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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CARBENOXOLONE
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Accession:CHEBI:41462 term browser browse the term
Definition:A triterpenoid that has formula C34H50O7.
Synonyms:xref_mesh: MESH:D002229



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CARBENOXOLONE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Carbenoxolone affects the expression of AKT1 mRNA CTD PMID:23678415 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein
[perfluorooctanoic acid co-treated with Carbenoxolone] results in increased expression of BAX protein
CTD PMID:32971237 PMID:33242459 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
ISO
EXP
Carbenoxolone affects the expression of BCL2 mRNA
[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein
[perfluorooctanoic acid co-treated with Carbenoxolone] results in decreased expression of BCL2 protein
CTD PMID:23678415 PMID:32971237 PMID:33242459 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein]
[perfluorooctanoic acid co-treated with Carbenoxolone] results in increased cleavage of CASP3 protein
CTD PMID:32971237 PMID:33242459 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein] CTD PMID:33242459 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:27523796 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Carbenoxolone affects the expression of CYCS mRNA CTD PMID:23678415 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Carbenoxolone results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP GJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate] CTD PMID:26926986 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity
multiple interactions
ISO
EXP
Carbenoxolone results in decreased activity of HSD11B1 protein
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]
CTD PMID:23814014 PMID:24135201 PMID:27523796 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO
EXP
Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:16857225 PMID:23814014 PMID:24135201 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Carbenoxolone co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27523796 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Carbenoxolone inhibits the reaction [Sodium Glutamate results in increased secretion of INS1 protein] CTD PMID:31077719 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27523796 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27523796 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] CTD PMID:32006539 PMID:32531310 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27523796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Panx1 Pannexin 1 multiple interactions
decreases activity
ISO Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
Carbenoxolone results in decreased activity of PANX1 protein
CTD PMID:19023039 PMID:19213873 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:27523796 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases activity
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]
Carbenoxolone results in decreased activity of SGK1 protein
CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 mRNA]; Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 protein] CTD PMID:31077719 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
affects activity
EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SREBF1 mRNA]
Carbenoxolone affects the activity of SREBF1 protein
CTD PMID:31077719 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO Carbenoxolone affects the expression of STAT1 mRNA CTD PMID:23678415 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27523796 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 affects expression ISO Carbenoxolone affects the expression of TP53 mRNA CTD PMID:23678415 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] CTD PMID:31077719 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      atom 19832
        nonmetal atom 19770
          carbon atom 19727
            organic molecular entity 19727
              isoprenoid 13835
                terpenoid 13532
                  triterpenoid 872
                    CARBENOXOLONE 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19105
                            organic hydride 18665
                              organic fundamental parent 18665
                                hydrocarbon 18401
                                  terpene 13835
                                    triterpene 876
                                      triterpenoid 872
                                        CARBENOXOLONE 27
paths to the root