CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mercaptoethanol
Accession: CHEBI:41218
browse the term
Definition: An alkanethiol that has formula C2H6OS.
Synonyms: exact_synonym: 2-sulfanylethanol
related_synonym: 2-Mercaptoethanol; BETA-MERCAPTOETHANOL; Formula=C2H6OS; InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2; InChIKey=DGVVWUTYPXICAM-UHFFFAOYSA-N; SMILES=OCCS; Thioglycol
alt_id: CHEBI:41215; CHEBI:6766
xref: Beilstein:773648; CAS:60-24-2; DrugBank:DB03345; Gmelin:1368; KEGG:C00928
xref_mesh: MESH:D008623
xref: PDBeChem:BME; PMID:6334792
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[Mercaptoethanol co-treated with Ascorbic Acid] results in increased expression of ACTA2 protein
CTD
PMID:17053324
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aqp1
aquaporin 1
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein]
CTD
PMID:24028651
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Aqp11
aquaporin 11
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]]
CTD
PMID:21251984
NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
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Aqp3
aquaporin 3 (Gill blood group)
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]
CTD
PMID:9124401
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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Aqp7
aquaporin 7
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein]
CTD
PMID:10777495
NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
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Casp1
caspase 1
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]
CTD
PMID:25929180
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [Mercaptoethanol results in increased abundance of Hydrogen Peroxide]
CTD
PMID:7491977
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases activity
EXP
Mercaptoethanol results in increased activity of CYP7A1 protein
CTD
PMID:1175606
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Hmox1
heme oxygenase 1
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
CTD
PMID:26111761
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]
CTD
PMID:7476933
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein]
CTD
PMID:10644709
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
CTD
PMID:15907790
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Pigl
phosphatidylinositol glycan anchor biosynthesis, class L
affects response to substance
ISO
PIGL protein affects the susceptibility to Mercaptoethanol deficiency
CTD
PMID:25250048
NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145
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Rela
RELA proto-oncogene, NF-kB subunit
increases activity
ISO
Mercaptoethanol results in increased activity of RELA protein
CTD
PMID:7491977
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
affects response to substance
ISO
RFFL protein affects the susceptibility to Mercaptoethanol deficiency
CTD
PMID:25250048
NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
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Slc2a1
solute carrier family 2 member 1
multiple interactions
ISO
Mercaptoethanol inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]
CTD
PMID:20955755
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc39a10
solute carrier family 39 member 10
multiple interactions
EXP
Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]
CTD
PMID:16804107
NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
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Slc3a2
solute carrier family 3 member 2
multiple interactions
ISO
Mercaptoethanol promotes the reaction [Mercuric Chloride inhibits the reaction [SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins]]
CTD
PMID:9761775
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc9a1
solute carrier family 9 member A1
multiple interactions
ISO
Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]; Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein]
CTD
PMID:18951995
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Sod1
superoxide dismutase 1
multiple interactions increases oxidation
ISO
Mercaptoethanol inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] promotes the reaction [SOD1 protein binds to SOD1 protein]] Mercaptoethanol results in increased oxidation of SOD1 protein
CTD
PMID:15096637
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions increases expression
ISO
[Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA]
CTD
PMID:7476933
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Tiam1
TIAM Rac1 associated GEF 1
affects response to substance
ISO
TIAM1 protein affects the susceptibility to Mercaptoethanol deficiency
CTD
PMID:25250048
NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901
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Tnf
tumor necrosis factor
multiple interactions
ISO
[Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA]
CTD
PMID:7476933
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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