Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:celecoxib
go back to main search page
Accession:CHEBI:41423 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Synonyms:exact_synonym: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
 related_synonym: Celebrex;   Formula=C17H14F3N3O2S;   InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25);   InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F;   celecoxibum;   p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
 alt_id: CHEBI:3520;   CHEBI:41418
 xref: CAS:169590-42-5;   CAS:184007-95-2;   DrugBank:DB00482;   Drug_Central:568;   HMDB:HMDB0005014;   KEGG:C07589;   KEGG:D00567;   LINCS:LSM-2032
 xref_mesh: MESH:C105934
 xref: PDBeChem:CEL;   PMID:17983259;   PMID:18405470;   PMID:19137124;   PMID:19203891;   PMID:21955617;   PMID:22141388;   PMID:22419293;   PMID:22971036;   PMID:23296687;   PMID:23506230;   PMID:28166217;   Reaxys:8280770;   Wikipedia:Celecoxib


show annotations for term's descendants           Sort by:
 
celecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Celecoxib results in decreased activity of ABCB11 protein
Celecoxib inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:22646477 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases methylation
multiple interactions
increases expression
decreases activity
ISO Celecoxib results in decreased expression of ABCB1 protein
Celecoxib results in increased methylation of ABCB1 promoter
[Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Tamoxifen
Celecoxib results in increased expression of ABCB1 mRNA
Celecoxib results in decreased activity of ABCB1A protein
CTD PMID:15458769 PMID:19562670 PMID:21745461 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression
increases expression
ISO Celecoxib results in decreased expression of ABCC1 mRNA
Celecoxib results in increased expression of ABCC1 mRNA
CTD PMID:18202791 PMID:21745461 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Celecoxib results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Celecoxib results in increased expression of ABCC4 mRNA; Celecoxib results in increased expression of ABCC4 protein CTD PMID:18690847 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Celecoxib results in increased expression of ABCC5 mRNA; Celecoxib results in increased expression of ABCC5 protein CTD PMID:18690847 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 affects expression ISO Celecoxib affects the expression of ABCF1 mRNA CTD PMID:20562220 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Abcf2 ATP binding cassette subfamily F member 2 affects expression ISO Celecoxib affects the expression of ABCF2 mRNA CTD PMID:20562220 NCBI chr 4:7,122,850...7,135,607
Ensembl chr 4:7,122,890...7,135,669
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Celecoxib results in decreased expression of ABCG2 mRNA CTD PMID:18202791 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acan aggrecan affects expression EXP Celecoxib affects the expression of ACAN mRNA CTD PMID:16273290 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
ISO donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Celecoxib results in increased activity of ACHE protein] CTD PMID:18208924 PMID:18343489 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Celecoxib results in decreased expression of ACTA2 mRNA; Celecoxib results in decreased expression of ACTA2 protein
CTD PMID:16420518 PMID:19201774 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akap1 A-kinase anchoring protein 1 affects expression ISO Celecoxib affects the expression of AKAP1 mRNA CTD PMID:20562220 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases expression
affects phosphorylation
decreases phosphorylation
decreases activity
increases phosphorylation
ISO
EXP
AKT1 protein results in decreased susceptibility to Celecoxib
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]
Celecoxib results in decreased expression of AKT1 protein
Celecoxib affects the phosphorylation of AKT1 protein
Celecoxib analog results in decreased phosphorylation of AKT1 protein; Celecoxib results in decreased phosphorylation of AKT1 protein
Celecoxib results in decreased activity of AKT1 protein
Celecoxib analog results in increased phosphorylation of AKT1 protein; Celecoxib results in increased phosphorylation of AKT1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with Docetaxel] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased phosphorylation of AKT1 protein; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]; Celecoxib results in decreased phosphorylation of and results in decreased activity of AKT1 protein
CTD PMID:10753955 PMID:12000750 PMID:12464646 PMID:14654083 PMID:15499625 PMID:15570007 PMID:15688368 PMID:17257745 PMID:17270149 PMID:17285134 PMID:17908994 PMID:18172863 PMID:19201774 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP Celecoxib inhibits the reaction [Gentamicins results in decreased expression of ALB protein] CTD PMID:31628940 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects localization EXP celecoxib increases the release of aldh2 protein from the mitochondrial matrix RGD PMID:29491208 RGD:15036803 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C affects expression ISO Celecoxib affects the expression of ALDOC mRNA CTD PMID:20562220 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein] CTD PMID:12376474 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G App amyloid beta precursor protein affects cleavage ISO Celecoxib affects the cleavage of APP protein CTD PMID:14690522 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
EXP
ISO
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein
Celecoxib results in decreased expression of AR protein
CTD PMID:15570007 PMID:17908994 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 affects expression ISO Celecoxib affects the expression of ATP6AP2 mRNA CTD PMID:20562220 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) affects expression ISO Celecoxib affects the expression of ATP9A mRNA CTD PMID:20562220 NCBI chr 3:165,405,588...165,511,104
Ensembl chr 3:165,412,803...165,477,771
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
decreases response to substance
ISO
EXP
Celecoxib analog results in increased expression of BAK1 protein; Celecoxib results in increased expression of BAK1 mRNA; Celecoxib results in increased expression of BAK1 protein
BAK1 results in decreased susceptibility to Celecoxib
CTD PMID:18349538 PMID:19428934 PMID:19682443 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
increases activity
ISO Celecoxib results in decreased expression of BAX mRNA
Celecoxib results in increased expression of BAX protein
[docetaxel co-treated with Celecoxib] results in increased expression of BAX protein; [tetracycline CMT-3 co-treated with Celecoxib] results in increased expression of BAX protein; BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; Celecoxib results in increased activity of and results in increased localization of BAX protein
Celecoxib results in increased activity of BAX protein
CTD PMID:15688368 PMID:17342322 PMID:17368424 PMID:17952603 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases response to substance
increases expression
multiple interactions
ISO BBC3 results in increased susceptibility to Celecoxib
Celecoxib results in increased expression of BBC3; Celecoxib results in increased expression of BBC3 protein
BBC3 mutant form inhibits the reaction [Celecoxib results in increased activity of and results in increased localization of BAX protein]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]
CTD PMID:17368424 PMID:18760266 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO Celecoxib results in increased cleavage of and results in increased localization of BCAR1 protein CTD PMID:16353145 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [docetaxel results in increased expression of BCL2 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased expression of BCL2 protein]; tetraarsenic tetrasulfide promotes the reaction [Celecoxib results in decreased expression of BCL2 protein]
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of BCL2 protein]
Celecoxib results in increased expression of BCL2 mRNA
CTD PMID:15688368 PMID:15911099 PMID:16230411 PMID:16391871 PMID:17342322 PMID:17612393 PMID:20104024 PMID:26586936 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
decreases expression
ISO [Celecoxib co-treated with docetaxel] results in decreased expression of BCL2L1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased expression of BCL2L1 protein; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in increased expression of BCL2L1 mRNA
Celecoxib results in decreased expression of BCL2L1 protein
CTD PMID:15688368 PMID:17342322 PMID:20104024 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions
ISO Celecoxib results in increased cleavage of BID protein
[ABT-737 co-treated with Celecoxib] results in increased cleavage of BID protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]
CTD PMID:15197583 PMID:15572759 PMID:20104024 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases expression
affects binding
ISO [Celecoxib binds to BIRC5 promoter] which results in decreased expression of BIRC5 mRNA; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein
Celecoxib results in increased expression of BIRC5 mRNA
Celecoxib results in decreased expression of BIRC5 mRNA; Celecoxib results in decreased expression of BIRC5 protein
CTD PMID:16004971 PMID:16123214 PMID:16707021 PMID:17270149 PMID:17342322 PMID:17466271 PMID:18634847 PMID:21268125 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Celecoxib binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO Celecoxib binds to and results in decreased activity of CA2 protein
Celecoxib results in decreased activity of CA2 protein
CTD PMID:16858005 PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity
increases cleavage
increases expression
ISO
EXP
Celecoxib analog results in decreased expression of CASP3 protein; Celecoxib results in decreased expression of CASP3 protein
Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]
Celecoxib results in increased activity of CASP3 protein
Celecoxib results in increased cleavage of CASP3 protein
Celecoxib results in increased expression of CASP3 protein
3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP3 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP3 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [Docetaxel results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib results in increased activity of and results in increased expression of CASP3 protein; Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein; Docetaxel promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]
Celecoxib results in increased activity of CASP3; Celecoxib results in increased activity of CASP3 protein
CTD PMID:10753955 PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 PMID:15688368 PMID:16123214 PMID:17201140 PMID:17461495 PMID:17466271 PMID:17761345 PMID:18172863 PMID:18202791 PMID:19635192 PMID:19665451 PMID:19682443 PMID:20104024 PMID:24932515 PMID:31628940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein] CTD PMID:15572759 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
affects activity
ISO Celecoxib results in increased activity of CASP7; Celecoxib results in increased activity of CASP7 protein
Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]
Celecoxib analog affects the activity of CASP7 protein
CTD PMID:15572759 PMID:18202791 PMID:18485224 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP8 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
Celecoxib analog results in increased activity of CASP8 protein; Celecoxib results in increased activity of CASP8 protein
CTD PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 PMID:18172863 PMID:20104024 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage
ISO 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP9 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP9 protein; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]
Celecoxib results in increased activity of CASP9 protein
CTD PMID:12824303 PMID:15197583 PMID:15499625 PMID:15572759 PMID:15688368 PMID:17201140 PMID:17612393 PMID:17761345 PMID:18172863 PMID:19665451 PMID:20104024 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO Celecoxib results in decreased expression of CAT protein
Celecoxib inhibits the reaction [Smoke results in increased activity of CAT protein]
CTD PMID:18848576 PMID:21280565 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 increases expression ISO Celecoxib results in increased expression of CAV1 protein CTD PMID:18848576 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Celecoxib inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]
Celecoxib results in decreased expression of CCL2 mRNA
CTD PMID:12902868 PMID:20039930 PMID:24530660 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Celecoxib results in decreased expression of CCL5 mRNA CTD PMID:12902868 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Celecoxib affects the expression of CCNB1 CTD PMID:19846907 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 affects expression
multiple interactions
decreases expression
ISO
EXP
Celecoxib affects the expression of CCND1
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of CCND1 protein]
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein
Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
Celecoxib results in decreased expression of CCND1 mRNA; Celecoxib results in decreased expression of CCND1 protein
CTD PMID:15489888 PMID:16060994 PMID:17270149 PMID:17908994 PMID:19846907 PMID:32416088 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Celecoxib results in decreased expression of CCND2 mRNA; Celecoxib results in decreased expression of CCND2 protein CTD PMID:19428934 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CCR2 mRNA CTD PMID:12902868
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO Celecoxib results in decreased expression of CCR5 mRNA CTD PMID:12902868 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA] CTD PMID:19194550 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
affects expression
ISO Celecoxib analog results in increased expression of CDH1 protein; Celecoxib results in increased expression of CDH1 mRNA; Celecoxib results in increased expression of CDH1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]
Celecoxib affects the expression of CDH1 protein
CTD PMID:17224647 PMID:19682443 PMID:29932878 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Celecoxib results in decreased expression of CDK2 protein; Celecoxib results in decreased expression of CDK2 protein modified form CTD PMID:16136956 PMID:19428934 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Celecoxib results in decreased expression of CDK4 protein CTD PMID:16136956 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases localization
increases expression
ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1A protein]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1A protein]
Celecoxib results in increased localization of CDKN1A protein
Celecoxib results in increased expression of CDKN1A mRNA; Celecoxib results in increased expression of CDKN1A protein
CTD PMID:16136956 PMID:18172863 PMID:19141979 PMID:19706164 PMID:21737646 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1B protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]
Celecoxib results in increased expression of CDKN1B mRNA; Celecoxib results in increased expression of CDKN1B protein
CTD PMID:18172863 PMID:19428934 PMID:21737646 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of CEBPA mRNA] CTD PMID:19247274 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Celecoxib results in decreased expression of CFLAR CTD PMID:17145853 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
Celecoxib results in decreased expression of COL1A1 mRNA
CTD PMID:16420518 PMID:19201774 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein] CTD PMID:32416088 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crp C-reactive protein decreases expression ISO Celecoxib results in decreased expression of CRP CTD PMID:12551863 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of CRYAB mRNA] CTD PMID:16420518 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Celecoxib affects the localization of CTNNB1 protein; Celecoxib analog affects the localization of CTNNB1 protein CTD PMID:19682443 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO Celecoxib results in decreased expression of CXCR1 mRNA CTD PMID:12902868 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Celecoxib results in decreased expression of CXCR2 mRNA CTD PMID:12902868 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO Celecoxib results in decreased activity of CYP19A1 protein
Celecoxib results in decreased expression of CYP19A1 mRNA
CTD PMID:15964185 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Celecoxib results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dap3 death associated protein 3 affects expression ISO Celecoxib affects the expression of DAP3 mRNA CTD PMID:20562220 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
affects expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]
Celecoxib results in increased expression of DDIT3; Celecoxib results in increased expression of DDIT3 protein
Celecoxib analog affects the expression of DDIT3 protein
CTD PMID:16463383 PMID:18485224 PMID:20104024 PMID:21567098 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Des desmin multiple interactions
increases expression
ISO PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA] CTD PMID:18089846 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dffa DNA fragmentation factor subunit alpha multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein] CTD PMID:15572759 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Celecoxib affects the expression of DHCR24 mRNA CTD PMID:20562220 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein] CTD PMID:25656942 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of EDNRB protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]; Celecoxib results in decreased susceptibility to [BQ 788 binds to and results in decreased activity of EDNRB protein] CTD PMID:24462674 PMID:25656942 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 PMID:17908994 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Emc3 ER membrane protein complex subunit 3 affects expression ISO Celecoxib affects the expression of EMC3 mRNA CTD PMID:20562220 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Fadd Fas associated via death domain multiple interactions
affects response to substance
ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]
FADD affects the susceptibility to Celecoxib
CTD PMID:15197583 PMID:15572759 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Celecoxib promotes the reaction [FAS protein binds to FADD protein]
Celecoxib results in increased expression of FAS mRNA; Celecoxib results in increased expression of FAS protein
CTD PMID:15197583 PMID:19141979 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase decreases activity
multiple interactions
ISO Celecoxib results in decreased activity of FASN protein
Dinoprostone promotes the reaction [Celecoxib results in decreased activity of FASN protein]
CTD PMID:19159447 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression
EXP
ISO
Celecoxib affects the expression of FOS protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of FOS protein]
Celecoxib results in decreased expression of FOS protein
CTD PMID:18988310 PMID:19463908 PMID:32416088 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Celecoxib results in increased expression of GDF15; Celecoxib results in increased expression of GDF15 mRNA
[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA; GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]
CTD PMID:17257745 PMID:17959037 PMID:18089846 PMID:20067113 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gorasp2 golgi reassembly stacking protein 2 affects expression ISO Celecoxib affects the expression of GORASP2 mRNA CTD PMID:20562220 NCBI chr 3:56,966,654...56,995,369
Ensembl chr 3:56,966,654...56,995,369
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]; PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Celecoxib results in increased expression of GPX1 protein CTD PMID:20883674 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA] CTD PMID:21589914 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA] CTD PMID:21589914 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA] CTD PMID:21589914 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA] CTD PMID:21589914 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] CTD PMID:21589914 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA CTD PMID:21589914 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA CTD PMID:21589914 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA CTD PMID:21589914 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA] CTD PMID:21589914 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA] CTD PMID:21589914 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] CTD PMID:21589914 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA] CTD PMID:21589914 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012
JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B multiple interactions ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA] CTD PMID:21589914 NCBI chr 7:12,764,993...12,771,310
Ensembl chr 7:12,764,993...12,771,310
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
ISO Celecoxib results in decreased phosphorylation of GSK3B protein
GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]
CTD PMID:17257745 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gss glutathione synthetase affects expression ISO Celecoxib affects the expression of GSS mRNA CTD PMID:20562220 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO Celecoxib results in increased expression of GSTP1 mRNA
PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]
CTD PMID:18089846 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of HK2 mRNA] CTD PMID:27452194 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
Celecoxib results in increased expression of HMOX1 protein CTD PMID:19356721 PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Celecoxib co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Celecoxib results in increased expression of HSPA5 CTD PMID:21567098 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]
Celecoxib results in increased expression of ICAM1 mRNA; Celecoxib results in increased expression of ICAM1 protein
CTD PMID:14762100 PMID:26513172 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IFNG protein] CTD PMID:32416088 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in decreased expression of IL10 protein]
Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
CTD PMID:16230411 PMID:24932515 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL17A protein] CTD PMID:32416088 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Celecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of IL1B protein]
CTD PMID:14762100 PMID:15309881 PMID:16230411 PMID:16357062 PMID:20844471 PMID:21893697 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Celecoxib inhibits the reaction [BQ 788 results in increased expression of IL2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of IL2 protein] CTD PMID:24462674 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of IL6; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]; Celecoxib inhibits the reaction [IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of IL6 protein]
CTD PMID:16702388 PMID:24285838 PMID:24530660 PMID:31048000 PMID:32416088 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased expression of JUN protein; Celecoxib promotes the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of JUN protein]
CTD PMID:18172863 PMID:32416088 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lct lactase increases activity EXP Celecoxib results in increased activity of LCT protein CTD PMID:18604318 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of LDHA mRNA] CTD PMID:27452194 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO Celecoxib results in decreased phosphorylation of MAP2K2 protein CTD PMID:16123214 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO
EXP
Celecoxib analog results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK1 protein]
Celecoxib inhibits the reaction [Acetic Acid results in increased activity of MAPK1]; Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Celecoxib analog results in decreased phosphorylation of MAPK1 protein; Celecoxib results in decreased phosphorylation of MAPK1 protein
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK1 protein
CTD PMID:11891194 PMID:12464646 PMID:15499625 PMID:16463383 PMID:18988310 PMID:19682443 PMID:32416088 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK14 protein CTD PMID:16463383 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO
EXP
Celecoxib analog results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK3 protein]
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK3 protein
Celecoxib analog results in decreased phosphorylation of MAPK3 protein; Celecoxib results in decreased phosphorylation of MAPK3 protein
CTD PMID:15499625 PMID:16463383 PMID:18988310 PMID:19682443 PMID:32416088 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Celecoxib inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]
Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]
CTD PMID:16442704 PMID:32416088 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Celecoxib results in decreased expression of MCL1 protein CTD PMID:14654083 PMID:17952603 PMID:19665451 PMID:20836993 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET mRNA]; Celecoxib inhibits the reaction [Acetic Acid results in increased expression of MET protein] CTD PMID:11891194 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions
ISO Celecoxib results in decreased expression of MKI67
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of MKI67 protein]
[FEC protocol co-treated with Celecoxib] results in decreased expression of MKI67 protein
CTD PMID:16507397 PMID:20697803 PMID:32416088 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
affects expression
ISO
EXP
Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 mRNA]; Celecoxib promotes the reaction [arsenic trioxide results in decreased expression of MMP2 protein]
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]
Celecoxib affects the expression of MMP2 mRNA
CTD PMID:16420518 PMID:18438340 PMID:21540248 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of MMP9 protein]
Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]
CTD PMID:16230411 PMID:16420518 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of MPO protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Celecoxib results in increased activity of MPO protein
CTD PMID:15309881 PMID:21893697 PMID:24932515 PMID:31628940 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrps26 mitochondrial ribosomal protein S26 affects expression ISO Celecoxib affects the expression of MRPS26 mRNA CTD PMID:20562220 NCBI chr 3:123,093,264...123,094,927
Ensembl chr 3:123,093,264...123,094,927
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 affects expression ISO Celecoxib affects the expression of MTUS1 mRNA CTD PMID:20562220 NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129
JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression ISO Celecoxib results in decreased expression of MVD CTD PMID:17224647 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Celecoxib analog results in decreased expression of MYC protein; Celecoxib results in decreased expression of MYC protein CTD PMID:19682443 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:15489888 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Celecoxib results in increased expression of NGFR mRNA; Celecoxib results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein]
CTD PMID:21893697 PMID:24932515 PMID:32416088 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Celecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; Celecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA] CTD PMID:19194550 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Celecoxib affects the localization of and results in increased activity of NR3C1 protein CTD PMID:15700047 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO Celecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]; Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]] CTD PMID:16357062 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein affects expression ISO Celecoxib affects the expression of OXA1L mRNA CTD PMID:20562220 NCBI chr15:33,004,957...33,012,584
Ensembl chr15:33,004,133...33,012,575
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases activity
affects cleavage
ISO [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein]
Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein]
Celecoxib results in increased activity of PARP1 protein
Celecoxib analog affects the cleavage of PARP1 protein
CTD PMID:12824303 PMID:15572759 PMID:15688368 PMID:15911099 PMID:16123214 PMID:16230411 PMID:17461495 PMID:17612393 PMID:18172863 PMID:18202791 PMID:18485224 PMID:19665451 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Celecoxib results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO
EXP
Celecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19201774 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases activity
multiple interactions
ISO Celecoxib analog results in decreased activity of PDPK1 protein; Celecoxib results in decreased activity of PDPK1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of and results in decreased expression of PDPK1 protein
CTD PMID:12000750 PMID:15499625 PMID:18172863 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdpn podoplanin decreases expression ISO Celecoxib results in decreased expression of PDPN mRNA CTD PMID:17285134 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP8 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein] CTD PMID:20104024 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [Celecoxib co-treated with docetaxel] results in decreased expression of PLA2G4A protein; Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 PMID:16052515 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plin2 perilipin 2 increases expression ISO Celecoxib results in increased expression of PLIN2 mRNA CTD PMID:19415698 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases response to substance ISO PMAIP1 results in increased susceptibility to Celecoxib CTD PMID:19665451 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Poglut2 protein O-glucosyltransferase 2 affects expression ISO Celecoxib affects the expression of POGLUT2 mRNA CTD PMID:20562220 NCBI chr 9:50,872,492...50,884,596
Ensembl chr 9:50,872,492...50,884,596
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Celecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA] CTD PMID:22902858 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Celecoxib results in increased expression of PPARA mRNA; Celecoxib results in increased expression of PPARA protein CTD PMID:19415698 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Celecoxib analog results in decreased expression of PPARD protein; Celecoxib results in decreased expression of PPARD protein CTD PMID:19682443 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
affects localization
ISO
EXP
2-chloro-5-nitrobenzanilide inhibits the reaction [Celecoxib affects the localization of PPARG protein]; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib affects the localization of PPARG protein]
[Celecoxib co-treated with docetaxel] results in increased expression of PPARG protein
Celecoxib inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]
Celecoxib results in increased expression of PPARG mRNA; Celecoxib results in increased expression of PPARG protein
CTD PMID:16052515 PMID:19247274 PMID:19522023 PMID:23943857 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Celecoxib promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:19293639 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Celecoxib inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Celecoxib results in increased expression of PTGDS protein CTD PMID:23943857 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO Celecoxib inhibits the reaction [PTGER1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene] CTD PMID:21739481 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions EXP Celecoxib inhibits the reaction [Heymann Nephritis Antigenic Complex results in increased expression of PTGER3 mRNA] CTD PMID:14636300 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions EXP [Celecoxib co-treated with Heymann Nephritis Antigenic Complex] affects the expression of PTGER4 mRNA CTD PMID:14636300 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression
ISO
EXP
[Celecoxib co-treated with docetaxel] results in decreased expression of PTGES protein
Celecoxib results in decreased expression of PTGES mRNA
CTD PMID:16052515 PMID:16273290 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO PTGES2 protein affects the reaction [Celecoxib promotes the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31444509 NCBI chr 3:11,424,195...11,431,379
Ensembl chr 3:11,424,099...11,431,402
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression
ISO
EXP
Celecoxib analog results in decreased activity of PTGS1 protein; Celecoxib results in decreased activity of PTGS1 protein
Celecoxib results in decreased expression of PTGS1 mRNA alternative form
CTD PMID:11375891 PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
decreases activity
multiple interactions
increases response to substance
increases expression
ISO
EXP
Celecoxib analog results in decreased expression of PTGS2 protein; Celecoxib results in decreased expression of PTGS2; Celecoxib results in decreased expression of PTGS2 mRNA; Celecoxib results in decreased expression of PTGS2 protein
Celecoxib results in decreased activity of PTGS2 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; Celecoxib inhibits the reaction [BQ 788 results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of PTGS2]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein alternative form
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane A2; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of COL10A1 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Mustard Gas; [Celecoxib results in decreased activity of PTGS2 protein] which results in increased susceptibility to Acetaminophen; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [potassium superoxide results in increased expression of PTGS2 mRNA]; Celecoxib results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
PTGS2 results in increased susceptibility to Celecoxib
Celecoxib results in increased expression of PTGS2 mRNA; Celecoxib results in increased expression of PTGS2 protein
Celecoxib analog results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein; Celecoxib results in decreased activity of PTGS2 protein mutant form
[Celecoxib analog results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein] which results in increased expression of PPARG; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [FEC protocol co-treated with Celecoxib] results in decreased expression of PTGS2 protein; [tetraarsenic tetrasulfide co-treated with Celecoxib] results in decreased expression of PTGS2 protein; Celecoxib binds to and results in decreased activity of PTGS2 protein; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; Celecoxib promotes the reaction [Quercetin results in decreased expression of PTGS2 protein]; Celecoxib results in decreased activity of and results in decreased expression of PTGS2 protein; Celecoxib results in increased expression of and results in increased activity of PTGS2 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Celecoxib results in increased activity of PTGS2 protein]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of DES mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]; PTGS2 protein affects the reaction [Celecoxib results in increased expression of GSTP1 mRNA]
CTD PMID:11743745 PMID:12417326 PMID:12727271 PMID:12888902 PMID:12967936 PMID:15126378 PMID:15197583 PMID:15326064 PMID:15451306 PMID:15465334 PMID:15489888 PMID:15570007 PMID:15870389 PMID:16004971 PMID:16144915 PMID:16507397 PMID:17164136 PMID:17201140 PMID:17224647 PMID:17285134 PMID:17612393 PMID:17908994 PMID:18089846 PMID:18202791 PMID:18485224 PMID:18848576 PMID:18988310 PMID:19024521 PMID:19194550 PMID:19198759 PMID:19201774 PMID:19247274 PMID:19293639 PMID:19356723 PMID:19522023 PMID:19635192 PMID:19682443 PMID:20039930 PMID:20844471 PMID:20883674 PMID:20933508 PMID:21177414 PMID:21268125 PMID:21513785 PMID:21540248 PMID:21893697 PMID:22245433 PMID:23943857 PMID:24462674 PMID:24932515 PMID:25714890 PMID:26586936 PMID:27050768 PMID:28624453 PMID:31628940 PMID:32416088 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pxk PX domain containing serine/threonine kinase affects expression ISO Celecoxib affects the expression of PXK mRNA CTD PMID:20562220 NCBI chr15:18,548,209...18,616,617
Ensembl chr15:18,548,212...18,616,589
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [Atorvastatin co-treated with Celecoxib] results in decreased expression of RB1 protein modified form; [Atorvastatin co-treated with Celecoxib] results in increased expression of RB1 protein
Celecoxib results in increased expression of RB1
CTD PMID:18172863 PMID:19846907 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO
EXP
[irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; Celecoxib inhibits the reaction [Doxorubicin affects the localization of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]
Celecoxib inhibits the reaction [Gentamicins results in increased expression of RELA protein]
Celecoxib results in decreased expression of RELA protein
CTD PMID:15489888 PMID:15570007 PMID:16685529 PMID:17097285 PMID:19635192 PMID:31628940 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases expression EXP Celecoxib results in decreased expression of REN protein CTD PMID:10742298 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein] CTD PMID:18172863 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [Atorvastatin co-treated with Celecoxib] results in increased localization of RHOB protein; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOB protein] CTD PMID:18172863 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOC protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOC protein] CTD PMID:18172863 NCBI chr 2:207,271,692...207,278,010
Ensembl chr 2:207,271,853...207,279,314
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Celecoxib affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 mRNA; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor affects expression ISO Celecoxib affects the expression of SARAF mRNA CTD PMID:20562220 NCBI chr16:61,735,189...61,753,438
Ensembl chr16:61,735,181...61,753,476
JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component affects expression ISO Celecoxib affects the expression of SEC23A mRNA CTD PMID:20562220 NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236
JBrowse link
G Sele selectin E multiple interactions ISO Celecoxib inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]] CTD PMID:14762100 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Celecoxib promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA] CTD PMID:16420518 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Si sucrase-isomaltase increases activity EXP Celecoxib results in increased activity of SI protein CTD PMID:18604318 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348
JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC16A3 mRNA] CTD PMID:27452194 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression
ISO Celecoxib inhibits the reaction [Nickel results in increased expression of SLC2A1 mRNA]
Celecoxib results in increased expression of SLC2A1 mRNA
CTD PMID:19327236 PMID:27452194 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
decreases expression
affects expression
ISO [Celecoxib results in decreased expression of SLC31A1 protein] which results in decreased import of and results in decreased susceptibility to Cisplatin
Celecoxib affects the expression of SLC31A1 mRNA
CTD PMID:20562220 PMID:21177414 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization
multiple interactions
ISO Celecoxib affects the localization of SNAI1 protein
Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]
CTD PMID:29932878 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Celecoxib results in decreased expression of SOD2 protein CTD PMID:18848576 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] CTD PMID:29396848 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Celecoxib co-treated with ABT-737] results in decreased expression of SQSTM1 protein CTD PMID:20104024 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Celecoxib results in increased expression of SSTR2 protein CTD PMID:17959037 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Celecoxib inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein CTD PMID:21268125 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sts steroid sulfatase multiple interactions ISO Celecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
affects activity
ISO Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]
Celecoxib affects the activity of SULT2A1 protein
CTD PMID:15483193 PMID:17239972 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP Celecoxib inhibits the reaction [Cyclosporine results in increased expression of TGFB1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Celecoxib results in decreased expression of TGFB1 mRNA
CTD PMID:19194550 PMID:19201774 PMID:24462674 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA CTD PMID:16420518 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tm9sf4 transmembrane 9 superfamily member 4 affects expression ISO Celecoxib affects the expression of TM9SF4 mRNA CTD PMID:20562220 NCBI chr 3:148,635,822...148,689,961
Ensembl chr 3:148,635,775...148,688,553
JBrowse link
G Tmem131 transmembrane protein 131 affects expression ISO Celecoxib affects the expression of TMEM131 mRNA CTD PMID:20562220 NCBI chr 9:43,357,866...43,515,317
Ensembl chr 9:43,358,588...43,454,078
JBrowse link
G Tmx2 thioredoxin-related transmembrane protein 2 affects expression ISO Celecoxib affects the expression of TMX2 mRNA CTD PMID:20562220 NCBI chr 3:72,073,429...72,081,079
Ensembl chr 3:72,073,431...72,081,079
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
[Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of TNF; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Celecoxib results in decreased expression of TNF protein
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of TNF protein]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Celecoxib inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of TNF protein]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of TNF protein]
CTD PMID:15489888 PMID:16230411 PMID:16702388 PMID:17908994 PMID:19247274 PMID:20039930 PMID:20844471 PMID:21893697 PMID:24530660 PMID:24932515 PMID:31048000 PMID:31628940 PMID:32416088 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Celecoxib results in increased expression of TNFRSF10A mRNA; Celecoxib results in increased expression of TNFRSF10A protein CTD PMID:15572759 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases secretion
increases expression
ISO Celecoxib results in decreased secretion of TNFRSF11B protein
Celecoxib results in increased expression of TNFRSF11B mRNA
CTD PMID:19327236 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP6 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP7 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of BID protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of DFFA protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein] CTD PMID:15572759 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
increases response to substance
ISO
EXP
Celecoxib results in increased expression of TP53 mRNA; Celecoxib results in increased expression of TP53 protein
Celecoxib inhibits the reaction [Gentamicins results in increased expression of TP53 protein]
[Celecoxib co-treated with docetaxel] results in increased expression of TRP53 protein; Celecoxib promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]
TP53 results in increased susceptibility to Celecoxib
[FEC protocol co-treated with Celecoxib] results in decreased expression of TP53 protein; Celecoxib results in increased activity of and results in increased localization of TP53 protein; Celecoxib results in increased expression of and results in increased phosphorylation of TP53 protein; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]
CTD PMID:15458769 PMID:16052515 PMID:16507397 PMID:18202791 PMID:18760266 PMID:19706164 PMID:31628940 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vapb VAMP associated protein B and C affects expression ISO Celecoxib affects the expression of VAPB mRNA CTD PMID:20562220 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
affects expression
increases expression
ISO
EXP
Celecoxib results in decreased expression of VEGFA; Celecoxib results in decreased expression of VEGFA protein
Celecoxib results in decreased expression of VEGFA mRNA; Celecoxib results in decreased expression of VEGFA protein
Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]
[Celecoxib co-treated with docetaxel] results in decreased expression of VEGFA protein; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of VEGFA protein]
Celecoxib affects the expression of VEGFA mRNA
Celecoxib results in increased expression of VEGFA mRNA; Celecoxib results in increased expression of VEGFA protein
CTD PMID:15126378 PMID:16052515 PMID:16230411 PMID:17201140 PMID:17224647 PMID:18438340 PMID:19024521 PMID:21567098 PMID:21893697 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        pharmacological role 18842
          analgesic 13304
            non-narcotic analgesic 12004
              celecoxib 213
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  heteroarene 16526
                                    monocyclic heteroarene 13396
                                      azole 12575
                                        diazole 8253
                                          pyrazoles 1555
                                            celecoxib 213
paths to the root