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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azoxystrobin
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Accession:CHEBI:40909 term browser browse the term
Definition:An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.
Synonyms:exact_synonym: methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyprop-2-enoate
 related_synonym: (alphaE)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene) benzeneacetic acid methyl ester;   Formula=C22H17N3O5;   InChI=1S/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+;   InChIKey=WFDXOXNFNRHQEC-GHRIWEEISA-N;   SMILES=CO\\C=C(\\C(=O)OC)c1ccccc1Oc1cc(Oc2ccccc2C#N)ncn1;   methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylate
 xref: Beilstein:8350244;   CAS:131860-33-8;   KEGG:C18558
 xref_mesh: MESH:C087670
 xref: PDBeChem:AZO;   PMID:20818521;   PMID:21153804;   PMID:21671616;   PMID:21777591;   PMID:21884765;   PMID:22092932;   PMID:22224459;   PMID:22278367;   PMID:24125711;   PMID:24405376;   PMID:24700092;   PMID:24726979;   PMID:25011117;   PMID:25090100;   PMID:25196149;   PPDB:54;   Patent:EP382375;   Patent:US5395837;   Pesticides:azoxystrobin;   Reaxys:8350244;   Wikipedia:Azoxystrobin


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azoxystrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
ISO
EXP
azoxystrobin results in increased phosphorylation of ACACA protein
[azoxystrobin co-treated with Dietary Fats] affects the phosphorylation of ACACA protein
dorsomorphin inhibits the reaction [azoxystrobin results in increased phosphorylation of ACACA protein]
CTD PMID:24726979 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO azoxystrobin results in decreased phosphorylation of AKT1 protein CTD PMID:32339800 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arg1 arginase 1 decreases expression ISO azoxystrobin results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO azoxystrobin results in increased expression of CYP1A1 mRNA; azoxystrobin results in increased expression of CYP1A1 protein
[cyproconazole co-treated with azoxystrobin] results in increased expression of CYP1A1 mRNA
CTD PMID:21784029 PMID:29294346 PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO azoxystrobin results in increased expression of CYP1A2 mRNA; azoxystrobin results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [cyproconazole co-treated with azoxystrobin] results in increased expression of CYP2B6 protein
azoxystrobin results in increased expression of CYP2B6 protein
CTD PMID:29294346 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO azoxystrobin results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO azoxystrobin results in decreased expression of CYP7A1 mRNA; azoxystrobin results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of FASN mRNA CTD PMID:24726979 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO azoxystrobin results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Lep leptin multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO azoxystrobin results in increased expression of MDM2 protein CTD PMID:32339800 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 decreases expression ISO azoxystrobin results in decreased expression of ATP6 protein CTD PMID:32339800 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO azoxystrobin results in decreased expression of CYTB protein CTD PMID:32339800 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO azoxystrobin binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Rorc RAR-related orphan receptor C increases activity ISO azoxystrobin results in increased activity of RORC protein CTD PMID:20143881 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of SREBF1 mRNA CTD PMID:24726979 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the phosphorylation of TBC1D4 protein CTD PMID:24726979 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Acetylcysteine inhibits the reaction [azoxystrobin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; azoxystrobin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:33226166 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19781
    role 19726
      biological role 19726
        xenobiotic 18398
          azoxystrobin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic ester 15517
                                        alpha,beta-unsaturated carboxylic ester 932
                                          enoate ester 932
                                            methoxyacrylate strobilurin antifungal agent 28
                                              azoxystrobin 19
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