Term: | anthramycin |
|
Accession: | CHEBI:40699
|
browse the term
|
Definition: | A member of the class of pyrrolobenzodiazepines that is (11aS)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted at positions 2, 5, 8, 9 and 11R by a (1E)-3-amino-3-oxoprop-1-en-1-yl, oxo, methyl, hydroxy and hydroxy groups, respectively. It is a natural product isolated from Streptomyces refuineus subsp. thermotolerans. |
Synonyms: | exact_synonym: | (2E)-3-[(11R,11aS)-9,11-dihydroxy-8-methyl-5-oxo-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl]prop-2-enamide |
| related_synonym: | Formula=C16H17N3O4; InChI=1S/C16H17N3O4/c1-8-2-4-10-13(14(8)21)18-15(22)11-6-9(3-5-12(17)20)7-19(11)16(10)23/h2-5,7,11,15,18,21-22H,6H2,1H3,(H2,17,20)/b5-3+/t11-,15+/m0/s1; InChIKey=VGQOVCHZGQWAOI-YQRHFANHSA-N; Ro 5-9000; SMILES=[H][C@@]12CC(\\C=C\\C(N)=O)=CN1C(=O)C1=C(N[C@@H]2O)C(O)=C(C)C=C1; antramicina; antramycin; antramycine; antramycinum |
| xref: | CAS:4803-27-4; KEGG:D02952; MetaCyc:CPD-18441; PDBeChem:ANT; PMID:15599; PMID:1695729; PMID:17134232; PMID:17584616; PMID:18512205; PMID:21919439; PMID:2342065; PMID:2620069; PMID:2720404; PMID:27862776; PMID:28373034; PMID:3210245; PMID:354779; PMID:3973905; PMID:5647054; PMID:582801; PMID:6736032; PMID:6928034; PMID:7672363; PMID:7947769; PMID:8343501; PMID:8357813; Wikipedia:Anthramycin |
|
|