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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-phenylbutyric acid
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Accession:CHEBI:41500 term browser browse the term
Definition:A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Synonyms:related_synonym: 4-PHENYL-BUTANOIC ACID;   4-Phenyl-n-butyric acid;   4-phenylbutanoic acid;   Benzenebutyric acid;   Formula=C10H12O2;   InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12);   InChIKey=OBKXEAXTFZPCHS-UHFFFAOYSA-N;   PBA;   SMILES=OC(=O)CCCc1ccccc1;   gamma-Phenyl-n-butyric acid;   gamma-phenylbutyric acid;   omega-Phenylbutanoic acid;   omega-phenylbutyric acid
 alt_id: CHEBI:64058
 xref: CAS:1821-12-1;   Drug_Central:24;   HMDB:HMDB0000543;   LINCS:LSM-5751
 xref_mesh: MESH:C075773
 xref: MetaCyc:CPD-14367;   PDBeChem:CLT;   PMID:19918981;   PMID:20399799;   PMID:21237159;   PMID:21726539;   PMID:21887297;   PMID:21894430;   PMID:22101259;   PMID:22359472;   Reaxys:638180
 cyclic_relationship: is_conjugate_acid_of CHEBI:75317


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4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression
increases expression
ISO 4-phenylbutyric acid results in decreased expression of AARS1 mRNA
4-phenylbutyric acid results in increased expression of AARS1 mRNA
CTD PMID:14583596 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO 4-phenylbutyric acid results in increased expression of ACTA2 mRNA CTD PMID:30481203 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO 4-phenylbutyric acid results in increased expression of AHSA1 mRNA CTD PMID:14583596 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of AJUBA mRNA CTD PMID:14583596 NCBI chr15:33,208,210...33,218,456
Ensembl chr15:33,208,216...33,218,456
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]
4-phenylbutyric acid inhibits the reaction [titanium dioxide results in decreased phosphorylation of AKT1 protein]
4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
CTD PMID:25398788, PMID:28245985, PMID:31298478, PMID:32283200 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein affects activity EXP 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
decreases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased phosphorylation of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]
4-phenylbutyric acid results in decreased expression of ATF4 protein
CTD PMID:27470132, PMID:27484784, PMID:27634458, PMID:28063906, PMID:28844859, PMID:28988120, PMID:29653943, PMID:30025493, PMID:30602124, PMID:30980806, PMID:32578922 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]
4-phenylbutyric acid results in decreased expression of ATF6 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased cleavage of ATF6 protein]
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein]
CTD PMID:20165829, PMID:26804720, PMID:27578021, PMID:28245985, PMID:30796460, PMID:30980806, PMID:31298478 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
4-phenylbutyric acid results in decreased expression of BAX protein
4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]
4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]
CTD PMID:25450231, PMID:27816613, PMID:29306025, PMID:30980806 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]] CTD PMID:27816613, PMID:29306025 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 4-phenylbutyric acid results in increased expression of BCL6 mRNA CTD PMID:14583596 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Becn1 beclin 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein] CTD PMID:27511942 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression
increases expression
ISO 4-phenylbutyric acid results in decreased expression of CARS1 mRNA
4-phenylbutyric acid results in increased expression of CARS1 mRNA
CTD PMID:14583596 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp1 caspase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA] CTD PMID:30796460 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [arsenic trioxide results in increased expression of CASP12 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased activity of CASP12 protein] CTD PMID:17459145, PMID:27638049, PMID:28245985 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]
4-phenylbutyric acid inhibits the reaction [arsenic trioxide results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
4-phenylbutyric acid results in decreased expression of CASP3 protein
CTD PMID:21804221, PMID:24865413, PMID:25450231, PMID:25870318, PMID:27578021, PMID:27638049, PMID:29306025, PMID:29981725, PMID:30980806 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:24865413, PMID:25870318 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP9 protein modified form] CTD PMID:29306025 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CCL2 mRNA CTD PMID:28698385 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 4-phenylbutyric acid promotes the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of CD36 mRNA] CTD PMID:32434321 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN1A mRNA
4-phenylbutyric acid results in increased expression of CDKN1A protein
CTD PMID:17210717, PMID:23770000 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN2A mRNA CTD PMID:17210717 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO 4-phenylbutyric acid results in increased activity of and affects the localization of CFTR protein mutant form; 4-phenylbutyric acid results in increased stability of and affects the localization of CFTR protein
4-phenylbutyric acid results in increased activity of CFTR protein mutant form
CTD PMID:14583596, PMID:15191910, PMID:15880796 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA] CTD PMID:28962527 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CITED2 mRNA CTD PMID:14583596 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cldn1 claudin 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CLDN1 mRNA CTD PMID:14583596 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cmss1 cms1 ribosomal small subunit homolog decreases expression ISO 4-phenylbutyric acid results in decreased expression of CMSS1 mRNA CTD PMID:14583596 NCBI chr11:45,031,627...45,330,481
Ensembl chr11:45,304,068...45,330,481
JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNIH4 mRNA CTD PMID:14583596 NCBI chr13:99,469,382...99,490,693
Ensembl chr13:99,473,044...99,489,263
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNOT2 mRNA CTD PMID:14583596 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein] CTD PMID:29653943 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col5a1 collagen type V alpha 1 chain increases expression ISO 4-phenylbutyric acid results in increased expression of COL5A1 mRNA CTD PMID:14583596 NCBI chr 3:6,430,180...6,581,010
Ensembl chr 3:6,430,201...6,578,882
JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CSDE1 mRNA CTD PMID:14583596 NCBI chr 2:205,525,194...205,552,987
Ensembl chr 2:205,525,204...205,552,991
JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 increases expression ISO 4-phenylbutyric acid results in increased expression of CSPG5 mRNA CTD PMID:14583596 NCBI chr 8:118,333,695...118,348,040
Ensembl chr 8:118,333,706...118,347,582
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CYCS protein] CTD PMID:29306025 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 protein]
4-phenylbutyric acid results in decreased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
CTD PMID:24865413, PMID:25450231, PMID:26804720, PMID:27470132, PMID:27484784, PMID:27578021, PMID:27613715, PMID:27634458, PMID:27638049, PMID:27816613, PMID:28063906, PMID:28245985, PMID:28698385, PMID:28844859, PMID:28988120, PMID:29653943, PMID:29981725, PMID:30025493, PMID:30602124, PMID:30980806, PMID:31298478, PMID:32578922, PMID:32590070 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddx55 DEAD-box helicase 55 decreases expression ISO 4-phenylbutyric acid results in decreased expression of DDX55 mRNA CTD PMID:14583596 NCBI chr12:37,453,005...37,468,935
Ensembl chr12:37,453,005...37,468,935
JBrowse link
G Derl1 derlin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DERL1 protein] CTD PMID:30980806 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions
decreases expression
ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]
4-phenylbutyric acid results in decreased expression of DNAJB9 mRNA
CTD PMID:28698385, PMID:28962527 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions
decreases expression
ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]
4-phenylbutyric acid results in decreased expression of EDEM1 mRNA
CTD PMID:23274897, PMID:28698385 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EEF1E1 mRNA CTD PMID:14583596 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EFTUD2 mRNA CTD PMID:14583596 NCBI chr10:90,932,071...90,983,971
Ensembl chr10:90,932,075...90,983,928
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 increases expression
multiple interactions
ISO 4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form
[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form
CTD PMID:19116145 NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936
JBrowse link
G Ehd3 EH-domain containing 3 increases expression ISO 4-phenylbutyric acid results in increased expression of EHD3 mRNA CTD PMID:14583596 NCBI chr 6:25,076,012...25,102,457
Ensembl chr 6:25,074,955...25,100,977
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions
EXP
ISO
4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]
CTD PMID:27470132, PMID:27484784, PMID:28063906, PMID:28245985, PMID:29653943, PMID:30796460 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]
4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein]
4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
4-phenylbutyric acid results in decreased expression of EIF2S1 protein modified form
CTD PMID:20876807, PMID:26804720, PMID:27484784, PMID:27638049, PMID:28063906, PMID:28844859, PMID:29653943, PMID:30602124 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
decreases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]
4-phenylbutyric acid results in decreased expression of ERN1 protein
4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]
CTD PMID:20399799, PMID:23885834, PMID:29444456, PMID:30796460 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO 4-phenylbutyric acid results in increased expression of FAAH mRNA CTD PMID:14583596 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO 4-phenylbutyric acid results in decreased expression of FARSB mRNA CTD PMID:14583596 NCBI chr 9:84,324,456...84,383,674
Ensembl chr 9:84,324,442...84,383,687
JBrowse link
G Fbln1 fibulin 1 increases expression ISO 4-phenylbutyric acid results in increased expression of FBLN1 mRNA CTD PMID:14583596 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of FBXO32 protein] CTD PMID:30980806 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of FGF2 mRNA CTD PMID:14583596 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 multiple interactions ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS5 mRNA CTD PMID:14583596 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS6 mRNA CTD PMID:14583596 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA] CTD PMID:23274897 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [TAK-875 results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
CTD PMID:27470132, PMID:28063906, PMID:28844859, PMID:30243991 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO 4-phenylbutyric acid results in increased expression of GPX3 mRNA CTD PMID:14583596 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO 4-phenylbutyric acid results in increased expression of GRB10 mRNA CTD PMID:14583596 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA] CTD PMID:30796460 NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression ISO 4-phenylbutyric acid results in increased expression of GSTA4 mRNA CTD PMID:14583596 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions
EXP 4-phenylbutyric acid results in increased expression of HGF mRNA; 4-phenylbutyric acid results in increased expression of HGF protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]
CTD PMID:28844859 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HMGA1 mRNA CTD PMID:14583596 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPA2B1 mRNA CTD PMID:14583596 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPC mRNA CTD PMID:14583596 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HS6ST mRNA CTD PMID:14583596 NCBI chr 9:42,620,006...42,659,184
Ensembl chr 9:42,620,006...42,659,184
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA1A mRNA CTD PMID:14583596 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA2 mRNA CTD PMID:14583596 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA4L mRNA CTD PMID:14583596 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 protein]
4-phenylbutyric acid results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]
4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]
CTD PMID:17459145, PMID:20165829, PMID:23743301, PMID:26804720, PMID:27470132, PMID:27484784, PMID:27578021, PMID:27638049, PMID:27816613, PMID:28063906, PMID:28245985, PMID:28698385, PMID:28844859, PMID:29981725, PMID:30602124, PMID:30980806, PMID:31298478, PMID:32434321, PMID:32590070 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPH1 mRNA CTD PMID:14583596 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of ID1 mRNA CTD PMID:14583596 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Il18 interleukin 18 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA] CTD PMID:30796460 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:17709599, PMID:28245985, PMID:30796460 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
4-phenylbutyric acid results in decreased expression of IL6 mRNA
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of IL6 protein]
CTD PMID:17709599, PMID:28245985, PMID:28698385 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]] CTD PMID:20165829, PMID:32283200 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kmt5b lysine methyltransferase 5B decreases expression ISO 4-phenylbutyric acid results in decreased expression of KMT5B mRNA CTD PMID:14583596 NCBI chr 1:219,000,844...219,050,211
Ensembl chr 1:219,000,844...219,050,211
JBrowse link
G Lepr leptin receptor multiple interactions ISO 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mafa MAF bZIP transcription factor A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA] CTD PMID:23274897 NCBI chr 7:116,779,368...116,781,815
Ensembl chr 7:116,780,681...116,781,766
JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 mRNA]; 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 protein] CTD PMID:17290406 NCBI chr  X:147,491,247...147,496,650
Ensembl chr  X:147,493,880...147,496,649
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO
EXP
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD PMID:26804720, PMID:30025493 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression
multiple interactions
ISO 4-phenylbutyric acid results in decreased expression of MAP3K5 protein
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein]
CTD PMID:29444456 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein] CTD PMID:21147958 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein] CTD PMID:21147958 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein] CTD PMID:21147958 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein] CTD PMID:21147958 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 4-phenylbutyric acid results in decreased expression of MAT2A mRNA CTD PMID:14583596 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO
EXP
4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of MET mRNA] CTD PMID:28844859 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mief1 mitochondrial elongation factor 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MIEF1 mRNA CTD PMID:14583596 NCBI chr 7:121,462,962...121,478,545
Ensembl chr 7:121,462,966...121,478,546
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS18C mRNA CTD PMID:14583596 NCBI chr14:10,440,691...10,446,909
Ensembl chr14:10,440,691...10,446,909
JBrowse link
G Mrps22 mitochondrial ribosomal protein S22 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS22 mRNA CTD PMID:14583596 NCBI chr 8:106,604,421...106,617,591
Ensembl chr 8:106,604,379...106,617,597
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein] CTD PMID:28245985 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 protein] CTD PMID:20399799 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nde1 nudE neurodevelopment protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NDE1 mRNA CTD PMID:14583596 NCBI chr10:860,513...904,624
Ensembl chr10:860,521...896,938
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 protein] CTD PMID:20399799 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:28245985 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NIFK mRNA CTD PMID:14583596 NCBI chr13:34,267,442...34,277,543
Ensembl chr13:34,267,471...34,277,530
JBrowse link
G Nkx6-1 NK6 homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA] CTD PMID:23274897 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Nln neurolysin decreases expression ISO 4-phenylbutyric acid results in decreased expression of NLN mRNA CTD PMID:14583596 NCBI chr 2:34,086,970...34,185,835
Ensembl chr 2:34,087,880...34,185,812
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein] CTD PMID:30796460 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOLC1 mRNA CTD PMID:14583596 NCBI chr 1:265,829,055...265,839,819
Ensembl chr 1:265,829,108...265,839,818
JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOM1 mRNA CTD PMID:14583596 NCBI chr 4:2,340,034...2,356,427
Ensembl chr 4:2,340,148...2,356,068
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of NR1D2 mRNA CTD PMID:14583596 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Ostn osteocrin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of OSTN mRNA] CTD PMID:30602124 NCBI chr11:76,851,923...76,888,140
Ensembl chr11:76,851,322...76,888,178
JBrowse link
G Padi2 peptidyl arginine deiminase 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PADI2 mRNA CTD PMID:28698385 NCBI chr 5:159,428,479...159,471,113
Ensembl chr 5:159,428,515...159,471,144
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]
4-phenylbutyric acid results in increased expression of PARK7 protein
[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide; [4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine
4-phenylbutyric acid results in increased expression of PARK7 mRNA; 4-phenylbutyric acid results in increased expression of PARK7 protein
CTD PMID:17459145, PMID:21372141 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]
CTD PMID:27578021, PMID:27634458, PMID:29981725 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO 4-phenylbutyric acid results in decreased expression of PAWR mRNA CTD PMID:14583596 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA] CTD PMID:23274897 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pdcd2l programmed cell death 2-like decreases expression ISO 4-phenylbutyric acid results in decreased expression of PDCD2L mRNA CTD PMID:14583596 NCBI chr 1:90,045,468...90,057,756
Ensembl chr 1:90,045,509...90,057,923
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA] CTD PMID:23274897 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLE4 mRNA CTD PMID:14583596 NCBI chr 4:113,491,644...113,497,455
Ensembl chr 4:113,491,644...113,497,455
JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLR1H mRNA CTD PMID:14583596 NCBI chr20:2,088,518...2,092,436
Ensembl chr20:2,088,533...2,092,436
JBrowse link
G Polr2a RNA polymerase II subunit A increases expression
decreases expression
ISO 4-phenylbutyric acid results in increased expression of POLR2A mRNA
4-phenylbutyric acid results in decreased expression of POLR2A mRNA
CTD PMID:14583596 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]
4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]
CTD PMID:20165829, PMID:28482072 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PPIL1 mRNA CTD PMID:14583596 NCBI chr20:6,515,638...6,864,571
Ensembl chr20:6,515,638...6,864,571
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:17709599 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA] CTD PMID:30796460 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rbm8a RNA binding motif protein 8A decreases expression ISO 4-phenylbutyric acid results in decreased expression of RBM8A mRNA CTD PMID:14583596 NCBI chr 2:198,755,261...198,758,028
Ensembl chr 2:198,755,262...198,758,028
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:28245985 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpl7a ribosomal protein L7a decreases expression ISO 4-phenylbutyric acid results in decreased expression of RPL7A mRNA CTD PMID:14583596 NCBI chr 3:5,458,985...5,461,627
Ensembl chr 3:5,459,160...5,461,583
Ensembl chr 3:5,459,160...5,461,583
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO 4-phenylbutyric acid results in increased expression of HLA-E mRNA CTD PMID:14583596 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression ISO 4-phenylbutyric acid results in decreased expression of SARNP mRNA CTD PMID:14583596 NCBI chr 7:3,246,220...3,300,467
Ensembl chr 7:3,246,220...3,300,455
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein] CTD PMID:29653943 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc22a18 solute carrier family 22, member 18 increases expression ISO 4-phenylbutyric acid results in increased expression of SLC22A18 mRNA CTD PMID:14583596 NCBI chr 1:216,676,330...216,700,632
Ensembl chr 1:216,677,373...216,700,641
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA] CTD PMID:22215663 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc44a2 solute carrier family 44 member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of CTL2 mRNA CTD PMID:14583596 NCBI chr 8:22,351,277...22,385,869
Ensembl chr 8:22,368,745...22,385,864
JBrowse link
G Slu7 SLU7 homolog, splicing factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of SLU7 mRNA CTD PMID:14583596 NCBI chr10:29,029,556...29,044,919
Ensembl chr10:29,029,590...29,044,583
JBrowse link
G Snca synuclein alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; 4-phenylbutyric acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:17459145, PMID:21372141 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Snx5 sorting nexin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SNX5 mRNA CTD PMID:14583596 NCBI chr 3:138,378,032...138,397,944
Ensembl chr 3:138,378,202...138,397,870
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; [4-phenylbutyric acid co-treated with Thapsigargin] results in increased expression of SOD1 mRNA CTD PMID:32578922 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]
4-phenylbutyric acid results in increased expression of SOD3 mRNA
CTD PMID:21804221 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SOX4 mRNA CTD PMID:14583596 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA] CTD PMID:25398788 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf10 serine and arginine rich splicing factor 10 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SRSF10 mRNA CTD PMID:14583596 NCBI chr 5:154,205,358...154,219,550
Ensembl chr 5:154,205,402...154,213,801
JBrowse link
G Syvn1 synoviolin 1 decreases expression
multiple interactions
ISO
EXP
4-phenylbutyric acid results in decreased expression of SYVN1 mRNA
4-phenylbutyric acid inhibits the reaction [Streptozocin results in decreased expression of SYVN1 protein]
CTD PMID:14583596, PMID:30980806 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tax1bp1 Tax1 binding protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP1 mRNA CTD PMID:14583596 NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
JBrowse link
G Tax1bp3 Tax1 binding protein 3 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP3 mRNA CTD PMID:14583596 NCBI chr10:59,743,356...59,748,063
Ensembl chr10:59,743,544...59,748,062
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TGFB1 protein CTD PMID:25450231 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase increases expression ISO 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TIMM50 mRNA CTD PMID:14583596 NCBI chr 1:85,470,810...85,480,813
Ensembl chr 1:85,470,831...85,480,407
JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 increases expression
decreases expression
ISO 4-phenylbutyric acid results in increased expression of TMED5 mRNA
4-phenylbutyric acid results in decreased expression of TMED5 mRNA
CTD PMID:14583596 NCBI chr14:2,613,318...2,624,773
Ensembl chr14:2,613,406...2,633,950
JBrowse link
G Tmpo thymopoietin decreases expression ISO 4-phenylbutyric acid results in decreased expression of TMPO mRNA CTD PMID:14583596 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of TNF protein]
4-phenylbutyric acid results in decreased expression of TNF mRNA
CTD PMID:27578021, PMID:28245985, PMID:28698385 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:30980806 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tra2a transformer 2 alpha homolog decreases expression ISO 4-phenylbutyric acid results in decreased expression of TRA2A mRNA CTD PMID:14583596 NCBI chr 4:78,905,380...78,924,203
Ensembl chr 4:78,905,380...78,924,181
JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO 4-phenylbutyric acid results in increased expression of TSC2 mRNA CTD PMID:14583596 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tsr1 TSR1, ribosome maturation factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of TSR1 mRNA CTD PMID:14583596 NCBI chr10:61,746,070...61,757,518
Ensembl chr10:61,746,059...61,757,518
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
affects expression
ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein; [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein; [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein
4-phenylbutyric acid affects the expression of TUBB3 protein
CTD PMID:18497984 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UBA1 protein] CTD PMID:30980806 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBA6 mRNA CTD PMID:14583596 NCBI chr14:23,507,628...23,571,446
Ensembl chr14:23,507,628...23,571,446
JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBE2W mRNA CTD PMID:14583596 NCBI chr 5:29,798,845...29,812,777 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL1 protein] CTD PMID:30980806 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL5 protein] CTD PMID:30980806 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811
JBrowse link
G Umod uromodulin increases expression ISO 4-phenylbutyric acid results in increased expression of UMOD protein; 4-phenylbutyric acid results in increased expression of UMOD protein mutant form CTD PMID:24567330 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Utp4 UTP4 small subunit processome component decreases expression ISO 4-phenylbutyric acid results in decreased expression of UTP4 mRNA CTD PMID:14583596 NCBI chr19:39,087,995...39,116,124
Ensembl chr19:39,087,990...39,116,125
JBrowse link
G Vcp valosin-containing protein multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of VCP protein] CTD PMID:30980806 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP 4-phenylbutyric acid results in decreased expression of VEGFA protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA protein]
CTD PMID:28844859 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdr4 WD repeat domain 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WDR4 mRNA CTD PMID:14583596 NCBI chr20:10,240,571...10,264,818
Ensembl chr20:10,239,154...10,257,044
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WWTR1 mRNA CTD PMID:14583596 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]
4-phenylbutyric acid results in decreased expression of XBP1 protein alternative form
4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased splicing of XBP1 mRNA]
CTD PMID:20165829, PMID:23274897, PMID:27578021, PMID:28245985, PMID:29444456, PMID:30602124, PMID:30796460, PMID:31298478 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xpo5 exportin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of XPO5 mRNA CTD PMID:14583596 NCBI chr 9:17,125,201...17,163,170
Ensembl chr 9:17,125,201...17,163,170
JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of YTHDF2 mRNA CTD PMID:14583596 NCBI chr 5:150,364,490...150,390,173
Ensembl chr 5:150,365,101...150,390,099
JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of ZBTB2 mRNA CTD PMID:14583596 NCBI chr 1:40,914,175...40,933,586
Ensembl chr 1:40,914,171...40,921,508
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pro-agent 8830
          prodrug 8610
            4-phenylbutyric acid 171
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            short-chain fatty acid 15500
                                              fatty acid 4:0 7011
                                                butyric acid 5292
                                                  4-phenylbutyric acid 171
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.