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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminoguanidine
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Accession:CHEBI:40618 term browser browse the term
Definition:A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Synonyms:related_synonym: 2-aminoguanidine;   2-azanylguanidine;   AG;   Formula=CH6N4;   Guanyl hydrazine;   Imino semicarbazide;   InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5);   InChIKey=HAMNKKUPIHEESI-UHFFFAOYSA-N;   Monoaminoguanidine;   SMILES=NNC(N)=N;   hydrazinecarboximidamide;   pimagedine
 alt_id: CHEBI:475161
 xref: Beilstein:741921;   CAS:79-17-4;   DrugBank:DB02533
 xref_mesh: MESH:C004479
 xref: PDBeChem:AGU;   PMID:10848923;   PMID:11328740;   PMID:11812359


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aminoguanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein] CTD PMID:12161173 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein] CTD PMID:26723916 PMID:29148590 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Alb albumin multiple interactions ISO
EXP
pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]
CTD PMID:12196478 PMID:22287321 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
decreases activity
ISO
EXP
pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine results in decreased activity of AOC1 protein
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]
CTD PMID:6218830 PMID:8144586 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression EXP pimagedine results in decreased expression of ATP2B1 mRNA CTD PMID:15003327 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA] CTD PMID:28242320 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO pimagedine results in decreased expression of BAX protein CTD PMID:19266598 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein
CTD PMID:16980304 PMID:17135264 PMID:17786558 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:14729435 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions EXP pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein] CTD PMID:15545282 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]
CTD PMID:17786558 PMID:19556603 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP
ISO
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein
CTD PMID:12123627 PMID:19107871 PMID:19266598 PMID:19481068 PMID:22287321 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 decreases expression ISO pimagedine results in decreased expression of CAV1 protein CTD PMID:19706615 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cd34 CD34 molecule decreases expression ISO pimagedine results in decreased expression of CD34 protein CTD PMID:19266598 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein] CTD PMID:19061877 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP pimagedine results in increased expression of COL1A1 mRNA CTD PMID:18380797 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO pimagedine results in decreased phosphorylation of CREB1 protein CTD PMID:17135264 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein CTD PMID:17138957 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] CTD PMID:18594475 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA] CTD PMID:9853001 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] CTD PMID:18594475 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Fcer2 Fc fragment of IgE receptor II multiple interactions ISO pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein] CTD PMID:11500085 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions EXP pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein] CTD PMID:10462538 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA] CTD PMID:12763045 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP [7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein] CTD PMID:20826152 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO
EXP
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:26723916 PMID:28919305 PMID:29148590 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA] CTD PMID:12763045 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA] CTD PMID:12763045 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA] CTD PMID:12763045 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein] CTD PMID:25406100 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein] CTD PMID:29148590 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
CTD PMID:7689037 PMID:11498278 PMID:12612912 PMID:12892526 PMID:12911628 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]
CTD PMID:9698594 PMID:11500085 PMID:12123627 PMID:25406100 PMID:28223158 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]
CTD PMID:25042521 PMID:26723916 PMID:28223158 PMID:29148590 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:12473873 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:12473873 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO pimagedine results in decreased expression of MKI67 mRNA CTD PMID:19266598 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP pimagedine results in increased expression of MMP13 mRNA CTD PMID:18380797 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp14 matrix metallopeptidase 14 increases expression EXP pimagedine results in increased expression of MMP14 mRNA CTD PMID:18380797 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA] CTD PMID:18594475 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11713966 PMID:18209962 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I affects activity
affects expression
EXP pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA
CTD PMID:17936468 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP pimagedine affects the expression of NOS1 mRNA CTD PMID:22777123 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
affects expression
decreases activity
multiple interactions
ISO
EXP
pimagedine results in decreased expression of NOS2 protein
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
pimagedine results in decreased activity of NOS2 protein
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]
CTD PMID:9306416 PMID:9810145 PMID:9853001 PMID:11574821 PMID:12054156 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression
multiple interactions
ISO pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]
CTD PMID:18483403 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein] CTD PMID:12763045 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] CTD PMID:10856522 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD PMID:26723916 PMID:28919305 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA] CTD PMID:28242320 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA] CTD PMID:28242320 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein CTD PMID:15067210 PMID:17637181 PMID:29935243 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein] CTD PMID:29935243 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein] CTD PMID:19494442 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO
EXP
pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA
CTD PMID:10856522 PMID:18380797 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO pimagedine results in decreased expression of SOD1 protein CTD PMID:19266598 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
ISO pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein
CTD PMID:18483403 PMID:19266598 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein] CTD PMID:19061877 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP
ISO
pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]
CTD PMID:18380797 PMID:25406100 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP pimagedine results in increased expression of TIMP1 mRNA CTD PMID:18380797 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:12123627 PMID:12612912 PMID:22287321 PMID:25042521 PMID:25406100 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]] CTD PMID:14550746 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO pimagedine inhibits the reaction [Spermidine results in increased expression of UGT1A6 mRNA] CTD PMID:12763045 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid] CTD PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          carbon atom 19630
            organic molecular entity 19630
              one-carbon compound 17665
                aminoguanidine 69
                  mitoguazone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      p-block molecular entity 19716
                        carbon group molecular entity 19640
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organonitrogen compound 18538
                                guanidines 2213
                                  aminoguanidine 69
                                    mitoguazone 0
paths to the root