		JBrowse link
G Gsdmd gasdermin D multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of GSDMD protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of GSDMD protein]		 CTD PMID:30796460 PMID:35297523 PMID:36646296 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 increases expression ISO 4-phenylbutyric acid results in increased expression of HLA-E mRNA CTD PMID:14583596 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased expression of HDAC3 protein] CTD PMID:34973135 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions		 ISO 4-phenylbutyric acid results in increased expression of HGF mRNA; 4-phenylbutyric acid results in increased expression of HGF protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]		 CTD PMID:28844859 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HK2 protein] CTD PMID:32569804 PMID:36473502 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HMGA1 mRNA CTD PMID:14583596 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HMGA2 protein]
4-phenylbutyric acid results in decreased expression of HMGA2 protein		 CTD PMID:36473502 NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPA2B1 mRNA CTD PMID:14583596 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPC mRNA CTD PMID:14583596 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HS6ST mRNA CTD PMID:14583596 NCBI chr 1:36,107,481...36,145,527
Ensembl chr 1:36,107,481...36,145,527 		JBrowse link
G Hspa1a heat shock protein 1A increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA1A mRNA CTD PMID:14583596 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa2 heat shock protein 2 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA2 mRNA CTD PMID:14583596 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712 		JBrowse link
G Hspa4l heat shock protein 4 like increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA4L mRNA CTD PMID:14583596 NCBI chr 3:40,698,664...40,750,538
Ensembl chr 3:40,699,814...40,750,538 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
decreases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in decreased expression of HSPA5 protein]
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]		 CTD PMID:17459145 PMID:20165829 PMID:23743301 PMID:25295624 PMID:26804720 More... NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPH1 mRNA CTD PMID:14583596 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of ID1 mRNA CTD PMID:14583596 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA] CTD PMID:35413383 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNG mRNA]; 4-phenylbutyric acid results in decreased expression of and results in decreased secretion of IFNG protein CTD PMID:35413383 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL10 mRNA] CTD PMID:35413383 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL17A mRNA] CTD PMID:35413383 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of and results in increased secretion of IL18 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased secretion of IL18 protein]		 CTD PMID:30796460 PMID:35297523 PMID:36646296 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1A mRNA] CTD PMID:35413383 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL1B protein]		 CTD PMID:17709599 PMID:28245985 PMID:30796460 PMID:35297523 PMID:35413383 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of IL6 protein]
4-phenylbutyric acid results in decreased expression of IL6 mRNA		 CTD PMID:17709599 PMID:28245985 PMID:28698385 PMID:35413383 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS1 results in increased uptake of Deoxyglucose]]
4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]		 CTD PMID:20165829 PMID:32283200 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:20165829 PMID:32283200 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Ipo11 importin 11 decreases expression ISO 4-phenylbutyric acid results in decreased expression of IPO11 mRNA CTD PMID:14583596 NCBI chr13:106,930,947...107,073,466
Ensembl chr13:106,930,947...107,073,466 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Kmt5b lysine methyltransferase 5B decreases expression ISO 4-phenylbutyric acid results in decreased expression of KMT5B mRNA CTD PMID:14583596 NCBI chr19:3,816,436...3,868,303
Ensembl chr19:3,817,421...3,868,303 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of LDHA protein] CTD PMID:32569804 PMID:36473502 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Lepr leptin receptor multiple interactions EXP 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Mafa MAF bZIP transcription factor A multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA] CTD PMID:23274897 NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077 		JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 4-phenylbutyric acid affects the reaction [Decitabine affects the expression of MAGEA9 mRNA]; 4-phenylbutyric acid affects the reaction [Decitabine affects the expression of MAGEA9 protein] CTD PMID:17290406 NCBI chr  X:63,217,154...63,222,385
Ensembl chr  X:63,217,154...63,222,384 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in increased expression of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]		 CTD PMID:26804720 PMID:30025493 PMID:36058351 PMID:36640941 PMID:36700298 More... NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein]
4-phenylbutyric acid results in decreased expression of MAP3K5 protein		 CTD PMID:29444456 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein]
4-phenylbutyric acid results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21147958 PMID:34520753 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein]
4-phenylbutyric acid results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21147958 PMID:34520753 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of MAPK8 mRNA]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:21147958 PMID:31364909 PMID:35413383 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein] CTD PMID:21147958 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 4-phenylbutyric acid results in decreased expression of MAT2A mRNA CTD PMID:14583596 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541 		JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mef2a myocyte enhancer factor 2A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606 		JBrowse link
G Met met proto-oncogene multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of MET mRNA] CTD PMID:28844859 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions		 ISO 4-phenylbutyric acid results in increased expression of MFN2 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein]		 CTD PMID:33651226 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mief1 mitochondrial elongation factor 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MIEF1 mRNA CTD PMID:14583596 NCBI chr15:80,118,284...80,137,572
Ensembl chr15:80,118,219...80,137,572 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased secretion of MPO protein] CTD PMID:35413383 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS18C mRNA CTD PMID:14583596 NCBI chr 5:100,946,625...100,952,333
Ensembl chr 5:100,946,493...100,952,337 		JBrowse link
G Mrps22 mitochondrial ribosomal protein S22 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS22 mRNA CTD PMID:14583596 NCBI chr 9:98,470,783...98,483,732
Ensembl chr 9:98,470,783...98,483,713 		JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of ND1 protein] CTD PMID:36473502 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased phosphorylation of MTOR protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein]
4-phenylbutyric acid results in decreased phosphorylation of MTOR protein		 CTD PMID:28245985 PMID:36640941 PMID:37148176 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 protein] CTD PMID:20399799 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of NCOA4 protein] CTD PMID:36700298 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NDE1 mRNA CTD PMID:14583596 NCBI chr16:13,981,139...14,010,792
Ensembl chr16:13,981,139...14,010,792 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 protein]
ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein]		 CTD PMID:20399799 PMID:32407927 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:28245985 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NIFK mRNA CTD PMID:14583596 NCBI chr 1:118,249,573...118,261,561
Ensembl chr 1:118,249,569...118,261,552 		JBrowse link
G Nkx6-1 NK6 homeobox 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA] CTD PMID:23274897 NCBI chr 5:101,807,050...101,812,577
Ensembl chr 5:101,806,005...101,812,862 		JBrowse link
G Nln neurolysin (metallopeptidase M3 family) decreases expression ISO 4-phenylbutyric acid results in decreased expression of NLN mRNA CTD PMID:14583596 NCBI chr13:104,159,558...104,246,170
Ensembl chr13:104,159,565...104,246,122 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of NLRP3 protein]		 CTD PMID:30796460 PMID:35297523 PMID:36646296 PMID:37692514 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOLC1 mRNA CTD PMID:14583596 NCBI chr19:46,064,286...46,073,982
Ensembl chr19:46,064,302...46,073,969 		JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOM1 mRNA CTD PMID:14583596 NCBI chr 5:29,637,338...29,658,504
Ensembl chr 5:29,639,662...29,662,841 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of NR1D2 mRNA CTD PMID:14583596 NCBI chr14:4,230,549...4,265,639
Ensembl chr14:4,230,569...4,265,642 		JBrowse link
G Ocln occludin multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of OCLN protein] CTD PMID:35533795 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Ostn osteocrin multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of OSTN mRNA] CTD PMID:30602124 NCBI chr16:27,125,733...27,169,959
Ensembl chr16:27,126,239...27,169,962 		JBrowse link
G Padi2 peptidyl arginine deiminase, type II decreases expression EXP 4-phenylbutyric acid results in decreased expression of PADI2 mRNA CTD PMID:28698385 NCBI chr 4:140,633,685...140,679,897
Ensembl chr 4:140,633,655...140,679,897 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 multiple interactions
increases expression		 EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]
4-phenylbutyric acid results in increased expression of PARK7 mRNA; 4-phenylbutyric acid results in increased expression of PARK7 protein
[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide; [4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine		 CTD PMID:17459145 PMID:21372141 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [pendulone results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]		 CTD PMID:27578021 PMID:27634458 PMID:29981725 PMID:32407927 PMID:34214594 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator decreases expression ISO 4-phenylbutyric acid results in decreased expression of PAWR mRNA CTD PMID:14583596 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pcx pyruvate carboxylase multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA] CTD PMID:23274897 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pdcd2l programmed cell death 2-like decreases expression ISO 4-phenylbutyric acid results in decreased expression of PDCD2L mRNA CTD PMID:14583596 NCBI chr 7:33,883,922...33,896,154
Ensembl chr 7:33,883,924...33,896,086 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA] CTD PMID:23274897 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein] CTD PMID:37692514 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Pkm pyruvate kinase, muscle multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of PKM protein] CTD PMID:32569804 PMID:36473502 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLE4 mRNA CTD PMID:14583596 NCBI chr 6:82,593,513...82,629,985
Ensembl chr 6:82,595,973...82,682,346 		JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLR1H mRNA CTD PMID:14583596 NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451 		JBrowse link
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A increases expression
decreases expression		 ISO 4-phenylbutyric acid results in increased expression of POLR2A mRNA
4-phenylbutyric acid results in decreased expression of POLR2A mRNA		 CTD PMID:14583596 NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA] CTD PMID:36670177 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]
4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]		 CTD PMID:20165829 PMID:28482072 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PPIL1 mRNA CTD PMID:14583596 NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein] CTD PMID:17709599 PMID:36700298 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]
4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of PYCARD protein]		 CTD PMID:30796460 PMID:36646296 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rbm8a RNA binding motif protein 8a decreases expression ISO 4-phenylbutyric acid results in decreased expression of RBM8A mRNA CTD PMID:14583596 NCBI chr 3:96,537,244...96,541,107
Ensembl chr 3:96,537,249...96,541,107 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased expression of RELA protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:28245985 PMID:34973135 PMID:36646296 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rnf185 ring finger protein 185 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of RNF185 protein] CTD PMID:34958886 NCBI chr11:3,365,973...3,402,956
Ensembl chr11:3,365,982...3,402,363 		JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO 4-phenylbutyric acid results in decreased expression of RPL7A mRNA CTD PMID:14583596 NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330 		JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression ISO 4-phenylbutyric acid results in decreased expression of SARNP mRNA CTD PMID:14583596 NCBI chr10:128,657,633...128,713,507
Ensembl chr10:128,653,202...128,713,498 		JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 protein] CTD PMID:32407927 NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812 		JBrowse link
G Sftpc surfactant associated protein C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CTSD protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ADAM17 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased phosphorylation of EIF2S1 protein] CTD PMID:27638906 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein] CTD PMID:29653943 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc22a18 solute carrier family 22 (organic cation transporter), member 18 increases expression ISO 4-phenylbutyric acid results in increased expression of SLC22A18 mRNA CTD PMID:14583596 NCBI chr 7:143,027,502...143,053,071
Ensembl chr 7:143,027,473...143,053,071 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of SLC2A1 protein] CTD PMID:32569804 PMID:36473502 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA] CTD PMID:22215663 NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611 		JBrowse link
G Slc44a2 solute carrier family 44, member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of CTL2 mRNA CTD PMID:14583596 NCBI chr 9:21,232,015...21,266,324
Ensembl chr 9:21,231,994...21,266,324 		JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 multiple interactions
increases expression		 ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in increased expression of SLC5A6 protein] CTD PMID:36005737 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of SLC7A11 protein] CTD PMID:36700298 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slu7 SLU7 splicing factor homolog (S. cerevisiae) decreases expression ISO 4-phenylbutyric acid results in decreased expression of SLU7 mRNA CTD PMID:14583596 NCBI chr11:43,324,550...43,338,809
Ensembl chr11:43,324,571...43,338,808 		JBrowse link
G Snca synuclein, alpha multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; 4-phenylbutyric acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:17459145 PMID:21372141 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Snx5 sorting nexin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SNX5 mRNA CTD PMID:14583596 NCBI chr 2:144,092,043...144,112,713
Ensembl chr 2:144,092,043...144,112,826 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; [4-phenylbutyric acid co-treated with Thapsigargin] results in increased expression of SOD1 mRNA CTD PMID:32578922 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod3 superoxide dismutase 3, extracellular multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]
4-phenylbutyric acid results in increased expression of SOD3 mRNA		 CTD PMID:21804221 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760 		JBrowse link
G Sox4 SRY (sex determining region Y)-box 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SOX4 mRNA CTD PMID:14583596 NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in decreased expression of SQSTM1 protein]
4-phenylbutyric acid results in increased expression of SQSTM1 protein		 CTD PMID:32569804 PMID:33127495 PMID:36640941 PMID:36700298 PMID:37741534 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]
4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]		 CTD PMID:25398788 PMID:36670177 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srsf10 serine and arginine-rich splicing factor 10 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SRSF10 mRNA CTD PMID:14583596 NCBI chr 4:135,582,454...135,597,219
Ensembl chr 4:135,583,058...135,597,219 		JBrowse link
G Syvn1 synovial apoptosis inhibitor 1, synoviolin decreases expression
multiple interactions		 ISO 4-phenylbutyric acid results in decreased expression of SYVN1 mRNA
4-phenylbutyric acid inhibits the reaction [Streptozocin results in decreased expression of SYVN1 protein]		 CTD PMID:14583596 PMID:30980806 NCBI chr19:6,096,586...6,103,748
Ensembl chr19:6,096,606...6,103,742 		JBrowse link
G Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP1 mRNA CTD PMID:14583596 NCBI chr 6:52,690,677...52,743,765
Ensembl chr 6:52,690,714...52,743,765 		JBrowse link
G Tax1bp3 Tax1 (human T cell leukemia virus type I) binding protein 3 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP3 mRNA CTD PMID:14583596 NCBI chr11:73,067,909...73,072,872
Ensembl chr11:73,067,909...73,073,988 		JBrowse link
G Tg thyroglobulin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in decreased expression of TG protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TG protein] CTD PMID:25295624 PMID:36005737 NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP 4-phenylbutyric acid results in decreased expression of TGFB1 protein CTD PMID:25450231 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TIMM50 mRNA CTD PMID:14583596 NCBI chr 7:28,004,947...28,011,517
Ensembl chr 7:28,004,941...28,011,497 		JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 increases expression
decreases expression		 ISO 4-phenylbutyric acid results in increased expression of TMED5 mRNA
4-phenylbutyric acid results in decreased expression of TMED5 mRNA		 CTD PMID:14583596 NCBI chr 5:108,269,422...108,280,486
Ensembl chr 5:108,254,232...108,280,486 		JBrowse link
G Tmpo thymopoietin decreases expression ISO 4-phenylbutyric acid results in decreased expression of TMPO mRNA CTD PMID:14583596 NCBI chr10:90,983,433...91,017,614
Ensembl chr10:90,983,433...91,017,177 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of TNF protein]
4-phenylbutyric acid results in decreased expression of TNF mRNA		 CTD PMID:27578021 PMID:28245985 PMID:28698385 PMID:35413383 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tra2a transformer 2 alpha decreases expression ISO 4-phenylbutyric acid results in decreased expression of TRA2A mRNA CTD PMID:14583596 NCBI chr 6:49,220,855...49,241,182
Ensembl chr 6:49,220,858...49,240,967 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:30980806 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO 4-phenylbutyric acid results in increased expression of TSC2 mRNA CTD PMID:14583596 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Tsr1 TSR1 20S rRNA accumulation decreases expression ISO 4-phenylbutyric acid results in decreased expression of TSR1 mRNA CTD PMID:14583596 NCBI chr11:74,788,906...74,800,166
Ensembl chr11:74,788,897...74,800,168 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
affects expression		 ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein; [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein; [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein
4-phenylbutyric acid affects the expression of TUBB3 protein		 CTD PMID:18497984 NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UBA1 protein] CTD PMID:30980806 NCBI chr  X:20,524,660...20,549,420
Ensembl chr  X:20,524,565...20,549,418 		JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBA6 mRNA CTD PMID:14583596 NCBI chr 5:86,258,579...86,320,602
Ensembl chr 5:86,257,146...86,320,662 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of UBE2D1 protein] CTD PMID:34958886 NCBI chr10:71,090,810...71,121,048
Ensembl chr10:71,090,810...71,121,092 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W (putative) decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBE2W mRNA CTD PMID:14583596 NCBI chr 1:16,611,012...16,689,676
Ensembl chr 1:16,611,014...16,689,713 		JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL1 protein] CTD PMID:30980806 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577 		JBrowse link
G Uchl5 ubiquitin carboxyl-terminal esterase L5 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL5 protein] CTD PMID:30980806 NCBI chr 1:143,652,993...143,683,204
Ensembl chr 1:143,653,010...143,683,204 		JBrowse link
G Umod uromodulin increases expression EXP 4-phenylbutyric acid results in increased expression of UMOD protein; 4-phenylbutyric acid results in increased expression of UMOD protein mutant form CTD PMID:24567330 NCBI chr 7:119,061,931...119,078,485
Ensembl chr 7:119,061,934...119,078,505 		JBrowse link
G Utp4 UTP4 small subunit processome component decreases expression ISO 4-phenylbutyric acid results in decreased expression of UTP4 mRNA CTD PMID:14583596 NCBI chr 8:107,620,272...107,649,726
Ensembl chr 8:107,620,268...107,649,720 		JBrowse link
G Vcp valosin containing protein multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of VCP protein] CTD PMID:30980806 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA protein]
4-phenylbutyric acid results in decreased expression of VEGFA protein		 CTD PMID:28844859 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wdr4 WD repeat domain 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WDR4 mRNA CTD PMID:14583596 NCBI chr17:31,713,296...31,738,946
Ensembl chr17:31,713,296...31,738,954 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WWTR1 mRNA CTD PMID:14583596 NCBI chr 3:57,363,065...57,483,331
Ensembl chr 3:57,363,070...57,483,331 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [[Amiodarone results in increased splicing of XBP1 mRNA] which results in increased expression of XBP1 mRNA alternative form]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of XBP1 protein alternative form]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of XBP1 protein alternative form]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]]; 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased splicing of XBP1 mRNA]
4-phenylbutyric acid results in decreased expression of XBP1 protein alternative form		 CTD PMID:20165829 PMID:23274897 PMID:25295624 PMID:27578021 PMID:27638906 More... NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
G Xpo5 exportin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of XPO5 mRNA CTD PMID:14583596 NCBI chr17:46,513,737...46,554,524
Ensembl chr17:46,513,708...46,554,524 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of YTHDF2 mRNA CTD PMID:14583596 NCBI chr 4:131,912,227...131,939,567
Ensembl chr 4:131,912,223...131,939,614 		JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of ZBTB2 mRNA CTD PMID:14583596 NCBI chr10:4,317,074...4,353,114
Ensembl chr10:4,317,075...4,338,108 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pro-agent 11483
          prodrug 11220
            4-phenylbutyric acid 238
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      monocarboxylic acid 18952
                                        fatty acid 17131
                                          short-chain fatty acid 16331
                                            fatty acid 4:0 8379
                                              butyric acid 6796
                                                4-phenylbutyric acid 238
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