Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
go back to main search page
Accession:CHEBI:41072 term browser browse the term
Definition:An indole that has formula C25H24N4O2.
Synonyms:xref_mesh: MESH:C070515


show annotations for term's descendants           Sort by:
 
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA] CTD PMID:11331069 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO bisindolylmaleimide I inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
bisindolylmaleimide I inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 mRNA]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
bisindolylmaleimide I inhibits the reaction [AGT protein results in increased expression of KDR mRNA]
CTD PMID:12409145 PMID:15005273 PMID:18250367 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; bisindolylmaleimide I results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:16236484 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein] CTD PMID:10779545 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases activity EXP bisindolylmaleimide I results in decreased activity of ALPL protein CTD PMID:11171635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Areg amphiregulin multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]] CTD PMID:22643241 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO bisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA] CTD PMID:14529614 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [INS protein results in increased expression of ATP1A1 protein] CTD PMID:22162761 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases activity EXP bisindolylmaleimide I results in decreased activity of ATP2A2 protein CTD PMID:17003265 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin multiple interactions EXP bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP bisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]] CTD PMID:17376781 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of CCN2 mRNA] CTD PMID:10026205 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO bisindolylmaleimide I inhibits the reaction [4-phenylenediamine results in increased expression of CD86 protein]; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]; bisindolylmaleimide I inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein] CTD PMID:24136171 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 mRNA]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 protein] CTD PMID:28780155 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP
ISO
bisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]
CTD PMID:27554787 PMID:29149324 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CLDN1 mRNA] CTD PMID:28780155 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cnn1 calponin 1 decreases expression ISO bisindolylmaleimide I results in decreased expression of CNN1 mRNA; bisindolylmaleimide I results in decreased expression of CNN1 protein CTD PMID:15380616 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]
bisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
CTD PMID:16280361 PMID:19282384 PMID:22138297 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Aflatoxin B1 results in increased expression of CRH mRNA] CTD PMID:26026912 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of CXCL12 mRNA]] CTD PMID:22643241 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
EXP bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]; bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]
bisindolylmaleimide I results in decreased expression of EDN1 mRNA; bisindolylmaleimide I results in decreased expression of EDN1 protein
CTD PMID:12169099 PMID:15245872 PMID:16080914 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; bisindolylmaleimide I inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egf epidermal growth factor multiple interactions EXP bisindolylmaleimide I inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:11742803 PMID:12947092 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; bisindolylmaleimide I inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein] CTD PMID:15723263 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of EGR1 protein] CTD PMID:29149324 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12720544 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
ISO bisindolylmaleimide I results in increased expression of ESR1 protein
[Estradiol co-treated with bisindolylmaleimide I] results in increased expression of ESR1 mRNA
CTD PMID:12927369 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]; bisindolylmaleimide I inhibits the reaction [indoleacetic acid results in increased expression of F3 protein] CTD PMID:30324315 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP bisindolylmaleimide I promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA]
bisindolylmaleimide I promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]
CTD PMID:11742803 PMID:12403780 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of FOS protein]
bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]
CTD PMID:11687581 PMID:12112414 PMID:29149324 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA] CTD PMID:29149324 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of GJA1 protein] CTD PMID:15685554 PMID:16352648 PMID:18445782 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO bisindolylmaleimide I promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:61,563,458...61,576,818
Ensembl chr18:61,563,053...61,576,818
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [puerarin results in increased expression of HMOX1 protein] CTD PMID:20060010 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]
bisindolylmaleimide I results in increased expression of HSP90AA1 mRNA
CTD PMID:12927369 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA]; bisindolylmaleimide I promotes the reaction [bisphenol A results in increased expression of HSPA1B mRNA]
bisindolylmaleimide I results in increased expression of HSPA1B mRNA
CTD PMID:12927369 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression EXP bisindolylmaleimide I results in increased expression of HTR2A mRNA CTD PMID:22791651 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions ISO bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein] CTD PMID:18758753 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:16285992 PMID:23114885 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il11 interleukin 11 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il12b interleukin 12B multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16330529 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il5 interleukin 5 decreases activity ISO bisindolylmaleimide I results in decreased activity of IL5 protein CTD PMID:12562334 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; bisindolylmaleimide I inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein] CTD PMID:24631921 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein] CTD PMID:12966370 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Ins2 insulin 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [INS protein results in increased expression of ATP1A1 protein]; bisindolylmaleimide I inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:22162761 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein]
bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of JUN protein]
bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]; bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA]
CTD PMID:12169099 PMID:18628248 PMID:29149324 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of KCNIP2 mRNA] CTD PMID:16385079 NCBI chr 1:265,549,610...265,573,393
Ensembl chr 1:265,549,593...265,573,409
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:15005273 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of LHB mRNA] CTD PMID:29149324 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:11861786 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:11861786 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]
bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I promotes the reaction [muconaldehyde results in increased phosphorylation of MAPK1 protein]
bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]
CTD PMID:11687581 PMID:11861786 PMID:12083801 PMID:12460746 PMID:12720544 PMID:14511371 PMID:14610070 PMID:15231676 PMID:15690152 PMID:16407847 PMID:17080406 PMID:17306214 PMID:17620283 PMID:18445782 PMID:18628248 PMID:18758753 PMID:18950629 PMID:20522546 PMID:22162761 PMID:29149324 PMID:30205134 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK14 protein]
bisindolylmaleimide I inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK14 protein]
CTD PMID:15925026 PMID:16407847 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression
ISO
EXP
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of MAPK3 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]
bisindolylmaleimide I results in decreased expression of MAPK3 mRNA
bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I promotes the reaction [muconaldehyde results in increased phosphorylation of MAPK3 protein]
bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]
CTD PMID:11687581 PMID:11861786 PMID:12083801 PMID:12460746 PMID:12720544 PMID:14511371 PMID:14610070 PMID:15231676 PMID:15690152 PMID:16407847 PMID:17080406 PMID:17306214 PMID:17620283 PMID:18445782 PMID:18628248 PMID:18758753 PMID:18950629 PMID:20522546 PMID:22162761 PMID:23288142 PMID:28780155 PMID:29149324 PMID:30205134 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions
ISO bisindolylmaleimide I results in decreased expression of MAPK8 mRNA
bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of MAPK8 mRNA]
CTD PMID:28780155 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; bisindolylmaleimide I inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 PMID:19447859 PMID:23288142 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:8273558 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; bisindolylmaleimide I inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; bisindolylmaleimide I inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA]
bisindolylmaleimide I results in decreased expression of MT1 mRNA
CTD PMID:11551972 PMID:15142038 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [Glucose affects the localization of NCF1 protein]; bisindolylmaleimide I inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]
bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of and results in increased phosphorylation of NCF1 protein]
CTD PMID:17320767 PMID:17916771 PMID:25980585 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Hydrogen Peroxide results in increased activity of [RELA protein binds to NFKB1 protein]]; bisindolylmaleimide I inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11961005 PMID:14527959 PMID:23114885 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
bisindolylmaleimide I inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin]
CTD PMID:12815188 PMID:17324588 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NR0B1 protein] CTD PMID:18787026 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NR4A1 protein] CTD PMID:19282384 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO
EXP
bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein] CTD PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Ocln occludin multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Cadmium Chloride affects the localization of OCLN protein]; bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of OCLN protein]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of OCLN mRNA]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of OCLN protein] CTD PMID:25851441 PMID:28780155 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G P2ry1 purinergic receptor P2Y1 multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
CTD PMID:16236484 PMID:17620283 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]
bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]
CTD PMID:16407847 PMID:22155090 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein] CTD PMID:12223454 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pgr progesterone receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]] CTD PMID:22643241 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein] CTD PMID:16714034 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein] CTD PMID:16714034 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein] CTD PMID:16714034 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Pld1 phospholipase D1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein] CTD PMID:11243883 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA]; bisindolylmaleimide I inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA] CTD PMID:11701232 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein] CTD PMID:16945329 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] CTD PMID:20172950 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein] CTD PMID:16285992 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
decreases expression
ISO bisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCD protein]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of PRKCD mRNA]
bisindolylmaleimide I results in decreased expression of PRKCD mRNA
CTD PMID:15380616 PMID:16285992 PMID:28780155 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases expression
ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]]
bisindolylmaleimide I results in decreased expression of PRKCE mRNA
bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of PRKCE mRNA]
CTD PMID:24496235 PMID:28780155 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkd1 protein kinase D1 multiple interactions ISO bisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKD1 protein] CTD PMID:15380616 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
bisindolylmaleimide I inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
CTD PMID:17084486 PMID:19084589 PMID:19576865 PMID:21262218 PMID:27818125 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone multiple interactions ISO bisindolylmaleimide I inhibits the reaction [PTH protein results in decreased uptake of Phosphates] CTD PMID:27432882 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose affects the localization of RAC1 protein] CTD PMID:17916771 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased phosphorylation of RAF1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RAF1 protein] CTD PMID:14623285 PMID:29149324 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO bisindolylmaleimide I inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO bisindolylmaleimide I results in increased expression of RB1 mRNA; bisindolylmaleimide I results in increased expression of RB1 protein CTD PMID:14653808 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Hydrogen Peroxide results in increased activity of [RELA protein binds to NFKB1 protein]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; bisindolylmaleimide I inhibits the reaction [VEGFA protein affects the localization of RELA protein] CTD PMID:11961005 PMID:14527959 PMID:15308628 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12720544 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Tretinoin co-treated with bisindolylmaleimide I] results in decreased phosphorylation of RXRA protein CTD PMID:15225641 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sele selectin E multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of SELE mRNA]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of SELE protein] CTD PMID:16285992 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 mRNA]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]; bisindolylmaleimide I inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA] CTD PMID:12409145 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein] CTD PMID:12112414 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
ISO bisindolylmaleimide I inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein]; bisindolylmaleimide I inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; bisindolylmaleimide I inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; bisindolylmaleimide I promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]
bisindolylmaleimide I results in decreased expression of SOD2 protein
CTD PMID:9852137 PMID:15308628 PMID:15330761 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor increases expression
multiple interactions
ISO
EXP
bisindolylmaleimide I results in increased expression of SP1 mRNA; bisindolylmaleimide I results in increased expression of SP1 protein
bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein]
CTD PMID:12499119 PMID:14653808 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP
bisindolylmaleimide I inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR protein]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein]
bisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
CTD PMID:18787026 PMID:19282384 PMID:27554787 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of STAT3 protein] CTD PMID:24496235 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sts steroid sulfatase multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tagln transgelin decreases expression ISO bisindolylmaleimide I results in decreased expression of TAGLN mRNA CTD PMID:15380616 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 protein]] CTD PMID:22643241 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP bisindolylmaleimide I inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]; bisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]; bisindolylmaleimide I inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Cadmium Chloride affects the localization of TJP1 protein]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 mRNA]; bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 protein] CTD PMID:25851441 PMID:28780155 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA] CTD PMID:17306214 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO bisindolylmaleimide I results in decreased degradation of and results in increased expression of TP53 protein CTD PMID:16055726 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein] CTD PMID:18809416 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP bisindolylmaleimide I inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; bisindolylmaleimide I promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; bisindolylmaleimide I promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of VCAM1 protein] CTD PMID:16285992 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions EXP
ISO
bisindolylmaleimide I inhibits the reaction [Calcitriol results in increased expression of VDR mRNA]; bisindolylmaleimide I inhibits the reaction [Chenodeoxycholic Acid results in increased expression of VDR mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VDR mRNA]
bisindolylmaleimide I inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]
CTD PMID:18829283 PMID:20006981 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
bisindolylmaleimide I inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA]; bisindolylmaleimide I inhibits the reaction [VEGFA protein affects the localization of RELA protein]; bisindolylmaleimide I inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]; bisindolylmaleimide I inhibits the reaction [VEGFA protein results in increased expression of ACE protein]; bisindolylmaleimide I promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]
bisindolylmaleimide I results in decreased expression of VEGFA mRNA
CTD PMID:11158990 PMID:12590138 PMID:14704231 PMID:15308628 PMID:18210215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Yy1 YY1 transcription factor multiple interactions
decreases expression
ISO bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of YY1 protein]
bisindolylmaleimide I results in decreased expression of YY1 protein
CTD PMID:32363662 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          nitrogen atom 18646
            nitrogen molecular entity 18646
              organonitrogen compound 18422
                organonitrogen heterocyclic compound 17582
                  benzopyrrole 9549
                    indoles 9219
                      3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione 131
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteropolycyclic compound 17907
                                    organic heterobicyclic compound 16828
                                      benzopyrrole 9549
                                        indoles 9219
                                          3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione 131
paths to the root