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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butane-1,4-diol
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Accession:CHEBI:41189 term browser browse the term
Definition:A butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16degreeC) with a high boiling point (230degreeC), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF).
Synonyms:related_synonym: 1,4-BD;   1,4-BUTANEDIOL;   1,4-butylene glycol;   1,4-dihydroxybutane;   1,4-tetramethylene glycol;   Formula=C4H10O2;   HO(CH2)4OH;   HOCH2CH2CH2CH2OH;   InChI=1S/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2;   InChIKey=WERYXYBDKMZEQL-UHFFFAOYSA-N;   SMILES=OCCCCO;   tetramethylene 1,4-diol;   tetramethylene glycol
 xref: CAS:110-63-4;   DrugBank:DB01955;   PDBeChem:BU1;   PMID:11803699;   PMID:15298490;   PMID:16193534;   PMID:17854202;   PMID:18203723;   PMID:19915428;   PMID:20112336;   PMID:21548140;   PMID:21602812;   Reaxys:1633445;   Wikipedia:1\,4-Butanediol


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(-)-secoisolariciresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO secoisolariciresinol results in increased activity of NR1I2 protein CTD PMID:15885729 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
busulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 decreases response to substance ISO ADRB2 protein results in decreased susceptibility to Busulfan CTD PMID:7202579 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein CTD PMID:20933509 NCBI chr 5:62,070,709...62,094,633
Ensembl chr 5:62,071,346...62,094,633
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions ISO Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions
affects response to substance
ISO ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Busulfan
CTD PMID:17264767 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein CTD PMID:20933509 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Busulfan results in decreased expression of BMP4 mRNA CTD PMID:15786497 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767, PMID:18339423, PMID:19732952, PMID:20933509 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Busulfan results in increased activity of CASP8 protein
[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]
CTD PMID:18339423, PMID:19732952 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] CTD PMID:19732952, PMID:20933509 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein CTD PMID:20933509 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Busulfan results in decreased expression of CDK2 mRNA CTD PMID:15388331 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Busulfan results in increased expression of CDKN1A protein
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein
CTD PMID:16882877, PMID:20933509 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Busulfan affects the expression of COL4A1 mRNA CTD PMID:15941629 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Faslg Fas ligand decreases expression ISO Busulfan results in decreased expression of FASL mRNA CTD PMID:15388331 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP Busulfan results in decreased expression of FGF8 mRNA CTD PMID:15786497 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Gdnf glial cell derived neurotrophic factor affects expression
increases expression
ISO Busulfan affects the expression of GDNF mRNA
Busulfan results in increased expression of GDNF mRNA
CTD PMID:20684317, PMID:22082982, PMID:26524245 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression
ISO Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects response to substance
affects metabolic processing
affects abundance
decreases response to substance
ISO GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]
GSTA1 polymorphism affects the susceptibility to Busulfan
GSTA1 gene polymorphism affects the metabolism of Busulfan; GSTA1 protein affects the metabolism of Busulfan
GSTA1 gene polymorphism affects the abundance of Busulfan
GSTA1 protein results in decreased susceptibility to Busulfan
CTD PMID:8886613, PMID:10437668, PMID:10570028, PMID:12429583, PMID:20672371, PMID:21135089, PMID:21215809, PMID:21441958 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing
affects abundance
affects response to substance
multiple interactions
ISO GSTM1 protein affects the metabolism of Busulfan
GSTM1 gene polymorphism affects the abundance of Busulfan
GSTM1 gene polymorphism affects the susceptibility to Busulfan
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]
CTD PMID:8886613, PMID:15142875, PMID:19584821, PMID:20672371, PMID:21215809, PMID:28744217 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects abundance
ISO GSTP1 protein affects the metabolism of Busulfan
GSTP1 gene polymorphism affects the abundance of Busulfan
CTD PMID:8886613, PMID:20672371 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan CTD PMID:21215809 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Busulfan results in increased phosphorylation of H2AX protein
[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein
CTD PMID:18339423, PMID:20933509 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Inhba inhibin subunit beta A multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein]
Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein
CTD PMID:12966370, PMID:22286157 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Busulfan results in decreased expression of KIT mRNA CTD PMID:15388331 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO Busulfan affects the expression of LAMA1 mRNA CTD PMID:15941629 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO Busulfan affects the expression of LAMA4 mRNA CTD PMID:15941629 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Busulfan results in increased activity of MAPK1 protein CTD PMID:16882877 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Busulfan results in increased activity of MAPK3 protein CTD PMID:16882877 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases response to substance ISO MGST2 protein results in decreased susceptibility to Busulfan CTD PMID:15779864 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein CTD PMID:20933509 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanos2 nanos C2HC-type zinc finger 2 decreases expression ISO Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein CTD PMID:26524245 NCBI chr 1:79,894,450...79,895,910
Ensembl chr 1:79,894,450...79,895,910
JBrowse link
G Nanos3 nanos C2HC-type zinc finger 3 decreases expression ISO Busulfan results in decreased expression of NANOS3 mRNA CTD PMID:26524245 NCBI chr19:25,284,907...25,288,680
Ensembl chr19:25,284,909...25,288,335
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of NFE2L2 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]
CTD PMID:32416107 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]
Busulfan results in increased cleavage of PARP1 protein
CTD PMID:18339423, PMID:19732952, PMID:20933509 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phb prohibitin affects expression ISO Busulfan affects the expression of PHB mRNA CTD PMID:15388331 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Busulfan results in increased expression of PTGS2 mRNA
ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]
CTD PMID:12966370, PMID:32416107 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Busulfan results in decreased expression of RAD51 mRNA CTD PMID:15388331 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases expression ISO Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein CTD PMID:28578006 NCBI chr10:56,227,703...56,229,796
Ensembl chr10:56,227,692...56,229,850
JBrowse link
G Serpinc1 serpin family C member 1 affects expression ISO Busulfan affects the expression of SERPINC1 protein CTD PMID:15580502 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions
ISO Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]
CTD PMID:22286157 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of SLC40A1 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]
CTD PMID:32416107 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein CTD PMID:20933509 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Busulfan results in decreased expression of STRA8 mRNA CTD PMID:15388331 NCBI chr 4:62,447,724...62,474,802
Ensembl chr 4:62,457,694...62,473,360
JBrowse link
G Tf transferrin multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA]
Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein
CTD PMID:12966370, PMID:22286157 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Busulfan results in decreased expression of TFPI mRNA CTD PMID:22286157 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
ISO Busulfan results in decreased expression of TFRC protein
Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein]
CTD PMID:32416107 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Busulfan results in increased expression of TGFB1 mRNA CTD PMID:22286157 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Busulfan results in increased expression of THBS1 mRNA CTD PMID:22286157 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Busulfan results in increased expression of TNF mRNA CTD PMID:22286157 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Busulfan affects the phosphorylation of and affects the activity of TP53 protein CTD PMID:16882877 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Busulfan results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein CTD PMID:20933509 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 increases expression ISO Busulfan results in increased expression of ZBTB16 mRNA CTD PMID:26524245 NCBI chr 8:52,980,226...53,146,765
Ensembl chr 8:52,985,313...53,146,953
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pro-agent 8855
          prodrug 8621
            butane-1,4-diol 62
              1,4-diacetoxybutane 0
              busulfan 61
              naproxcinod 0
              secoisolariciresinol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              organic hydroxy compound 18661
                                polyol 7807
                                  diol 2719
                                    butanediols 143
                                      butanediol 66
                                        butane-1,4-diol 62
                                          1,4-diacetoxybutane 0
                                          busulfan 61
                                          naproxcinod 0
                                          secoisolariciresinol + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.