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ONTOLOGY REPORT - ANNOTATIONS


Term:doramapimod
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Accession:CHEBI:40953 term browser browse the term
Definition:A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
Synonyms:exact_synonym: N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
 related_synonym: 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea;   1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;   BIRB-796;   Formula=C31H37N5O3;   InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37);   InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N;   SMILES=C(=O)(NC=1N(N=C(C1)C(C)(C)C)C=2C=CC(=CC2)C)NC=3C4=C(C=CC=C4)C(=CC3)OCCN5CCOCC5
 alt_id: MESH:C452139
 xref: CAS:285983-48-4 "ChemIDplus";   KEGG:D03736;   LINCS:LSM-1170
 xref_mesh: MESH:C452139
 xref: PDBeChem:B96;   PMID:11896401 "Europe PMC";   PMID:19244237 "Europe PMC";   PMID:20655210 "Europe PMC";   PMID:23685672 "Europe PMC";   PMID:25358442 "Europe PMC";   PMID:25589935 "Europe PMC";   PMID:26044359 "Europe PMC";   PMID:26232862 "Europe PMC";   Reaxys:9170597 "Reaxys"


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doramapimod term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Actg2 actin gamma 2, smooth muscle JBrowse link 4 115,215,160 115,239,746 RGD:6480464
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6480464
G Ahsg alpha-2-HS-glycoprotein JBrowse link 11 81,711,269 81,717,594 RGD:6480464
G Ak5 adenylate kinase 5 JBrowse link 2 257,671,772 257,864,385 RGD:6480464
G Akr1b7 aldo-keto reductase family 1, member B7 JBrowse link 4 61,850,256 61,879,733 RGD:6480464
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:6480464
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:6480464
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:6480464
G Ca3 carbonic anhydrase 3 JBrowse link 2 88,126,519 88,136,063 RGD:6480464
G Cd5l Cd5 molecule-like JBrowse link 2 186,685,104 186,696,117 RGD:6480464
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:6480464
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:6480464
G Ces3a carboxylesterase 3a JBrowse link 19 37,070,705 37,079,411 RGD:6480464
G Clec1b C-type lectin domain family 1, member B JBrowse link 4 163,161,941 163,170,470 RGD:6480464
G Ctss cathepsin S JBrowse link 2 197,655,780 197,679,768 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:6480464
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:6480464
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6480464
G Cyss cystatin S JBrowse link 3 144,427,430 144,431,768 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:6480464
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gpx2 glutathione peroxidase 2 JBrowse link 6 99,839,960 99,843,245 RGD:6480464
G Grm8 glutamate metabotropic receptor 8 JBrowse link 4 54,474,344 55,409,526 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta6 glutathione S-transferase alpha 6 JBrowse link 9 27,475,273 27,533,939 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 2 210,685,338 210,688,133 RGD:6480464
G Hp haptoglobin JBrowse link 19 42,096,255 42,100,805 RGD:6480464
G Hpd 4-hydroxyphenylpyruvate dioxygenase JBrowse link 12 38,828,606 38,839,956 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Kcnk1 potassium two pore domain channel subfamily K member 1 JBrowse link 19 58,823,836 58,862,926 RGD:6480464
G Lmod1 leiomodin 1 JBrowse link 13 52,147,099 52,189,835 RGD:6480464
G Meig1 meiosis/spermiogenesis associated 1 JBrowse link 17 78,813,656 78,829,411 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mybpc1 myosin binding protein C, slow type JBrowse link 7 29,086,159 29,171,909 RGD:6480464
G Myh11 myosin heavy chain 11 JBrowse link 10 764,421 859,184 RGD:6480464
G Myh3 myosin heavy chain 3 JBrowse link 10 53,621,375 53,645,194 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Olr59 olfactory receptor 59 JBrowse link 1 167,906,030 167,940,688 RGD:6480464
G Otog otogelin JBrowse link 1 102,258,124 102,327,201 RGD:6480464
G Pfn2 profilin 2 JBrowse link 2 147,953,858 147,959,692 RGD:6480464
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Prm2 protamine 2 JBrowse link 10 4,950,484 4,950,920 RGD:6480464
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:6480464
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:6480464
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:6480464
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 JBrowse link 20 29,654,926 29,679,927 RGD:6480464
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 JBrowse link 5 166,913,734 166,978,534 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Stmn2 stathmin 2 JBrowse link 2 95,424,251 95,471,900 RGD:6480464
G Vsig4 V-set and immunoglobulin domain containing 4 JBrowse link X 65,370,851 65,400,298 RGD:6480464
G Zfp324 zinc finger protein 324 JBrowse link 1 65,604,342 65,612,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        immunomodulator 12649
          doramapimod 61
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  urea 4932
                                                    ureas 4929
                                                      doramapimod 61
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.