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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-phenylbutyric acid
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Accession:CHEBI:41500 term browser browse the term
Definition:A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Synonyms:exact_synonym: 4-phenylbutanoic acid
 related_synonym: 4-PHENYL-BUTANOIC ACID;   4-Phenyl-n-butyric acid;   Benzenebutyric acid;   Formula=C10H12O2;   InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12);   InChIKey=OBKXEAXTFZPCHS-UHFFFAOYSA-N;   PBA;   SMILES=OC(=O)CCCc1ccccc1;   gamma-Phenyl-n-butyric acid;   gamma-phenylbutyric acid;   omega-Phenylbutanoic acid;   omega-phenylbutyric acid
 alt_id: CHEBI:64058
 xref: CAS:1821-12-1;   Drug_Central:24;   HMDB:HMDB0000543;   LINCS:LSM-5751
 xref_mesh: MESH:C075773
 xref: MetaCyc:CPD-14367;   PDBeChem:CLT;   PMID:19918981;   PMID:20399799;   PMID:21237159;   PMID:21726539;   PMID:21887297;   PMID:21894430;   PMID:22101259;   PMID:22359472;   Reaxys:638180
 cyclic_relationship: is_conjugate_acid_of CHEBI:75317

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4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression
increases expression		 ISO 4-phenylbutyric acid results in decreased expression of AARS1 mRNA
4-phenylbutyric acid results in increased expression of AARS1 mRNA		 CTD PMID:14583596 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO 4-phenylbutyric acid results in increased expression of ACTA2 mRNA CTD PMID:30481203 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO 4-phenylbutyric acid results in increased expression of AHSA1 mRNA CTD PMID:14583596 NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345 		JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of AJUBA mRNA CTD PMID:14583596 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]
4-phenylbutyric acid inhibits the reaction [titanium dioxide results in decreased phosphorylation of AKT1 protein]
4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:25398788 PMID:28245985 PMID:31298478 PMID:32283200 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein] CTD PMID:32407927 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
decreases expression		 EXP 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]
4-phenylbutyric acid results in decreased expression of APAF1 protein		 CTD PMID:33651226 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein affects activity EXP 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
decreases expression		 EXP
ISO		 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased phosphorylation of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]
4-phenylbutyric acid results in decreased expression of ATF4 protein		 CTD PMID:27470132 PMID:27484784 PMID:27634458 PMID:28063906 PMID:28844859 More... NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]; [4-phenylbutyric acid co-treated with alpha-Chlorohydrin] results in decreased expression of ATF6 protein
4-phenylbutyric acid results in decreased expression of ATF6 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased cleavage of ATF6 protein]
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein]		 CTD PMID:20165829 PMID:26804720 PMID:27578021 PMID:28245985 PMID:30796460 More... NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions		 ISO
EXP		 4-phenylbutyric acid results in decreased expression of BAX protein
4-phenylbutyric acid results in increased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of BAX protein]]
4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]		 CTD PMID:25450231 PMID:27816613 PMID:29306025 PMID:30980806 PMID:33651226 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]
4-phenylbutyric acid results in increased expression of BCL2 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 protein]		 CTD PMID:27816613 PMID:29306025 PMID:33651226 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 4-phenylbutyric acid results in increased expression of BCL6 mRNA CTD PMID:14583596 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein] CTD PMID:27511942 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of CAMKK2 protein] CTD PMID:33651226 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression
increases expression		 ISO 4-phenylbutyric acid results in decreased expression of CARS1 mRNA
4-phenylbutyric acid results in increased expression of CARS1 mRNA		 CTD PMID:14583596 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA] CTD PMID:30796460 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in decreased expression of CASP12 protein]]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased activity of CASP12 protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid results in increased expression of and results in decreased cleavage of CASP12 protein		 CTD PMID:17459145 PMID:27638049 PMID:28245985 PMID:33651226 PMID:33771661 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
4-phenylbutyric acid results in decreased expression of CASP3 protein		 CTD PMID:21804221 PMID:24865413 PMID:25450231 PMID:25870318 PMID:27578021 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein]		 CTD PMID:24865413 PMID:25870318 PMID:33771661 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP9 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP9 protein modified form] CTD PMID:29306025 PMID:32569804 PMID:33651226 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CCL2 mRNA CTD PMID:28698385 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 4-phenylbutyric acid promotes the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of CD36 mRNA] CTD PMID:32434321 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN1A mRNA
4-phenylbutyric acid results in increased expression of CDKN1A protein		 CTD PMID:17210717 PMID:23770000 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN2A mRNA CTD PMID:17210717 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO 4-phenylbutyric acid results in increased activity of and affects the localization of CFTR protein mutant form; 4-phenylbutyric acid results in increased stability of and affects the localization of CFTR protein
4-phenylbutyric acid results in increased activity of CFTR protein mutant form		 CTD PMID:14583596 PMID:15191910 PMID:15880796 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA] CTD PMID:28962527 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CITED2 mRNA CTD PMID:14583596 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CLDN1 mRNA CTD PMID:14583596 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cmss1 cms1 ribosomal small subunit homolog decreases expression ISO 4-phenylbutyric acid results in decreased expression of CMSS1 mRNA CTD PMID:14583596 NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624 		JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNIH4 mRNA CTD PMID:14583596 NCBI chr13:92,910,315...92,926,428
Ensembl chr13:92,910,315...92,927,853 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNOT2 mRNA CTD PMID:14583596 NCBI chr 7:52,130,444...52,222,338
Ensembl chr 7:52,130,441...52,223,575 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein] CTD PMID:29653943 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col5a1 collagen type V alpha 1 chain increases expression ISO 4-phenylbutyric acid results in increased expression of COL5A1 mRNA CTD PMID:14583596 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588 		JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CSDE1 mRNA CTD PMID:14583596 NCBI chr 2:190,546,015...190,582,790
Ensembl chr 2:190,554,980...190,582,784 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 increases expression ISO 4-phenylbutyric acid results in increased expression of CSPG5 mRNA CTD PMID:14583596 NCBI chr 8:110,220,653...110,234,750
Ensembl chr 8:110,220,653...110,234,758 		JBrowse link
G Cst3 cystatin C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of CST3 protein] CTD PMID:33651226 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CYCS protein] CTD PMID:29306025 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases phosphorylation
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
4-phenylbutyric acid results in decreased phosphorylation of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
4-phenylbutyric acid results in decreased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]		 CTD PMID:24865413 PMID:25450231 PMID:26513129 PMID:26804720 PMID:27470132 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx55 DEAD-box helicase 55 decreases expression ISO 4-phenylbutyric acid results in decreased expression of DDX55 mRNA CTD PMID:14583596 NCBI chr12:32,034,462...32,050,218
Ensembl chr12:32,034,462...32,050,219 		JBrowse link
G Derl1 derlin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DERL1 protein] CTD PMID:30980806 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]
4-phenylbutyric acid results in decreased expression of DNAJB9 mRNA		 CTD PMID:28698385 PMID:28962527 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnm1l dynamin 1-like increases phosphorylation
multiple interactions		 ISO
EXP		 4-phenylbutyric acid results in increased phosphorylation of DNM1L protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of DNM1L protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of DNM1L protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DNM1L protein]		 CTD PMID:33651226 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]
4-phenylbutyric acid results in decreased expression of EDEM1 mRNA		 CTD PMID:23274897 PMID:28698385 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EEF1E1 mRNA CTD PMID:14583596 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EFTUD2 mRNA CTD PMID:14583596 NCBI chr10:87,804,893...87,852,181
Ensembl chr10:87,804,892...87,846,079 		JBrowse link
G Egfl7 EGF-like-domain, multiple 7 increases expression
multiple interactions		 ISO 4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form
[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form		 CTD PMID:19116145 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879 		JBrowse link
G Ehd3 EH-domain containing 3 increases expression ISO 4-phenylbutyric acid results in increased expression of EHD3 mRNA CTD PMID:14583596 NCBI chr 6:21,640,861...21,665,601
Ensembl chr 6:21,639,290...21,665,236 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions		 EXP
ISO		 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of EIF2AK3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]		 CTD PMID:27470132 PMID:27484784 PMID:28063906 PMID:28245985 PMID:29653943 More... NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid results in decreased expression of and results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [anandamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein]
4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
4-phenylbutyric acid results in decreased expression of EIF2S1 protein modified form		 CTD PMID:20876807 PMID:26513129 PMID:26804720 PMID:27484784 PMID:27638049 More... NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
decreases expression		 EXP
ISO		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]
4-phenylbutyric acid results in increased expression of ERN1 protein
4-phenylbutyric acid results in decreased expression of ERN1 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]		 CTD PMID:20399799 PMID:23885834 PMID:29444456 PMID:30796460 PMID:33651226 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO 4-phenylbutyric acid results in increased expression of FAAH mRNA CTD PMID:14583596 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO 4-phenylbutyric acid results in decreased expression of FARSB mRNA CTD PMID:14583596 NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of FASN mRNA] CTD PMID:32407927 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbln1 fibulin 1 increases expression ISO 4-phenylbutyric acid results in increased expression of FBLN1 mRNA CTD PMID:14583596 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of FBXO32 protein] CTD PMID:30980806 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of FGF2 mRNA CTD PMID:14583596 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:33651226 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 multiple interactions ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS5 mRNA CTD PMID:14583596 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS6 mRNA CTD PMID:14583596 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA] CTD PMID:23274897 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [TAK-875 results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]		 CTD PMID:27470132 PMID:28063906 PMID:28844859 PMID:30243991 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO 4-phenylbutyric acid results in increased expression of GPX3 mRNA CTD PMID:14583596 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO 4-phenylbutyric acid results in increased expression of GRB10 mRNA CTD PMID:14583596 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA] CTD PMID:30796460 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression ISO 4-phenylbutyric acid results in increased expression of GSTA4 mRNA CTD PMID:14583596 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions		 EXP 4-phenylbutyric acid results in increased expression of HGF mRNA; 4-phenylbutyric acid results in increased expression of HGF protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]		 CTD PMID:28844859 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HK2 protein] CTD PMID:32569804 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HMGA1 mRNA CTD PMID:14583596 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPA2B1 mRNA CTD PMID:14583596 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPC mRNA CTD PMID:14583596 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HS6ST mRNA CTD PMID:14583596 NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA1A mRNA CTD PMID:14583596
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA2 mRNA CTD PMID:14583596 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA4L mRNA CTD PMID:14583596 NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
4-phenylbutyric acid results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]
4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]		 CTD PMID:17459145 PMID:20165829 PMID:23743301 PMID:26804720 PMID:27470132 More... NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPH1 mRNA CTD PMID:14583596 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of ID1 mRNA CTD PMID:14583596 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA] CTD PMID:30796460 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]		 CTD PMID:17709599 PMID:28245985 PMID:30796460 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
4-phenylbutyric acid results in decreased expression of IL6 mRNA
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of IL6 protein]		 CTD PMID:17709599 PMID:28245985 PMID:28698385 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]] CTD PMID:20165829 PMID:32283200 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kmt5b lysine methyltransferase 5B decreases expression ISO 4-phenylbutyric acid results in decreased expression of KMT5B mRNA CTD PMID:14583596 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of LDHA protein] CTD PMID:32569804 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lepr leptin receptor multiple interactions ISO 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mafa MAF bZIP transcription factor A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA] CTD PMID:23274897 NCBI chr 7:107,432,292...107,435,061
Ensembl chr 7:107,433,605...107,434,690 		JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 mRNA]; 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 protein] CTD PMID:17290406 NCBI chr  X:142,619,282...142,624,654
Ensembl chr  X:142,619,395...142,624,653 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:26804720 PMID:30025493 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression
multiple interactions		 ISO 4-phenylbutyric acid results in decreased expression of MAP3K5 protein
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein]		 CTD PMID:29444456 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein] CTD PMID:21147958 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein] CTD PMID:21147958 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein] CTD PMID:21147958 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein] CTD PMID:21147958 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 4-phenylbutyric acid results in decreased expression of MAT2A mRNA CTD PMID:14583596 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of MET mRNA] CTD PMID:28844859 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions		 EXP
ISO		 4-phenylbutyric acid results in increased expression of MFN2 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein]		 CTD PMID:33651226 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mief1 mitochondrial elongation factor 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MIEF1 mRNA CTD PMID:14583596 NCBI chr 7:111,786,630...111,802,220
Ensembl chr 7:111,786,709...111,802,220 		JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS18C mRNA CTD PMID:14583596 NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516 		JBrowse link
G Mrps22 mitochondrial ribosomal protein S22 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS22 mRNA CTD PMID:14583596 NCBI chr 8:99,184,110...99,197,278
Ensembl chr 8:99,184,109...99,197,291 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein] CTD PMID:28245985 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 protein] CTD PMID:20399799 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NDE1 mRNA CTD PMID:14583596 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 protein]
ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein]		 CTD PMID:20399799 PMID:32407927 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:28245985 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NIFK mRNA CTD PMID:14583596 NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896 		JBrowse link
G Nkx6-1 NK6 homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA] CTD PMID:23274897 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681 		JBrowse link
G Nln neurolysin decreases expression ISO 4-phenylbutyric acid results in decreased expression of NLN mRNA CTD PMID:14583596 NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein] CTD PMID:30796460 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOLC1 mRNA CTD PMID:14583596 NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088 		JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOM1 mRNA CTD PMID:14583596 NCBI chr 4:5,891,220...5,910,741
Ensembl chr 4:5,892,909...5,909,709 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of NR1D2 mRNA CTD PMID:14583596 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Ostn osteocrin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of OSTN mRNA] CTD PMID:30602124 NCBI chr11:73,442,167...73,478,577
Ensembl chr11:73,442,487...73,468,603 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PADI2 mRNA CTD PMID:28698385 NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions
increases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]
4-phenylbutyric acid results in increased expression of PARK7 protein
[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide; [4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine
4-phenylbutyric acid results in increased expression of PARK7 mRNA; 4-phenylbutyric acid results in increased expression of PARK7 protein		 CTD PMID:17459145 PMID:21372141 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form]		 CTD PMID:27578021 PMID:27634458 PMID:29981725 PMID:32407927 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO 4-phenylbutyric acid results in decreased expression of PAWR mRNA CTD PMID:14583596 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA] CTD PMID:23274897 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pdcd2l programmed cell death 2-like decreases expression ISO 4-phenylbutyric acid results in decreased expression of PDCD2L mRNA CTD PMID:14583596 NCBI chr 1:86,810,292...86,822,554
Ensembl chr 1:86,810,292...86,822,554 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA] CTD PMID:23274897 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of PKM protein] CTD PMID:32569804 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLE4 mRNA CTD PMID:14583596 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097 		JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLR1H mRNA CTD PMID:14583596 NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854 		JBrowse link
G Polr2a RNA polymerase II subunit A increases expression
decreases expression		 ISO 4-phenylbutyric acid results in increased expression of POLR2A mRNA
4-phenylbutyric acid results in decreased expression of POLR2A mRNA		 CTD PMID:14583596 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]
4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]		 CTD PMID:20165829 PMID:28482072 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PPIL1 mRNA CTD PMID:14583596 NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:17709599 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA] CTD PMID:30796460 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rbm8a RNA binding motif protein 8A decreases expression ISO 4-phenylbutyric acid results in decreased expression of RBM8A mRNA CTD PMID:14583596 NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:28245985 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase increases expression ISO 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Rpl7a ribosomal protein L7a decreases expression ISO 4-phenylbutyric acid results in decreased expression of RPL7A mRNA CTD PMID:14583596 NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO 4-phenylbutyric acid results in increased expression of HLA-E mRNA CTD PMID:14583596 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression ISO 4-phenylbutyric acid results in decreased expression of SARNP mRNA CTD PMID:14583596 NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 protein] CTD PMID:32407927 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein] CTD PMID:29653943 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a18 solute carrier family 22, member 18 increases expression ISO 4-phenylbutyric acid results in increased expression of SLC22A18 mRNA CTD PMID:14583596 NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of SLC2A1 protein] CTD PMID:32569804 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO		 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA] CTD PMID:22215663 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slc44a2 solute carrier family 44 member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of CTL2 mRNA CTD PMID:14583596 NCBI chr 8:19,870,867...19,905,345
Ensembl chr 8:19,870,888...19,905,342 		JBrowse link
G Slu7 SLU7 homolog, splicing factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of SLU7 mRNA CTD PMID:14583596 NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349 		JBrowse link
G Snca synuclein alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; 4-phenylbutyric acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:17459145 PMID:21372141 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Snx5 sorting nexin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SNX5 mRNA CTD PMID:14583596 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; [4-phenylbutyric acid co-treated with Thapsigargin] results in increased expression of SOD1 mRNA CTD PMID:32578922 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
increases expression		 EXP 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]
4-phenylbutyric acid results in increased expression of SOD3 mRNA		 CTD PMID:21804221 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SOX4 mRNA CTD PMID:14583596 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of SQSTM1 protein] CTD PMID:32569804 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] CTD PMID:25398788 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srsf10 serine and arginine rich splicing factor 10 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SRSF10 mRNA CTD PMID:14583596 NCBI chr 5:148,088,765...148,102,964
Ensembl chr 5:148,088,823...148,101,768 		JBrowse link
G Syvn1 synoviolin 1 decreases expression
multiple interactions		 ISO
EXP		 4-phenylbutyric acid results in decreased expression of SYVN1 mRNA
4-phenylbutyric acid inhibits the reaction [Streptozocin results in decreased expression of SYVN1 protein]		 CTD PMID:14583596 PMID:30980806 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP1 mRNA CTD PMID:14583596 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tax1bp3 Tax1 binding protein 3 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP3 mRNA CTD PMID:14583596 NCBI chr10:57,795,785...57,800,363
Ensembl chr10:57,795,382...57,800,363 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TGFB1 protein CTD PMID:25450231 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase increases expression ISO 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TIMM50 mRNA CTD PMID:14583596 NCBI chr 1:83,574,872...83,582,769
Ensembl chr 1:83,556,757...83,582,793 		JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 increases expression
decreases expression		 ISO 4-phenylbutyric acid results in increased expression of TMED5 mRNA
4-phenylbutyric acid results in decreased expression of TMED5 mRNA		 CTD PMID:14583596 NCBI chr14:1,607,895...1,619,028
Ensembl chr14:1,607,819...1,628,426 		JBrowse link
G Tmpo thymopoietin decreases expression ISO 4-phenylbutyric acid results in decreased expression of TMPO mRNA CTD PMID:14583596 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of TNF protein]
4-phenylbutyric acid results in decreased expression of TNF mRNA		 CTD PMID:27578021 PMID:28245985 PMID:28698385 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:30980806 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tra2a transformer 2 alpha homolog decreases expression ISO 4-phenylbutyric acid results in decreased expression of TRA2A mRNA CTD PMID:14583596 NCBI chr 4:78,220,838...78,239,737
Ensembl chr 4:78,220,883...78,239,712 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO 4-phenylbutyric acid results in increased expression of TSC2 mRNA CTD PMID:14583596 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tsr1 TSR1, ribosome maturation factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of TSR1 mRNA CTD PMID:14583596 NCBI chr10:59,760,420...59,771,868
Ensembl chr10:59,760,409...59,771,864 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
affects expression		 ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein; [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein; [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein
4-phenylbutyric acid affects the expression of TUBB3 protein		 CTD PMID:18497984 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UBA1 protein] CTD PMID:30980806 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636 		JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBA6 mRNA CTD PMID:14583596 NCBI chr14:21,884,039...21,947,857
Ensembl chr14:21,884,039...21,947,857 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBE2W mRNA CTD PMID:14583596 NCBI chr 5:2,690,742...2,754,491 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL1 protein] CTD PMID:30980806 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL5 protein] CTD PMID:30980806 NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502 		JBrowse link
G Umod uromodulin increases expression ISO 4-phenylbutyric acid results in increased expression of UMOD protein; 4-phenylbutyric acid results in increased expression of UMOD protein mutant form CTD PMID:24567330 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Utp4 UTP4 small subunit processome component decreases expression ISO 4-phenylbutyric acid results in decreased expression of UTP4 mRNA CTD PMID:14583596 NCBI chr19:34,790,962...34,820,558
Ensembl chr19:34,792,457...34,820,550 		JBrowse link
G Vcp valosin-containing protein multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of VCP protein] CTD PMID:30980806 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 EXP 4-phenylbutyric acid results in decreased expression of VEGFA protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA protein]		 CTD PMID:28844859 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wdr4 WD repeat domain 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WDR4 mRNA CTD PMID:14583596 NCBI chr20:9,587,205...9,611,434
Ensembl chr20:9,587,207...9,603,581 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WWTR1 mRNA CTD PMID:14583596 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]
4-phenylbutyric acid results in decreased expression of XBP1 protein alternative form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]]; 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased splicing of XBP1 mRNA]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]		 CTD PMID:20165829 PMID:23274897 PMID:27578021 PMID:28245985 PMID:29444456 More... NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xpo5 exportin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of XPO5 mRNA CTD PMID:14583596 NCBI chr 9:14,740,182...14,778,171
Ensembl chr 9:14,740,182...14,778,171 		JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of YTHDF2 mRNA CTD PMID:14583596 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of ZBTB2 mRNA CTD PMID:14583596 NCBI chr 1:40,827,457...40,846,733
Ensembl chr 1:40,827,457...40,846,594 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            4-phenylbutyric acid 186
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7901
                                                butyric acid 6271
                                                  4-phenylbutyric acid 186
paths to the root