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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,3-diphenylurea
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Accession:CHEBI:41320 term browser browse the term
Definition:A member of the class of phenylureas that is urea in which one of the hydrogens of each amino group is replaced by a phenyl group. It is present in coconut milk (Cocos nucifera).
Synonyms:related_synonym: 1,3-diphenylcarbamide;   Formula=C13H12N2O;   InChI=1S/C13H12N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h1-10H,(H2,14,15,16);   InChIKey=GWEHVDNNLFDJLR-UHFFFAOYSA-N;   N,N'-diphenylurea;   N-phenyl-N'-phenylurea;   SMILES=C(NC1=CC=CC=C1)(NC2=CC=CC=C2)=O;   carbanilide;   diphenylcarbamide;   diphenylurea;   s-diphenylurea;   sym-diphenylurea
 xref: CAS:102-07-8;   DrugBank:DB07496;   Gmelin:143821;   HMDB:HMDB0032066;   PDBeChem:BSU;   PMID:20727675;   PMID:7498450;   Patent:US2010273876;   Reaxys:782650


show annotations for term's descendants           Sort by:
triclocarban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases expression EXP triclocarban results in increased expression of ACACA mRNA CTD PMID:31576746 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression		 ISO
EXP		 AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of AHR mRNA; triclocarban results in increased expression of AHR protein		 CTD PMID:23524099 PMID:31576746 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor multiple interactions ISO triclocarban analog promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; triclocarban promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Trenbolone Acetate results in increased activity of AR protein] CTD PMID:18795164 PMID:20821581 PMID:20943248 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO triclocarban results in increased expression of ATF4 protein CTD PMID:30592132 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO triclocarban results in increased expression of ATF6 mRNA; triclocarban results in increased expression of ATF6 protein CTD PMID:30592132 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Cers2 ceramide synthase 2 increases expression EXP triclocarban results in increased expression of CERS2 mRNA CTD PMID:31576746 NCBI chr 2:185,579,511...185,587,789
Ensembl chr 2:182,890,493...182,933,314 		JBrowse link
G Cers6 ceramide synthase 6 increases expression EXP triclocarban results in increased expression of CERS6 mRNA CTD PMID:31576746 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:53,630,959...53,876,848 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 [bisphenol A co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [butylparaben co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Genistein co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of CYP1A1 mRNA		 CTD PMID:23524099 PMID:31576746 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [Genistein results in increased expression of CYP1B1 mRNA] CTD PMID:22761658 PMID:23524099 PMID:31576746 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]
triclocarban results in increased expression of CYP2B10 mRNA; triclocarban results in increased expression of CYP2B10 protein
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]		 CTD PMID:22761658 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO triclocarban results in increased expression of EIF2AK3 protein modified form CTD PMID:30592132 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO triclocarban results in increased expression of EIF2S1 protein modified form CTD PMID:30592132 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression		 ISO ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]; triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein]; triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein]
triclocarban results in decreased expression of ESR1 mRNA; triclocarban results in decreased expression of ESR1 protein		 CTD PMID:18795164 PMID:22761658 PMID:23524099 PMID:24740835 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fasn fatty acid synthase increases expression EXP triclocarban results in increased expression of FASN mRNA CTD PMID:31576746 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression EXP triclocarban results in increased expression of FFAR2 mRNA CTD PMID:31576746 NCBI chr 1:95,199,277...95,202,599
Ensembl chr 1:86,072,184...86,075,033 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [triclocarban co-treated with osteum] results in increased expression of GCLM mRNA CTD PMID:38631510 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
decreases expression		 ISO triclocarban results in decreased expression of and affects the localization of GJA1 protein
triclocarban results in decreased expression of GJA1 protein modified form		 CTD PMID:35413382 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjc1 gap junction protein, gamma 1 decreases expression ISO triclocarban results in decreased expression of GJC1 protein CTD PMID:35413382 NCBI chr10:88,262,840...88,285,646
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression EXP triclocarban results in increased expression of GPER1 mRNA CTD PMID:31576746 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [triclocarban co-treated with osteum] results in increased expression of HMOX1 mRNA CTD PMID:38631510 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO triclocarban results in increased expression of HSPA5 mRNA; triclocarban results in increased expression of HSPA5 protein CTD PMID:30592132 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il10 interleukin 10 increases response to substance ISO IL10 gene mutant form results in increased susceptibility to triclocarban CTD PMID:31868902 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP triclocarban results in increased expression of IL1B mRNA CTD PMID:31576746 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
triclocarban results in increased expression of IL6 mRNA		 CTD PMID:21741984 PMID:31576746 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mir193b microRNA 193b increases expression ISO triclocarban results in increased expression of MIR193B mRNA CTD PMID:24740835 NCBI chr10:1,824,944...1,825,026
Ensembl chr10:1,317,742...1,317,824 		JBrowse link
G Mir206 microRNA 206 increases expression ISO triclocarban results in increased expression of MIR206 mRNA CTD PMID:24740835 NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir22 microRNA 22 increases expression ISO triclocarban results in increased expression of MIR22 mRNA CTD PMID:24740835 NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [triclocarban co-treated with osteum] results in increased expression of NFE2L2 mRNA CTD PMID:38631510 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]		 CTD PMID:22761658 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP triclocarban results in increased expression of SCD mRNA CTD PMID:31576746 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO triclocarban results in decreased secretion of SHBG protein CTD PMID:30940137 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 decreases activity
multiple interactions		 EXP
ISO		 triclocarban results in decreased activity of SLC5A5 protein
triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]		 CTD PMID:26827900 PMID:27979590 PMID:32065294 NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression EXP triclocarban results in increased expression of SPTLC2 mRNA CTD PMID:31576746 NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [triclocarban co-treated with osteum] results in increased expression of SQSTM1 mRNA CTD PMID:38631510 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO triclocarban results in increased expression of TFF1 mRNA; triclocarban results in increased expression of TFF1 protein CTD PMID:24740835 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO triclocarban results in decreased expression of TJP1 protein CTD PMID:35413382 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:21741984 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP triclocarban results in decreased activity of TPO protein CTD PMID:26827900 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO triclocarban results in increased expression of UGT1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]		 CTD PMID:22761658 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA] CTD PMID:22761658 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] CTD PMID:22761658 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions		 ISO triclocarban results in increased expression of UGT1A6 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]		 CTD PMID:22761658 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression
multiple interactions		 ISO triclocarban results in increased expression of UGT1A9 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]		 CTD PMID:22761658 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        molecular messenger 18700
          hormone 18534
            plant hormone 8899
              cytokinin 60
                1,3-diphenylurea 43
                  flucofuron 0
                  sulcofuron 0
                  triclocarban 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbon oxoacid 18696
                                    carboxylic acid 18693
                                      carboacyl group 17718
                                        univalent carboacyl group 17718
                                          carbamoyl group 17564
                                            carboxamide 17564
                                              monocarboxylic acid amide 15744
                                                urea 6236
                                                  ureas 6234
                                                    phenylureas 2631
                                                      1,3-diphenylurea 43
                                                        flucofuron 0
                                                        sulcofuron 0
                                                        triclocarban 43
paths to the root