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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mercaptoethanol
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Accession:CHEBI:41218 term browser browse the term
Definition:An alkanethiol that has formula C2H6OS.
Synonyms:exact_synonym: 2-sulfanylethanol
 related_synonym: 2-Mercaptoethanol;   BETA-MERCAPTOETHANOL;   Formula=C2H6OS;   InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2;   InChIKey=DGVVWUTYPXICAM-UHFFFAOYSA-N;   SMILES=OCCS;   Thioglycol
 alt_id: CHEBI:41215;   CHEBI:6766
 xref: Beilstein:773648;   CAS:60-24-2;   DrugBank:DB03345;   Gmelin:1368;   KEGG:C00928
 xref_mesh: MESH:D008623
 xref: PDBeChem:BME;   PMID:6334792



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mercaptoethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Mercaptoethanol co-treated with Ascorbic Acid] results in increased expression of ACTA2 protein CTD PMID:17053324 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein] CTD PMID:24028651 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp11 aquaporin 11 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]] CTD PMID:21251984 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]] CTD PMID:9124401 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp7 aquaporin 7 multiple interactions ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein] CTD PMID:10777495 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mercaptoethanol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Mercaptoethanol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein] CTD PMID:26111761 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Mercaptoethanol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L affects response to substance ISO PIGL protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity ISO Mercaptoethanol results in increased activity of RELA protein CTD PMID:7491977 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase affects response to substance ISO RFFL protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr10:67,740,711...67,803,694
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Mercaptoethanol inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein] CTD PMID:20955755 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions EXP Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc] CTD PMID:16804107 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Mercaptoethanol promotes the reaction [Mercuric Chloride inhibits the reaction [SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins]] CTD PMID:9761775 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]; Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein] CTD PMID:18951995 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases oxidation
ISO Mercaptoethanol inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] promotes the reaction [SOD1 protein binds to SOD1 protein]]
Mercaptoethanol results in increased oxidation of SOD1 protein
CTD PMID:15096637 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 affects response to substance ISO TIAM1 protein affects the susceptibility to Mercaptoethanol deficiency CTD PMID:25250048 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            protective agent 17994
              geroprotector 16933
                mercaptoethanol 23
                  2-methylthioethanol 0
                  sulfocholine + 0
                  thiodiglycol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            inorganic hydride 17893
                              chalcogen hydride 2535
                                sulfur hydride 2069
                                  hydrogen sulfide 2069
                                    thiol group 1953
                                      thiol 1953
                                        alkanethiol 102
                                          mercaptoethanol 23
                                            2-methylthioethanol 0
                                            sulfocholine + 0
                                            thiodiglycol 0
paths to the root