aminoguanidine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	aminoguanidine	go back to main search page
Accession:	CHEBI:40618	browse the term
Definition:	A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Synonyms:	related_synonym:	2-aminoguanidine; 2-azanylguanidine; AG; Formula=CH6N4; Guanyl hydrazine; Imino semicarbazide; InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5); InChIKey=HAMNKKUPIHEESI-UHFFFAOYSA-N; Monoaminoguanidine; SMILES=NNC(N)=N; hydrazinecarboximidamide; pimagedine
	alt_id:	CHEBI:475161
	xref:	Beilstein:741921; CAS:79-17-4; DrugBank:DB02533
	xref_mesh:	MESH:C004479
	xref:	PDBeChem:AGU; PMID:10848923; PMID:11328740; PMID:11812359

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Genes (72)

aminoguanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

advanced glycosylation end product-specific receptor

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]

PMID:26723916 PMID:29148590

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

allograft inflammatory factor 1

multiple interactions

pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

albumin

multiple interactions

pimagedine inhibits the reaction [[Fructose co-treated with Glucose] results in increased glycation of ALB protein]; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]

PMID:12196478 PMID:22287321 PMID:36933777

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

amine oxidase, copper-containing 1

multiple interactions
decreases activity

pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine results in decreased activity of AOC1 protein
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]

PMID:6218830 PMID:8144586

NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122

G

amyloid beta precursor protein

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

ATPase, Ca++ transporting, plasma membrane 1

decreases expression

pimagedine results in decreased expression of ATP2B1 mRNA

NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005

G

beta-site APP cleaving enzyme 1

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated X protein

decreases expression

pimagedine results in decreased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein

PMID:16980304 PMID:17135264 PMID:17786558

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

calcitonin/calcitonin-related polypeptide, alpha

multiple interactions

pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]

NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592

G

caspase 3

multiple interactions

pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]

PMID:15545282 PMID:33930484

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein]

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 9

multiple interactions

pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]

PMID:17786558 PMID:19556603 PMID:33930484

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions
decreases expression

[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein

PMID:12123627 PMID:19107871 PMID:19266598 PMID:19481068 PMID:22287321

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

decreases expression

pimagedine results in decreased expression of CAV1 protein

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

CD34 antigen

decreases expression

pimagedine results in decreased expression of CD34 protein

NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587

G

cystic fibrosis transmembrane conductance regulator

multiple interactions

pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein]

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

collagen, type I, alpha 1

increases expression

pimagedine results in increased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

cAMP responsive element binding protein 1

decreases phosphorylation

pimagedine results in decreased phosphorylation of CREB1 protein

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

C-X-C motif chemokine receptor 2

multiple interactions

[pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

cytochrome b-245, alpha polypeptide

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome P450, family 2, subfamily b, polypeptide 10

multiple interactions

pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

endothelin 1

multiple interactions

pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

endothelin receptor type A

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]

NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093

G

Fc receptor, IgE, low affinity II, alpha polypeptide

multiple interactions

pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]

NCBI chr 8:3,730,280...3,744,174
Ensembl chr 8:3,731,737...3,744,175

G

flavin containing monooxygenase 1

multiple interactions

pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein]

NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179

G

glutamate-cysteine ligase, modifier subunit

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA]

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glial fibrillary acidic protein

multiple interactions

[7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein]

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

glyoxalase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]

PMID:26723916 PMID:28919305 PMID:29148590 PMID:33930484

NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845

G

glutamic pyruvic transaminase, soluble

multiple interactions

pimagedine inhibits the reaction [sodium arsenite results in increased expression of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione S-transferase, alpha 3

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA]

NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885

G

glutathione S-transferase, mu 1

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA]

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

hypoxia inducible factor 1, alpha subunit

multiple interactions

pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]

PMID:29148590 PMID:33930484

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interferon gamma

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]

PMID:7689037 PMID:11498278 PMID:12612912 PMID:12892526 PMID:12911628 More...

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 1 beta

multiple interactions

pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]

PMID:9698594 PMID:11500085 PMID:12123627 PMID:25406100 PMID:28223158 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]

PMID:25042521 PMID:26723916 PMID:28223158 PMID:29148590

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

mitogen-activated protein kinase 1

multiple interactions

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

antigen identified by monoclonal antibody Ki 67

decreases expression

pimagedine results in decreased expression of MKI67 mRNA

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

matrix metallopeptidase 13

increases expression

pimagedine results in increased expression of MMP13 mRNA

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

matrix metallopeptidase 14 (membrane-inserted)

increases expression

pimagedine results in increased expression of MMP14 mRNA

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 9

multiple interactions

pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

multiple interactions

pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein]

PMID:11713966 PMID:18209962

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

cytochrome c oxidase I, mitochondrial

affects activity
affects expression

pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA

NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 1, neuronal

affects expression

pimagedine affects the expression of NOS1 mRNA

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

multiple interactions
decreases activity
decreases expression
affects expression

[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]
pimagedine results in decreased expression of NOS2 protein
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein

PMID:9306416 PMID:9810145 PMID:9853001 PMID:11574821 PMID:12054156 More...

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

affects expression
multiple interactions

pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein]

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

plasminogen activator, tissue

multiple interactions

pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

multiple interactions

[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein

PMID:26723916 PMID:28919305

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

presenilin 1

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]

NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973

G

presenilin 2

multiple interactions

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]

NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003

G

prostaglandin-endoperoxide synthase 2

multiple interactions

pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein

PMID:15067210 PMID:17637181 PMID:29935243

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

S100 protein, beta polypeptide, neural

multiple interactions

pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions
increases expression

pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA

PMID:10856522 PMID:18380797

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

sirtuin 1

multiple interactions

[pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

superoxide dismutase 1, soluble

decreases expression
multiple interactions

pimagedine results in decreased expression of SOD1 protein
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]

PMID:19266598 PMID:33930484

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions
decreases expression

pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein

PMID:18483403 PMID:19266598

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

signal transducer and activator of transcription 1

multiple interactions

pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

transforming growth factor, beta 1

increases expression
multiple interactions

pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]

PMID:18380797 PMID:25406100

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tyrosine hydroxylase

multiple interactions

pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

tissue inhibitor of metalloproteinase 1

increases expression

pimagedine results in increased expression of TIMP1 mRNA

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions

pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]

PMID:12123627 PMID:12612912 PMID:22287321 PMID:25042521 PMID:25406100 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 1a

multiple interactions

TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

multiple interactions

pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA]

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP glucuronosyltransferase 2 family, polypeptide B34

multiple interactions

pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
chemical entity	22208
atom	22170
nonmetal atom	22055
carbon atom	21859
organic molecular entity	21830
one-carbon compound	18569
aminoguanidine	72
mitoguazone	0
Path 2
Term	Annotations
CHEBI ontology	22178
subatomic particle	22170
composite particle	22170
hadron	22201
baryon	22170
nucleon	22170
atomic nucleus	22170
atom	22170
main group element atom	22104
p-block element atom	22104
p-block molecular entity	22104
carbon group molecular entity	21904
organic molecular entity	21830
heteroorganic entity	21482
organonitrogen compound	19809
guanidines	2327
aminoguanidine	72
mitoguazone	0

paths to the root