|
G |
Akt1 |
AKT serine/threonine kinase 1 |
affects expression |
ISO |
Carbenoxolone affects the expression of AKT1 mRNA |
CTD |
PMID:23678415 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein [perfluorooctanoic acid co-treated with Carbenoxolone] results in increased expression of BAX protein |
CTD |
PMID:32971237 PMID:33242459 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression multiple interactions |
ISO EXP |
Carbenoxolone affects the expression of BCL2 mRNA [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein [perfluorooctanoic acid co-treated with Carbenoxolone] results in decreased expression of BCL2 protein |
CTD |
PMID:23678415 PMID:32971237 PMID:33242459 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein] [perfluorooctanoic acid co-treated with Carbenoxolone] results in increased cleavage of CASP3 protein |
CTD |
PMID:32971237 PMID:33242459 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein] |
CTD |
PMID:33242459 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] |
CTD |
PMID:27523796 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cycs |
cytochrome c, somatic |
affects expression |
ISO |
Carbenoxolone affects the expression of CYCS mRNA |
CTD |
PMID:23678415 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Dhrs11 |
dehydrogenase/reductase 11 |
decreases activity |
ISO |
Carbenoxolone results in decreased activity of DHRS11 protein |
CTD |
PMID:30926317 |
|
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP |
GJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate] |
CTD |
PMID:26926986 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
|
|
G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases activity multiple interactions |
ISO EXP |
Carbenoxolone results in decreased activity of HSD11B1 protein Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA] |
CTD |
PMID:23814014 PMID:24135201 PMID:27523796 |
|
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases activity |
ISO EXP |
Carbenoxolone results in decreased activity of HSD11B2 protein |
CTD |
PMID:16857225 PMID:23814014 PMID:24135201 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
ISO |
[Carbenoxolone co-treated with NADP] binds to HSD3B1 protein |
CTD |
PMID:25526675 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:27523796 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Carbenoxolone inhibits the reaction [Sodium Glutamate results in increased secretion of INS1 protein] |
CTD |
PMID:31077719 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:27523796 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:27523796 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] |
CTD |
PMID:32006539 PMID:32531310 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:27523796 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Panx1 |
Pannexin 1 |
multiple interactions decreases activity |
ISO |
Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate] Carbenoxolone results in decreased activity of PANX1 protein |
CTD |
PMID:19023039 PMID:19213873 |
|
NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:27523796 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions decreases activity |
EXP |
Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA] Carbenoxolone results in decreased activity of SGK1 protein |
CTD |
PMID:16533503 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 mRNA]; Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 protein] |
CTD |
PMID:31077719 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions affects activity |
EXP |
Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SREBF1 mRNA] Carbenoxolone affects the activity of SREBF1 protein |
CTD |
PMID:31077719 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
affects expression |
ISO |
Carbenoxolone affects the expression of STAT1 mRNA |
CTD |
PMID:23678415 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] |
CTD |
PMID:27523796 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
affects expression |
ISO |
Carbenoxolone affects the expression of TP53 mRNA |
CTD |
PMID:23678415 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Ube2i |
ubiquitin-conjugating enzyme E2I |
multiple interactions |
EXP |
Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] |
CTD |
PMID:31077719 |
|
NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443 Ensembl chr10:69,701,618...69,702,443
|
|