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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyhalothrin
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Accession:CHEBI:4035 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Synonyms:exact_synonym: cyano(3-phenoxyphenyl)methyl 3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate
 related_synonym: 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester;   Formula=C23H19ClF3NO3;   InChI=1S/C23H19ClF3NO3/c1-22(2)17(12-19(24)23(25,26)27)20(22)21(29)31-18(13-28)14-7-6-10-16(11-14)30-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/b19-12-;   InChIKey=ZXQYGBMAQZUVMI-UNOMPAQXSA-N;   SMILES=CC1(C)C(\\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1
 xref: CAS:68085-85-8;   KEGG:C10983;   KEGG:D07762
 xref_mesh: MESH:C037304
 xref: Patent:DE2802962;   Patent:US4183948


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cyhalothrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression EXP cyhalothrin results in increased expression of ADH4 mRNA CTD PMID:29727961 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) increases expression EXP cyhalothrin results in increased expression of ADH6 mRNA CTD PMID:29727961 NCBI chr 2:243,656,568...243,687,857
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity ISO cyhalothrin results in increased activity of AKT1 CTD PMID:26969072 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP cyhalothrin results in increased expression of ALDH1A1 mRNA CTD PMID:29727961 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP cyhalothrin results in decreased expression of ALDH1B1 mRNA CTD PMID:29727961 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 increases expression EXP cyhalothrin results in increased expression of ALDH3B1 mRNA CTD PMID:29727961 NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860
JBrowse link
G Ar androgen receptor decreases activity
multiple interactions
ISO cyhalothrin results in decreased activity of AR protein
cyhalothrin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:20410157, PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP cyhalothrin results in increased expression of BAX mRNA CTD PMID:29727961 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
multiple interactions
EXP cyhalothrin results in decreased expression of CAMK2A protein
cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]
CTD PMID:28385489, PMID:28487251 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Casp3 caspase 3 increases expression EXP cyhalothrin results in increased expression of CASP3 mRNA CTD PMID:29727961 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP thymoquinone inhibits the reaction [cyhalothrin results in decreased activity of CAT protein] CTD PMID:26645134, PMID:27348886, PMID:28058584 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP cyhalothrin results in increased expression of CCL2 protein CTD PMID:27348886 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 affects expression
multiple interactions
ISO cyhalothrin affects the expression of CCND1 mRNA
fulvestrant inhibits the reaction [cyhalothrin affects the expression of CCND1 mRNA]
CTD PMID:26877835 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression EXP cyhalothrin results in increased expression of CDK5 protein CTD PMID:28487251 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases metabolic processing
ISO CES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein]
CES1 protein results in increased metabolism of cyhalothrin
CTD PMID:19249324 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
decreases expression
EXP cyhalothrin results in decreased phosphorylation of CREB1 protein
cyhalothrin results in decreased expression of CREB1 protein modified form
CTD PMID:28487251, PMID:28495607 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
EXP cyhalothrin results in increased expression of CYP1A1 mRNA
cyhalothrin results in increased activity of CYP1A1 protein
CTD PMID:29727961 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
ISO
EXP
cyhalothrin results in increased activity of CYP1A2 protein
cyhalothrin results in increased expression of CYP1A2 mRNA
CTD PMID:22310298, PMID:29727961 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP cyhalothrin results in decreased expression of CYP26B1 mRNA CTD PMID:29727961 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity
increases expression
EXP cyhalothrin results in increased activity of CYP2A1 protein
cyhalothrin results in increased expression of CYP2A1 mRNA
CTD PMID:29727961 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity
increases expression
EXP cyhalothrin results in increased activity of CYP2B1 protein
cyhalothrin results in increased expression of CYP2B1 mRNA
CTD PMID:29727961 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP cyhalothrin results in increased expression of CYP2B2 mRNA CTD PMID:29727961 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
decreases activity
multiple interactions
increases expression
ISO cyhalothrin results in increased activity of CYP2B6 protein
cyhalothrin results in decreased activity of CYP2B6 protein
cyhalothrin inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
cyhalothrin results in increased expression of CYP2B6 mRNA
CTD PMID:22310298, PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP cyhalothrin results in decreased expression of CYP2C22 mRNA CTD PMID:29727961 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
increases expression
ISO
EXP
cyhalothrin results in decreased activity of CYP2D6 protein
cyhalothrin results in increased expression of CYP2D4 mRNA
CTD PMID:20183062, PMID:29727961 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP cyhalothrin results in increased expression of CYP2E1 mRNA CTD PMID:29727961 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 decreases expression EXP cyhalothrin results in decreased expression of CYP2T1 mRNA CTD PMID:29727961 NCBI chr 1:83,965,370...83,969,466
Ensembl chr 1:83,965,608...83,969,559
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP cyhalothrin results in increased expression of CYP3A18 mRNA CTD PMID:29727961 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP cyhalothrin results in increased expression of CYP3A2 mRNA CTD PMID:29727961 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP cyhalothrin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:29727961 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP cyhalothrin results in increased expression of CYP4A1 mRNA CTD PMID:29727961 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions
decreases expression
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of DLG4]; cyhalothrin inhibits the reaction [Estradiol results in increased expression of DLG4 protein]; fulvestrant inhibits the reaction [cyhalothrin results in increased expression of DLG4 protein]
cyhalothrin results in decreased expression of DLG4 protein
CTD PMID:26969072, PMID:28487251 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP cyhalothrin results in decreased expression of DRD2 mRNA; cyhalothrin results in decreased expression of DRD2 protein CTD PMID:22366556, PMID:28495607 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases activity ISO cyhalothrin results in increased activity of EIF4EBP1 CTD PMID:26969072 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 increases expression EXP cyhalothrin results in increased expression of ENTPD1 mRNA CTD PMID:31421116 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 increases expression EXP cyhalothrin results in increased expression of ENTPD2 mRNA CTD PMID:31421116 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression EXP cyhalothrin results in increased expression of ENTPD3 mRNA CTD PMID:31421116 NCBI chr 8:129,201,000...129,232,436
Ensembl chr 8:129,201,669...129,232,677
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO cyhalothrin binds to ERBB2 protein CTD PMID:32278787 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
multiple interactions
decreases expression
EXP
ISO
cyhalothrin results in increased activity of ESR1 protein
cyhalothrin results in increased expression of ESR1
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of ESR1]; fulvestrant inhibits the reaction [cyhalothrin results in increased expression of ESR1]
cyhalothrin results in decreased expression of ESR1 mRNA; cyhalothrin results in decreased expression of ESR1 protein
CTD PMID:18419197, PMID:20097460, PMID:20410157, PMID:26969072 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO cyhalothrin results in decreased expression of ESR2 mRNA; cyhalothrin results in decreased expression of ESR2 protein CTD PMID:18419197 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fasn fatty acid synthase increases expression EXP cyhalothrin results in increased expression of FASN mRNA; cyhalothrin results in increased expression of FASN protein CTD PMID:27348886 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects binding ISO cyhalothrin binds to FGFR2 protein CTD PMID:32278787 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression EXP cyhalothrin results in increased expression of FMO5 mRNA CTD PMID:29727961 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP cyhalothrin promotes the reaction [NGF protein results in increased expression of GAP43 mRNA] CTD PMID:28385489 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP cyhalothrin results in increased activity of GPT protein CTD PMID:28058584 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP cyhalothrin results in decreased expression of GRIN1 mRNA; cyhalothrin results in decreased expression of GRIN1 protein CTD PMID:28487251 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP cyhalothrin results in decreased expression of GRIN2B mRNA; cyhalothrin results in decreased expression of GRIN2B protein CTD PMID:28487251 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP cyhalothrin results in increased activity of GSR protein CTD PMID:29727961 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP cyhalothrin results in increased expression of HPRT1 mRNA CTD PMID:29727961 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression EXP cyhalothrin results in increased expression of HTR2A protein CTD PMID:22366556 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
EXP cyhalothrin results in increased expression of IFNG mRNA; cyhalothrin results in increased expression of IFNG protein
thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG protein]
CTD PMID:26645134 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
EXP thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 protein]
cyhalothrin results in decreased expression of IL10 mRNA; cyhalothrin results in decreased expression of IL10 protein
CTD PMID:26645134 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B protein]
cyhalothrin results in increased expression of IL1B mRNA; cyhalothrin results in increased expression of IL1B protein
CTD PMID:26645134, PMID:28058584 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 protein]
cyhalothrin results in decreased expression of IL4 mRNA; cyhalothrin results in decreased expression of IL4 protein
CTD PMID:26645134 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 protein]
cyhalothrin results in increased expression of IL6 mRNA; cyhalothrin results in increased expression of IL6 protein
CTD PMID:26645134, PMID:28058584 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lep leptin increases expression EXP cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression EXP cyhalothrin results in decreased expression of MAPK1 protein modified form CTD PMID:28487251 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression EXP cyhalothrin results in decreased expression of MAPK3 protein modified form CTD PMID:28487251 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO cyhalothrin binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ngf nerve growth factor multiple interactions EXP cyhalothrin promotes the reaction [NGF protein results in decreased expression of TUBA3A mRNA]; cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]; cyhalothrin promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; cyhalothrin promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO cyhalothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO
EXP
cyhalothrin results in increased activity of NR1I2 protein; cyhalothrin results in increased activity of NR1I2 protein polymorphism
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; CES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein]; cyhalothrin binds to and results in increased activity of NR1I2 protein
CTD PMID:19249324, PMID:21115097, PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO cyhalothrin inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pgr progesterone receptor increases expression
affects binding
ISO cyhalothrin results in increased expression of PGR mRNA
cyhalothrin binds to PGR protein
CTD PMID:18419197, PMID:32278787 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma affects binding ISO cyhalothrin binds to PIK3CG protein CTD PMID:32278787 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP cyhalothrin results in increased expression of PPARA mRNA CTD PMID:27348886 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP cyhalothrin results in increased expression of PPARG mRNA CTD PMID:27348886 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases expression EXP cyhalothrin results in increased expression of PPP1CA protein CTD PMID:28495607 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases expression EXP cyhalothrin results in decreased expression of PPP1R1B protein CTD PMID:28495607 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
EXP cyhalothrin results in increased expression of RELA mRNA
thymoquinone inhibits the reaction [cyhalothrin results in increased expression of RELA mRNA]
CTD PMID:26645134 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO cyhalothrin binds to RORA protein CTD PMID:32278787 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rorc RAR-related orphan receptor C affects binding ISO cyhalothrin binds to RORC protein CTD PMID:32278787 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression EXP cyhalothrin results in increased expression of RPLP1 mRNA CTD PMID:29727961 NCBI chr 8:66,862,143...66,863,476
Ensembl chr 8:66,862,143...66,863,476
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions
affects activity
EXP cyhalothrin affects the reaction [SCN10A protein results in increased transport of Sodium]
cyhalothrin affects the activity of SCN10A protein
CTD PMID:16051293, PMID:19766671 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression EXP cyhalothrin results in decreased expression of SLC18A2 protein CTD PMID:28495607 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression EXP cyhalothrin results in decreased expression of SLC6A3 protein CTD PMID:28495607 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Sod2 superoxide dismutase 2 increases activity EXP cyhalothrin results in increased activity of SOD2 protein CTD PMID:29727961 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects binding ISO cyhalothrin binds to SRC protein CTD PMID:32278787 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP cyhalothrin results in increased expression of SREBF1 mRNA CTD PMID:27348886 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 increases expression EXP cyhalothrin results in increased expression of SYNGAP1 protein CTD PMID:28487251 NCBI chr20:5,535,434...5,564,657
Ensembl chr20:5,535,432...5,564,437
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO cyhalothrin results in increased expression of TFF1 mRNA CTD PMID:18419197, PMID:20097460 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP cyhalothrin results in decreased expression of TH protein CTD PMID:22366556, PMID:28495607 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO cyhalothrin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein] CTD PMID:28531659 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF protein]
cyhalothrin results in increased expression of TNF mRNA; cyhalothrin results in increased expression of TNF protein
CTD PMID:26645134, PMID:27348886, PMID:28058584 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO cyhalothrin results in increased expression of TRP53 mRNA CTD PMID:20097460 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO cyhalothrin inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:26647222 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP cyhalothrin promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Xdh xanthine dehydrogenase decreases expression EXP cyhalothrin results in decreased expression of XDH mRNA CTD PMID:29727961 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        agrochemical 14436
          cyhalothrin 90
            gamma-cyhalothrin + 0
            lambda-cyhalothrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          cyclopropanecarboxylic acid 738
                                            3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid 90
                                              cyhalothrin 90
                                                gamma-cyhalothrin + 0
                                                lambda-cyhalothrin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.