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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(aminooxy)acetic acid
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Accession:CHEBI:40823 term browser browse the term
Definition:A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.
Synonyms:related_synonym: (O-carboxymethyl)hydroxylamine;   (carboxymethoxy)amine;   2-(aminooxy)acetic acid;   2-aminooxyethanoic acid;   AOA;   AOAA;   Formula=C2H5NO3;   InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5);   InChIKey=NQRKYASMKDDGHT-UHFFFAOYSA-N;   SMILES=NOCC(O)=O;   U-7524;   aminooxyacetic acid;   carboxymethoxyamine
 xref: CAS:645-88-5;   Chemspider:280;   DrugBank:DB02079
 xref_mesh: MESH:D000625
 xref: MetaCyc:CARBOXYMETHOXYLAMINE;   PDBeChem:AOA;   PMID:12234190;   PMID:12899834;   PMID:15480681;   PMID:15791207;   PMID:18687801;   PMID:20208150;   PMID:22128428;   PMID:25462081;   PMID:27157912;   PMID:27257787;   PMID:27639598;   PMID:28533892;   PMID:30127117;   PMID:31032581;   PMID:31410589;   PMID:31912705;   PMID:31930778;   PMID:32072910;   PMID:32194794;   PMID:3251251;   PMID:8930249;   Reaxys:878238;   Wikipedia:Aminooxyacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:157642



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(aminooxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases activity EXP Aminooxyacetic Acid results in decreased activity of ABAT protein CTD PMID:3933514 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein CTD PMID:25321483 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP Aminooxyacetic Acid inhibits the reaction [S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased activity of DLD protein]; Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein] CTD PMID:2360207 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of G6PC1 mRNA CTD PMID:31974165 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gad2 glutamate decarboxylase 2 decreases activity EXP Aminooxyacetic Acid results in decreased activity of GAD2 protein CTD PMID:12634427 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]; dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]] CTD PMID:26639393 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of GPD2 mRNA; [GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10199125 PMID:10464266 PMID:31974165 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Aminooxyacetic Acid inhibits the reaction [N-acetyl-S-pentachloro-1,3-butadienylcysteine results in decreased activity of GSR protein] CTD PMID:2360207 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of MLXIPL mRNA alternative form CTD PMID:31974165 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form CTD PMID:25321483 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc6a12 solute carrier family 6 member 12 decreases activity EXP Aminooxyacetic Acid results in decreased activity of SLC6A12 protein CTD PMID:12634427 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            nootropic agent 95
              (aminooxy)acetic acid 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          (aminooxy)acetic acid 11
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