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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-phenylbutyric acid
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Accession:CHEBI:41500 term browser browse the term
Definition:A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Synonyms:exact_synonym: 4-phenylbutanoic acid
 related_synonym: 4-PHENYL-BUTANOIC ACID;   4-Phenyl-n-butyric acid;   Benzenebutyric acid;   Formula=C10H12O2;   InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12);   InChIKey=OBKXEAXTFZPCHS-UHFFFAOYSA-N;   PBA;   SMILES=OC(=O)CCCc1ccccc1;   gamma-Phenyl-n-butyric acid;   gamma-phenylbutyric acid;   omega-Phenylbutanoic acid;   omega-phenylbutyric acid
 alt_id: CHEBI:64058
 xref: CAS:1821-12-1;   Drug_Central:24;   HMDB:HMDB0000543;   LINCS:LSM-5751
 xref_mesh: MESH:C075773
 xref: MetaCyc:CPD-14367;   PDBeChem:CLT;   PMID:19918981;   PMID:20399799;   PMID:21237159;   PMID:21726539;   PMID:21887297;   PMID:21894430;   PMID:22101259;   PMID:22359472;   Reaxys:638180
 cyclic_relationship: is_conjugate_acid_of CHEBI:75317


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4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression
increases expression 		ISO 4-phenylbutyric acid results in decreased expression of AARS1 mRNA
4-phenylbutyric acid results in increased expression of AARS1 mRNA 		CTD PMID:14583596 NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of ACSL4 protein] CTD PMID:36700298 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO 4-phenylbutyric acid results in increased expression of ACTA2 mRNA CTD PMID:30481203 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ADAM17 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ADAM17 protein] CTD PMID:27638906 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:25398788 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO 4-phenylbutyric acid results in increased expression of AHSA1 mRNA CTD PMID:14583596 NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595 		JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 4-phenylbutyric acid results in decreased expression of AJUBA mRNA CTD PMID:14583596 NCBI chr15:31,989,796...32,000,042
Ensembl chr15:31,989,799...32,000,042 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]
4-phenylbutyric acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
4-phenylbutyric acid inhibits the reaction [titanium dioxide results in decreased phosphorylation of AKT1 protein] 		CTD PMID:25398788 PMID:28245985 PMID:31298478 PMID:32283200 PMID:36640941 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein] CTD PMID:36640941 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein] CTD PMID:36640941 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein] CTD PMID:32407927 NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
decreases expression 		EXP 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]
4-phenylbutyric acid results in decreased expression of APAF1 protein 		CTD PMID:33651226 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G App amyloid beta precursor protein affects activity EXP 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
decreases expression 		EXP
ISO 		4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased phosphorylation of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]
4-phenylbutyric acid results in decreased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Cisplatin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein] 		CTD PMID:27470132 PMID:27484784 PMID:27634458 PMID:28063906 PMID:28844859 More... NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Sodium Selenite results in increased expression of ATF6 protein]; [4-phenylbutyric acid co-treated with alpha-Chlorohydrin] results in decreased expression of ATF6 protein
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased cleavage of ATF6 protein]; [4-phenylbutyric acid co-treated with Palmitic Acid] results in decreased expression of ATF6 protein
4-phenylbutyric acid results in decreased expression of ATF6 protein 		CTD PMID:20165829 PMID:26804720 PMID:27578021 PMID:27638906 PMID:28245985 More... NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of ATF6B protein] CTD PMID:34214594 NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,095,534...4,106,032 		JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG12 mRNA]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG12 protein] CTD PMID:34175825 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261 		JBrowse link
G Atg3 autophagy related 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of ATG3 protein] CTD PMID:35398186 NCBI chr11:69,130,948...69,159,280
Ensembl chr11:69,121,952...69,159,280 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression
multiple interactions 		ISO 4-phenylbutyric acid results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein] 		CTD PMID:36640941 NCBI chr 9:101,729,772...101,761,456
Ensembl chr 9:101,726,782...101,761,622 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG5 mRNA]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased expression of ATG5 protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATG5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of ATG5 protein] 		CTD PMID:34175825 PMID:37654027 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression 		ISO
EXP 		4-phenylbutyric acid results in decreased expression of BAX protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of BAX protein]]; 4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of BAX protein]
4-phenylbutyric acid results in increased expression of BAX protein 		CTD PMID:25450231 PMID:27816613 PMID:29306025 PMID:30980806 PMID:31364909 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BBC3 protein] CTD PMID:34214594 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Silver Compounds results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
4-phenylbutyric acid results in increased expression of BCL2 protein
4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in decreased expression of BCL2 protein]; [4-phenylbutyric acid co-treated with Ficusin] results in increased expression of BCL2 protein 		CTD PMID:27816613 PMID:29306025 PMID:33651226 PMID:34214594 PMID:38065397 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BCL2L11 protein] CTD PMID:34214594 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 4-phenylbutyric acid results in increased expression of BCL6 mRNA CTD PMID:14583596 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in increased expression of BECN1 protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of BECN1 protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of BECN1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of BECN1 protein]
4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of BECN1 protein] 		CTD PMID:27511942 PMID:33127495 PMID:35398186 PMID:36058351 PMID:36700298 More... NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein] CTD PMID:33127495 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of CAMKK2 protein] CTD PMID:33651226 NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964 		JBrowse link
G Capn2 calpain 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in increased expression of CAPN2 protein] CTD PMID:34973135 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression
increases expression 		ISO 4-phenylbutyric acid results in decreased expression of CARS1 mRNA
4-phenylbutyric acid results in increased expression of CARS1 mRNA 		CTD PMID:14583596 NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP1 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased cleavage of CASP1 protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased activity of CASP1 protein] 		CTD PMID:30796460 PMID:35297523 PMID:36646296 PMID:37654027 PMID:37692514 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in decreased expression of CASP12 protein]]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased cleavage of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased activity of CASP12 protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of CASP12 protein]; 4-phenylbutyric acid results in increased expression of and results in decreased cleavage of CASP12 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased degradation of CASP12 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP12 protein] 		CTD PMID:17459145 PMID:27638049 PMID:28245985 PMID:33651226 PMID:33771661 More... NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]
4-phenylbutyric acid results in decreased expression of CASP3 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased activity of and results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form] 		CTD PMID:21804221 PMID:24865413 PMID:25450231 PMID:25870318 PMID:27578021 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein]]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP7 protein] 		CTD PMID:24865413 PMID:25870318 PMID:33771661 PMID:33922211 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] CTD PMID:31364909 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of CASP9 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CASP9 protein modified form]
4-phenylbutyric acid inhibits the reaction [Arecoline results in increased cleavage of CASP9 protein] 		CTD PMID:29306025 PMID:32569804 PMID:33651226 PMID:38450909 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in decreased activity of CAT protein] CTD PMID:39299507 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions 		ISO 4-phenylbutyric acid results in decreased expression of CCL2 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA] 		CTD PMID:28698385 PMID:35413383 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CCNB1 protein] CTD PMID:36058351 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 4-phenylbutyric acid promotes the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of CD36 mRNA] CTD PMID:32434321 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein] CTD PMID:36058351 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein] CTD PMID:36058351 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN1A mRNA
4-phenylbutyric acid results in increased expression of CDKN1A protein 		CTD PMID:17210717 PMID:23770000 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [4-phenylbutyric acid co-treated with decitabine] results in increased expression of CDKN2A mRNA CTD PMID:17210717 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased activity of CEBPB protein] CTD PMID:34973135 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity 		ISO 4-phenylbutyric acid results in increased activity of and affects the localization of CFTR protein mutant form; 4-phenylbutyric acid results in increased stability of and affects the localization of CFTR protein
4-phenylbutyric acid results in increased activity of CFTR protein mutant form 		CTD PMID:14583596 PMID:15191910 PMID:15880796 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA] CTD PMID:28962527 NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CITED2 mRNA CTD PMID:14583596 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CLDN1 mRNA CTD PMID:14583596 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529 		JBrowse link
G Cldn11 claudin 11 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of CLDN11 protein] CTD PMID:35533795 NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:114,136,234...114,149,539 		JBrowse link
G Cmss1 cms1 ribosomal small subunit homolog decreases expression ISO 4-phenylbutyric acid results in decreased expression of CMSS1 mRNA CTD PMID:14583596 NCBI chr11:56,403,620...56,701,751
Ensembl chr11:56,403,499...56,701,755 		JBrowse link
G Cnih4 cornichon family member 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNIH4 mRNA CTD PMID:14583596 NCBI chr13:95,442,054...95,458,163
Ensembl chr13:95,442,054...95,459,590 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CNOT2 mRNA CTD PMID:14583596 NCBI chr 7:54,016,447...54,117,511
Ensembl chr 7:54,016,447...54,107,960 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein] CTD PMID:29653943 NCBI chr20:39,737,536...39,744,518
Ensembl chr20:39,716,822...39,751,440 		JBrowse link
G Col5a1 collagen type V alpha 1 chain increases expression ISO 4-phenylbutyric acid results in increased expression of COL5A1 mRNA CTD PMID:14583596 NCBI chr 3:31,606,475...31,755,097
Ensembl chr 3:31,606,486...31,753,020 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of COX4I1 protein] CTD PMID:36473502 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624 		JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of CSDE1 mRNA CTD PMID:14583596 NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:193,243,526...193,271,301 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA] CTD PMID:35413383 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein] CTD PMID:35413383 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF3 mRNA] CTD PMID:35413383 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 increases expression ISO 4-phenylbutyric acid results in increased expression of CSPG5 mRNA CTD PMID:14583596 NCBI chr 8:119,098,932...119,113,191
Ensembl chr 8:119,098,925...119,143,907 		JBrowse link
G Cst3 cystatin C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of CST3 protein] CTD PMID:33651226 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CTSD protein] CTD PMID:27638906 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of CYCS protein]; 4-phenylbutyric acid inhibits the reaction [Silver Compounds results in increased expression of CYCS protein] CTD PMID:29306025 PMID:37741534 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
decreases phosphorylation 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cisplatin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of and affects the localization of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Leflunomide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
4-phenylbutyric acid results in decreased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Acrylamide promotes the reaction [elaidic acid results in increased expression of DDIT3 protein]]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [elaidic acid promotes the reaction [Acrylamide results in increased expression of DDIT3 protein]]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased phosphorylation of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Sunitinib results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid promotes the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA]
4-phenylbutyric acid results in decreased phosphorylation of DDIT3 protein 		CTD PMID:24053669 PMID:24865413 PMID:25295624 PMID:25450231 PMID:26513129 More... NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddx55 DEAD-box helicase 55 decreases expression ISO 4-phenylbutyric acid results in decreased expression of DDX55 mRNA CTD PMID:14583596 NCBI chr12:37,695,444...37,711,198
Ensembl chr12:37,695,444...37,711,198 		JBrowse link
G Derl1 derlin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DERL1 protein] CTD PMID:30980806 NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of DGAT1 mRNA] CTD PMID:36670177 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]
4-phenylbutyric acid results in decreased expression of DNAJB9 mRNA 		CTD PMID:28698385 PMID:28962527 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344 		JBrowse link
G Dnm1l dynamin 1-like increases phosphorylation
multiple interactions 		ISO
EXP 		4-phenylbutyric acid results in increased phosphorylation of DNM1L protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and affects the localization of DNM1L protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased phosphorylation of DNM1L protein]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of DNM1L protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DNM1L protein] 		CTD PMID:33651226 PMID:39299507 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]
4-phenylbutyric acid results in decreased expression of EDEM1 mRNA 		CTD PMID:23274897 PMID:28698385 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EEF1E1 mRNA CTD PMID:14583596 NCBI chr17:26,354,247...26,364,953
Ensembl chr17:26,354,228...26,370,687 		JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of EFTUD2 mRNA CTD PMID:14583596 NCBI chr10:88,304,992...88,352,229
Ensembl chr10:88,304,992...88,346,299 		JBrowse link
G Egfl7 EGF-like-domain, multiple 7 increases expression
multiple interactions 		ISO 4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form
[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form 		CTD PMID:19116145 NCBI chr 3:29,802,481...29,814,966
Ensembl chr 3:29,802,690...29,814,951 		JBrowse link
G Ehd3 EH-domain containing 3 increases expression ISO 4-phenylbutyric acid results in increased expression of EHD3 mRNA CTD PMID:14583596 NCBI chr 6:27,392,709...27,417,445
Ensembl chr 6:27,392,709...27,417,445 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF2A protein]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2A protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of EIF2A mRNA]
4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2A protein] 		CTD PMID:31364909 PMID:34175825 PMID:38242296 PMID:38604440 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions 		EXP
ISO 		4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]
4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of EIF2AK3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of EIF2AK3 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased phosphorylation of EIF2AK3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form]
4-phenylbutyric acid results in decreased expression of EIF2AK3 protein; 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form
4-phenylbutyric acid inhibits the reaction [Arecoline results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of EIF2AK3 protein] 		CTD PMID:27470132 PMID:27484784 PMID:27638906 PMID:28063906 PMID:28245985 More... NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
decreases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Sodium Selenite results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid results in decreased expression of and results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid results in decreased expression of EIF2S1 protein modified form
4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA]; 4-phenylbutyric acid inhibits the reaction [anandamide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:20876807 PMID:25295624 PMID:26513129 PMID:26804720 PMID:27484784 More... NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
decreases expression
increases expression 		EXP
ISO 		4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]
4-phenylbutyric acid results in decreased expression of ERN1 protein
4-phenylbutyric acid results in increased expression of ERN1 protein
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid promotes the reaction [Palmitic Acid results in increased expression of ERN1 mRNA] 		CTD PMID:20399799 PMID:23885834 PMID:29444456 PMID:30796460 PMID:33651226 More... NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO 4-phenylbutyric acid results in increased expression of FAAH mRNA CTD PMID:14583596 NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396 		JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO 4-phenylbutyric acid results in decreased expression of FARSB mRNA CTD PMID:14583596 NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:87,336,326...87,395,505 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of FASN mRNA]
4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of FASN mRNA] 		CTD PMID:32407927 PMID:36670177 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fbln1 fibulin 1 increases expression ISO 4-phenylbutyric acid results in increased expression of FBLN1 mRNA CTD PMID:14583596 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of FBXO32 protein] CTD PMID:30980806 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of FGF2 mRNA CTD PMID:14583596 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:33651226 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 multiple interactions ISO 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 7:131,750,828...131,757,784
Ensembl chr 7:131,750,672...131,770,123 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:25398788 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 protein] CTD PMID:36030031 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein] 		CTD PMID:33127495 PMID:34214594 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS5 mRNA CTD PMID:14583596 NCBI chr13:75,836,963...75,840,284 JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of GAS6 mRNA CTD PMID:14583596 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of GJA1 protein] CTD PMID:35533795 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA] CTD PMID:23274897 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of GPT protein]; 4-phenylbutyric acid inhibits the reaction [TAK-875 results in increased expression of GPT protein]; 4-phenylbutyric acid inhibits the reaction [triptolide results in increased expression of GPT protein] 		CTD PMID:27470132 PMID:28063906 PMID:28844859 PMID:30243991 PMID:36520315 More... NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO 4-phenylbutyric acid results in increased expression of GPX3 mRNA CTD PMID:14583596 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of GPX4 protein] CTD PMID:36700298 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO 4-phenylbutyric acid results in increased expression of GRB10 mRNA CTD PMID:14583596 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of GSDMD protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of GSDMD protein] 		CTD PMID:30796460 PMID:35297523 PMID:36646296 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression ISO 4-phenylbutyric acid results in increased expression of GSTA4 mRNA CTD PMID:14583596 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased expression of HDAC3 protein] CTD PMID:34973135 NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025 		JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions 		EXP 4-phenylbutyric acid results in increased expression of HGF mRNA; 4-phenylbutyric acid results in increased expression of HGF protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein] 		CTD PMID:28844859 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HK2 protein] CTD PMID:32569804 PMID:36473502 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HMGA1 mRNA CTD PMID:14583596 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593 		JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HMGA2 protein]; HMGA2 protein inhibits the reaction [4-phenylbutyric acid results in increased expression of MPC1 protein]
4-phenylbutyric acid results in decreased expression of HMGA2 protein 		CTD PMID:36473502 PMID:38992767 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA] CTD PMID:40015660 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPA2B1 mRNA CTD PMID:14583596 NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO 4-phenylbutyric acid results in decreased expression of HNRNPC mRNA CTD PMID:14583596 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:27,253,098...27,282,715 		JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HS6ST mRNA CTD PMID:14583596 NCBI chr 9:45,779,402...45,818,583
Ensembl chr 9:45,779,019...45,818,582 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA1A mRNA CTD PMID:14583596 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA2 mRNA CTD PMID:14583596 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133 		JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO 4-phenylbutyric acid results in increased expression of HSPA4L mRNA CTD PMID:14583596 NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression 		ISO
EXP 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[2,3,5-trichloro-6-phenyl-(1,4)benzoquinone co-treated with malondialdehyde-low density lipoprotein, human] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Arecoline results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [chromium hexavalent ion results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in decreased expression of HSPA5 protein]
4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Acrylamide promotes the reaction [elaidic acid results in increased expression of HSPA5 protein]]; 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [elaidic acid promotes the reaction [Acrylamide results in increased expression of HSPA5 protein]]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA] 		CTD PMID:17459145 PMID:20165829 PMID:23743301 PMID:25295624 PMID:26804720 More... NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of HSPA9 protein] CTD PMID:39442789 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO 4-phenylbutyric acid results in increased expression of HSPH1 mRNA CTD PMID:14583596 NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of ID1 mRNA CTD PMID:14583596 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA] CTD PMID:35413383 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ifng interferon gamma multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNG mRNA]; 4-phenylbutyric acid results in decreased expression of and results in decreased secretion of IFNG protein CTD PMID:35413383 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL10 mRNA] CTD PMID:35413383 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL17A mRNA] CTD PMID:35413383 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of and results in increased secretion of IL18 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased secretion of IL18 protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein] 		CTD PMID:30796460 PMID:35297523 PMID:36646296 PMID:37654027 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1A mRNA] CTD PMID:35413383 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL1B protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] 		CTD PMID:17709599 PMID:28245985 PMID:30796460 PMID:35297523 PMID:35413383 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of IL6 protein]
4-phenylbutyric acid results in decreased expression of IL6 mRNA 		CTD PMID:17709599 PMID:28245985 PMID:28698385 PMID:35413383 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]
4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS1 results in increased uptake of Deoxyglucose]] 		CTD PMID:20165829 PMID:32283200 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]
4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2A protein]; 4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of ERN1 protein] 		CTD PMID:20165829 PMID:32283200 PMID:38604440 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased phosphorylation of IRS1 protein] CTD PMID:31298478 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Kmt5b lysine methyltransferase 5B decreases expression ISO 4-phenylbutyric acid results in decreased expression of KMT5B mRNA CTD PMID:14583596 NCBI chr 1:210,429,672...210,479,042
Ensembl chr 1:210,430,127...210,479,035 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of LDHA protein] CTD PMID:32569804 PMID:36473502 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lepr leptin receptor multiple interactions ISO 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of GPD2 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA]; 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]; 4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of FKBP11 mRNA] CTD PMID:23274897 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Mafa MAF bZIP transcription factor A multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of MAFA mRNA] CTD PMID:23274897 NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:109,313,121...109,315,760 		JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 mRNA]; 4-phenylbutyric acid affects the reaction [decitabine affects the expression of MAGEA9 protein] CTD PMID:17290406 NCBI chr  X:147,655,721...147,661,093
Ensembl chr  X:147,655,721...147,661,093 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [dibromoacetonitrile results in increased expression of and results in increased localization of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]
4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased lipidation of MAP1LC3B protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in increased expression of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein] 		CTD PMID:26804720 PMID:30025493 PMID:36058351 PMID:36640941 PMID:36700298 More... NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression
multiple interactions 		ISO 4-phenylbutyric acid results in decreased expression of MAP3K5 protein
4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] 		CTD PMID:29444456 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation 		EXP
ISO 		4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein]
4-phenylbutyric acid results in decreased phosphorylation of MAPK1 protein 		CTD PMID:21147958 PMID:34520753 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		EXP
ISO 		4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein]
4-phenylbutyric acid results in decreased phosphorylation of MAPK3 protein 		CTD PMID:21147958 PMID:34520753 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO 		4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein]
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of MAPK8 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of MAPK8 protein] 		CTD PMID:21147958 PMID:31364909 PMID:35413383 PMID:38242296 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein] CTD PMID:21147958 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 4-phenylbutyric acid results in decreased expression of MAT2A mRNA CTD PMID:14583596 NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645 		JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 NCBI chr  X:156,932,481...156,995,981
Ensembl chr  X:156,941,234...156,943,560 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of MET mRNA] CTD PMID:28844859 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions 		EXP
ISO 		4-phenylbutyric acid results in increased expression of MFN2 protein
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein]
4-phenylbutyric acid inhibits the reaction [Ficusin results in decreased expression of MFN2 protein]
4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of MFN2 protein] 		CTD PMID:33651226 PMID:39299507 PMID:39442789 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mief1 mitochondrial elongation factor 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MIEF1 mRNA CTD PMID:14583596 NCBI chr 7:113,666,918...113,679,550
Ensembl chr 7:113,666,901...113,683,977 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 increases expression
multiple interactions 		ISO 4-phenylbutyric acid results in increased expression of MPC1 protein
4-phenylbutyric acid inhibits the reaction [chromium hexavalent ion results in decreased expression of MPC1 protein]; HMGA2 protein inhibits the reaction [4-phenylbutyric acid results in increased expression of MPC1 protein] 		CTD PMID:38992767 NCBI chr 1:54,985,305...54,996,979
Ensembl chr 1:54,985,301...54,997,064 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased secretion of MPO protein] CTD PMID:35413383 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS18C mRNA CTD PMID:14583596 NCBI chr14:9,116,688...9,122,943 JBrowse link
G Mrps22 mitochondrial ribosomal protein S22 decreases expression ISO 4-phenylbutyric acid results in decreased expression of MRPS22 mRNA CTD PMID:14583596 NCBI chr 8:108,063,468...108,076,638
Ensembl chr 8:108,063,471...108,076,638 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of ND1 protein] CTD PMID:36473502 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation 		ISO 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in decreased phosphorylation of MTOR protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of MTOR protein]
4-phenylbutyric acid results in decreased phosphorylation of MTOR protein 		CTD PMID:28245985 PMID:36640941 PMID:37148176 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NCF1 protein] CTD PMID:20399799 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of NCOA4 protein] CTD PMID:36700298 NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NDE1 mRNA CTD PMID:14583596 NCBI chr10:1,347,010...1,391,167
Ensembl chr10:1,347,018...1,383,447 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO 		4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of NFE2L2 protein]
ALPI protein inhibits the reaction [4-phenylbutyric acid results in increased phosphorylation of NFE2L2 protein] 		CTD PMID:20399799 PMID:32407927 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:28245985 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NIFK mRNA CTD PMID:14583596 NCBI chr13:31,946,119...31,955,950
Ensembl chr13:31,946,108...31,959,561 		JBrowse link
G Nkx6-1 NK6 homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA] CTD PMID:23274897 NCBI chr14:8,274,238...8,281,171
Ensembl chr14:8,274,238...8,281,163 		JBrowse link
G Nln neurolysin decreases expression ISO 4-phenylbutyric acid results in decreased expression of NLN mRNA CTD PMID:14583596 NCBI chr 2:36,867,436...36,966,749
Ensembl chr 2:36,853,551...36,966,680 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]
4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of NLRP3 protein]
4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] 		CTD PMID:30796460 PMID:35297523 PMID:36646296 PMID:37654027 PMID:37692514 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOLC1 mRNA CTD PMID:14583596 NCBI chr 1:254,870,195...254,881,070
Ensembl chr 1:254,870,319...254,881,069 		JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of NOM1 mRNA CTD PMID:14583596 NCBI chr 4:6,562,931...6,586,093
Ensembl chr 4:6,567,836...6,585,036 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of NR1D2 mRNA CTD PMID:14583596 NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330 		JBrowse link
G Ocln occludin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of OCLN protein] CTD PMID:35533795 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in decreased expression of OPA1 protein] CTD PMID:39299507 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955 		JBrowse link
G Ostn osteocrin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of OSTN mRNA] CTD PMID:30602124 NCBI chr11:86,947,023...86,983,322
Ensembl chr11:86,947,313...86,973,427 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PADI2 mRNA CTD PMID:28698385 NCBI chr 5:158,492,087...158,534,662
Ensembl chr 5:158,492,066...158,534,662 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions
increases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]
4-phenylbutyric acid results in increased expression of PARK7 mRNA; 4-phenylbutyric acid results in increased expression of PARK7 protein
[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Hydrogen Peroxide; [4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine 		CTD PMID:17459145 PMID:21372141 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [pendulone results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein] 		CTD PMID:27578021 PMID:27634458 PMID:29981725 PMID:32407927 PMID:34214594 More... NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO 4-phenylbutyric acid results in decreased expression of PAWR mRNA CTD PMID:14583596 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492 		JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PCX mRNA] CTD PMID:23274897 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940 		JBrowse link
G Pdcd2l programmed cell death 2-like decreases expression ISO 4-phenylbutyric acid results in decreased expression of PDCD2L mRNA CTD PMID:14583596 NCBI chr 1:95,947,476...95,959,738
Ensembl chr 1:95,947,476...95,959,906 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of PDX1 mRNA] CTD PMID:23274897 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PHGDH protein] CTD PMID:39427783 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein] CTD PMID:37692514 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of PKM protein] CTD PMID:32569804 PMID:36473502 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLE4 mRNA CTD PMID:14583596 NCBI chr 4:116,723,040...116,728,873
Ensembl chr 4:116,716,719...116,728,851 		JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression ISO 4-phenylbutyric acid results in decreased expression of POLR1H mRNA CTD PMID:14583596 NCBI chr20:1,600,170...1,604,088
Ensembl chr20:1,595,945...1,604,088 		JBrowse link
G Polr2a RNA polymerase II subunit A increases expression
decreases expression 		ISO 4-phenylbutyric acid results in increased expression of POLR2A mRNA
4-phenylbutyric acid results in decreased expression of POLR2A mRNA 		CTD PMID:14583596 NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA] CTD PMID:36670177 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]
4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA] 		CTD PMID:20165829 PMID:28482072 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of PPIL1 mRNA CTD PMID:14583596 NCBI chr20:7,303,919...7,323,962
Ensembl chr20:7,303,922...7,318,781 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein] CTD PMID:17709599 PMID:36700298 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]
4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of PYCARD protein] 		CTD PMID:30796460 PMID:36646296 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rbm8a RNA binding motif protein 8A decreases expression ISO 4-phenylbutyric acid results in decreased expression of RBM8A mRNA CTD PMID:14583596 NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:186,854,036...186,856,802 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [honokiol results in decreased expression of RELA protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:28245985 PMID:34973135 PMID:36646296 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of RMDN3 protein] CTD PMID:39442789 NCBI chr 3:126,579,811...126,601,016
Ensembl chr 3:126,579,812...126,600,418 		JBrowse link
G Rnf185 ring finger protein 185 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of RNF185 protein] CTD PMID:34958886 NCBI chr14:82,516,153...82,554,199
Ensembl chr14:82,516,154...82,553,466 		JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO 4-phenylbutyric acid results in decreased expression of RPL7A mRNA CTD PMID:14583596 NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression ISO 4-phenylbutyric acid results in increased expression of HLA-E mRNA CTD PMID:14583596 NCBI chr20:4,872,720...4,876,425 JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression ISO 4-phenylbutyric acid results in decreased expression of SARNP mRNA CTD PMID:14583596 NCBI chr 7:1,835,597...1,889,833
Ensembl chr 7:1,835,597...1,897,295 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of SESN2 protein] CTD PMID:32407927 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255 		JBrowse link
G Sftpc surfactant protein C multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased cleavage of CTSD protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ADAM17 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of ATF6 protein]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased phosphorylation of EIF2S1 protein] CTD PMID:27638906 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the phosphorylation of EIF2S1 protein] CTD PMID:29653943 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc22a18 solute carrier family 22, member 18 increases expression ISO 4-phenylbutyric acid results in increased expression of SLC67A1 mRNA CTD PMID:14583596 NCBI chr 1:208,100,032...208,124,382
Ensembl chr 1:208,101,136...208,124,380 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of SLC2A1 protein] CTD PMID:32569804 PMID:36473502 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO 		4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA] CTD PMID:22215663 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619 		JBrowse link
G Slc44a2 solute carrier family 44 member 2 increases expression ISO 4-phenylbutyric acid results in increased expression of CTL2 mRNA CTD PMID:14583596 NCBI chr 8:28,147,023...28,181,496
Ensembl chr 8:28,147,030...28,181,495 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions
increases expression 		ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [4-phenylbutyric acid results in increased expression of SLC5A6 protein] CTD PMID:36005737 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of SLC7A11 protein] CTD PMID:36700298 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slu7 SLU7 homolog, splicing factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of SLU7 mRNA CTD PMID:14583596 NCBI chr10:28,406,908...28,425,253
Ensembl chr10:28,409,846...28,425,250 		JBrowse link
G Snca synuclein alpha multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; 4-phenylbutyric acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:17459145 PMID:21372141 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Snx5 sorting nexin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SNX5 mRNA CTD PMID:14583596 NCBI chr 3:152,075,258...152,094,508
Ensembl chr 3:152,075,258...152,094,877 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; [4-phenylbutyric acid co-treated with Thapsigargin] results in increased expression of SOD1 mRNA CTD PMID:32578922 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
increases expression 		EXP 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]
4-phenylbutyric acid results in increased expression of SOD3 mRNA 		CTD PMID:21804221 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SOX4 mRNA CTD PMID:14583596 NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Particulate Matter results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [SC-66 compound results in decreased expression of SQSTM1 protein]
4-phenylbutyric acid results in increased expression of SQSTM1 protein 		CTD PMID:32569804 PMID:33127495 PMID:36640941 PMID:36700298 PMID:37741534 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP
ISO 		4-phenylbutyric acid inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 4-phenylbutyric acid inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]
4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA] 		CTD PMID:25398788 PMID:36670177 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srsf10 serine and arginine rich splicing factor 10 decreases expression ISO 4-phenylbutyric acid results in decreased expression of SRSF10 mRNA CTD PMID:14583596 NCBI chr 5:153,372,307...153,386,520
Ensembl chr 5:153,372,316...153,386,513 		JBrowse link
G Syvn1 synoviolin 1 decreases expression
multiple interactions 		ISO
EXP 		4-phenylbutyric acid results in decreased expression of SYVN1 mRNA
4-phenylbutyric acid inhibits the reaction [Streptozocin results in decreased expression of SYVN1 protein] 		CTD PMID:14583596 PMID:30980806 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP1 mRNA CTD PMID:14583596 NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:83,110,062...83,209,657 		JBrowse link
G Tax1bp3 Tax1 binding protein 3 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TAX1BP3 mRNA CTD PMID:14583596 NCBI chr10:58,294,357...58,298,875
Ensembl chr10:58,294,073...58,298,875 		JBrowse link
G Tg thyroglobulin multiple interactions ISO 4-phenylbutyric acid inhibits the reaction [Amiodarone results in decreased expression of TG protein]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TG protein] CTD PMID:25295624 PMID:36005737 NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TGFB1 protein CTD PMID:25450231 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Th tyrosine hydroxylase increases expression ISO 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 decreases expression ISO 4-phenylbutyric acid results in decreased expression of TIMM50 mRNA CTD PMID:14583596 NCBI chr 1:92,702,437...92,710,311
Ensembl chr 1:92,702,437...92,710,311 		JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 increases expression
decreases expression 		ISO 4-phenylbutyric acid results in increased expression of TMED5 mRNA
4-phenylbutyric acid results in decreased expression of TMED5 mRNA 		CTD PMID:14583596 NCBI chr14:1,752,857...1,763,990
Ensembl chr14:1,752,745...1,773,389 		JBrowse link
G Tmpo thymopoietin decreases expression ISO 4-phenylbutyric acid results in decreased expression of TMPO mRNA CTD PMID:14583596 NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		ISO 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of TNF protein]
4-phenylbutyric acid results in decreased expression of TNF mRNA 		CTD PMID:27578021 PMID:28245985 PMID:28698385 PMID:35413383 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:30980806 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tra2a transformer 2 alpha decreases expression ISO 4-phenylbutyric acid results in decreased expression of TRA2A mRNA CTD PMID:14583596 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO 4-phenylbutyric acid results in increased expression of TSC2 mRNA CTD PMID:14583596 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600 		JBrowse link
G Tsr1 TSR1, ribosome maturation factor decreases expression ISO 4-phenylbutyric acid results in decreased expression of TSR1 mRNA CTD PMID:14583596 NCBI chr10:60,258,790...60,270,238
Ensembl chr10:60,258,784...60,274,309 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
affects expression 		ISO [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein; [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein; [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein
4-phenylbutyric acid affects the expression of TUBB3 protein 		CTD PMID:18497984 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UBA1 protein] CTD PMID:30980806 NCBI chr  X:4,062,216...4,084,192
Ensembl chr  X:4,062,182...4,084,246 		JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBA6 mRNA CTD PMID:14583596 NCBI chr14:22,238,832...22,302,650
Ensembl chr14:22,211,601...22,302,650 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Chlormequat results in increased expression of UBE2D1 protein] CTD PMID:34958886 NCBI chr20:17,308,459...17,341,427
Ensembl chr20:17,331,646...17,341,427 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO 4-phenylbutyric acid results in decreased expression of UBE2W mRNA CTD PMID:14583596 NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:7,474,003...7,598,245 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL1 protein] CTD PMID:30980806 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417 		JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL5 protein] CTD PMID:30980806 NCBI chr13:58,070,947...58,106,825
Ensembl chr13:58,042,029...58,107,441 		JBrowse link
G Umod uromodulin increases expression ISO 4-phenylbutyric acid results in increased expression of UMOD protein; 4-phenylbutyric acid results in increased expression of UMOD protein mutant form CTD PMID:24567330 NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:183,247,674...183,261,030 		JBrowse link
G Utp4 UTP4 small subunit processome component decreases expression ISO 4-phenylbutyric acid results in decreased expression of UTP4 mRNA CTD PMID:14583596 NCBI chr19:51,696,437...51,730,323
Ensembl chr19:51,701,739...51,730,325 		JBrowse link
G Vapb VAMP associated protein B and C multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of VAPB protein] CTD PMID:39442789 NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619 		JBrowse link
G Vcp valosin-containing protein multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of VCP protein] CTD PMID:30980806 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of VDAC1 protein] CTD PMID:39442789 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions 		EXP 4-phenylbutyric acid results in decreased expression of VEGFA protein
4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of VEGFA protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of VEGFA protein] 		CTD PMID:28844859 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wdr4 WD repeat domain 4 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WDR4 mRNA CTD PMID:14583596 NCBI chr20:9,588,532...9,604,718
Ensembl chr20:9,588,532...9,605,007 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO 4-phenylbutyric acid results in decreased expression of WWTR1 mRNA CTD PMID:14583596 NCBI chr 2:143,801,181...143,916,941
Ensembl chr 2:143,801,181...143,991,950 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [[Amiodarone results in increased splicing of XBP1 mRNA] which results in increased expression of XBP1 mRNA alternative form]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [bisphenol A results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [SFTPC protein mutant form results in increased expression of XBP1 protein alternative form]
4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of XBP1 protein alternative form]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]]; 4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [titanium dioxide results in increased splicing of XBP1 mRNA]
4-phenylbutyric acid results in decreased expression of XBP1 protein alternative form 		CTD PMID:20165829 PMID:23274897 PMID:25295624 PMID:27578021 PMID:27638906 More... NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xpo5 exportin 5 decreases expression ISO 4-phenylbutyric acid results in decreased expression of XPO5 mRNA CTD PMID:14583596 NCBI chr 9:22,237,760...22,275,745
Ensembl chr 9:22,237,760...22,275,745 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of YTHDF2 mRNA CTD PMID:14583596 NCBI chr 5:149,665,467...149,693,127
Ensembl chr 5:149,665,325...149,689,941 		JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO 4-phenylbutyric acid results in decreased expression of ZBTB2 mRNA CTD PMID:14583596 NCBI chr 1:43,232,839...43,252,115
Ensembl chr 1:43,232,839...43,252,614 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20870
    role 20828
      application 20631
        pro-agent 12345
          prodrug 12106
            4-phenylbutyric acid 245
Path 2
Term Annotations click to browse term
  CHEBI ontology 20870
    subatomic particle 20868
      composite particle 20868
        hadron 20868
          baryon 20868
            nucleon 20868
              atomic nucleus 20868
                atom 20868
                  main group element atom 20791
                    p-block element atom 20791
                      carbon group element atom 20724
                        carbon atom 20719
                          organic molecular entity 20719
                            heteroorganic entity 20223
                              organochalcogen compound 19908
                                organooxygen compound 19811
                                  carbon oxoacid 19156
                                    carboxylic acid 19153
                                      monocarboxylic acid 18302
                                        fatty acid 17000
                                          short-chain fatty acid 16026
                                            fatty acid 4:0 8297
                                              butyric acid 6783
                                                4-phenylbutyric acid 245
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